{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T17:56:33Z","timestamp":1777312593769,"version":"3.51.4"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T00:00:00Z","timestamp":1774051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFA1802300"],"award-info":[{"award-number":["2024YFA1802300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1100300"],"award-info":[{"award-number":["2021YFA1100300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32488101"],"award-info":[{"award-number":["32488101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32470908"],"award-info":[{"award-number":["32470908"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32270856"],"award-info":[{"award-number":["32270856"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32270855"],"award-info":[{"award-number":["32270855"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32571006"],"award-info":[{"award-number":["32571006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Science and Technology Innovation Action Plan","award":["23JC1403700"],"award-info":[{"award-number":["23JC1403700"]}]},{"name":"Shanghai Leading Talent Program of Eastern Talent Plan","award":["QNKJ2025009"],"award-info":[{"award-number":["QNKJ2025009"]}]},{"name":"Clinical Cohort Construction Program of Peking University Third Hospital","award":["BYSYSZKF2024003"],"award-info":[{"award-number":["BYSYSZKF2024003"]}]},{"name":"Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China","award":["JYB2025XDXM508"],"award-info":[{"award-number":["JYB2025XDXM508"]}]},{"name":"Peak Disciplines (Type IV) of Institutions of Higher Learning in Shanghai"},{"name":"Publication License Agreement","award":["CY29GG3LZ9"],"award-info":[{"award-number":["CY29GG3LZ9"]}]},{"name":"Publication License Agreement","award":["JK29GP4YVR"],"award-info":[{"award-number":["JK29GP4YVR"]}]},{"name":"Publication License Agreement","award":["CU29GLR69U"],"award-info":[{"award-number":["CU29GLR69U"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The human placenta sustains pregnancy through intricate trophoblast lineage dynamics that are critical for fetal development and pregnancy success. While studies on protein-coding genes (PCGs) have advanced our understanding of placental biology, the regulatory roles of noncoding RNAs, particularly long noncoding RNAs (lncRNAs), in trophoblast lineage specification and function remain poorly understood. Here, we profile single-cell lncRNA dynamics across human placental development, revealing distinct cell-type- and gestational stage-specific expression profiles. Integrated analysis revealed that lncRNAs modulate histone modification levels at the regulatory regions of target genes via cis-action, thereby regulating the expression of key genes essential for trophoblast differentiation. Functional studies by using in vivo and in vitro models fully identify ECEL1P2\u2013ALPP, SEMA3B\u2013AS1\u2013SEMA3B, and MYCNUT\/MYCNOS\u2013MYCN as pivotal regulatory axes driving cytotrophoblast self-renewal, syncytiotrophoblast fusion, and epithelial\u2013mesenchymal transition, respectively, which are essential for trophoblast identity and function. Notably, dysregulation of lncRNA\u2013PCG pairs in pathological pregnancies underscores the clinical relevance of these noncoding networks. Together, our findings uncover an unappreciated layer of lineage-specific noncoding regulation, providing mechanistic insight and potential biomarkers for placental development and associated disorders.<\/jats:p>","DOI":"10.1093\/lifemedi\/lnag010","type":"journal-article","created":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T10:16:42Z","timestamp":1774088202000},"source":"Crossref","is-referenced-by-count":0,"title":["Single-cell analysis reveals essential lncRNAs regulating human trophoblast lineage differentiation"],"prefix":"10.1093","volume":"5","author":[{"given":"Weiyi","family":"Zhang","sequence":"first","affiliation":[{"name":"Clinical and Translation Research Center of Shanghai First Maternity & Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University , Shanghai 200092,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyan","family":"Le","sequence":"additional","affiliation":[{"name":"Clinical and Translation Research Center of Shanghai First Maternity & Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University , Shanghai 200092,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanru","family":"Yi","sequence":"additional","affiliation":[{"name":"Clinical and Translation Research Center of Shanghai First Maternity & Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University , Shanghai 200092,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5974-9900","authenticated-orcid":false,"given":"Wenqiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical and Translation Research Center of Shanghai First Maternity & Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University , Shanghai 200092,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6622-9316","authenticated-orcid":false,"given":"Xiaoyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical and Translation Research Center of Shanghai First Maternity & Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University , Shanghai 200092,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Control Science and Engineering, State Key Laboratory of Autonomous Intelligent Unmanned Systems, Tongji University , Shanghai 201210,","place":["China"]},{"name":"Shanghai Innovation Institute , Shanghai 200030,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical and Translation Research Center of Shanghai First Maternity & Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University , Shanghai 200092,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Gao","sequence":"additional","affiliation":[{"name":"Clinical and Translation Research Center of Shanghai First Maternity & Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University , Shanghai 200092,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1041-3928","authenticated-orcid":false,"given":"Shaorong","family":"Gao","sequence":"additional","affiliation":[{"name":"Clinical and Translation Research Center of Shanghai First Maternity & Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University , Shanghai 200092,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayu","family":"Chen","sequence":"additional","affiliation":[{"name":"Clinical and Translation Research Center of Shanghai First Maternity & Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University , Shanghai 200092,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"2026042713215477500_lnag010-B1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature11233","article-title":"Landscape of transcription in human cells","volume":"489","author":"Djebali","year":"2012","journal-title":"Nature"},{"key":"2026042713215477500_lnag010-B2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1101\/gr.214205.116","article-title":"Chromatin environment, transcriptional regulation, and splicing distinguish lincRNAs and mRNAs","volume":"27","author":"Mel\u00e9","year":"2017","journal-title":"Genome Res"},{"key":"2026042713215477500_lnag010-B3","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.gde.2014.03.009","article-title":"Intergenic lncRNAs and the evolution of gene expression","volume":"27","author":"Marques","year":"2014","journal-title":"Curr Opin Genet Dev"},{"key":"2026042713215477500_lnag010-B4","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature12787","article-title":"An atlas of active enhancers across human cell types and tissues","volume":"507","author":"Andersson","year":"2014","journal-title":"Nature"},{"key":"2026042713215477500_lnag010-B5","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jgg.2025.04.022","article-title":"Unveiling cell-type-specific mode of evolution in comparative single-cell expression data","volume":"53","author":"Qin","year":"2026","journal-title":"J Genet Genomics"},{"key":"2026042713215477500_lnag010-B6","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.cell.2007.05.022","article-title":"Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs","volume":"129","author":"Rinn","year":"2007","journal-title":"Cell"},{"key":"2026042713215477500_lnag010-B7","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1126\/science.1163045","article-title":"Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome","volume":"322","author":"Zhao","year":"2008","journal-title":"Science"},{"key":"2026042713215477500_lnag010-B8","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nature20149","article-title":"Local regulation of gene expression by lncRNA promoters, transcription and splicing","volume":"539","author":"Engreitz","year":"2016","journal-title":"Nature"},{"key":"2026042713215477500_lnag010-B9","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.stem.2016.01.024","article-title":"Divergent lncRNAs regulate gene expression and lineage differentiation in pluripotent cells","volume":"18","author":"Luo","year":"2016","journal-title":"Cell Stem Cell"},{"key":"2026042713215477500_lnag010-B10","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nature11884","article-title":"Activating RNAs associate with mediator