{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T16:53:05Z","timestamp":1772643185758,"version":"3.50.1"},"reference-count":113,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","award":["72536"],"award-info":[{"award-number":["72536"]}],"id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The role of gut and vaginal microbiota has been examined as potential markers in the progression of cervical cancer and inspired heightened attention. We attempted to identify the current status, the influence of changing trends in the gut and vaginal microbiota, and their impact on cervical cancer. All publications were searched in online databases such as PubMed, Scopus, Medline, and Google Scholar using the keywords \u201ccervical cancer,\u201d \u201cvaginal microbiota,\u201d \u201cgut microbiota,\u201d \u201cdysbiosis,\u201d \u201ccervical intraepithelial neoplasia,\u201d and \u201cHPV.\u201d Growing evidence that gut microbiota dysbiosis is involved in many diseases has attracted many researchers. The vaginal microbiome is a micro-ecosystem complex that undergoes continuous fluctuations throughout a woman\u2019s life. Decrease in Lactobacilli spp. Levels can lead to an overgrowth of anaerobic bacteria, resulting in bacterial vaginosis that accounts for adverse health outcomes, including increased susceptibility to sexually transmitted infections, including human papillomavirus, and cervical intraepithelial neoplasia, leading to cervical cancer. Thus, dysbiosis, characterized by an imbalance of beneficial and harmful bacteria, can negatively affect health. Understanding the intricate interactions between the microbiota and cervical cancer can provide valuable insights into potential therapeutic strategies and the development of preventive measures.<\/jats:p>","DOI":"10.1093\/lambio\/ovaf088","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T12:02:12Z","timestamp":1751630532000},"source":"Crossref","is-referenced-by-count":5,"title":["Cervical cancer pathology and vaginal and gut microbiota: conception of the association"],"prefix":"10.1093","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5806-7214","authenticated-orcid":false,"given":"Samaneh","family":"Mazinani","sequence":"first","affiliation":[{"name":"Research Center of Infectious and Tropical Diseases, Faculty of Medicine, Tabriz University of Medical Sciences , Tabriz, 51666\/15731 ,","place":["Iran"]},{"name":"Faculty of Medicine, Tabriz University of Medical Sciences Department of Bacteriology and Virology, , Tabriz, 51666\/15731 ,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5273-110X","authenticated-orcid":false,"given":"Mohammad","family":"Aghazadeh","sequence":"additional","affiliation":[{"name":"Research Center of Infectious and Tropical Diseases, Faculty of Medicine, Tabriz University of Medical Sciences , Tabriz, 51666\/15731 ,","place":["Iran"]},{"name":"Faculty of Medicine, Tabriz University of Medical Sciences Department of Bacteriology and Virology, , Tabriz, 51666\/15731 ,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9273-0953","authenticated-orcid":false,"given":"Vahdat","family":"Poortahmasebi","sequence":"additional","affiliation":[{"name":"Research Center of Infectious and Tropical Diseases, Faculty of Medicine, Tabriz University of Medical Sciences , Tabriz, 51666\/15731 ,","place":["Iran"]},{"name":"Faculty of Medicine, Tabriz University of Medical Sciences Department of Bacteriology and Virology, , Tabriz, 51666\/15731 ,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1176-8472","authenticated-orcid":false,"given":"Vahid","family":"Arafi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tabriz University of Medical Sciences Department of Bacteriology and Virology, , Tabriz, 51666\/15731 ,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6648-0893","authenticated-orcid":false,"given":"Alka","family":"Hasani","sequence":"additional","affiliation":[{"name":"Research Center of Infectious and Tropical Diseases, Faculty of Medicine, Tabriz University of Medical Sciences , Tabriz, 51666\/15731 ,","place":["Iran"]},{"name":"Faculty of Medicine, Tabriz University of Medical Sciences Department of Bacteriology and Virology, , Tabriz, 51666\/15731 ,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"2025070408020856800_bib1","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s00018-018-2943-4","article-title":"An insight into gut microbiota and its functionalities","volume":"76","author":"Adak","year":"2019","journal-title":"Cell Mol Life Sci"},{"key":"2025070408020856800_bib2","doi-asserted-by":"publisher","first-page":"100010","DOI":"10.1016\/j.hsr.2021.100010","article-title":"The role of gut microbiome in cancer genesis and cancer prevention","volume":"2","author":"Akbar","year":"2022","journal-title":"Health Sciences