{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:55:58Z","timestamp":1791190558627,"version":"4.1.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Recent advances in human blastoids have opened new avenues for modeling early human development and implantation. Human blastoids can be generated in large numbers, making them well-suited for high-throughput screening. However, automated methods for evaluating and characterizing blastoid morphology are lacking. We developed a deep-learning model\u2014deepBlastoid\u2014for automated classification of live human blastoids using only brightfield images. The model processes 273.6 images per second with an average accuracy of 87%, which is further improved to 97% by integrating a Confidence Rate metric. deepBlastoid outperformed human experts in throughput while matching accuracy in blastoid classification. We demonstrated the utility of the model in two use cases: (i) systematic assessment of the effect of lysophosphatidic acid (LPA) on blastoid formation and (ii) evaluating the impact of dimethyl sulfoxide (DMSO) on blastoid formation. The evaluation results of deepBlastoid using over 10,000 images were consistent with the known drug effects and showed subtle but significant effects that might have been overlooked in manual assessments. The publicly available deepBlastoid model enables researchers to train customized models based on their imaging and protocols, providing an efficient, automated tool for blastoid classification with broad applications in research, drug screening, and in-vitro-fertilization applications.<\/jats:p>","DOI":"10.1093\/lifemedi\/lnaf026","type":"journal-article","created":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T07:50:08Z","timestamp":1751701808000},"source":"Crossref","is-referenced-by-count":5,"title":["deepBlastoid: a deep learning model for automated and efficient evaluation of human blastoids"],"prefix":"10.1093","volume":"4","author":[{"given":"Zejun","family":"Fan","sequence":"first","affiliation":[{"name":"Bioengineering Program, Biological and Environmental Science and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST) , Thuwal 23955 ,","place":["Saudi Arabia"]},{"name":"Bioscience Program, Biological and Environmental Science and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST) , Thuwal 23955 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Li","sequence":"additional","affiliation":[{"name":"Computer Science Program, Computer, Electrical and Mathematical Science and Engineering Division (CEMSE), King Abdullah University of Science and Technology (KAUST) , Thuwal 23955 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Jin","sequence":"additional","affiliation":[{"name":"Bioscience Program, Biological and Environmental Science and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST) , Thuwal 23955 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun Pandian","family":"Chandrasekaran","sequence":"additional","affiliation":[{"name":"Bioscience Program, Biological and Environmental Science and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST) , Thuwal 23955 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8026-9549","authenticated-orcid":false,"given":"Ismail M","family":"Shakir","sequence":"additional","affiliation":[{"name":"Bioscience Program, Biological and Environmental Science and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST) , Thuwal 23955 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Bioscience Program, Biological and Environmental Science and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST) , Thuwal 23955 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisha","family":"Siddique","sequence":"additional","affiliation":[{"name":"Bioscience Program, Biological and Environmental Science and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST) , Thuwal 23955 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengge","family":"Wang","sequence":"additional","affiliation":[{"name":"Bioscience Program, Biological and Environmental Science and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST) , Thuwal 23955 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Bioscience Program, Biological and Environmental Science and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST) , Thuwal 23955 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeteng","family":"Tian","sequence":"additional","affiliation":[{"name":"Bioscience Program, Biological and Environmental Science and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST) , Thuwal 23955 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wonka","sequence":"additional","affiliation":[{"name":"Computer Science Program, Computer, Electrical and Mathematical Science and Engineering Division (CEMSE), King Abdullah University