{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:35:41Z","timestamp":1791588941731,"version":"4.3.4"},"reference-count":90,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Psoriasis, a chronic skin autoimmune disease characterized by abnormal immune responses, is influenced by genetic and environmental factors. Recent microbiota research has revealed that short-chain fatty acids (SCFAs), metabolites produced by gut microbiota, play a pivotal role in regulating immune function and inflammation. This review examines the current literature on the relationship between gut dysbiosis, SCFA production, and immune modulation in psoriasis, focusing on emerging evidence from microbiota and immunological studies. SCFAs have been shown to influence key immune pathways, including T-cell activation and cytokine production, which are critical in psoriasis pathogenesis. Reduced SCFA levels have been observed in psoriasis, highlighting the role of gut dysbiosis in disease progression. Understanding the gut-skin axis and the role of SCFAs offers novel insights into developing effective, safe, and accessible treatments for psoriasis. Restoring microbial balance and SCFA production may serve as a promising therapeutic approach for managing psoriasis.<\/jats:p>","DOI":"10.1093\/lambio\/ovaf091","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T10:44:10Z","timestamp":1750848250000},"source":"Crossref","is-referenced-by-count":13,"title":["Short-chain fatty acids and their role in modulating autoimmune responses in psoriasis: insights from recent microbiota research"],"prefix":"10.1093","volume":"78","author":[{"given":"Narges","family":"Fallahi","sequence":"first","affiliation":[{"name":"Student Research Committee, Birjand University of Medical Sciences , Birjand, 9717853076 ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitra","family":"Rafiee","sequence":"additional","affiliation":[{"name":"School of Medicine, Cellular and Molecular Research Center, Birjand University of Medical Sciences Department of Immunology, , Birjand, 9717853076 ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyedeh Sindokht","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Student Research Committee, Birjand University of Medical Sciences , Birjand, 9717853076 ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasrin","family":"Sereshki","sequence":"additional","affiliation":[{"name":"School of Medicine, Isfahan University of Medical Sciences Department of Immunology, , Isfahan, 8174673461 ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholamreza","family":"Anani\u00a0Sarab","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center , Department of Hematology and Blood Bank, Birjand University of Medical Sciences, Birjand, 9717853076 ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nafiseh","family":"Erfanian","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center, Birjand University of Medical Sciences , Birjand, 9717853076 ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"2025071003561914900_bib1","doi-asserted-by":"publisher","first-page":"14204","DOI":"10.1038\/s41598-025-96893-9","article-title":"Gut microbiota diversity in obese rats treated with intermittent fasting, probiotic-fermented camel milk with or without dates and their combinations","volume":"15","author":"Aljutaily","year":"2025","journal-title":"Sci Rep"},{"key":"2025071003561914900_bib2","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s40813-023-00316-y","article-title":"Acetate and propionate effects in response to LPS in a porcine intestinal co-culture model","volume":"9","author":"Andrani","year":"2023","journal-title":"Porcine Health Manage"},{"key":"2025071003561914900_bib3","doi-asserted-by":"publisher","first-page":"34145","DOI":"10.1038\/srep34145","article-title":"Human and mouse monocytes display distinct signalling and cytokine profiles upon stimulation with FFAR2\/FFAR3 short-chain fatty acid receptor agonists","volume":"6","author":"Ang","year":"2016","journal-title":"Sci Rep"},{"key":"2025071003561914900_bib4","doi-asserted-by":"publisher","first-page":"205","DOI":"10.3390\/fermentation9030205","article-title":"Butyrate properties in immune-related diseases: friend or foe?","volume":"9","author":"Anshory","year":"2023","journal-title":"Fermentation"},{"key":"2025071003561914900_bib5","doi-asserted-by":"publisher","first-page":"205","DOI":"10.3390\/fermentation9030205","article-title":"Butyrate properties in immune-related diseases: friend or