Review"},{"key":"2025070408020856800_bib3","doi-asserted-by":"publisher","first-page":"1178223420976388","DOI":"10.1177\/1178223420976388","article-title":"Human mammary tumor virus, human papilloma virus, and Epstein\u2013Barr virus infection are associated with sporadic breast cancer metastasis","volume":"14","author":"Al\u00a0Hamad","year":"2020","journal-title":"Breast Cancer (Auckl)"},{"key":"2025070408020856800_bib4","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1038\/s41598-020-80834-9","article-title":"Knowledge and awareness about human papillomavirus infection and its vaccination among women in Arab communities","volume":"11","author":"Alsous","year":"2021","journal-title":"Sci Rep"},{"key":"2025070408020856800_bib5","doi-asserted-by":"publisher","first-page":"2675","DOI":"10.1093\/annonc\/mdr015","article-title":"Worldwide burden of cervical cancer in 2008","volume":"22","author":"Arbyn","year":"2011","journal-title":"Ann Oncol"},{"key":"2025070408020856800_bib6","doi-asserted-by":"publisher","first-page":"686167","DOI":"10.3389\/fcimb.2021.686167","article-title":"The vaginal microbiome: a long urogenital colonization throughout woman life","volume":"11","author":"Auriemma","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"2025070408020856800_bib7","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/j.arcmed.2017.11.008","article-title":"On the search to elucidate the role of microbiota in the genesis of cancer: the cases of gastrointestinal and cervical cancer","volume":"48","author":"Avil\u00e9s-Jim\u00e9nez","year":"2017","journal-title":"Arch Med Res"},{"key":"2025070408020856800_bib8","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00281-014-0456-2","article-title":"Toward the comprehensive understanding of the gut ecosystem via metabolomics-based integrated omics approach","volume":"37","author":"Aw","year":"2015","journal-title":"Semin Immunopathol"},{"key":"2025070408020856800_bib9","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.ajog.2018.10.014","article-title":"Diversity of vaginal microbiota in sub-Saharan Africa and its effects on HIV transmission and prevention","volume":"220","author":"Bayigga","year":"2019","journal-title":"Am J Obstet Gynecol"},{"key":"2025070408020856800_bib10","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.sxmr.2019.09.005","article-title":"Cervical cancer screening: past, present, and future","volume":"8","author":"Bedell","year":"2020","journal-title":"Sex Med Rev"},{"key":"2025070408020856800_bib11","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.bpobgyn.2020.02.008","article-title":"Primary HPV screening for cervical cancer","volume":"65","author":"Bhatla","year":"2020","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"2025070408020856800_bib12","doi-asserted-by":"publisher","first-page":"e1009876","DOI":"10.1371\/journal.pcbi.1009876","article-title":"Multi-omics data integration reveals metabolome as the top predictor of the cervicovaginal microenvironment","volume":"18","author":"Bokulich","year":"2022","journal-title":"PLoS Comput Biol"},{"key":"2025070408020856800_bib13","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1186\/s12889-019-7354-4","article-title":"Genital self-sampling for HPV-based cervical cancer screening: a qualitative study of preferences and barriers in rural Ethiopia","volume":"19","author":"Brandt","year":"2019","journal-title":"BMC Public Health"},{"key":"2025070408020856800_bib14","doi-asserted-by":"publisher","first-page":"100170","DOI":"10.1016\/j.pvr.2019.100170","article-title":"Towards the global elimination of cervical cancer","volume":"8","author":"Canfell","year":"2019","journal-title":"Papillomavirus Res"},{"key":"2025070408020856800_bib15","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1136\/gutjnl-2018-316723","article-title":"Human gut microbiome: hopes, threats and promises","volume":"67","author":"Cani","year":"2018","journal-title":"Gut"},{"key":"2025070408020856800_bib16","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.3390\/biology11081114","article-title":"Association between cervical microbiota and HPV: could this be the key to complete cervical cancer eradication?","volume":"11","author":"Cascardi","year":"2022","journal-title":"Biology"},{"key":"2025070408020856800_bib17","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1159\/000511477","article-title":"Microbiome and cervical cancer","volume":"88","author":"Castanheira","year":"2021","journal-title":"Pathobiology"},{"key":"2025070408020856800_bib18","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1017\/S0950268815002198","article-title":"Prophylactic HPV vaccination: past, present, and future","volume":"144","author":"Castle","year":"2016","journal-title":"Epidemiol Infect"},{"key":"2025070408020856800_bib19","doi-asserted-by":"publisher","first-page":"14095","DOI":"10.1038\/s41598-019-50410-x","article-title":"Diversity