to enhance chromatin architecture and transcription","volume":"494","author":"Lai","year":"2013","journal-title":"Nature"},{"key":"2026042713215477500_lnag010-B11","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nature20128","article-title":"Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development","volume":"539","author":"Anderson","year":"2016","journal-title":"Nature"},{"key":"2026042713215477500_lnag010-B12","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.stem.2015.03.007","article-title":"Opposing roles for the lncRNA haunt and its genomic locus in regulating HOXA gene activation during embryonic stem cell differentiation","volume":"16","author":"Yin","year":"2015","journal-title":"Cell Stem Cell"},{"key":"2026042713215477500_lnag010-B13","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.molcel.2016.02.029","article-title":"Unlinking an lncRNA from its associated cis element","volume":"62","author":"Paralkar","year":"2016","journal-title":"Mol Cell"},{"key":"2026042713215477500_lnag010-B14","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.stem.2018.11.023","article-title":"Combined single-cell profiling of lncRNAs and functional screening reveals that H19 is pivotal for embryonic hematopoietic stem cell development","volume":"24","author":"Zhou","year":"2019","journal-title":"Cell Stem Cell"},{"key":"2026042713215477500_lnag010-B15","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1007\/s11427-023-2502-5","article-title":"Pivotal role for long noncoding RNAs in zygotic genome activation in mice","volume":"67","author":"Chen","year":"2024","journal-title":"Sci China Life Sci"},{"key":"2026042713215477500_lnag010-B16","article-title":"Single-cell profiling of lncRNAs in human germ cells and molecular analysis reveals transcriptional regulation of LNC1845 on LHX8","volume":"12","author":"Wang","year":"2023","journal-title":"Elife"},{"key":"2026042713215477500_lnag010-B17","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.thromres.2004.06.038","article-title":"Growth and function of the normal human placenta","volume":"114","author":"Gude","year":"2004","journal-title":"Thromb Res"},{"key":"2026042713215477500_lnag010-B18","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1152\/physrev.00029.2015","article-title":"Placental origins of chronic disease","volume":"96","author":"Burton","year":"2016","journal-title":"Physiol Rev"},{"key":"2026042713215477500_lnag010-B19","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.stem.2017.11.004","article-title":"Derivation of human trophoblast stem cells","volume":"22","author":"Okae","year":"2018","journal-title":"Cell Stem Cell"},{"key":"2026042713215477500_lnag010-B20","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ceb.2020.08.010","article-title":"Progress in deciphering trophoblast cell differentiation during human placentation","volume":"67","author":"Xiao","year":"2020","journal-title":"Curr Opin Cell Biol"},{"key":"2026042713215477500_lnag010-B21","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1095\/biolreprod.110.088724","article-title":"Trophoblast stem cells","volume":"84","author":"Roberts","year":"2011","journal-title":"Biol Reprod"},{"key":"2026042713215477500_lnag010-B22","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1242\/dev.133462","article-title":"From the stem of the placental tree: trophoblast stem cells and their progeny","volume":"143","author":"Latos","year":"2016","journal-title":"Development"},{"key":"2026042713215477500_lnag010-B23","doi-asserted-by":"crossref","DOI":"10.1242\/dev.163428","article-title":"Development of the human placenta","volume":"146","author":"Turco","year":"2019","journal-title":"Development"},{"key":"2026042713215477500_lnag010-B24","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1161\/01.HYP.0000188408.49896.c5","article-title":"Preeclampsia: recent insights","volume":"46","author":"Roberts","year":"2005","journal-title":"Hypertension"},{"key":"2026042713215477500_lnag010-B25","doi-asserted-by":"crossref","first-page":"j1","DOI":"10.1136\/bmj.j1","article-title":"Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child","volume":"356","author":"Catalano","year":"2017","journal-title":"BMJ"},{"key":"2026042713215477500_lnag010-B26","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41586-018-0051-0","article-title":"Blastocyst-like structures generated solely from stem cells","volume":"557","author":"Rivron","year":"2018","journal-title":"Nature"},{"key":"2026042713215477500_lnag010-B27","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/s41588-023-01647-w","article-title":"Single-nucleus