of Science and Technology (KAUST) , Thuwal 23955 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0827-8907","authenticated-orcid":false,"given":"Mo","family":"Li","sequence":"additional","affiliation":[{"name":"Bioengineering Program, Biological and Environmental Science and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST) , Thuwal 23955 ,","place":["Saudi Arabia"]},{"name":"Bioscience Program, Biological and Environmental Science and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST) , Thuwal 23955 ,","place":["Saudi Arabia"]},{"name":"KAUST Center of Excellence for Smart Health (KCSH) , Thuwal 23955 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"key":"2026100504370463500_CIT0001","doi-asserted-by":"crossref","first-page":"203934","DOI":"10.1016\/j.cdev.2024.203934","article-title":"Epigenetic signatures of trophoblast lineage and their biological functions","volume":"179","author":"Wang","year":"2024","journal-title":"Cells Dev"},{"key":"2026100504370463500_CIT0002","doi-asserted-by":"crossref","first-page":"D708","DOI":"10.2741\/Watson","article-title":"Regulation of blastocyst formation","volume":"6","author":"Watson","year":"2001","journal-title":"Front Biosci-Landmrk"},{"key":"2026100504370463500_CIT0003","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/mrd.1080330417","article-title":"The cell biology of blastocyst development","volume":"33","author":"Watson","year":"1992","journal-title":"Mol Reprod Dev"},{"key":"2026100504370463500_CIT0004","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.3390\/ani14131882","article-title":"Early embryonic development in agriculturally important species","volume":"14","author":"Bazer","year":"2024","journal-title":"Animals-Basel"},{"key":"2026100504370463500_CIT0005","doi-asserted-by":"crossref","first-page":"4206","DOI":"10.1111\/febs.17077","article-title":"Spatial and molecular anatomy of the endometrium during embryo implantation: a current overview of key regulators of blastocyst invasion","volume":"291","author":"Akaeda","year":"2024","journal-title":"FEBS J"},{"key":"2026100504370463500_CIT0006","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/wdev.220","article-title":"The mammalian blastocyst","volume":"5","author":"Frankenberg","year":"2016","journal-title":"WIREs Dev Biol"},{"key":"2026100504370463500_CIT0007","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.anireprosci.2004.04.004","article-title":"Molecular regulation of blastocyst formation","volume":"82-83","author":"Watson","year":"2004","journal-title":"Anim Reprod Sci"},{"key":"2026100504370463500_CIT0008","doi-asserted-by":"crossref","first-page":"e6082","DOI":"10.1371\/journal.pone.0006082","article-title":"Early cell fate decisions of human embryonic stem cells and mouse epiblast stem cells are controlled by the same signalling pathways","volume":"4","author":"Vallier","year":"2009","journal-title":"PLoS One"},{"key":"2026100504370463500_CIT0009","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nrg2564","article-title":"Making a firm decision: multifaceted regulation of cell fate in the early mouse embryo","volume":"10","author":"Zernicka-Goetz","year":"2009","journal-title":"Nat Rev Genet"},{"key":"2026100504370463500_CIT0010","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.stem.2024.01.004","article-title":"Extra (embryonic) dialogues keys to improved stem cell-based embryo models","volume":"31","author":"Chandrasekaran","year":"2024","journal-title":"Cell Stem Cell"},{"key":"2026100504370463500_CIT0011","doi-asserted-by":"crossref","first-page":"111122","DOI":"10.1016\/j.isci.2024.111122","article-title":"A comparative analysis of blastoid models through single-cell transcriptomics","volume":"27","author":"Balubaid","year":"2024","journal-title":"Iscience"},{"key":"2026100504370463500_CIT0012","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.stem.2023.08.002","article-title":"Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross talk","volume":"30","author":"Yu","year":"2023","journal-title":"Cell Stem Cell"},{"key":"2026100504370463500_CIT0013","doi-asserted-by":"crossref","first-page":"102135","DOI":"10.1016\/j.gde.2023.102135","article-title":"Human blastoid as an in vitro model of human blastocysts","volume":"84","author":"Liu","year":"2024","journal-title":"Curr Opin Genet Dev"},{"key":"2026100504370463500_CIT0014","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.stem.2023.08.005","article-title":"3D-cultured blastoids model human embryogenesis from pre-implantation to early gastrulation stages","volume":"30","author":"Karvas","year":"2023","journal-title":"Cell Stem Cell"},{"key":"2026100504370463500_CIT0015","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41586-021-04267-8","article-title":"Human blastoids model blastocyst development