{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:02:48Z","timestamp":1791820968760,"version":"4.3.4"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ISIS@MACH ITALIA Research Infrastructure"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Eosinophilic esophagitis (EoE) is a chronic immune disease requiring repeated endoscopies for diagnosis and monitoring in children. Saliva represents a promising non-invasive biofluid, and volatile organic compounds (VOCs) may indicate disease presence and activity. This study aimed to examine the VOCs profile in saliva samples from children with EoE and to compare it with other gastrointestinal (GI) conditions and healthy controls. Thirty-five samples from children with EoE (including 13 active and 22 non-active cases), 19 from children with other GI conditions, and 46 from healthy controls were analyzed. Gas chromatography\u2013ion mobility spectrometry (GC\u2013IMS) identified 63 distinct VOC signal areas. The abundance of 16 of them was found significantly different (P\u2009&amp;lt;\u20090.01) in EoE vs. controls, EoE vs. other GI conditions, and active vs. non-active EoE. Among them, cis-3-hexen-1-ol and 2-phenylethanol show a ubiquitous capability to discriminate EoE against different populations. Linear discriminant analysis (LDA) of the panel of 16 VOCs achieved 83.3% accuracy in classifying EoE vs. healthy controls, 81.2% accuracy in distinguishing EoE from GI controls, and 80.0% accuracy in classifying active vs. non-active EoE. Salivary VOC profiling enables accurate discrimination of pediatric EoE from controls and stratification by disease activity. This non-invasive approach holds promise as a diagnostic and monitoring tool in clinical practice, especially in children.<\/jats:p>","DOI":"10.1093\/lifemedi\/lnag012","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T11:50:31Z","timestamp":1775217031000},"source":"Crossref","is-referenced-by-count":1,"title":["Salivary volatilome profiling in pediatric eosinophilic esophagitis: a pilot study on a non-invasive approach in clinical practice"],"prefix":"10.1093","volume":"5","author":[{"given":"Rosamaria","family":"Capuano","sequence":"first","affiliation":[{"name":"Department of Electronic Engineering, and Interdepartmental Centre for Volatilomics \u201cA. D\u2019Amico\u201d, University of Rome Tor Vergata , Rome 00133,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Petrella","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Sapienza University of Rome , Rome 00161,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Barbato","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Sapienza University of Rome , Rome 00161,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"D\u2019Arcangelo","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza University of Rome , Rome 00161,","place":["Italy"]},{"name":"Pediatric Gastroenterology, Hepatology and Cystic Fibrosis Unit, Fondazione IRCCS C\u00e0 Granda, Ospedale Maggiore Policlinico di Milano , Milan 20122,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giusy","family":"Russo","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza University of Rome , Rome 00161,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandro","family":"Catini","sequence":"additional","affiliation":[{"name":"Department of Electronic Engineering, and Interdepartmental Centre for Volatilomics \u201cA. D\u2019Amico\u201d, University of Rome Tor Vergata , Rome 00133,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Minni","sequence":"additional","affiliation":[{"name":"Department of Sensory Organs, Sapienza University of Rome , Rome 00161,","place":["Italy"]},{"name":"Division of Otolaryngology-Head and Neck Surgery, San Camillo de Lellis Hospital, ASL Rieti-Sapienza University , Rieti 02100,","place":["Italy"]},{"name":"Interdisciplinary Department of Well-being, Health and Environmental Sustainability (BeSSA), Sapienza University of Rome , Rieti 02100,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Di Natale","sequence":"additional","affiliation":[{"name":"Department of Electronic Engineering, and Interdepartmental Centre for Volatilomics \u201cA. D\u2019Amico\u201d, University of Rome Tor Vergata , Rome 00133,","place":["Italy"]},{"name":"Centre for Interdisciplinary Research (CIDR), SRM University-AP , Amaravati, Andhra Pradesh 522502,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2348-2308","authenticated-orcid":false,"given":"Salvatore","family":"Oliva","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza University of Rome , Rome 00161,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"2026050613270803200_lnag012-B1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/jpn3.12188","article-title":"Diagnosis and management of eosinophilic esophagitis in children: an update from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN)","volume":"79","author":"Amil-Dias","year":"2024","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2026050613270803200_lnag012-B2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/ueg2.12465","article-title":"Incidence and prevalence of eosinophilic oesophagitis across Europe: a systematic review and meta-analysis","volume":"12","author":"Roberts","year":"2024","journal-title":"United European Gastroenterol J"},{"key":"2026050613270803200_lnag012-B3","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1080\/17474124.2020.1806054","article-title":"Epidemiology and risk factors for eosinophilic esophagitis: lessons for clinicians","volume":"14","author":"Arias","year":"2020","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"2026050613270803200_lnag012-B4","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1016\/j.cgh.2023.06.005","article-title":"Global incidence and prevalence of eosinophilic esophagitis, 1976-2022: a systematic review and meta-analysis","volume":"21","author":"Hahn","year":"2023","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2026050613270803200_lnag012-B5","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1053\/j.gastro.2017.06.067","article-title":"Epidemiology and natural history of eosinophilic esophagitis","volume":"154","author":"Dellon","year":"2018","journal-title":"Gastroenterology"},{"key":"2026050613270803200_lnag012-B6","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s11882-022-01042-1","article-title":"Nature with nurture: the role of intrinsic genetic and extrinsic environmental factors on eosinophilic esophagitis","volume":"22","author":"Chang","year":"2022","journal-title":"Curr Allergy Asthma Rep"},{"key":"2026050613270803200_lnag012-B7","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.dld.2024.02.020","article-title":"The 1st EoETALY consensus on the diagnosis and management of eosinophilic esophagitis\u2013current treatment and monitoring","volume":"56","author":"De Bortoli","year":"2024","journal-title":"Dig Liver Dis"},{"key":"2026050613270803200_lnag012-B8","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.dld.2021.02.016","article-title":"Gastrointestinal endoscopy in children and adults: how do they differ?","volume":"53","author":"Isoldi","year":"2021","journal-title":"Dig Liver Dis"},{"key":"2026050613270803200_lnag012-B9","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/MPG.0000000000002672","article-title":"Differences in management of eosinophilic esophagitis in Europe: an assessment of current practice","volume":"71","author":"Tourlamain","year":"2020","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2026050613270803200_lnag012-B10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1053\/j.gastro.2023.09.004","article-title":"ASCENT WORKING GROUP. 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