{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:28:10Z","timestamp":1793042890063,"version":"4.5.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Project of China","award":["2022YFC2702500"],"award-info":[{"award-number":["2022YFC2702500"]}]},{"name":"National Key Research and Development Project of China","award":["2021YFC2700303"],"award-info":[{"award-number":["2021YFC2700303"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82288102"],"award-info":[{"award-number":["82288102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81925013"],"award-info":[{"award-number":["81925013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82225019"],"award-info":[{"award-number":["82225019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101714"],"award-info":[{"award-number":["82101714"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wing-Tat Lee Foundation"},{"name":"Postdoctoral Fellowship Program","award":["GZB20240044"],"award-info":[{"award-number":["GZB20240044"]}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["GZB20240044"],"award-info":[{"award-number":["GZB20240044"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Recurrent implantation failure (RIF) is a leading impediment to assisted reproductive technology, yet the underlying pathogenesis of RIF remains elusive. Recent studies have sought to uncover novel biomarkers and etiological factors of RIF by profiling transcriptomes of endometrial samples. Nonetheless, the inherent heterogeneity among published studies and a scarcity of experimental validations hinder the identification of robust markers of RIF. Hence, we integrated six publicly accessible datasets with 209 samples, including microarray profiles of endometrial samples in the secretory phase. After removing batch effects, we identified 175 differentially expressed genes. Gene set enrichment analysis identified dysregulation of immunological pathways in RIF. We also observed altered immune infiltration and pro-inflammatory cytokines in RIF. Protein\u2013protein interaction network analysis identified ten hub genes, representing two co-expression modules significantly related to RIF. Knockdown of ENTPD3, one of the hub genes, promoted the epithelial-mesenchymal transition process and resulted in elevated levels of pro-inflammatory cytokines. Collectively, our study reveals abnormal gene expressions involving the regulation of epithelial-mesenchymal transition and immune status in RIF, providing valuable insights into its pathogenesis.<\/jats:p>","DOI":"10.1093\/lifemedi\/lnae036","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T16:19:56Z","timestamp":1729527596000},"source":"Crossref","is-referenced-by-count":10,"title":["Integrated transcriptomic analysis reveals dysregulated immune infiltration and pro-inflammatory cytokines in the secretory endometrium of recurrent implantation failure patients"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8183-7747","authenticated-orcid":false,"given":"Ping","family":"Zhou","sequence":"first","affiliation":[{"name":"State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital , Beijing 100191,","place":["China"]},{"name":"Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital) , Beijing 100191,","place":["China"]},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education , Beijing 100191,","place":["China"]},{"name":"Center for Reproductive Medicine, Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology , Beijing 100191,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Mo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital , Beijing 100191,","place":["China"]},{"name":"Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital) , Beijing 100191,","place":["China"]},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education , Beijing 100191,","place":["China"]},{"name":"Center for Reproductive Medicine, Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology , Beijing 100191,","place":["China"]},{"name":"Center of Reproductive Medicine, The First Affiliated Hospital of Guangxi Medical University , Nanning 530021,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanji","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region , Nanning 530003,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital , Beijing 100191,","place":["China"]},{"name":"Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital) , Beijing 100191,","place":["China"]},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education , Beijing 100191,","place":["China"]},{"name":"Center for Reproductive Medicine, Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology , Beijing 100191,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1859-001X","authenticated-orcid":false,"given":"Baoying","family":"Liao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital , Beijing 100191,","place":["China"]},{"name":"Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital) , Beijing 100191,","place":["China"]},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education , Beijing 100191,","place":["China"]},{"name":"Center for Reproductive Medicine, Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology , Beijing 100191,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinxue","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital , Beijing 100191,","place":["China"]},{"name":"Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital) , Beijing 100191,","place":["China"]},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education , Beijing 100191,","place":["China"]},{"name":"Center for Reproductive Medicine, Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology , Beijing 100191,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Mao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital , Beijing 100191,","place":["China"]},{"name":"Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital) , Beijing 100191,","place":["China"]},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education , Beijing 100191,","place":["China"]},{"name":"Center for Reproductive Medicine, Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology , Beijing 100191,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghong","family":"Zeng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital , Beijing 100191,","place":["China"]},{"name":"Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital) , Beijing 100191,","place":["China"]},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education , Beijing 100191,","place":["China"]},{"name":"Center for Reproductive Medicine, Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology , Beijing 100191,","place":["China"]},{"name":"Center of Reproductive Medicine, The First Affiliated Hospital of Guangxi Medical University , Nanning 530021,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziying","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital , Beijing 100191,","place":["China"]},{"name":"Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital) , Beijing 100191,","place":["China"]},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education , Beijing 100191,","place":["China"]},{"name":"Center for Reproductive Medicine, Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology , Beijing 100191,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Boston University School of Medicine , Boston, MA 02118,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5371-3843","authenticated-orcid":false,"given":"Yihua","family":"Yang","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine, The First Affiliated Hospital of Guangxi Medical University , Nanning 530021,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4310-1966","authenticated-orcid":false,"given":"Yang","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital , Beijing 100191,","place":["China"]},{"name":"Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital) , Beijing 100191,","place":["China"]},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education , Beijing 100191,","place":["China"]},{"name":"Center for Reproductive Medicine, Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology , Beijing 100191,","place":["China"]},{"name":"Clinical Stem Cell Research Center, Peking University Third Hospital , Beijing 100191 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Pan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital , Beijing 100191,","place":["China"]},{"name":"Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital) , Beijing 100191,","place":["China"]},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education , Beijing 100191,","place":["China"]},{"name":"Center for Reproductive Medicine, Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology , Beijing 100191,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0305-5579","authenticated-orcid":false,"given":"Rong","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital , Beijing 100191,","place":["China"]},{"name":"Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital) , Beijing 100191,","place":["China"]},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education , Beijing 100191,","place":["China"]},{"name":"Center for Reproductive Medicine, Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology , Beijing 100191,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,21]]},"reference":[{"key":"2024121018190524400_CIT0001","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.rbmo.2013.08.011","article-title":"Recurrent implantation failure: definition and management","volume":"28","author":"Coughlan","year":"2014","journal-title":"Reprod Biomed Online"},{"key":"2024121018190524400_CIT0002","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.rbmo.2019.10.014","article-title":"How common is real repeated implantation failure? An indirect estimate of the prevalence","volume":"40","author":"Busnelli","year":"2020","journal-title":"Reprod Biomed Online"},{"key":"2024121018190524400_CIT0003","doi-asserted-by":"crossref","first-page":"936173","DOI":"10.3389\/fcell.2022.936173","article-title":"Role of endometrial microRNAs in repeated implantation failure (mini-review)","volume":"10","author":"Goharitaban","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"2024121018190524400_CIT0004","first-page":"371","article-title":"The role of mesenchymal-epithelial transition in endometrial function and receptivity","volume":"84","author":"Crha","year":"2019","journal-title":"Ceska Gynekol"},{"key":"2024121018190524400_CIT0005","doi-asserted-by":"crossref","first-page":"3792","DOI":"10.3390\/cimb44090260","article-title":"Inflammation-related molecules