foe?","volume":"9","author":"Anshory","year":"2023","journal-title":"Fermentation"},{"key":"2025071003561914900_bib6","doi-asserted-by":"publisher","first-page":"e000062","DOI":"10.1161\/JAHA.113.000062","article-title":"Psoriasis and major adverse cardiovascular events: a systematic review and meta-analysis of observational studies","volume":"2","author":"Armstrong","year":"2013","journal-title":"J Am Heart Assoc"},{"key":"2025071003561914900_bib7","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/nature12726","article-title":"Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation","volume":"504","author":"Arpaia","year":"2013","journal-title":"Nature"},{"key":"2025071003561914900_bib8","doi-asserted-by":"publisher","first-page":"449","DOI":"10.3390\/pharmaceutics16040449","article-title":"Recent approaches for the topical treatment of psoriasis using nanoparticles","volume":"16","author":"Bodn\u00e1r","year":"2024","journal-title":"Pharmaceutics"},{"key":"2025071003561914900_bib9","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.3390\/biomedicines9111511","article-title":"Psoriasis as an immune-mediated and inflammatory systemic disease: from pathophysiology to novel therapeutic approaches","volume":"9","author":"Campanati","year":"2021","journal-title":"Biomedicines"},{"key":"2025071003561914900_bib10","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1111\/jdv.12847","article-title":"Risk of non-alcoholic fatty liver disease in patients with psoriasis: a systematic review and meta-analysis","volume":"29","author":"Candia","year":"2015","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2025071003561914900_bib11","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1042\/CS20200128","article-title":"Short-chain fatty acid, acylation and cardiovascular diseases","volume":"134","author":"Chen","year":"2020","journal-title":"Clin Sci (Colch)"},{"key":"2025071003561914900_bib12","doi-asserted-by":"publisher","first-page":"17495","DOI":"10.1038\/s41598-024-67325-x","article-title":"Short-chain fatty acids ameliorate imiquimod-induced skin thickening and IL-17 levels and alter gut microbiota in mice: a metagenomic association analysis","volume":"14","author":"Chen","year":"2024","journal-title":"Sci Rep"},{"key":"2025071003561914900_bib13","doi-asserted-by":"publisher","first-page":"17495","DOI":"10.1038\/s41598-024-67325-x","article-title":"Short-chain fatty acids ameliorate imiquimod-induced skin thickening and IL-17 levels and alter gut microbiota in mice: a metagenomic association analysis","volume":"14","author":"Chen","year":"2024","journal-title":"Sci Rep"},{"key":"2025071003561914900_bib14","doi-asserted-by":"publisher","first-page":"101052","DOI":"10.1016\/j.crfs.2025.101052","article-title":"Fermented beetroot modulates gut microbial carbohydrate metabolism in prediabetes and prevents high-fat diet induced hyperglycemia in a prediabetic model","volume":"10","author":"Daliri","year":"2025","journal-title":"Curr Res Food Sci"},{"key":"2025071003561914900_bib15","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.chom.2020.01.006","article-title":"Precision microbiome modulation with discrete dietary fiber structures directs short-chain fatty acid production","volume":"27","author":"Deehan","year":"2020","journal-title":"Cell Host Microbe"},{"key":"2025071003561914900_bib16","doi-asserted-by":"crossref","first-page":"103293","DOI":"10.1016\/j.ebiom.2021.103293","article-title":"Short chain fatty acids and its producing organisms: an overlooked therapy for IBD?","volume":"66","author":"Deleu","year":"2021","journal-title":"EBioMedicine"},{"key":"2025071003561914900_bib17","doi-asserted-by":"publisher","first-page":"353","DOI":"10.3390\/microorganisms9020353","article-title":"Gut\u2013skin axis: current knowledge of the interrelationship between microbial dysbiosis and skin conditions","volume":"9","author":"De\u00a0Pessemier","year":"2021","journal-title":"Microorganisms"},{"key":"2025071003561914900_bib18","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1038\/jid.2012.426","article-title":"CD8 T cells and IFN-\u03b3 emerge as critical players for psoriasis in a novel model of mouse psoriasiform skin inflammation","volume":"133","author":"Di\u00a0Meglio","year":"2013","journal-title":"J Invest Dermatol"},{"key":"2025071003561914900_bib19","doi-asserted-by":"publisher","first-page":"915218","DOI":"10.3389\/fimmu.2022.915218","article-title":"Gut microflora modulates Th17\/treg cell differentiation in experimental autoimmune prostatitis via the short-chain fatty acid propionate","volume":"13","author":"Du","year":"2022","journal-title":"Front