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In the study, we integrated ours and published single-cell RNA sequencing data from E11.5 (embryonic day 11.5) until M12 (12-month-old) ovaries to show the dynamics of somatic cells along the developmental timeline. The intercellular crosstalk among somatic cell types was depicted with collagen signaling pathway as the most outgoing signals from stromal cells. We identified mesenchymal progenitor cells (CD24+) as the origin of stromal cells. Although their numbers decreased significantly in adults, the cells served as the major signal sender until ovarian senescence. Moreover, the ovarian injury could activate these stem cells and induce stroma remodeling in the aged ovary. Thus, mesenchymal progenitor cells may represent a new strategy to delay ovarian aging in the future.<\/jats:p>","DOI":"10.1093\/lifemedi\/lnae041","type":"journal-article","created":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T08:52:16Z","timestamp":1735375936000},"source":"Crossref","is-referenced-by-count":13,"title":["Single-cell RNA sequencing reveals the intercellular crosstalk and the regulatory landscape of stromal cells during the whole life of the mouse ovary"],"prefix":"10.1093","volume":"3","author":[{"given":"Wan","family":"Jiang","sequence":"first","affiliation":[{"name":"Bioinformatics Center of AMMS , Beijing 100850 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenya","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University , Nanjing 210029 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