{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:45:11Z","timestamp":1792118711065,"version":"4.4.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401945"],"award-info":[{"award-number":["82401945"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82495190"],"award-info":[{"award-number":["82495190"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82495190"],"award-info":[{"award-number":["82495190"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271689"],"award-info":[{"award-number":["82271689"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20230058"],"award-info":[{"award-number":["BK20230058"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20240522"],"award-info":[{"award-number":["BK20240522"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC2707300"],"award-info":[{"award-number":["2024YFC2707300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Impaired fertility in obese women is closely associated with disruptions in follicular microenvironment homeostasis. However, the underlying metabolic signatures remain poorly characterized. In this study, we employed a high-fat diet induced obese mouse model and conducted comparative metabolomic analyses of granulosa cells, follicular fluid, and serum from obese mice and women. Our results revealed prevalent metabolic disturbances across species, including dysregulated amino acid metabolism, suppressed steroidogenesis, and impaired fatty acid \u03b2-oxidation. Notably, ceramide accumulation in granulosa cells and follicular fluid suggested an insulin-resistant follicular microenvironment. These findings indicate obesity-induced metabolic reprogramming in the follicular niche, highlighting conserved disruptions in energy metabolism and steroidogenic capacity. Overall, our data provide a metabolic framework to elucidate obesity-associated subfertility and suggest potential metabolic targets for diagnosing and treating reproductive disorders.<\/jats:p>","DOI":"10.1093\/lifemedi\/lnag028","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:58:20Z","timestamp":1783684700000},"source":"Crossref","is-referenced-by-count":0,"title":["Cross-species metabolic profiling of follicular compartments in obesity"],"prefix":"10.1093","volume":"5","author":[{"given":"Yiqiu","family":"Wu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University , Nanjing 211166,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Xie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University , Nanjing 211166,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University , Nanjing 211166,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Tian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University , Jinan 250012,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Nanjing Women and Children\u2019s Healthcare Hospital, Women\u2019s Hospital of Nanjing Medical University , Nanjing 210004,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoubin","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University , Nanjing 211166,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjian","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University , Nanjing 211166,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University , Nanjing 211166,","place":["China"]},{"name":"Changzhou Maternity and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University , Changzhou 213000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longsen","family":"Han","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University , Nanjing 211166,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8426-9554","authenticated-orcid":false,"given":"Shuai","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University , Nanjing 211166,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,11]]},"reference":[{"key":"2026101522213812200_lnag028-B1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1210\/jcem-49-5-687","article-title":"The production of progesterone, androgens, and estrogens by granulosa cells, thecal tissue, and stromal tissue from human ovaries in vitro","volume":"49","author":"McNatty","year":"1979","journal-title":"J Clin Endocrinol Metab"},{"key":"2026101522213812200_lnag028-B2","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/bies.950131105","article-title":"Intercommunication between mammalian oocytes and companion somatic cells","volume":"13","author":"Eppig","year":"1991","journal-title":"Bioessays"},{"key":"2026101522213812200_lnag028-B3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.taap.2018.02.011","article-title":"Bisphenol a alters oocyte maturation by prematurely closing gap junctions in the cumulus cell-oocyte complex","volume":"344","author":"Acuna-Hernandez","year":"2018","journal-title":"Toxicol Appl Pharmacol"},{"key":"2026101522213812200_lnag028-B4","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/s41588-018-0055-6","article-title":"Embryonic defects induced by maternal obesity in mice derive from stella insufficiency in oocytes","volume":"50","author":"Han","year":"2018","journal-title":"Nat Genet"},{"key":"2026101522213812200_lnag028-B5","doi-asserted-by":"crossref","first-page":"15346","DOI":"10.1038\/ncomms15346","article-title":"Maternal age-dependent APC\/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II","volume":"8","author":"Nabti","year":"2017","journal-title":"Nat Commun"},{"key":"2026101522213812200_lnag028-B6","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1095\/biolreprod28.4.797","article-title":"Mechanisms of amino acid uptake in cumulus-enclosed mouse oocytes","volume":"28","author":"Colonna","year":"1983","journal-title":"Biol Reprod"},{"key":"2026101522213812200_lnag028-B7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1242\/dev.009068","article-title":"Oocyte regulation of metabolic cooperativity between mouse cumulus cells and oocytes: BMP15 and GDF9 control cholesterol biosynthesis in cumulus cells","volume":"135","author":"Su","year":"2008","journal-title":"Development"},{"key":"2026101522213812200_lnag028-B8","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1186\/s12859-019-2825-2","article-title":"Dynamic genome-scale cell-specific metabolic models reveal novel inter-cellular and intra-cellular metabolic communications during ovarian follicle development","volume":"20","author":"Bernab\u00e9","year":"2019","journal-title":"BMC Bioinformatics"},{"key":"2026101522213812200_lnag028-B9","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s43032-021-00505-6","article-title":"Reprogramming of glucose metabolism of cumulus cells and oocytes and its therapeutic significance","volume":"29","author":"Imanaka","year":"2022","journal-title":"Reprod