of vaginal microbiome and metabolome during genital infections","volume":"9","author":"Ceccarani","year":"2019","journal-title":"Sci Rep"},{"key":"2025070408020856800_bib20","doi-asserted-by":"publisher","first-page":"R81","DOI":"10.1530\/JME-21-0238","article-title":"Female reproductive dysfunctions and the gut microbiota","volume":"69","author":"Chadchan","year":"2022","journal-title":"J Mol Endocrinol"},{"key":"2025070408020856800_bib21","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1111\/1471-0528.14631","article-title":"The role of the vaginal microbiome in gynaecological cancer","volume":"125","author":"Champer","year":"2018","journal-title":"BJOG"},{"key":"2025070408020856800_bib22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/3257939","article-title":"Human papillomavirus infection and cervical cancer: epidemiology, screening, and vaccination\u2014review of current perspectives","volume":"2019","author":"Chan","year":"2019","journal-title":"J Oncol"},{"key":"2025070408020856800_bib23","doi-asserted-by":"publisher","first-page":"186","DOI":"10.3389\/fcimb.2023.1145950","article-title":"Characterization of fecal microbiota in cervical cancer patients associated with tumor stage and prognosis","volume":"13","author":"Chang","year":"2023","journal-title":"Front Cell Infect Microbiol"},{"key":"2025070408020856800_bib24","doi-asserted-by":"publisher","first-page":"631972","DOI":"10.3389\/fcimb.2021.631972","article-title":"The female vaginal microbiome in health and bacterial vaginosis","volume":"11","author":"Chen","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"2025070408020856800_bib25","doi-asserted-by":"publisher","first-page":"298","DOI":"10.3390\/pathogens12020298","article-title":"HPV and cervical cancer: a review of epidemiology and screening uptake in the UK","volume":"12","author":"Choi","year":"2023","journal-title":"Pathogens"},{"key":"2025070408020856800_bib26","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.2217\/fmb-2022-0112","article-title":"Vaginal microbiome: considerations for reproductive health","volume":"17","author":"Chopra","year":"2022","journal-title":"Future Microbiol"},{"key":"2025070408020856800_bib27","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/S0140-6736(18)32470-X","article-title":"Cervical cancer","volume":"393","author":"Cohen","year":"2019","journal-title":"The Lancet"},{"key":"2025070408020856800_bib28","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.bjid.2015.10.008","article-title":"Cervical human papillomavirus infection and persistence: a clinic-based study in the countryside from South Brazil","volume":"20","author":"Coser","year":"2016","journal-title":"Braz J Infect Dis"},{"key":"2025070408020856800_bib29","doi-asserted-by":"publisher","first-page":"222","DOI":"10.3390\/ijms21010222","article-title":"The role of the cervicovaginal microbiome on the genesis and as a biomarker of premalignant cervical intraepithelial neoplasia and invasive cervical cancer","volume":"21","author":"Curty","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2025070408020856800_bib30","doi-asserted-by":"publisher","first-page":"722639","DOI":"10.3389\/fonc.2021.722639","article-title":"Cervicovaginal microbiome factors in clearance of human papillomavirus infection","volume":"11","author":"Dai","year":"2021","journal-title":"Front Oncol"},{"key":"2025070408020856800_bib31","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.cca.2015.01.003","article-title":"The role of the gut microbiome in the healthy adult status","volume":"451","author":"D'Argenio","year":"2015","journal-title":"Clin Chim Acta"},{"key":"2025070408020856800_bib32","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1002\/jobm.202100421","article-title":"Insights into the role of vaginal microbiome in women's health","volume":"61","author":"Deka","year":"2021","journal-title":"J Basic Microbiol"},{"key":"2025070408020856800_bib33","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s13027-022-00465-9","article-title":"Lactobacillus crispatus M247 oral administration: is it really an effective strategy in the management of papillomavirus-infected women?","volume":"17","author":"Dellino","year":"2022","journal-title":"Infect Agent Cancer"},{"key":"2025070408020856800_bib34","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1097\/LGT.0000000000000645","article-title":"The vaginal microbiome: III. The vaginal microbiome in various urogenital disorders","volume":"26","author":"De\u00a0Seta","year":"2022","journal-title":"J Low Genit Tract Dis"},{"key":"2025070408020856800_bib35","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1136\/gutjnl-2021-326789","article-title":"Gut microbiome and health: mechanistic