{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:27:16Z","timestamp":1793053636134,"version":"4.5.0"},"reference-count":229,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The ovary is a crucial gonadal organ that supports female reproductive and endocrine functions. Ovarian aging can result in decreased fertility and dysfunction across multiple organs. Research has demonstrated that cellular senescence in various cell types within the ovary can trigger a decline in ovarian function through distinct stress responses, resulting in ovarian aging. This review explores how cellular senescence may contribute to ovarian aging and reproductive failure. Additionally, we discuss the factors that cause ovarian cellular senescence, including the accumulation of advanced glycation end products, oxidative stress, mitochondrial dysfunction, DNA damage, telomere shortening, and exposure to chemotherapy. Furthermore, we discuss senescence in six distinct cell types, including oocytes, granulosa cells, ovarian theca cells, immune cells, ovarian surface epithelium, and ovarian endothelial cells, inside the ovary and explore their contribution to the accelerated ovarian aging. Lastly, we describe potential senotherapeutics for the treatment of ovarian aging and offer novel strategies for ovarian longevity.<\/jats:p>","DOI":"10.1093\/lifemedi\/lnaf004","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T07:14:08Z","timestamp":1737530048000},"source":"Crossref","is-referenced-by-count":34,"title":["Exploration of the mechanism and therapy of ovarian aging by targeting cellular senescence"],"prefix":"10.1093","volume":"4","author":[{"given":"Weicheng","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030,","place":["China"]},{"name":"National Clinical Research Center for Obstetrical and Gynecological Diseases , Wuhan 430030,","place":["China"]},{"name":"Key Laboratory of Cancer Invasion and Metastasis, Ministry of Education , Wuhan 430030,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaichen","family":"Wang","sequence":"additional","affiliation":[{"name":"Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yourong","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030,","place":["China"]},{"name":"National Clinical Research Center for Obstetrical and Gynecological Diseases , Wuhan 430030,","place":["China"]},{"name":"Key Laboratory of Cancer Invasion and Metastasis, Ministry of Education , Wuhan 430030,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan-Hao","family":"Tsui","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital , Kaohsiung 813779, Taiwan ,","place":["China"]},{"name":"Department of Obstetrics and Gynecology, Yang-Ming University , Taipei 112304, Taiwan ,","place":["China"]},{"name":"Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University , Pingtung 900391, Taiwan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keshav K","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Genetics, School of Medicine, The University of Alabama at Birmingham , Birmingham, AL 35294,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B","family":"Stout","sequence":"additional","affiliation":[{"name":"Aging & Metabolism Research Program, Oklahoma Medical Research Foundation , Oklahoma City, OK 73104,","place":["USA"]},{"name":"Oklahoma City Veterans Affairs Medical Center , Oklahoma City, OK 73104,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8610-952X","authenticated-orcid":false,"given":"Shixuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030,","place":["China"]},{"name":"National Clinical Research Center for Obstetrical and Gynecological Diseases , Wuhan 430030,","place":["China"]},{"name":"Key Laboratory of Cancer Invasion and Metastasis, Ministry of Education , Wuhan 430030,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030,","place":["China"]},{"name":"National Clinical Research Center for Obstetrical and Gynecological Diseases , Wuhan 430030,","place":["China"]},{"name":"Key Laboratory of Cancer Invasion and Metastasis, Ministry of Education , Wuhan 430030,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,1,23]]},"reference":[{"key":"2025031814273212800_CIT0001","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1055\/s-0035-1567818","article-title":"Strategies for controlled ovarian stimulation in the setting of ovarian aging","volume":"33","author":"Ata","year":"2015","journal-title":"Semin Reprod Med"},{"key":"2025031814273212800_CIT0002","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ogc.2019.04.008","article-title":"Menopause: hormones, lifestyle, and optimizing aging","volume":"46","author":"Minkin","year":"2019","journal-title":"Obstet Gynecol Clin North Am"},{"key":"2025031814273212800_CIT0003","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1126\/science.339.6121.749","article-title":"Reproductive biology. 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