Immunol"},{"key":"2025071003561914900_bib20","doi-asserted-by":"publisher","first-page":"115276","DOI":"10.1016\/j.biopha.2023.115276","article-title":"the impact of microbiota-derived short-chain fatty acids on macrophage activities in disease: mechanisms and therapeutic potentials","volume":"165","author":"Duan","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"2025071003561914900_bib21","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1158\/0008-5472.CAN-13-1451","article-title":"The niacin\/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival","volume":"74","author":"Elangovan","year":"2014","journal-title":"Cancer Res"},{"key":"2025071003561914900_bib22","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1097\/MIB.0000000000001169","article-title":"Prevalence and phenotype of concurrent psoriasis and inflammatory bowel disease","volume":"23","author":"Eppinga","year":"2017","journal-title":"Inflamm Bowel Dis"},{"key":"2025071003561914900_bib23","doi-asserted-by":"publisher","first-page":"116489","DOI":"10.1016\/j.foodres.2025.116489","article-title":"Evidence of synbiotic potential of oat beverage enriched with inulin and fermented by L. rhamnosus LR B in a dynamic in vitro model of human colon","volume":"211","author":"Fabiano","year":"2025","journal-title":"Food Res Int"},{"key":"2025071003561914900_bib24","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1159\/000492853","article-title":"Short-chain fatty acids manifest stimulative and protective effects on intestinal barrier function through the inhibition of NLRP3 inflammasome and autophagy","volume":"49","author":"Feng","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"2025071003561914900_bib25","doi-asserted-by":"publisher","first-page":"289","DOI":"10.4161\/gmic.19897","article-title":"Microbial degradation of complex carbohydrates in the gut","volume":"3","author":"Flint","year":"2012","journal-title":"Gut Microbes"},{"key":"2025071003561914900_bib26","doi-asserted-by":"crossref","first-page":"101961","DOI":"10.1016\/j.berh.2024.101961","article-title":"Exploring the role of gut microbes in spondyloarthritis: implications for pathogenesis and therapeutic strategies","volume":"38","author":"Furst","year":"2024","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"2025071003561914900_bib27","doi-asserted-by":"publisher","first-page":"117","DOI":"10.3389\/fphar.2020.00117","article-title":"Pathogenesis of chronic plaque psoriasis and its intersection with cardio-metabolic comorbidities","volume":"11","author":"Gisondi","year":"2020","journal-title":"Front Pharmacol"},{"key":"2025071003561914900_bib28","doi-asserted-by":"publisher","first-page":"ii14","DOI":"10.1136\/ard.2004.032482","article-title":"Psoriatic arthritis: epidemiology, clinical features, course, and outcome","volume":"64","author":"Gladman","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"2025071003561914900_bib29","doi-asserted-by":"publisher","first-page":"114763","DOI":"10.1016\/j.biopha.2023.114763","article-title":"Short chain fatty acids, a possible treatment option for autoimmune diseases","volume":"163","author":"Golpour","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"2025071003561914900_bib30","doi-asserted-by":"crossref","first-page":"11525","DOI":"10.1039\/D4FO04028G","article-title":"Investigating serum concentration profiles of orally ingested short-chain fatty acid supplements","volume":"15","author":"Green","year":"2024","journal-title":"Food Funct"},{"key":"2025071003561914900_bib31","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1093\/eurheartj\/ehab644","article-title":"Propionate attenuates atherosclerosis by immune-dependent regulation of intestinal cholesterol metabolism","volume":"43","author":"Haghikia","year":"2022","journal-title":"Eur Heart J"},{"key":"2025071003561914900_bib32","doi-asserted-by":"publisher","first-page":"1211271","DOI":"10.3389\/fmicb.2023.1211271","article-title":"Probiotics for the treatment of ulcerative colitis: a review of experimental research from 2018 to 2022","volume":"14","author":"Huang","year":"2023","journal-title":"Front Microbiol"},{"key":"2025071003561914900_bib33","first-page":"4074832","article-title":"Short-chain fatty acids ameliorate diabetic nephropathy via GPR43-mediated inhibition of oxidative stress and NF-\u03bab signaling","volume":"2020","author":"Huang","year":"2020","journal-title":"Oxid Med Cell Long"},{"key":"2025071003561914900_bib34","first-page":"133","article-title":"Polymorphic variation in FFA receptors: functions and consequences","author":"Ichimura","year":"2017","journal-title":"Free Fatty Acid Recept"},{"key":"2025071003561914900_bib35","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1177\/1203475418814234","article-title":"Comparison of management guidelines for moderate-to-severe plaque psoriasis: a review of phototherapy, systemic therapies, and biologic agents","volume":"23","author":"Ighani","year":"2019","journal-title":"J Cutan Med Surg"},{"key":"2025071003561914900_bib36","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.3389\/fimmu.2017.01429","article-title":"Butyrate conditions human dendritic cells to prime type 1 regulatory T cells via both histone deacetylase inhibition and G protein-coupled receptor 109A signaling","volume":"8","author":"Kaisar","year":"2017","journal-title":"Front Immunol"},{"key":"2025071003561914900_bib37","first-page":"22","article-title":"Variability of quantitative changes in short-chain fatty acids in serum and epidermis in psoriasis","volume":"8","author":"Khyshiktuev","year":"2008","journal-title":"Klin Lab Diagn"},{"key":"2025071003561914900_bib38","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1111\/exd.14431","article-title":"Decrease of ceramides with long-chain fatty acids in psoriasis: possible inhibitory effect of interferon gamma on chain elongation","volume":"31","author":"Kim","year":"2022","journal-title":"Exp Dermatol"},{"key":"2025071003561914900_bib39","doi-asserted-by":"publisher","first-page":"133.23","DOI":"10.4049\/jimmunol.192.Supp.133.23","article-title":"the commensal bacteria metabolites short chain fatty acids positively regulate epithelial innate immune responses in the gut (MUC4P. 847)","volume":"192","author":"Kim","year":"2014","journal-title":"J Immunol"},{"key":"2025071003561914900_bib40","doi-asserted-by":"publisher","first-page":"127127","DOI":"10.1016\/j.micres.2022.127127","article-title":"Emerging frontiers of antibiotics use and their impacts on the human gut microbiome","volume":"263","author":"Kumari","year":"2022","journal-title":"Microbiol Res"},{"key":"2025071003561914900_bib41","doi-asserted-by":"publisher","first-page":"5621","DOI":"10.1038\/ncomms6621","article-title":"the antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis","volume":"5","author":"Lande","year":"2014","journal-title":"Nat Commun"},{"key":"2025071003561914900_bib42","doi-asserted-by":"crossref","first-page":"116735","DOI":"10.1016\/j.biopha.2024.116735","article-title":"GPR41 and GPR43: from development to metabolic regulation","volume":"175","author":"Lee","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"2025071003561914900_bib43","doi-asserted-by":"publisher","first-page":"108926","DOI":"10.1016\/j.jnutbio.2021.108926","article-title":"Impact of short-chain fatty acid supplementation on gut inflammation and microbiota composition in a murine colitis model","volume":"101","author":"Lee","year":"2022","journal-title":"J Nutr Biochem"},{"key":"2025071003561914900_bib44","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1111\/exd.12333","article-title":"Combined treatment with sodium butyrate and PD 153035 enhances keratinocyte differentiation","volume":"23","author":"Leon\u00a0Carrion","year":"2014","journal-title":"Exp Dermatol"},{"key":"2025071003561914900_bib45","doi-asserted-by":"publisher","first-page":"1968257","DOI":"10.1080\/19490976.2021.1968257","article-title":"Microbiota metabolite butyrate constrains neutrophil functions and ameliorates mucosal inflammation in inflammatory bowel disease","volume":"13","author":"Li","year":"2021","journal-title":"Gut Microbes"},{"key":"2025071003561914900_bib46","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1146\/annurev-immunol-032713-120225","article-title":"Immunology of psoriasis","volume":"32","author":"Lowes","year":"2014","journal-title":"Annu Rev Immunol"},{"key":"2025071003561914900_bib47","doi-asserted-by":"publisher","first-page":"417","DOI":"10.3389\/fimmu.2017.00417","article-title":"The microbiota and epigenetic regulation of T helper 17\/regulatory T cells: in search of a balanced immune system","volume":"8","author":"Luo","year":"2017","journal-title":"Front Immunol"},{"key":"2025071003561914900_bib48","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1038\/s41467-019-08711-2","article-title":"The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes","volume":"10","author":"Luu","year":"2019","journal-title":"Nat Commun"},{"key":"2025071003561914900_bib49","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/s41577-024-01014-8","article-title":"Short-chain