insights","volume":"71","author":"De\u00a0Vos","year":"2022","journal-title":"Gut"},{"key":"2025070408020856800_bib36","doi-asserted-by":"publisher","first-page":"10200","DOI":"10.1038\/s41598-017-09842-6","article-title":"Characterization of cervico-vaginal microbiota in women developing persistent high-risk human papillomavirus infection","volume":"7","author":"Di\u00a0Paola","year":"2017","journal-title":"Sci Rep"},{"key":"2025070408020856800_bib37","doi-asserted-by":"publisher","first-page":"7094","DOI":"10.3390\/ijerph19127094","article-title":"New advances in cervical cancer: from bench to bedside","volume":"19","author":"D'oria","year":"2022","journal-title":"Int J Environ Res Public Health"},{"key":"2025070408020856800_bib38","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.3390\/biology11121742","article-title":"Commensal intestinal protozoa\u2014underestimated members of the gut microbial community","volume":"11","author":"Dubik","year":"2022","journal-title":"Biology"},{"key":"2025070408020856800_bib39","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1084\/jem.20180448","article-title":"The gut microbiome: relationships with disease and opportunities for therapy","volume":"216","author":"Durack","year":"2019","journal-title":"J Exp Med"},{"key":"2025070408020856800_bib40","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.virusres.2016.12.017","article-title":"The low-risk papillomaviruses","volume":"231","author":"Egawa","year":"2017","journal-title":"Virus Res"},{"key":"2025070408020856800_bib41","doi-asserted-by":"publisher","first-page":"1059825","DOI":"10.3389\/fcimb.2022.1059825","article-title":"Gut and genital tract microbiomes: dysbiosis and link to gynecological disorders","volume":"12","author":"Elkafas","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"2025070408020856800_bib42","doi-asserted-by":"publisher","first-page":"355","DOI":"10.3389\/fonc.2019.00355","article-title":"Mucosal and cutaneous human papillomavirus infections and cancer biology","volume":"9","author":"Gheit","year":"2019","journal-title":"Front Oncol"},{"key":"2025070408020856800_bib43","doi-asserted-by":"publisher","first-page":"133","DOI":"10.3389\/fcimb.2019.00133","article-title":"The current evidence on the association between the urinary microbiome and urinary incontinence in women","volume":"9","author":"Govender","year":"2019","journal-title":"Front Cell Infect Microbiol"},{"key":"2025070408020856800_bib44","doi-asserted-by":"publisher","first-page":"326","DOI":"10.3389\/fpubh.2020.00326","article-title":"Diversity of vaginal microbiome in pregnancy: deciphering the obscurity","volume":"8","author":"Gupta","year":"2020","journal-title":"Frontiers in Public Health"},{"key":"2025070408020856800_bib45","doi-asserted-by":"publisher","first-page":"103696","DOI":"10.1016\/j.micpath.2019.103696","article-title":"Crosstalk between vaginal microbiome and female health: a review","volume":"136","author":"Gupta","year":"2019","journal-title":"Microb Pathog"},{"key":"2025070408020856800_bib46","doi-asserted-by":"publisher","first-page":"101902","DOI":"10.1016\/j.tranon.2024.101902","article-title":"Specific vaginal and gut microbiome and the anti-tumor effect of butyrate in cervical cancer women","volume":"44","author":"Han","year":"2024","journal-title":"Transl Oncol"},{"key":"2025070408020856800_bib47","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.tim.2017.11.002","article-title":"Human gut microbiome: function matters","volume":"26","author":"Heintz-Buschart","year":"2018","journal-title":"Trends Microbiol"},{"key":"2025070408020856800_bib48","doi-asserted-by":"publisher","first-page":"ftz048","DOI":"10.1093\/femspd\/ftz048","article-title":"Association of human papillomavirus infection and inflammation in cervical cancer","volume":"77","author":"Hemmat","year":"2019","journal-title":"Pathog Dis"},{"key":"2025070408020856800_bib49","doi-asserted-by":"publisher","first-page":"2058","DOI":"10.3892\/ol.2020.11754","article-title":"Cervical cancer in low and middle\u2013income countries","volume":"20","author":"Hull","year":"2020","journal-title":"Oncol Lett"},{"key":"2025070408020856800_bib50","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.ebiom.2019.04.028","article-title":"Deciphering the complex interplay between microbiota, HPV, inflammation and cancer through cervicovaginal metabolic profiling","volume":"44","author":"Ilhan","year":"2019","journal-title":"EBioMedicine"},{"key":"2025070408020856800_bib51","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/B978-0-323-91797-1.00010-7","article-title":"Chapter 5\u2013Cervicovaginal microbiota and HPV-induced cervical cancer","volume-title":"Immunopathology, Diagnosis and Treatment of HPV Induced Malignancies","author":"Jain","year":"2022"},{"key":"2025070408020856800_bib52","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1080\/08830185.2020.1811859","article-title":"Immunology of HPV-mediated cervical