and implantation","volume":"601","author":"Kagawa","year":"2022","journal-title":"Nature"},{"key":"2026100504370463500_CIT0016","article-title":"Protocol for Human Blastoids Modeling Blastocyst Development and Implantation","volume":"186","author":"Kagawa","year":"2022","journal-title":"Jove-J Vis Exp"},{"key":"2026100504370463500_CIT0017","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/s41467-024-44969-x","article-title":"Self-renewing human na\u00efve pluripotent stem cells dedifferentiate in 3D culture and form blastoids spontaneously","volume":"15","author":"Guo","year":"2024","journal-title":"Nat Commun"},{"key":"2026100504370463500_CIT0018","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/s41586-021-03356-y","article-title":"Blastocyst-like structures generated from human pluripotent stem cells","volume":"591","author":"Yu","year":"2021","journal-title":"Nature"},{"key":"2026100504370463500_CIT0019","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.stem.2021.04.031","article-title":"Naive stem cell blastocyst model captures human embryo lineage segregation","volume":"28","author":"Yanagida","year":"2021","journal-title":"Cell Stem Cell"},{"key":"2026100504370463500_CIT0020","doi-asserted-by":"crossref","first-page":"5550","DOI":"10.1038\/s41467-021-25853-4","article-title":"Reconstructing aspects of human embryogenesis with pluripotent stem cells","volume":"12","author":"Sozen","year":"2021","journal-title":"Nat Commun"},{"key":"2026100504370463500_CIT0021","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41421-021-00316-8","article-title":"Generation of human blastocyst-like structures from pluripotent stem cells","volume":"7","author":"Fan","year":"2021","journal-title":"Cell Discov"},{"key":"2026100504370463500_CIT0022","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.semcdb.2022.07.003","article-title":"Human embryoids: a new strategy of recreating the first steps of embryonic development","volume":"141","author":"Zhang","year":"2023","journal-title":"Semin Cell Dev Biol"},{"key":"2026100504370463500_CIT0023","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1093\/nar\/gkad209","article-title":"Quantitative haplotype-resolved analysis of mitochondrial DNA heteroplasmy in Human single oocytes, blastoids, and pluripotent stem cells","volume":"51","author":"Bi","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"2026100504370463500_CIT0024","doi-asserted-by":"publisher","DOI":"10.1101\/2023.12.31.573770","article-title":"DMSO derives trophectoderm and clonal blastoid from 1 single human pluripotent","author":"Alsolami","year":"2024","journal-title":"Stem Cell"},{"key":"2026100504370463500_CIT0025","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/s41596-023-00802-1","article-title":"Generating human blastoids modeling blastocyst-stage embryos and implantation","volume":"18","author":"Khoei","year":"2023","journal-title":"Nat Protoc"},{"key":"2026100504370463500_CIT0026","doi-asserted-by":"crossref","first-page":"102125","DOI":"10.1016\/j.gde.2023.102125","article-title":"An update on human pre- and peri-implantation development: a blueprint for blastoids","volume":"83","author":"David","year":"2023","journal-title":"Curr Opin Genet Dev"},{"key":"2026100504370463500_CIT0027","doi-asserted-by":"crossref","first-page":"7756","DOI":"10.1038\/s41467-024-51823-7","article-title":"Automatic ploidy prediction and quality assessment of human blastocysts using time-lapse imaging","volume":"15","author":"Rajendran","year":"2024","journal-title":"Nat Commun"},{"key":"2026100504370463500_CIT0028","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.3390\/app12073531","article-title":"An image processing protocol to extract variables predictive of human embryo fitness for assisted reproduction","volume":"12","author":"Ch\u00e9les","year":"2022","journal-title":"Appl Sci-Basel"},{"key":"2026100504370463500_CIT0029","doi-asserted-by":"crossref","first-page":"e10010","DOI":"10.2196\/10010","article-title":"Artificial intelligence versus clinicians in disease diagnosis: systematic review","volume":"7","author":"Shen","year":"2019","journal-title":"Jmir Med Inf"},{"key":"2026100504370463500_CIT0030","doi-asserted-by":"crossref","first-page":"891","DOI":"10.3390\/ph16060891","article-title":"The role of AI in drug discovery: challenges, opportunities, and strategies","volume":"16","author":"Blanco-Gonz\u00e1lez","year":"2023","journal-title":"Pharmaceuticals-Base."