fatty acids: linking diet, the microbiome and immunity","volume":"24","author":"Mann","year":"2024","journal-title":"Nat Rev Immunol"},{"key":"2025071003561914900_bib50","doi-asserted-by":"publisher","first-page":"106659","DOI":"10.1016\/j.fbio.2025.106659","article-title":"Prebiotic potential of olive leaf by-product throughout in vitro human colon fermentation","volume":"68","author":"M\u00f3nica","year":"2025","journal-title":"Food Biosci"},{"key":"2025071003561914900_bib51","doi-asserted-by":"publisher","first-page":"16148","DOI":"10.1038\/srep16148","article-title":"The effect of short-chain fatty acids on human monocyte-derived dendritic cells","volume":"5","author":"Nastasi","year":"2015","journal-title":"Sci Rep"},{"key":"2025071003561914900_bib52","first-page":"1078","article-title":"Efficacy and safety of oral administration of a mixture of probiotic strains in patients with psoriasis: a randomized controlled clinical trial","volume":"99","author":"Navarro-L\u00f3pez","year":"2019","journal-title":"Acta Derm Venereol"},{"key":"2025071003561914900_bib53","doi-asserted-by":"publisher","first-page":"84","DOI":"10.5114\/pdia.2014.40920","article-title":"Chemokines and cytokines network in the pathogenesis of the inflammatory skin diseases: atopic dermatitis, psoriasis and skin mastocytosis","volume":"31","author":"Nedoszytko","year":"2014","journal-title":"Postepy Dermatol Alergol"},{"key":"2025071003561914900_bib54","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1084\/jem.20050500","article-title":"Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production","volume":"202","author":"Nestle","year":"2005","journal-title":"J Exp Med"},{"key":"2025071003561914900_bib55","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.micpath.2018.03.021","article-title":"Gut microbiota and mTOR signaling: insight on a new pathophysiological interaction","volume":"118","author":"Noureldein","year":"2018","journal-title":"Microb Pathog"},{"key":"2025071003561914900_bib56","first-page":"73","article-title":"Updated perspectives on keratinocytes and psoriasis: keratinocytes are more than innocent bystanders","volume":"12","author":"Ortiz-Lopez","year":"2022","journal-title":"Psoriasis (Auckl)"},{"key":"2025071003561914900_bib57","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1034\/j.1600-0625.2001.010003168.x","article-title":"Epidermal CD8+ T cells in chronic plaque psoriasis are Tc1 cells producing heterogeneous levels of interferon-gamma","volume":"10","author":"Ovigne","year":"2001","journal-title":"Exp Dermatol"},{"key":"2025071003561914900_bib58","first-page":"1","article-title":"Synergistic interactions between probiotics and anticancer drugs: mechanisms, benefits, and challenges","author":"Pezeshki","year":"2025","journal-title":"Probiotics Antimicrob Proteins"},{"key":"2025071003561914900_bib59","doi-asserted-by":"publisher","first-page":"4529","DOI":"10.3390\/ijms22094529","article-title":"Psoriasis and gut microbiome-current State of art","volume":"22","author":"Polak","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2025071003561914900_bib60","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.3390\/ijms23031105","article-title":"Gut microbiota and short chain fatty acids: implications in glucose homeostasis","volume":"23","author":"Portincasa","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2025071003561914900_bib61","doi-asserted-by":"publisher","first-page":"979","DOI":"10.3389\/fmicb.2016.00979","article-title":"Bifidobacteria and butyrate-producing colon bacteria: importance and strategies for their stimulation in the Human gut","volume":"7","author":"Rivi\u00e8re","year":"2016","journal-title":"Front Microbiol"},{"key":"2025071003561914900_bib62","doi-asserted-by":"publisher","first-page":"1038689","DOI":"10.3389\/fimmu.2023.1038689","article-title":"Crosstalk between microbiome, regulatory T cells and HCA2 orchestrates the inflammatory response in a murine psoriasis model","volume":"14","author":"Schwarz","year":"2023","journal-title":"Front Immunol"},{"key":"2025071003561914900_bib64","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.jid.2020.04.031","article-title":"Induction of regulatory T cells and correction of cytokine disbalance by short-chain fatty acids: implications for psoriasis therapy","volume":"141","author":"Schwarz","year":"2021","journal-title":"J Invest Dermatol"},{"key":"2025071003561914900_bib66","doi-asserted-by":"publisher","first-page":"1516010","DOI":"10.3389\/fcimb.2025.1516010","article-title":"The