cancer: current understanding","volume":"40","author":"Jee","year":"2021","journal-title":"Int Rev Immunol"},{"key":"2025070408020856800_bib53","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/s13238-020-00748-0","article-title":"Gut microbiota alterations are distinct for primary colorectal cancer and hepatocellular carcinoma","volume":"12","author":"Jia","year":"2021","journal-title":"Protein Cell"},{"key":"2025070408020856800_bib54","first-page":"e00064","article-title":"Cervicovaginal DNA virome alterations are associated with genital inflammation and microbiota composition","volume":"7","author":"Kaelin\u00a0Emily","year":"2022","journal-title":"mSystems"},{"key":"2025070408020856800_bib55","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/s00203-022-03103-5","article-title":"Cervicovaginal microbiota isolated from healthy women exhibit probiotic properties and antimicrobial activity against pathogens isolated from cervical cancer patients","volume":"204","author":"Kamble","year":"2022","journal-title":"Arch Microbiol"},{"key":"2025070408020856800_bib56","doi-asserted-by":"publisher","first-page":"3800","DOI":"10.3390\/cancers12123800","article-title":"Dynamics of fecal microbiota with and without invasive cervical cancer and its application in early diagnosis","volume":"12","author":"Kang","year":"2020","journal-title":"Cancers"},{"key":"2025070408020856800_bib57","doi-asserted-by":"publisher","first-page":"320","DOI":"10.6004\/jnccn.2013.0043","article-title":"Cervical cancer","volume":"11","author":"Koh","year":"2013","journal-title":"J Natl Compr Canc Netw"},{"key":"2025070408020856800_bib58","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s00248-014-0414-5","article-title":"Obstetric and gynecological diseases and complications resulting from vaginal dysbacteriosis","volume":"68","author":"Kovachev","year":"2014","journal-title":"Microb Ecol"},{"key":"2025070408020856800_bib59","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.semcancer.2022.03.005","article-title":"Vaginal microbiome and cervical cancer","volume":"86","author":"Kyrgiou","year":"2022","journal-title":"Semin Cancer Biol"},{"key":"2025070408020856800_bib60","doi-asserted-by":"publisher","first-page":"e01074","DOI":"10.1128\/Spectrum.01074-21","article-title":"The vaginal microbiome of nonhuman primates can be only transiently altered to become Lactobacillus dominant without reducing inflammation","volume":"9","author":"Langner","year":"2021","journal-title":"Microbiol Spectr"},{"key":"2025070408020856800_bib61","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1038\/s41416-021-01467-x","article-title":"The gut microbiome: what the oncologist ought to know","volume":"125","author":"Lee","year":"2021","journal-title":"Br J Cancer"},{"key":"2025070408020856800_bib62","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1186\/s12967-023-04676-5","article-title":"Characteristics of vaginal microbiota in various cervical intraepithelial neoplasia: a cross-sectional study","volume":"21","author":"Liu","year":"2023","journal-title":"J Transl Med"},{"key":"2025070408020856800_bib63","doi-asserted-by":"publisher","first-page":"11446","DOI":"10.18632\/aging.206032","article-title":"Effectiveness of vaginal probiotics Lactobacillus crispatus chen-01 in women with high-risk HPV infection: a prospective controlled pilot study","volume":"16","author":"Liu","year":"2024","journal-title":"Aging"},{"key":"2025070408020856800_bib64","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1146\/annurev-micro-092611-150157","article-title":"Vaginal microbiome: rethinking health and disease","volume":"66","author":"Ma","year":"2012","journal-title":"Annu Rev Microbiol"},{"key":"2025070408020856800_bib65","doi-asserted-by":"publisher","first-page":"838491","DOI":"10.3389\/fcimb.2022.838491","article-title":"Preliminary identification of the aerobic cervicovaginal microbiota in Mexican women with cervical cancer as the first step towards metagenomic studies","volume":"12","author":"Manzanares-Leal","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"2025070408020856800_bib66","doi-asserted-by":"publisher","first-page":"S367","DOI":"10.1093\/infdis\/jiaa621","article-title":"Human papillomavirus vaccines","volume":"224","author":"Markowitz","year":"2021","journal-title":"J Infect Dis"},{"key":"2025070408020856800_bib67","doi-asserted-by":"publisher","first-page":"S36","DOI":"10.1093\/infdis\/jiw184","article-title":"The vaginal microbiome: current understanding and future directions","volume":"214","author":"Martin","year":"2016","journal-title":"J Infect Dis"},{"key":"2025070408020856800_bib68","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.3390\/cancers14081933","article-title":"Noninvasive physical plasma as innovative and tissue-preserving therapy for women positive for cervical intraepithelial