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In addition to the ovary, multiple organs, including the hypothalamus, adipose tissue, gut, liver, thyroid, adrenal gland, and heart, converge to regulate ovarian function. These interactions span endocrine signals (e.g. insulin hormones), immune mediators (e.g. cytokines), and metabolic cues (e.g. adipokines), collectively impacting folliculogenesis, steroidogenesis, and ovulation. Importantly, these interactions suggest novel therapeutic targets to mitigate ovarian dysfunction. However, causal relationships and organ-specific contributions require further mechanistic exploration. This synthesis underscores the necessity of a multisystem perspective in both the research and clinical management of ovarian disorders.<\/jats:p>","DOI":"10.1093\/lifemedi\/lnaf029","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T11:33:19Z","timestamp":1756207999000},"source":"Crossref","is-referenced-by-count":6,"title":["Peripheral organ crosstalk in the regulation of ovarian endocrine function and reproductive homeostasis"],"prefix":"10.1093","volume":"4","author":[{"given":"Lixuan","family":"Huang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital , Beijing 100191 ,","place":["China"]},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing 100191 ,","place":["China"]},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education , Beijing 100191 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Peking University Third Hospital , Beijing 100191 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuyu","family":"Yun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital , Beijing 100191 ,","place":["China"]},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing 100191 ,","place":["China"]},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education , Beijing 100191 ,","place":["China"]},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology , Beijing 100191 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2126-1376","authenticated-orcid":false,"given":"Jie","family":"Qiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital , Beijing 100191 ,","place":["China"]},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing 100191 ,","place":["China"]},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education , Beijing 100191 ,","place":["China"]},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology , Beijing 100191 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Qi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital , Beijing 100191 ,","place":["China"]},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing 100191 ,","place":["China"]},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education , Beijing 100191 ,","place":["China"]},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology , Beijing 100191 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"key":"2026100504370229900_CIT0001","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13048-025-01669-4","article-title":"The role of Chinese herbal medicine in diminished ovarian reserve management","volume":"18","author":"Zhang","year":"2025","journal-title":"J Ovarian Res"},{"key":"2026100504370229900_CIT0002","doi-asserted-by":"crossref","first-page":"Article 27","DOI":"10.1038\/s41572-024-00511-3","article-title":"Polycystic ovary syndrome","volume":"10","author":"Stener-Victorin","year":"2024","journal-title":"Nat Rev Primer"},{"key":"2026100504370229900_CIT0003","first-page":"34","article-title":"Demographic and evolutionary trends in ovarian function and aging","volume":"25","author":"Laisk","year":"2019","journal-title":"Hum Reprod Update"},{"key":"2026100504370229900_CIT0004","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1056\/NEJMcp2116488","article-title":"Primary ovarian insufficiency. 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