at the maternal-fetal interface during pregnancy and in pathologically altered endometrium","volume":"44","author":"Sieg","year":"2022","journal-title":"Curr Issues Mol Biol"},{"key":"2024121018190524400_CIT0006","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1530\/REP-12-0217","article-title":"Endometrial inflammation and effect on implantation improvement and pregnancy outcome","volume":"144","author":"Granot","year":"2012","journal-title":"Reproduction"},{"key":"2024121018190524400_CIT0007","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1038\/s41591-020-1040-z","article-title":"Single-cell transcriptomic atlas of the human endometrium during the menstrual cycle","volume":"26","author":"Wang","year":"2020","journal-title":"Nat Med"},{"key":"2024121018190524400_CIT0008","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.imbio.2004.04.009","article-title":"Immunology of human endometrium","volume":"209","author":"Kammerer","year":"2004","journal-title":"Immunobiology"},{"key":"2024121018190524400_CIT0009","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.4049\/jimmunol.1003153","article-title":"Two unique human decidual macrophage populations","volume":"186","author":"Houser","year":"2011","journal-title":"J Immunol"},{"key":"2024121018190524400_CIT0010","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1095\/biolreprod.103.017574","article-title":"Dendritic cells in the human decidua","volume":"69","author":"Gardner","year":"2003","journal-title":"Biol Reprod"},{"key":"2024121018190524400_CIT0011","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1084\/jem.20030305","article-title":"Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential","volume":"198","author":"Koopman","year":"2003","journal-title":"J Exp Med"},{"key":"2024121018190524400_CIT0012","doi-asserted-by":"crossref","first-page":"e94188","DOI":"10.1371\/journal.pone.0094188","article-title":"The pro-inflammatory cytokine, interleukin-6, enhances the polarization of alternatively activated macrophages","volume":"9","author":"Fernando","year":"2014","journal-title":"PLoS One"},{"key":"2024121018190524400_CIT0013","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev-immunol-032712-100003","article-title":"Immunology of the maternal-fetal interface","volume":"31","author":"Erlebacher","year":"2013","journal-title":"Annu Rev Immunol"},{"key":"2024121018190524400_CIT0014","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/aji.12234","article-title":"Immunological modes of pregnancy loss: inflammation, immune effectors, and stress","volume":"72","author":"Kwak-Kim","year":"2014","journal-title":"Am J Reprod Immunol"},{"key":"2024121018190524400_CIT0015","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/aji.12208","article-title":"Intravenous immunoglobulin G modulates peripheral blood Th17 and Foxp3(+) regulatory T cells in pregnant women with recurrent pregnancy loss","volume":"71","author":"Kim","year":"2014","journal-title":"Am J Reprod Immunol"},{"key":"2024121018190524400_CIT0016","doi-asserted-by":"crossref","first-page":"e12998","DOI":"10.1111\/aji.12998","article-title":"Downregulation of ILT4(+) dendritic cells in recurrent miscarriage and recurrent implantation failure","volume":"80","author":"Liu","year":"2018","journal-title":"Am J Reprod Immunol"},{"key":"2024121018190524400_CIT0017","doi-asserted-by":"crossref","first-page":"10082","DOI":"10.3390\/ijms221810082","article-title":"Biomolecular markers of recurrent implantation failure \u2013 a review","volume":"22","author":"Mrozikiewicz","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2024121018190524400_CIT0018","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nri.2017.64","article-title":"The unique immunological and microbial aspects of pregnancy","volume":"17","author":"Mor","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"2024121018190524400_CIT0019","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/aji.12266","article-title":"The role of inflammation for a successful implantation","volume":"72","author":"Dekel","year":"2014","journal-title":"Am J Reprod Immunol"},{"key":"2024121018190524400_CIT0020","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/path.2948","article-title":"Specific and extensive endometrial deregulation is present before conception in IVF\/ICSI repeated implantation failures (IF) or recurrent miscarriages","volume":"225","author":"Ledee","year":"2011","journal-title":"J Pathol"},{"key":"2024121018190524400_CIT0021","doi-asserted-by":"crossref","first-page":"19411","DOI":"10.1038\/srep19411","article-title":"An endometrial gene expression signature accurately predicts recurrent implantation failure after IVF","volume":"6","author":"Koot","year":"2016","journal-title":"Sci Rep"},{"key":"2024121018190524400_CIT0022","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/14647273.2017.1324180","article-title":"Diverse endometrial mRNA signatures during the window of implantation in patients with repeated implantation failure","volume":"21","author":"Shi","year":"2018","journal-title":"Hum Fertil (Camb)"},{"key":"2024121018190524400_CIT0023","doi-asserted-by":"crossref","first-page":"e12679","DOI":"10.1111\/aji.12679","article-title":"Downregulation of genes related to immune and inflammatory response in IVF implantation