neoplasia","volume":"14","author":"Marzi","year":"2022","journal-title":"Cancers"},{"key":"2025070408020856800_bib69","doi-asserted-by":"publisher","first-page":"891679","DOI":"10.3389\/fmicb.2022.891679","article-title":"Development of the gut microbiota in healthy twins during the first 2 years of life and associations with body mass index z-score: results from the Wuhan twin birth cohort study","volume":"13","author":"Mei","year":"2022","journal-title":"Front Microbiol"},{"key":"2025070408020856800_bib70","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.3389\/fmicb.2016.01936","article-title":"Lactobacilli dominance and vaginal pH: why is the human vaginal microbiome unique?","volume":"7","author":"Miller","year":"2016","journal-title":"Front Microbiol"},{"key":"2025070408020856800_bib71","first-page":"e01619","article-title":"Assessing the cervicovaginal microbiota in the context of hrHPV infections: temporal dynamics and therapeutic strategies","volume":"13","author":"Molina\u00a0Mariano","year":"2022","journal-title":"mBio"},{"key":"2025070408020856800_bib72","doi-asserted-by":"publisher","first-page":"e1007835","DOI":"10.1371\/journal.ppat.1007835","article-title":"Autocrine STAT3 activation in HPV positive cervical cancer through a virus-driven Rac1\u2014NF\u03baB\u2014IL-6 signalling axis","volume":"15","author":"Morgan","year":"2019","journal-title":"PLoS Pathog"},{"key":"2025070408020856800_bib73","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1097\/QCO.0000000000000620","article-title":"Host\u2013vaginal microbiota interactions in the pathogenesis of bacterial vaginosis","volume":"33","author":"Muzny","year":"2020","journal-title":"Curr Opin Infect Dis"},{"key":"2025070408020856800_bib74","article-title":"Current methods for studying the human microbiome","volume-title":"Environmental Chemicals, the Human Microbiome, and Health Risk: A Research Strategy","author":"National Academies of Sciences, Engineering, and Medicine; Division on Earth and Life Studies; Board on Life Sciences; Board on Environmental Studies and Toxicology; Committee on Advancing Understanding of the Implications of Environmental-Chemical Interactions with the Human Microbiome","year":"2017"},{"key":"2025070408020856800_bib75","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.3390\/microorganisms11061417","article-title":"Relationship between human papillomavirus status and the cervicovaginal microbiome in cervical cancer","volume":"11","author":"Nguyen","year":"2023","journal-title":"Microorganisms"},{"key":"2025070408020856800_bib76","doi-asserted-by":"publisher","first-page":"e00143","DOI":"10.1128\/Spectrum.00143-21","article-title":"Cervical squamous intraepithelial lesions are associated with differences in the vaginal microbiota of Mexican women","volume":"9","author":"Nieves-Ram\u00edrez","year":"2021","journal-title":"Microbiol Spectr"},{"key":"2025070408020856800_bib77","first-page":"331","article-title":"Focus: microbiome: unraveling the dynamics of the human vaginal microbiome","volume":"89","author":"Nunn","year":"2016","journal-title":"Yale J Biol Med"},{"key":"2025070408020856800_bib78","doi-asserted-by":"publisher","first-page":"106554","DOI":"10.1016\/j.ypmed.2021.106554","article-title":"Provider communication and HPV vaccine uptake: a meta-analysis and systematic review","volume":"148","author":"Oh","year":"2021","journal-title":"Prev Med"},{"key":"2025070408020856800_bib79","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1080\/01443615.2019.1634030","article-title":"Human papillomavirus and cervical cancer","volume":"40","author":"Okunade","year":"2020","journal-title":"J Obstet Gynaecol"},{"key":"2025070408020856800_bib80","doi-asserted-by":"publisher","first-page":"622","DOI":"10.3390\/cells8060622","article-title":"Human papilloma virus-associated cervical cancer and health disparities","volume":"8","author":"Olusola","year":"2019","journal-title":"Cells"},{"key":"2025070408020856800_bib81","doi-asserted-by":"publisher","first-page":"e7488","DOI":"10.7717\/peerj.7488","article-title":"Factors associated with the composition and diversity of the cervical microbiota of reproductive-age Black South African women: a retrospective cross-sectional study","volume":"7","author":"Onywera","year":"2019","journal-title":"PeerJ"},{"key":"2025070408020856800_bib82","doi-asserted-by":"publisher","first-page":"11619","DOI":"10.1021\/acs.analchem.2c02094","article-title":"Rapid point-of-care test kit for bacterial vaginosis: detection of vaginolysin and clue cells using paper strips and a smartphone","volume":"94","author":"Pawley","year":"2022","journal-title":"Anal Chem"},{"key":"2025070408020856800_bib83","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.3389\/fcimb.2022.1042663","article-title":"A systematic assessment of stress insomnia as the high-risk