},{"key":"2026100504370463500_CIT0031","doi-asserted-by":"crossref","first-page":"5831","DOI":"10.1097\/MS9.0000000000001320","article-title":"Artificial intelligence (AI) in personalized medicine: AI-generated personalized therapy regimens based on genetic and medical history: short communication","volume":"85","author":"Parekh","year":"2023","journal-title":"Ann Med Surg (Lond)"},{"key":"2026100504370463500_CIT0032","doi-asserted-by":"crossref","first-page":"815-+","DOI":"10.1038\/s41592-023-01873-4","article-title":"EmbryoNet: using deep learning to link embryonic phenotypes to signaling pathways","volume":"20","author":"Capek","year":"2023","journal-title":"Nat Methods"},{"key":"2026100504370463500_CIT0033","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1038\/s41467-025-56908-5","article-title":"AI-based approach to dissect the variability of mouse stem cell-derived embryo models","volume":"16","author":"Caldarelli","year":"2025","journal-title":"Nat Commun"},{"key":"2026100504370463500_CIT0034","doi-asserted-by":"crossref","first-page":"041212","DOI":"10.1117\/1.JEI.31.4.041212","article-title":"COVID-19 detection using machine learning: a large scale assessment of x-ray and CT image datasets","volume":"31","author":"Sohan","year":"2022","journal-title":"J Electron Imag"},{"key":"2026100504370463500_CIT0035","first-page":"2986","article-title":"A convolutional neural network-based, quantitative complete blood count scattergram-mapping framework promptly screens acute promyelocytic leukemia with high sensitivity","volume":"129","author":"Liao","year":"2023","journal-title":"Cancer-Am Cancer Soc"},{"key":"2026100504370463500_CIT0036","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s12530-023-09559-0","article-title":"An enhanced ResNet-50 deep learning model for arrhythmia detection using electrocardiogram biomedical indicators","volume":"15","author":"Anand","year":"2024","journal-title":"Evol Syst-Ger"},{"key":"2026100504370463500_CIT0037","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1007\/s00403-022-02494-1","article-title":"Dimethyl sulfoxide (DMSO): a solvent that may solve selected cutaneous clinical challenges","volume":"315","author":"Karim","year":"2023","journal-title":"Arch Dermatol Res"},{"key":"2026100504370463500_CIT0038","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2174\/1385272826666220112162942","article-title":"Recent advances in Dimethyl Sulfoxide (DMSO) used as a multipurpose reactant","volume":"26","author":"Cai","year":"2022","journal-title":"Curr Org Chem"},{"key":"2026100504370463500_CIT0039","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.3390\/cells13171403","article-title":"Centriole translational planar polarity in monociliated epithelia","volume":"13","author":"Donati","year":"2024","journal-title":"Cells-Basel"},{"key":"2026100504370463500_CIT0040","doi-asserted-by":"crossref","first-page":"203903","DOI":"10.1016\/j.cdev.2024.203903","article-title":"Spemann-Mangold organizer and mesoderm induction","volume":"178","author":"Asashima","year":"2024","journal-title":"Cells Dev"},{"key":"2026100504370463500_CIT0041","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1080\/14767058.2020.1765157","article-title":"The impact of state legalization on rates of marijuana use in pregnancy in a universal drug screening population","volume":"35","author":"Lee","year":"2022","journal-title":"J Matern-Fetal Neo M"},{"key":"2026100504370463500_CIT0042","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/dta.1767","article-title":"Monitoring of drug intake during pregnancy by questionnaires and LC-MS\/MS drug urine screening: evaluation of both monitoring methods","volume":"7","author":"Hoeke","year":"2015","journal-title":"Drug Test Anal"},{"key":"2026100504370463500_CIT0043","first-page":"S47","article-title":"Screening for alcohol and other drug use during pregnancy: Exploring rates of detection and intervention during antenatal care visits","volume":"42","author":"Briley","year":"2023","journal-title":"Drug Alcohol Rev"},{"key":"2026100504370463500_CIT0044","first-page":"286","article-title":"Vanishing Gradient Mitigation with Deep Learning Neural Network Optimization","author":"Tan","year":"2019"},{"key":"2026100504370463500_CIT0045","doi-asserted-by":"crossref","first-page":"14665","DOI":"10.1038\/s41598-018-33013-w","article-title":"Development of a deep residual learning algorithm to screen for glaucoma from fundus photography","volume":"8","author":"Shibata","year":"2018","journal-title":"Sci Rep-Uk"},{"key":"2026100504370463500_CIT0046","first-page":"511","article-title":"A Review of deep learning methods applied on load forecasting","author":"Almalaq","year":"2017"},{"key":"2026100504370463500_CIT0047","first-page":"23803","article-title":"Cross-entropy loss functions: theoretical analysis and applications","volume":"202","author":"Mao","year":"2023","journal-title":"Pr Mach Learn Res"},{"key":"2026100504370463500_CIT0048","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3390\/e26060491","article-title":"Correlations of cross-entropy loss in machine