multi-omic profiling of human placental syncytiotrophoblasts identifies cellular trajectories during pregnancy","volume":"56","author":"Wang","year":"2024","journal-title":"Nat Genet"},{"key":"2026042713215477500_lnag010-B28","doi-asserted-by":"crossref","first-page":"e3104","DOI":"10.1038\/cddis.2017.503","article-title":"The lncRNA TUG1 modulates proliferation in trophoblast cells via epigenetic suppression of RND3","volume":"8","author":"Xu","year":"2017","journal-title":"Cell Death Dis"},{"key":"2026042713215477500_lnag010-B29","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.omtn.2019.11.031","article-title":"MSC-Secreted exosomal H19 promotes trophoblast cell invasion and migration by downregulating let-7b and upregulating FOXO1","volume":"19","author":"Chen","year":"2020","journal-title":"Mol Ther Nucleic Acids"},{"key":"2026042713215477500_lnag010-B30","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s10020-021-00337-9","article-title":"The long noncoding RNA MEG3 regulates Ras-MAPK pathway through RASA1 in trophoblast and is associated with unexplained recurrent spontaneous abortion","volume":"27","author":"Zhang","year":"2021","journal-title":"Mol Med"},{"key":"2026042713215477500_lnag010-B31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21082969","article-title":"RNA-Binding proteins as important regulators of long non-coding RNAs in cancer","volume":"21","author":"Jonas","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2026042713215477500_lnag010-B32","doi-asserted-by":"crossref","first-page":"1044198","DOI":"10.3389\/fcell.2022.1044198","article-title":"The diversity of trophoblast cells and niches of placenta accreta spectrum disorders revealed by single-cell RNA sequencing","volume":"10","author":"Ma","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"2026042713215477500_lnag010-B33","doi-asserted-by":"crossref","DOI":"10.3390\/cells12010087","article-title":"Human placental endothelial cell and trophoblast heterogeneity and differentiation revealed by single-cell RNA sequencing","volume":"12","author":"Li","year":"2022","journal-title":"Cells"},{"key":"2026042713215477500_lnag010-B34","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.1038\/s41591-024-03073-9","article-title":"Spatial multiomic landscape of the human placenta at molecular resolution","volume":"30","author":"Ounadjela","year":"2024","journal-title":"Nat Med"},{"key":"2026042713215477500_lnag010-B35","doi-asserted-by":"crossref","first-page":"1053819","DOI":"10.3389\/fimmu.2022.1053819","article-title":"Identification and validation of a signature based on macrophage cell marker genes to predict recurrent miscarriage by integrated analysis of single-cell and bulk RNA-sequencing","volume":"13","author":"Wei","year":"2022","journal-title":"Front Immunol"},{"key":"2026042713215477500_lnag010-B36","doi-asserted-by":"crossref","DOI":"10.1242\/dev.200171","article-title":"An integrated atlas of human placental development delineates essential regulators of trophoblast stem cells","volume":"149","author":"Chen","year":"2022","journal-title":"Development"},{"key":"2026042713215477500_lnag010-B37","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41586-023-05869-0","article-title":"Spatial multiomics map of trophoblast development in early pregnancy","volume":"616","author":"Arutyunyan","year":"2023","journal-title":"Nature"},{"key":"2026042713215477500_lnag010-B38","doi-asserted-by":"crossref","first-page":"102527","DOI":"10.3748\/wjg.v31.i13.102527","article-title":"Long noncoding RNA semaphorin 6A-antisense RNA 1 reduces hepatocellular carcinoma by promoting semaphorin 6A mRNA degradation","volume":"31","author":"Yu","year":"2025","journal-title":"World J Gastroenterol"},{"key":"2026042713215477500_lnag010-B39","doi-asserted-by":"crossref","first-page":"679582","DOI":"10.3389\/fendo.2021.679582","article-title":"Transcriptomic profiling of human placenta in gestational diabetes mellitus at the single-cell level","volume":"12","author":"Yang","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2026042713215477500_lnag010-B40","doi-asserted-by":"crossref","first-page":"317","DOI":"10.14348\/molcells.2021.0211","article-title":"Trophoblast cell subtypes and dysfunction in the placenta of individuals with preeclampsia revealed by single\u2011cell RNA sequencing","volume":"45","author":"Zhou","year":"2022","journal-title":"Mol Cells"},{"key":"2026042713215477500_lnag010-B41","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1007\/s00018-019-03104-6","article-title":"Human placenta and trophoblast development: key molecular mechanisms and model