relationship between gut microbiome and human diseases: mechanisms, predisposing factors and potential intervention","volume":"15","author":"Shabani","year":"2025","journal-title":"Front Cell Infect Microbiol"},{"key":"2025071003561914900_bib67","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1126\/science.1241165","article-title":"The microbial metabolites, short-chain fatty acids, regulate colonic treg cell homeostasis","volume":"341","author":"Smith","year":"2013","journal-title":"Science"},{"key":"2025071003561914900_bib68","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1093\/ajcn\/nqab402","article-title":"Tolerability and SCFA production after resistant starch supplementation in humans: a systematic review of randomized controlled studies","volume":"115","author":"Sobh","year":"2022","journal-title":"Am J Clin Nutr"},{"key":"2025071003561914900_bib69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2021.1907272","article-title":"Butyrate-producing human gut symbiont, Clostridium butyricum, and its role in health and disease","volume":"13","author":"Stoeva","year":"2021","journal-title":"Gut Microbes"},{"key":"2025071003561914900_bib70","doi-asserted-by":"publisher","first-page":"3555","DOI":"10.1038\/s41467-018-05901-2","article-title":"Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis","volume":"9","author":"Sun","year":"2018","journal-title":"Nat Commun"},{"key":"2025071003561914900_bib71","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jaad.2016.07.064","article-title":"Psoriasis and comorbid diseases: epidemiology","volume":"76","author":"Takeshita","year":"2017","journal-title":"J Am Acad Dermatol"},{"key":"2025071003561914900_bib72","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.3389\/fphar.2019.01553","article-title":"Butyric acid increases the therapeutic effect of EHLJ7 on ulcerative colitis by inhibiting JAK2\/STAT3\/SOCS1 signaling pathway","volume":"10","author":"Tang","year":"2019","journal-title":"Front Pharmacol"},{"key":"2025071003561914900_bib73","doi-asserted-by":"crossref","first-page":"604","DOI":"10.31729\/jnma.8225","article-title":"Metabolic syndrome among patients with psoriasis attending the outpatient department of dermatology, venereology and leprology in a tertiary care centre: a descriptive cross-sectional study","volume":"61","author":"Thapa","year":"2023","journal-title":"J Nepal Med Assoc"},{"key":"2025071003561914900_bib74","article-title":"How to overcome barriers in the adoption of microbiome-based therapies","volume-title":"Eur Pharm Rev","author":"Thomson","year":"2023"},{"key":"2025071003561914900_bib75","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1038\/s41385-022-00524-9","article-title":"Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation","volume":"15","author":"Trompette","year":"2022","journal-title":"Mucosal Immunol"},{"key":"2025071003561914900_bib76","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/j.jnutbio.2010.07.009","article-title":"Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils","volume":"22","author":"Vinolo","year":"2011","journal-title":"J Nutr Biochem"},{"key":"2025071003561914900_bib77","doi-asserted-by":"publisher","first-page":"703218","DOI":"10.3389\/fcell.2021.703218","article-title":"The role of short-chain fatty acids and bile acids in intestinal and liver function, inflammation, and carcinogenesis","volume":"9","author":"Visekruna","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"2025071003561914900_bib78","doi-asserted-by":"publisher","first-page":"1365554","DOI":"10.3389\/fimmu.2024.1365554","article-title":"Emerging role of gut microbiota in autoimmune diseases","volume":"15","author":"Wang","year":"2024","journal-title":"Front Immunol"},{"key":"2025071003561914900_bib79","doi-asserted-by":"publisher","first-page":"1083432","DOI":"10.3389\/fmicb.2022.1083432","article-title":"The role of short-chain fatty acids in inflammatory skin diseases","volume":"13","author":"Xiao","year":"2023","journal-title":"Front Microbiol"},{"key":"2025071003561914900_bib80","doi-asserted-by":"publisher","first-page":"2863","DOI":"10.3390\/foods11182863","article-title":"Health benefits and side effects of short-chain fatty acids","volume":"11","author":"Xiong","year":"2022","journal-title":"Foods"},{"key":"2025071003561914900_bib81","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.bbrc.2020.09.027","article-title":"Microbiota-derived short chain fatty acid promotion of amphiregulin expression by dendritic cells is regulated by GPR43 and