learning","volume":"26","author":"Connor","year":"2024","journal-title":"Entropy-Switz"},{"key":"2026100504370463500_CIT0049","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/s12911-022-01942-2","article-title":"On the analysis of data augmentation methods for spectral imaged based heart sound classification using convolutional neural networks","volume":"22","author":"Zhou","year":"2022","journal-title":"Bmc Med Inform Decis"},{"key":"2026100504370463500_CIT0050","first-page":"979","article-title":"Data augmentation for deep learning based cattle segmentation in precision livestock farming","volume":"20","author":"Qiao","year":"2020","journal-title":"Ieee Int Con Auto Sc"},{"key":"2026100504370463500_CIT0051","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3390\/diagnostics12010016","article-title":"Weakly supervised ternary stream data augmentation fine-grained classification network for identifying acute lymphoblastic leukemia","volume":"12","author":"Liu","year":"2022","journal-title":"Diagnostics"},{"key":"2026100504370463500_CIT0052","doi-asserted-by":"crossref","first-page":"3912","DOI":"10.3390\/ijms25073912","article-title":"Effects of regulating hippo and Wnt on the development and fate differentiation of bovine embryo","volume":"25","author":"Zhang","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2026100504370463500_CIT0053","doi-asserted-by":"crossref","first-page":"12597","DOI":"10.1002\/rmb2.12597","article-title":"Roles of lipid mediators in early pregnancy events","volume":"23","author":"Aikawa","year":"2024","journal-title":"Reprod Med Biol"},{"key":"2026100504370463500_CIT0054","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/bs.ctdb.2015.11.015","article-title":"Making the mouse blastocyst: past, present, and future","volume":"117","author":"Rossant","year":"2016","journal-title":"Curr Top Dev Biol"},{"key":"2026100504370463500_CIT0055","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s41586-020-2759-x","article-title":"Initiation of a conserved trophectoderm program in human, cow and mouse embryos","volume":"587","author":"Gerri","year":"2020","journal-title":"Nature"},{"key":"2026100504370463500_CIT0056","doi-asserted-by":"crossref","first-page":"12407","DOI":"10.1371\/journal.pntd.0012407","article-title":"Burbano RMR. Prevention of congenital chagas disease by trypanocide treatment in women of reproductive age: A meta-analysis of observational studies","volume":"18","author":"de Moraes","year":"2024","journal-title":"Plos Neglect Trop D"},{"key":"2026100504370463500_CIT0057","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.slasd.2022.03.004","article-title":"deepOrganoid: A brightfield cell viability model for screening matrix-embedded organoids","volume":"27","author":"Powell","year":"2022","journal-title":"SLAS Discovery"},{"key":"2026100504370463500_CIT0058","doi-asserted-by":"crossref","first-page":"e27398","DOI":"10.1016\/j.heliyon.2024.e27398","article-title":"Reviewing 3D convolutional neural network approaches for medical image segmentation","volume":"10","author":"Ilesanmi","year":"2024","journal-title":"Heliyon"},{"key":"2026100504370463500_CIT0059","article-title":"An LSTM based approach for the classification of customer reviews: an exploratory study","author":"Vyas","year":"2021"},{"key":"2026100504370463500_CIT0060","first-page":"1526","article-title":"MoCoGAN: decomposing motion and content for video generation","author":"Tulyakov","year":"2018"},{"key":"2026100504370463500_CIT0061","first-page":"1205","article-title":"Convolutional method for modeling video temporal context effectively in transformer","author":"Park","year":"2023"},{"key":"2026100504370463500_CIT0062","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1242\/dev.146811","article-title":"Epigenetic resetting of human pluripotency","volume":"144","author":"Guo","year":"2017","journal-title":"Development"}],"container-title":["Life Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/lifemedi\/advance-article-pdf\/doi\/10.1093\/lifemedi\/lnaf026\/63727839\/lnaf026.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/lifemedi\/article-pdf\/4\/6\/lnaf026\/63727839\/lnaf026.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/lifemedi\/article-pdf\/4\/6\/lnaf026\/63727839\/lnaf026.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:37:20Z","timestamp":1791189440000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/lifemedi\/article\/doi\/10.1093\/lifemedi\/lnaf026\/8196602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,11]]},"references-count":62,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12,5]]}},"URL":"https:\/\/doi.org\/10.1093\/lifemedi\/lnaf026","relation":{},"ISSN":["2755-1733"],"issn-type":[{"value":"2755-1733","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,12]]},"published":{"date-parts":[[2025,7,11]]},"article-number":"lnaf026"}}