{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T17:46:52Z","timestamp":1782409612327,"version":"3.54.5"},"reference-count":182,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Noncommunicable Chronic Diseases-National Science and Technology Major Project","award":["2023ZD0507200"],"award-info":[{"award-number":["2023ZD0507200"]}]},{"name":"Scientific Research Innovation Capability Support Project for Young Faculty","award":["ZYGXQNJSKYCXNLZCXM-H14"],"award-info":[{"award-number":["ZYGXQNJSKYCXNLZCXM-H14"]}]},{"name":"the Central Guidance for Local Science and Technology Development Projects","award":["2023ZYDF074"],"award-info":[{"award-number":["2023ZYDF074"]}]},{"DOI":"10.13039\/'10.13039\/100031910","name":"Changping Laboratory","doi-asserted-by":"publisher","award":["2025B-07-11"],"award-info":[{"award-number":["2025B-07-11"]}],"id":[{"id":"10.13039\/'10.13039\/100031910","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"publisher","award":["32500860"],"award-info":[{"award-number":["32500860"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"West China Hospital 1.3.5 Project for Disciplines of Excellence","award":["ZYYC23016"],"award-info":[{"award-number":["ZYYC23016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tau is a microtubule-associated protein traditionally involved in a collective group of disorders termed \u201ctauopathy\u201d, including Alzheimer\u2019s disease. Tau protein self-aggregates and forms neurofibrillary tangles in neurons, which are considered a pathological hallmark of tauopathies. While the roles of neuronal tau in tauopathies have been extensively investigated, recent studies have shed light on its roles in other diseases without tau pathology and in other cells. In this review, we aim to discuss the \u201catypical\u201d pathological involvement of tau in diseases other than tauopathies, including brain diseases (e.g., amyotrophic lateral sclerosis, multiple sclerosis, and spinal cord injury), vascular diseases (stroke and hypertension), diabetes, and cancers. We have discussed the expression and functions of tau in cell types other than neurons, and have summarized the evidence supporting a role of tau in these diseases. These cross-disease studies collectively suggest that tau protein is more broadly implicated in mechanisms such as axonal instability, dysregulated cell signaling, inflammatory activation, and cell death, independent of its aggregation, contributing to our knowledge of the functions of tau and the myriad ways in which it may be involved in pathological processes.<\/jats:p>","DOI":"10.1093\/lifemedi\/lnag016","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T11:47:15Z","timestamp":1778240835000},"source":"Crossref","is-referenced-by-count":0,"title":["Atypical involvement of Alzheimer\u2019s tau proteins in diseases beyond tauopathies"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0184-4136","authenticated-orcid":false,"given":"Jie","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Geriatrics and State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University , Chengdu 610000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Jie","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Neurology and State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University , Chengdu 610000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology and State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University , Chengdu 610000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Yu","sequence":"additional","affiliation":[{"name":"Fujiang Laboratory, Southwest University of Science and Technology , Mianyang 621000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics and State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University , Chengdu 610000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5652-1962","authenticated-orcid":false,"given":"Peng","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Neurology and State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University , Chengdu 610000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"2026062512585364600_lnag016-B1","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/s41580-024-00753-9","article-title":"Cellular and pathological functions of tau","volume":"25","author":"Parra Bravo","year":"2024","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026062512585364600_lnag016-B2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/nrn.2015.1","article-title":"Tau in physiology and pathology","volume":"17","author":"Wang","year":"2016","journal-title":"Nat Rev Neurosci"},{"key":"2026062512585364600_lnag016-B3","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1073\/pnas.72.5.1858","article-title":"A protein factor essential for microtubule assembly","volume":"72","author":"Weingarten","year":"1975","journal-title":"Proc Natl Acad Sci 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