systems","volume":"76","author":"Kn\u00f6fler","year":"2019","journal-title":"Cell Mol Life Sci"},{"key":"2026042713215477500_lnag010-B42","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/s41580-021-00447-6","article-title":"Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics","volume":"23","author":"Nojima","year":"2022","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026042713215477500_lnag010-B43","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1016\/j.molcel.2022.05.027","article-title":"Integrated lncRNA function upon genomic and epigenomic regulation","volume":"82","author":"Herman","year":"2022","journal-title":"Mol Cell"},{"key":"2026042713215477500_lnag010-B44","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.3389\/fimmu.2018.03184","article-title":"The lncRNA connection between cellular metabolism and epigenetics in trained immunity","volume":"9","author":"Fok","year":"2018","journal-title":"Front Immunol"},{"key":"2026042713215477500_lnag010-B45","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1016\/j.celrep.2019.02.047","article-title":"Displacement of WDR5 from chromatin by a WIN site inhibitor with picomolar affinity","volume":"26","author":"Aho","year":"2019","journal-title":"Cell Rep"},{"key":"2026042713215477500_lnag010-B46","doi-asserted-by":"crossref","first-page":"e2303570","DOI":"10.1002\/advs.202303570","article-title":"LncRNAs-circRNAs as rising epigenetic binary superstars in regulating lipid metabolic reprogramming of cancers","volume":"11","author":"Liu","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"2026042713215477500_lnag010-B47","doi-asserted-by":"crossref","first-page":"739780","DOI":"10.3389\/fcell.2021.739780","article-title":"Is there a histone code for cellular quiescence?","volume":"9","author":"Bonitto","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"2026042713215477500_lnag010-B48","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41398-019-0367-z","article-title":"The lncRNA BDNF-AS is an epigenetic regulator in the human amygdala in early onset alcohol use disorders","volume":"9","author":"Bohnsack","year":"2019","journal-title":"Transl Psychiatry"},{"key":"2026042713215477500_lnag010-B49","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.devcel.2021.04.001","article-title":"Human placental cytotrophoblast epigenome dynamics over gestation and alterations in placental disease","volume":"56","author":"Zhang","year":"2021","journal-title":"Dev Cell"},{"key":"2026042713215477500_lnag010-B50","doi-asserted-by":"crossref","first-page":"6037","DOI":"10.1073\/pnas.1215145110","article-title":"The human placenta methylome","volume":"110","author":"Schroeder","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026042713215477500_lnag010-B51","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.placenta.2010.06.012","article-title":"A sequence variation in the promoter of the placental alkaline phosphatase gene (ALPP) is associated with allele-specific expression in human term placenta","volume":"31","author":"Bellazi","year":"2010","journal-title":"Placenta"},{"key":"2026042713215477500_lnag010-B52","doi-asserted-by":"crossref","first-page":"e2318176121","DOI":"10.1073\/pnas.2318176121","article-title":"Endogenous retrovirus HERVH-derived lncRNA UCA1 controls human trophoblast development","volume":"121","author":"Kong","year":"2024","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026042713215477500_lnag010-B53","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/s13238-021-00896-x","article-title":"BMP4 preserves the developmental potential of mESCs through Ube2s- and Chmp4b-mediated chromosomal stability safeguarding","volume":"13","author":"Wang","year":"2022","journal-title":"Protein Cell"}],"container-title":["Life Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/lifemedi\/advance-article-pdf\/doi\/10.1093\/lifemedi\/lnag010\/67454289\/lnag010.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/lifemedi\/article-pdf\/5\/2\/lnag010\/67454289\/lnag010.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/lifemedi\/article-pdf\/5\/2\/lnag010\/67454289\/lnag010.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T17:22:37Z","timestamp":1777310557000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/lifemedi\/article\/doi\/10.1093\/lifemedi\/lnag010\/8532535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4,25]]}},"URL":"https:\/\/doi.org\/10.1093\/lifemedi\/lnag010","relation":{},"ISSN":["2755-1733"],"issn-type":[{"value":"2755-1733","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,4]]},"published":{"date-parts":[[2026,4]]},"article-number":"lnag010"}}