{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:10:22Z","timestamp":1793419822162,"version":"4.5.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T00:00:00Z","timestamp":1740268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Rosacea, as a progressive and chronic inflammatory skin disease, lacks safe and effective treatment options. Our previous study reported metabolic disturbance in rosacea patients, containing abnormal lipid metabolism. Building on this, we characterized significant alterations in fatty acid metabolism among rosacea patients, with a notable increase in linoleic acid (LNA) levels. We further demonstrated that LNA prevents rosacea-like dermatitis in LL37-induced rosacea-like mouse model. Our evidence indicated that LNA hyperactivates PPAR\u03b3 signaling in the epidermis, a phenomenon observed in both rosacea patients and mouse model. Inhibiting PPAR\u03b3 rescued the effect of LNA in LL37-induced mice. Additionally, our in vivo and in vitro evidence strongly supported the presence of mitochondrial damage in the keratinocytes of rosacea. LNA stimulated PPAR\u03b3 to reduce the reactive oxygen species production, increasing the generation of ATP and recovering mitochondrial membrane potential. Finally, through a prospective cohort study utilizing UK Biobank data and linkage disequilibrium score regression (LDSC) regression analysis, we further confirmed LNA levels are negatively related to the risk of rosacea, highlighting LNA as a promising therapeutic strategy for rosacea treatment.<\/jats:p>","DOI":"10.1093\/lifemedi\/lnaf005","type":"journal-article","created":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T04:41:46Z","timestamp":1740285706000},"source":"Crossref","is-referenced-by-count":7,"title":["Linoleic acid improves rosacea through repairing mitochondrial damage in keratinocytes"],"prefix":"10.1093","volume":"4","author":[{"given":"Mei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology, Xiangya Hospital, Central South University , Changsha 410008 ,","place":["China"]},{"name":"Hunan Key Laboratory of Aging Biology, Xiangya Hospital, Central South University , Changsha 410008 ,","place":["China"]},{"name":"National Clinical 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410008 ,","place":["China"]},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , Changsha 410008 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfu","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xiangya Hospital, Central South University , Changsha 410008 ,","place":["China"]},{"name":"Hunan Key Laboratory of Aging Biology, Xiangya Hospital, Central South University , Changsha 410008 ,","place":["China"]},{"name":"Department of Dermatology, The First Hospital of Changsha , Changsha 410005 ,","place":["China"]},{"name":"The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University , Changsha 410008 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shuguang Hospital Affiliated with 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