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The precise pathogenic mechanisms underlying NAFLD and its related metabolic disturbances remain elusive. Epigenetic modifications, which entail stable transcriptional changes without altering the DNA sequence, are increasingly recognized as pivotal. The principal forms of epigenetic modifications include DNA methylation, histone modifications, chromatin remodeling, and noncoding RNAs. These alterations participate in the regulation of hepatic lipid metabolism, insulin resistance, mitochondrial injury, oxidative stress response, and release of inflammatory cytokines, all of which are associated with the onset and progression of NAFLD. This review discussed recent advances in understanding the potential epigenetic regulation of inflammation in NAFLD. Unraveling these epigenetic mechanisms may facilitate the identification of early diagnostic biomarkers and the development of targeted therapeutic strategies for NAFLD.<\/jats:p>","DOI":"10.1093\/lifemedi\/lnae030","type":"journal-article","created":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T11:42:16Z","timestamp":1725104536000},"source":"Crossref","is-referenced-by-count":7,"title":["Research on the function of epigenetic regulation in the inflammation of non-alcoholic fatty liver disease"],"prefix":"10.1093","volume":"3","author":[{"given":"Lin","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical University , Changle West Road, Xincheng District,\u00a0Xi\u2019an, Shaanxi 710032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhensheng","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical University , Changle West Road, Xincheng District,\u00a0Xi\u2019an, Shaanxi 710032 ,","place":["China"]},{"name":"Department of Ophthalmology, Xi-Jing Hospital, Fourth Military Medical University , Changle West Road, Xincheng District, Xi\u2019an, Shaanxi 710032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical University , Changle West Road, Xincheng District,\u00a0Xi\u2019an, Shaanxi 710032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,31]]},"reference":[{"key":"2024101008213319400_CIT0001","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.jhep.2011.10.027","article-title":"Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging 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