failure cases under controlled ovarian stimulation","volume":"78","author":"Pathare","year":"2017","journal-title":"Am J Reprod Immunol"},{"key":"2024121018190524400_CIT0024","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1177\/1933719118792104","article-title":"Potential marker pathways in the endometrium that may cause recurrent implantation failure","volume":"26","author":"Bastu","year":"2019","journal-title":"Reprod Sci"},{"key":"2024121018190524400_CIT0025","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1093\/humrep\/dey022","article-title":"Decreased PECAM1-mediated TGF-beta1 expression in the mid-secretory endometrium in women with recurrent implantation failure","volume":"33","author":"Guo","year":"2018","journal-title":"Hum Reprod"},{"key":"2024121018190524400_CIT0026","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1186\/1752-0509-8-S4-S11","article-title":"cytoHubba: identifying hub objects and sub-networks from complex interactome","volume":"8","author":"Chin","year":"2014","journal-title":"BMC Syst Biol"},{"key":"2024121018190524400_CIT0027","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1071\/RD17257","article-title":"Expression of ENPP3 in human cyclic endometrium: a novel molecule involved in embryo implantation","volume":"30","author":"Chen","year":"2018","journal-title":"Reprod Fertil Dev"},{"key":"2024121018190524400_CIT0028","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.fertnstert.2009.07.1668","article-title":"Defective endometrial prostaglandin synthesis identified in patients with repeated implantation failure undergoing in vitro fertilization","volume":"94","author":"Achache","year":"2010","journal-title":"Fertil Steril"},{"key":"2024121018190524400_CIT0029","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1016\/j.cca.2010.06.025","article-title":"Association of -765G&gt;C polymorphism of the COX-2 gene with recurrent embryo implantation failure in Southern Chilean women","volume":"411","author":"Salazar","year":"2010","journal-title":"Clin Chim Acta"},{"key":"2024121018190524400_CIT0030","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/rmb2.12030","article-title":"Thin endometrium transcriptome analysis reveals a potential mechanism of implantation failure","volume":"16","author":"Maekawa","year":"2017","journal-title":"Reprod Med Biol"},{"key":"2024121018190524400_CIT0031","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1111\/jcmm.16586","article-title":"Construction of circRNA-miRNA-mRNA network in the pathogenesis of recurrent implantation failure using integrated bioinformatics study","volume":"26","author":"Ahmadi","year":"2022","journal-title":"J Cell Mol Med"},{"key":"2024121018190524400_CIT0032","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1111\/j.1467-9868.2005.00527.x","article-title":"Regularization and variable selection via the elastic net","volume":"67","author":"Zou","year":"2005","journal-title":"J R Stat Soc Ser B Stat Method"},{"key":"2024121018190524400_CIT0033","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1002\/imt2.36","article-title":"Sangerbox: a comprehensive, interaction-friendly clinical bioinformatics analysis platform","volume":"1","author":"Shen","year":"2022","journal-title":"Imeta"},{"key":"2024121018190524400_CIT0034","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.fertnstert.2022.04.023","article-title":"Immune determinants of endometrial receptivity: a biological perspective","volume":"117","author":"Robertson","year":"2022","journal-title":"Fertil Steril"},{"key":"2024121018190524400_CIT0035","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2017.05.031","article-title":"Endometrial receptivity in the eutopic endometrium of women with endometriosis: it is affected, and let me show you why","volume":"108","author":"Lessey","year":"2017","journal-title":"Fertil Steril"},{"key":"2024121018190524400_CIT0036","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0753-3322(94)90005-1","article-title":"Cytokines and macrophages","volume":"48","author":"Cavaillon","year":"1994","journal-title":"Biomed Pharmacother"},{"key":"2024121018190524400_CIT0037","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0171-2985(96)80017-9","article-title":"TNF-alpha-induced regulation and signalling in macrophages","volume":"195","author":"Riches","year":"1996","journal-title":"Immunobiology"},{"key":"2024121018190524400_CIT0038","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0171-2985(98)80075-2","article-title":"Human dendritic cells express functional interleukin-7","volume":"198","author":"Sorg","year":"1998","journal-title":"Immunobiology"},{"key":"2024121018190524400_CIT0039","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/S0167-5699(00)01648-0","article-title":"Interleukin 18: a pleiotropic participant in chronic inflammation","volume":"21","author":"McInnes","year":"2000","journal-title":"Immunol Today"},{"key":"2024121018190524400_CIT0040","first-page":"311","article-title":"Venous stasis causes release of interleukin 1beta (IL-1beta), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNFalpha) by monocyte-macrophage","volume":"22","author":"Signorelli","year":"2000","journal-title":"Clin Hemorheol Microcirc"},{"key":"2024121018190524400_CIT0041","first-page":"169","article-title":"CSF-1 