Blimp-1","volume":"533","author":"Xiu","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"key":"2025071003561914900_bib82","doi-asserted-by":"publisher","first-page":"926710","DOI":"10.3389\/fmicb.2022.926710","article-title":"Functional characterization of Clostridium tyrobutyricum L319: a promising next-generation probiotic for short-chain fatty acid production","volume":"13","author":"Yang","year":"2022","journal-title":"Front Microbiol"},{"key":"2025071003561914900_bib83","doi-asserted-by":"publisher","first-page":"14197","DOI":"10.3390\/ijms241814197","article-title":"Dietary fiber inulin improves murine imiquimod-induced psoriasis-like dermatitis","volume":"24","author":"Yoshida","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2025071003561914900_bib85","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s12865-022-00495-3","article-title":"Three important short-chain fatty acids (SCFAs) attenuate the inflammatory response induced by 5-FU and maintain the integrity of intestinal mucosal tight junction","volume":"23","author":"Yue","year":"2022","journal-title":"BMC Immunol"},{"key":"2025071003561914900_bib86","doi-asserted-by":"publisher","first-page":"2715","DOI":"10.1038\/s41598-023-29731-5","article-title":"Butyrate limits human natural killer cell effector function","volume":"13","author":"Zaiatz-Bittencourt","year":"2023","journal-title":"Sci Rep"},{"key":"2025071003561914900_bib87","doi-asserted-by":"publisher","first-page":"106289","DOI":"10.1016\/j.phrs.2022.106289","article-title":"The crosstalk between NLRP3 inflammasome and gut microbiome in atherosclerosis","volume":"181","author":"Zhang","year":"2022","journal-title":"Pharmacol Res"},{"key":"2025071003561914900_bib88","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.aninu.2021.08.004","article-title":"Ferulic acid mediates prebiotic responses of cereal-derived arabinoxylans on host health","volume":"9","author":"Zhang","year":"2022","journal-title":"Anim Nutr"},{"key":"2025071003561914900_bib89","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s12964-022-00869-5","article-title":"Regulatory role of short-chain fatty acids in inflammatory bowel disease","volume":"20","author":"Zhang","year":"2022","journal-title":"Cell Commun Signal"},{"key":"2025071003561914900_bib90","doi-asserted-by":"publisher","first-page":"2976","DOI":"10.4049\/jimmunol.1700105","article-title":"Microbial-derived butyrate promotes epithelial barrier function through IL-10 receptor\u2013dependent repression of claudin-2","volume":"199","author":"Zheng","year":"2017","journal-title":"J Immunol"},{"key":"2025071003561914900_bib91","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/s41419-022-04523-3","article-title":"Advances in the pathogenesis of psoriasis: from keratinocyte perspective","volume":"13","author":"Zhou","year":"2022","journal-title":"Cell Death Dis"},{"key":"2025071003561914900_bib92","doi-asserted-by":"publisher","first-page":"100520","DOI":"10.1016\/j.bpsgos.2025.100520","article-title":"Consumption of the prebiotic-rich chicory taproot contrasts the cognitive and motivational consequences of chronic corticosterone exposure and modulates gut microbiota composition in mice","volume":"5","author":"Zoratto","year":"2025","journal-title":"Biol Psych Glob Open Sci"},{"key":"2025071003561914900_bib93","doi-asserted-by":"publisher","first-page":"1430586","DOI":"10.3389\/fcimb.2024.1430586","article-title":"Gut microbiota and psoriasis: pathogenesis, targeted therapy, and future directions","volume":"14","author":"Zou","year":"2024","journal-title":"Front Cell Infect Microbiol"}],"container-title":["Letters in Applied Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/lambio\/advance-article-pdf\/doi\/10.1093\/lambio\/ovaf091\/63580025\/ovaf091.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/lambio\/article-pdf\/78\/7\/ovaf091\/63580025\/ovaf091.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/lambio\/article-pdf\/78\/7\/ovaf091\/63580025\/ovaf091.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T07:56:24Z","timestamp":1752134184000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/lambio\/article\/doi\/10.1093\/lambio\/ovaf091\/8173758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,25]]},"references-count":90,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7,2]]}},"URL":"https:\/\/doi.org\/10.1093\/lambio\/ovaf091","relation":{},"ISSN":["1472-765X"],"issn-type":[{"value":"1472-765X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,7]]},"published":{"date-parts":[[2025,6,25]]},"article-number":"ovaf091"}}