factor for cervical cancer and interplay of cervicovaginal microbiome","volume":"12","author":"Rai","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"2025070408020856800_bib84","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1111\/1471-0528.14704","article-title":"The vaginal microbiome and gynaecological cancer: exercise caution when considering causation","volume":"125","author":"Ramchander","year":"2018","journal-title":"BJOG"},{"key":"2025070408020856800_bib85","first-page":"8","article-title":"Unmet clinical needs in cervical cancer screening","volume":"48","author":"Rao","year":"2016","journal-title":"MLO Med Lab Obs"},{"key":"2025070408020856800_bib86","doi-asserted-by":"publisher","first-page":"4680","DOI":"10.1073\/pnas.1002611107","article-title":"Vaginal microbiome of reproductive-age women","volume":"108","author":"Ravel","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025070408020856800_bib87","doi-asserted-by":"publisher","first-page":"2130","DOI":"10.3390\/v14102130","article-title":"Is the physiological composition of the vaginal microbiome altered in high-risk HPV infection of the uterine cervix?","volume":"14","author":"Rokos","year":"2022","journal-title":"Viruses"},{"key":"2025070408020856800_bib88","doi-asserted-by":"publisher","first-page":"e28762","DOI":"10.1002\/jmv.28762","article-title":"Impact of cervicovaginal microbiome on the risk of cervical abnormalities development","volume":"95","author":"Ros\u00e1rio","year":"2023","journal-title":"J Med Virol"},{"key":"2025070408020856800_bib89","doi-asserted-by":"publisher","first-page":"3954","DOI":"10.3390\/ijms26093954","article-title":"Vaginal microbiota and local immunity in HPV-induced high-grade cervical dysplasia: a narrative review","volume":"26","author":"Schellekens","year":"2025","journal-title":"Int J Mol Sci"},{"key":"2025070408020856800_bib90","doi-asserted-by":"publisher","first-page":"726792","DOI":"10.3389\/fmicb.2021.726792","article-title":"Gut microbiome in retina health: the crucial role of the gut-retina axis","volume":"12","author":"Scuderi","year":"2022","journal-title":"Front Microbiol"},{"key":"2025070408020856800_bib91","doi-asserted-by":"publisher","first-page":"3780","DOI":"10.3390\/curroncol29050303","article-title":"HPV vaccination: an underused strategy for the prevention of cancer","volume":"29","author":"Shapiro","year":"2022","journal-title":"Curr Oncol"},{"key":"2025070408020856800_bib92","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s13027-024-00573-8","article-title":"Cervicovaginal microbiota: a promising direction for prevention and treatment in cervical cancer","volume":"19","author":"Shen","year":"2024","journal-title":"Infect Agent Cancer"},{"key":"2025070408020856800_bib93","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1097\/MOG.0000000000000139","article-title":"The gut microbiome in health and in disease","volume":"31","author":"Shreiner","year":"2015","journal-title":"Curr Opin Gastroenterol"},{"key":"2025070408020856800_bib94","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.3390\/biology11111683","article-title":"The gut microbiome and female health","volume":"11","author":"Siddiqui","year":"2022","journal-title":"Biology"},{"key":"2025070408020856800_bib95","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/s42003-021-01741-x","article-title":"Gut microbiome diversity is an independent predictor of survival in cervical cancer patients receiving chemoradiation","volume":"4","author":"Sims","year":"2021","journal-title":"Commun Biol"},{"key":"2025070408020856800_bib96","doi-asserted-by":"publisher","first-page":"2404","DOI":"10.1002\/cncr.30667","article-title":"Cervical cancer: a global health crisis","volume":"123","author":"Small","year":"2017","journal-title":"Cancer"},{"key":"2025070408020856800_bib97","doi-asserted-by":"publisher","first-page":"5756","DOI":"10.3390\/ijms23105756","article-title":"The role of microbiota in the immunopathogenesis of endometrial cancer","volume":"23","author":"Sobstyl","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2025070408020856800_bib98","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.resmic.2017.04.001","article-title":"The role of lactic acid production by probiotic Lactobacillus species in vaginal health","volume":"168","author":"Tachedjian","year":"2017","journal-title":"Res Microbiol"},{"key":"2025070408020856800_bib99","doi-asserted-by":"publisher","first-page":"833","DOI":"10.3390\/microorganisms11040833","article-title":"Cervicovaginal microbiota profiles in precancerous lesions and cervical cancer among Ethiopian women","volume":"11","author":"Teka","year":"2023","journal-title":"Microorganisms"},{"key":"2025070408020856800_bib100","doi-asserted-by":"publisher","first-page":"833","DOI":"10.3390\/microorganisms11040833","article-title":"Cervicovaginal microbiota