as a regulator of macrophage activation and immune responses","volume":"51","author":"Sweet","year":"2003","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"2024121018190524400_CIT0042","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.immuni.2006.09.007","article-title":"A distal conserved sequence element controls Ifng gene expression by T cells and NK cells","volume":"25","author":"Hatton","year":"2006","journal-title":"Immunity"},{"key":"2024121018190524400_CIT0043","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.4049\/jimmunol.2001342","article-title":"Ectonucleotidases in inflammation, immunity, and cancer","volume":"206","author":"Haas","year":"2021","journal-title":"J Immunol"},{"key":"2024121018190524400_CIT0044","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/humupd\/dmy035","article-title":"The role of mesenchymal-epithelial transition in endometrial function","volume":"25","author":"Owusu-Akyaw","year":"2019","journal-title":"Hum Reprod Update"},{"key":"2024121018190524400_CIT0045","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/nan.12221","article-title":"Purine metabolism gene deregulation in Parkinson\u2019s disease","volume":"41","author":"Garcia-Esparcia","year":"2015","journal-title":"Neuropathol Appl Neurobiol"},{"key":"2024121018190524400_CIT0046","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1093\/ecco-jcc\/jjx058","article-title":"Expression of ecto-nucleoside triphosphate diphosphohydrolases-2 and -3 in the enteric nervous system affects inflammation in experimental colitis and Crohn\u2019s disease","volume":"11","author":"Feldbr\u00fcgge","year":"2017","journal-title":"J Crohns Colitis"},{"key":"2024121018190524400_CIT0047","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12967-019-1770-1","article-title":"In vitro effects of interleukin (IL)-1 beta inhibition on the epithelial-to-mesenchymal transition (EMT) of renal tubular and hepatic stellate cells","volume":"17","author":"Masola","year":"2019","journal-title":"J Transl Med"},{"key":"2024121018190524400_CIT0048","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13402-019-00489-1","article-title":"The dual role of tumor necrosis factor-alpha (TNF-alpha) in breast cancer: molecular insights and therapeutic approaches","volume":"43","author":"Cruceriu","year":"2020","journal-title":"Cell Oncol (Dordr)"},{"key":"2024121018190524400_CIT0049","doi-asserted-by":"crossref","first-page":"19970","DOI":"10.1038\/srep19970","article-title":"Intracrine androgens enhance decidualization and modulate expression of human endometrial receptivity genes","volume":"6","author":"Gibson","year":"2016","journal-title":"Sci Rep"},{"key":"2024121018190524400_CIT0050","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/s41577-022-00694-4","article-title":"Immunomodulation by endothelial cells \u2013 partnering up with the immune system","volume":"22","author":"Amersfoort","year":"2022","journal-title":"Nat Rev Immunol"},{"key":"2024121018190524400_CIT0051","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/s41577-021-00540-z","article-title":"Fibroblasts as immune regulators in infection, inflammation and cancer","volume":"21","author":"Davidson","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"2024121018190524400_CIT0052","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s12935-020-01195-x","article-title":"The yin and yang functions of extracellular ATP and adenosine in tumor immunity","volume":"20","author":"Feng","year":"2020","journal-title":"Cancer Cell Int"},{"key":"2024121018190524400_CIT0053","first-page":"5051","article-title":"Autocrine regulation of TGF-beta1-induced cell migration by exocytosis of ATP and activation of P2 receptors in human lung cancer cells","volume":"125","author":"Takai","year":"2012","journal-title":"J Cell Sci"},{"key":"2024121018190524400_CIT0054","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.1093\/nar\/28.18.3442","article-title":"STRING: a web-server to retrieve and display the repeatedly occurring neighbourhood of a gene","volume":"28","author":"Snel","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"2024121018190524400_CIT0055","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/s13059-017-1349-1","article-title":"xCell: digitally portraying the tissue cellular heterogeneity landscape","volume":"18","author":"Aran","year":"2017","journal-title":"Genome Biol"}],"container-title":["Life Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/lifemedi\/advance-article-pdf\/doi\/10.1093\/lifemedi\/lnae036\/59931965\/lnae036.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/lifemedi\/article-pdf\/3\/5\/lnae036\/60949471\/lnae036.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/lifemedi\/article-pdf\/3\/5\/lnae036\/60949471\/lnae036.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T18:48:31Z","timestamp":1733856511000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/lifemedi\/article\/doi\/10.1093\/lifemedi\/lnae036\/7829039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,1]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/lifemedi\/lnae036","relation":{},"ISSN":["2755-1733"],"issn-type":[{"value":"2755-1733","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,10]]},"published":{"date-parts":[[2024,10,1]]},"article-number":"lnae036"}}