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Due to their persistence in the environment, pharmaceutical residues have been detected in water and soil sources, causing adverse effects on ecosystems. Therefore, methods and techniques are necessary to degrade this pollution. An environmentally sustainable option is fungal remediation, which can decompose or degrade various xenobiotics. In this study, 30 phenanthrene-tolerant fungal isolates were analyzed to determine their potential for pharmaceutical degradation. Nine isolates were tolerant to 100\u00a0mg L\u22121 and three to 200\u00a0mg L\u22121 of naproxen and ampicillin. An enzyme activity analysis detected the production of laccase and manganese peroxidase. Penicillium crustosum H10 causes a high degradation of naproxen 95 % at 5\u00a0mg L\u22121 in 7 days and 100 % at 50\u00a0mg L\u22121 in 15 days and a low degradation of ampicillin (11.15% at 5\u00a0mg L\u22121). These results encourage exploring P. crustosum H10 as a viable alternative for the elimination of non-steroidal anti-inflammatory drugs.<\/jats:p>","DOI":"10.1093\/lambio\/ovag040","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T11:31:11Z","timestamp":1774956671000},"source":"Crossref","is-referenced-by-count":0,"title":["Naproxen and ampicillin degradation by the Ascomycota fungi\n                    <i>Penicillium<\/i>\n                    and\n                    <i>Aspergillus<\/i>"],"prefix":"10.1093","volume":"79","author":[{"given":"Mailyn S","family":"Porras-Garcia","sequence":"first","affiliation":[{"name":"Laboratorio de Biotecnolog\u00eda Farmac\u00e9utica, Centro de Biotecnolog\u00eda Gen\u00f3mica, Instituto Polit\u00e9cnico Nacional , Reynosa 88710 ,","place":["M\u00e9xico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alma D","family":"Paz-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Laboratorio de Biotecnolog\u00eda Farmac\u00e9utica, Centro de Biotecnolog\u00eda Gen\u00f3mica, Instituto Polit\u00e9cnico Nacional , Reynosa 88710 ,","place":["M\u00e9xico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana V","family":"Mart\u00ednez-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Centro de Biotecnolog\u00eda Gen\u00f3mica, Instituto Polit\u00e9cnico Nacional , Reynosa 88710 ,","place":["M\u00e9xico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timoteo","family":"Delgado-Maldonado","sequence":"additional","affiliation":[{"name":"Laboratorio de Biotecnolog\u00eda Farmac\u00e9utica, Centro de Biotecnolog\u00eda Gen\u00f3mica, Instituto Polit\u00e9cnico Nacional , Reynosa 88710 ,","place":["M\u00e9xico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyra","family":"Ortiz-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Laboratorio de Biotecnolog\u00eda Farmac\u00e9utica, Centro de Biotecnolog\u00eda Gen\u00f3mica, Instituto Polit\u00e9cnico Nacional , Reynosa 88710 ,","place":["M\u00e9xico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9842-4167","authenticated-orcid":false,"given":"Gildardo","family":"Rivera","sequence":"additional","affiliation":[{"name":"Laboratorio de Biotecnolog\u00eda Farmac\u00e9utica, Centro de Biotecnolog\u00eda Gen\u00f3mica, Instituto Polit\u00e9cnico Nacional , Reynosa 88710 ,","place":["M\u00e9xico"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"2026042004060908200_bib59_956_093126","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.ibiod.2017.04.024","article-title":"Degradation of polycyclic aromatic hydrocarbon (pyrene) using novel fungal strain Coriolopsis byrsina strain APC5","volume":"181","author":"Agrawal","year":"2017","journal-title":"Appl Biochem Biotechnol"},{"key":"2026042004060908200_bib1","doi-asserted-by":"publisher","first-page":"85","DOI":"10.4103\/mtsp.mtsp_15_23","article-title":"Environmental impact of pharmaceuticals: a comprehensive review","volume":"7","author":"Ashiwaju","year":"2023","journal-title":"Matrix Sci Pharma"},{"key":"2026042004060908200_bib2","doi-asserted-by":"publisher","first-page":"111742","DOI":"10.1016\/j.ecoenv.2020.111742","article-title":"Impact of redox-mediators in the degradation of olsalazine by marine-derived fungus, Aspergillus aculeatus strain bpo2: response surface metho dology, laccase stability and kinetics","volume":"208","author":"Bankole","year":"2021","journal-title":"Ecotoxicol Environ Saf"},{"key":"2026042004060908200_bib3","volume-title":"Illustrated Genera of Imperfect Fungi","author":"Barnett","year":"1999"},{"key":"2026042004060908200_bib4","doi-asserted-by":"publisher","first-page":"127483","DOI":"10.1016\/j.micres.2023.127483","article-title":"Enzymatic degradation and metabolic pathway of phenanthrene by manglicolous filamentous fungus Trichoderma sp. 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