profiles in precancerous lesions and cervical cancer among Ethiopian women","volume":"11","author":"Teka","year":"2023","journal-title":"Microorganisms"},{"key":"2025070408020856800_bib101","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1111\/aogs.14121","article-title":"Benefits and potential harms of human papillomavirus (HPV)-based cervical cancer screening: a real-world comparison of HPV testing versus cytology","volume":"100","author":"Thomsen","year":"2021","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2025070408020856800_bib102","doi-asserted-by":"publisher","first-page":"266","DOI":"10.3390\/ijms20020266","article-title":"Interplay among vaginal microbiome, immune response and sexually transmitted viral infections","volume":"20","author":"Torcia","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2025070408020856800_bib103","doi-asserted-by":"publisher","first-page":"S38","DOI":"10.1111\/j.1753-4887.2012.00493.x","article-title":"Defining the human microbiome","volume":"70","author":"Ursell","year":"2012","journal-title":"Nutr Rev"},{"key":"2025070408020856800_bib104","doi-asserted-by":"publisher","first-page":"e1008376","DOI":"10.1371\/journal.ppat.1008376","article-title":"Cervicovaginal microbiome and natural history of HPV in a longitudinal study","volume":"16","author":"Usyk","year":"2020","journal-title":"PLoS Pathog"},{"key":"2025070408020856800_bib105","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1097\/LGT.0000000000000646","article-title":"The vaginal microbiome: IV. The role of vaginal microbiome in reproduction and in gynecologic cancers","volume":"26","author":"Ventolini","year":"2022","journal-title":"J Low Genit Tract Dis"},{"key":"2025070408020856800_bib106","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1016\/S0140-6736(03)13778-6","article-title":"Cervical cancer","volume":"361","author":"Waggoner","year":"2003","journal-title":"The Lancet"},{"key":"2025070408020856800_bib107","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s13568-019-0763-z","article-title":"Altered diversity and composition of the gut microbiome in patients with cervical cancer","volume":"9","author":"Wang","year":"2019","journal-title":"AMB Expr"},{"key":"2025070408020856800_bib108","doi-asserted-by":"publisher","first-page":"606335","DOI":"10.3389\/fonc.2020.606335","article-title":"Human papillomavirus-negative cervical cancer: a comprehensive review","volume":"10","author":"Xing","year":"2021","journal-title":"Front Oncol"},{"key":"2025070408020856800_bib109","doi-asserted-by":"publisher","first-page":"6609","DOI":"10.1038\/s41598-022-10532-1","article-title":"A cross-sectional analysis about bacterial vaginosis, high-risk human papillomavirus infection, and cervical intraepithelial neoplasia in Chinese women","volume":"12","author":"Xu","year":"2022","journal-title":"Sci Rep"},{"key":"2025070408020856800_bib110","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.2147\/CMAR.S165228","article-title":"Role of Lactobacillus in cervical cancer","volume":"10","author":"Yang","year":"2018","journal-title":"Cancer Manag Res"},{"key":"2025070408020856800_bib111","doi-asserted-by":"publisher","first-page":"343ra81","DOI":"10.1126\/scitranslmed.aad0917","article-title":"Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability","volume":"8","author":"Yassour","year":"2016","journal-title":"Sci Transl Med"},{"key":"2025070408020856800_bib112","doi-asserted-by":"publisher","first-page":"720","DOI":"10.21147\/j.issn.1000-9604.2020.06.05","article-title":"Cervical cancer: epidemiology, risk factors and screening","volume":"32","author":"Zhang","year":"2020","journal-title":"Ch J Cancer Res"},{"key":"2025070408020856800_bib113","doi-asserted-by":"publisher","first-page":"1325500","DOI":"10.3389\/fcimb.2024.1325500","article-title":"Human papillomavirus and cervical cancer in the microbial world: exploring the vaginal microecology","volume":"14","author":"Zhang","year":"2024","journal-title":"Front Cell Infect Microbiol"}],"container-title":["Letters in Applied Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/lambio\/article-pdf\/78\/7\/ovaf088\/63522250\/ovaf088.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/lambio\/article-pdf\/78\/7\/ovaf088\/63522250\/ovaf088.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T12:02:15Z","timestamp":1751630535000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/lambio\/article\/doi\/10.1093\/lambio\/ovaf088\/8168473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,18]]},"references-count":113,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7,2]]}},"URL":"https:\/\/doi.org\/10.1093\/lambio\/ovaf088","relation":{},"ISSN":["1472-765X"],"issn-type":[{"value":"1472-765X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,7]]},"published":{"date-parts":[[2025,6,18]]},"article-number":"ovaf088"}}