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Dysfunction in SSCs is caused by stress conditions like ageing and inflammation and is emerging as a contributor to skeletal pathology, such as the pathogenesis of fracture nonunion. Recent lineage tracing experiments have shown that SSCs exist in the bone marrow, periosteum, and resting zone of the growth plate. Unraveling their regulatory networks is crucial for understanding skeletal diseases and developing therapeutic strategies. In this review, we systematically introduce the definition, location, stem cell niches, regulatory signaling pathways, and clinical applications of SSCs.<\/jats:p>","DOI":"10.1093\/lifemedi\/lnac048","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T08:13:55Z","timestamp":1670487235000},"page":"276-293","source":"Crossref","is-referenced-by-count":22,"title":["Skeletal stem cells: origins, definitions, and functions in bone development and disease"],"prefix":"10.1093","volume":"1","author":[{"given":"Heng","family":"Feng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences , Shanghai 200031 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key 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