Sci"},{"key":"2026101522213812200_lnag028-B10","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/biolre\/ioab241","article-title":"Age-associated changes in cumulus cells and follicular fluid: the local oocyte microenvironment as a determinant of gamete quality","volume":"106","author":"Babayev","year":"2022","journal-title":"Biol Reprod"},{"key":"2026101522213812200_lnag028-B11","first-page":"414","article-title":"Obesity and time to pregnancy","volume":"22","author":"Law","year":"2007","journal-title":"Hum Reprod"},{"key":"2026101522213812200_lnag028-B12","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1093\/humrep\/den357","article-title":"Waiting time to pregnancy according to maternal birthweight and prepregnancy BMI","volume":"24","author":"Nohr","year":"2009","journal-title":"Hum Reprod"},{"key":"2026101522213812200_lnag028-B13","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/humrep\/dep360","article-title":"An internet-based prospective study of body size and time-to-pregnancy","volume":"25","author":"Wise","year":"2010","journal-title":"Hum Reprod"},{"key":"2026101522213812200_lnag028-B14","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s13048-023-01237-8","article-title":"Multi-omics reveal the metabolic patterns in mouse cumulus cells during oocyte maturation","volume":"16","author":"Chen","year":"2023","journal-title":"J Ovarian Res"},{"key":"2026101522213812200_lnag028-B15","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1038\/s43587-023-00498-8","article-title":"Polyamine metabolite spermidine rejuvenates oocyte quality by enhancing mitophagy during female reproductive aging","volume":"3","author":"Zhang","year":"2023","journal-title":"Nat Aging"},{"key":"2026101522213812200_lnag028-B16","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.molcel.2020.09.022","article-title":"Characterization of metabolic patterns in mouse oocytes during meiotic maturation","volume":"80","author":"Li","year":"2020","journal-title":"Mol Cell"},{"key":"2026101522213812200_lnag028-B17","doi-asserted-by":"crossref","first-page":"9936","DOI":"10.1038\/s41598-022-14201-1","article-title":"Glutamine and norepinephrine in follicular fluid synergistically enhance the antioxidant capacity of human granulosa cells and the outcome of IVF-ET","volume":"12","author":"Wang","year":"2022","journal-title":"Sci Rep"},{"key":"2026101522213812200_lnag028-B18","first-page":"84","article-title":"A potential role for endoplasmic reticulum stress in progesterone deficiency in obese women","volume":"158","author":"Takahashi","year":"2017","journal-title":"Endocrinology"},{"key":"2026101522213812200_lnag028-B19","doi-asserted-by":"crossref","first-page":"2412381","DOI":"10.1080\/19490976.2024.2412381","article-title":"High-fat diet-induced L-saccharopine accumulation inhibits estradiol synthesis and damages oocyte quality by disturbing mitochondrial homeostasis","volume":"16","author":"Wen","year":"2024","journal-title":"Gut Microbes"},{"key":"2026101522213812200_lnag028-B20","doi-asserted-by":"crossref","first-page":"806890","DOI":"10.3389\/fcell.2022.806890","article-title":"Lipid metabolic process involved in oocyte maturation during folliculogenesis","volume":"10","author":"Liu","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"2026101522213812200_lnag028-B21","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1186\/s12870-020-02692-x","article-title":"Metabolomics analysis reveals Embden Meyerhof Parnas pathway activation and flavonoids accumulation during dormancy transition in tree peony","volume":"20","author":"Zhang","year":"2020","journal-title":"BMC Plant Biol"},{"key":"2026101522213812200_lnag028-B22","doi-asserted-by":"crossref","first-page":"E1511","DOI":"10.1152\/ajpendo.00016.2012","article-title":"An intercellular pathway for glucose transport into mouse oocytes","volume":"302","author":"Wang","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2026101522213812200_lnag028-B23","doi-asserted-by":"crossref","first-page":"25291","DOI":"10.18632\/aging.203747","article-title":"Sorbitol accumulation decreases oocyte quality in aged mice by altering the intracellular redox balance","volume":"13","author":"Zhang","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"2026101522213812200_lnag028-B24","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1530\/REP-09-0345","article-title":"The pivotal role of glucose metabolism in determining oocyte developmental competence","volume":"139","author":"Sutton-McDowall","year":"2010","journal-title":"Reproduction"},{"key":"2026101522213812200_lnag028-B25","doi-asserted-by":"crossref","first-page":"865748","DOI":"10.3389\/fendo.2022.865748","article-title":"Arachidonic acid in follicular fluid of PCOS induces oxidative stress in a human ovarian granulosa tumor cell line (KGN) and upregulates GDF15 expression as a response","volume":"13","author":"Ma","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2026101522213812200_lnag028-B26","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0303-7207(94)90278-X","article-title":"Follicular oestrogen synthesis: the 'two-cell, two-gonadotrophin' model revisited","volume":"100","author":"Hillier","year":"1994","journal-title":"Mol Cell Endocrinol"},{"key":"2026101522213812200_lnag028-B27","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1017\/S0954422424000179","article-title":"Ceramides as the molecular link between impaired lipid metabolism, saturated fatty acid intake and insulin resistance: are all saturated fatty acids to be blamed for ceramide-mediated lipotoxicity?","volume":"38","author":"Sergi","year":"2025","journal-title":"Nutr Res Rev"},{"key":"2026101522213812200_lnag028-B28","doi-asserted-by":"crossref","first-page":"e0116858","DOI":"10.1371\/journal.pone.0116858","article-title":"New evidence for the role of ceramide in the development of hepatic insulin resistance","volume":"10","author":"Konstantynowicz-Nowicka","year":"2015","journal-title":"PLoS One"},{"key":"2026101522213812200_lnag028-B29","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1210\/jcem-61-4-728","article-title":"Distribution and characterization of insulin and insulin-like growth factor I receptors in normal human ovary","volume":"61","author":"Poretsky","year":"1985","journal-title":"J Clin Endocrinol Metab"},{"key":"2026101522213812200_lnag028-B30","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.fertnstert.2014.11.015","article-title":"Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health","volume":"103","author":"Dumesic","year":"2015","journal-title":"Fertil Steril"},{"key":"2026101522213812200_lnag028-B31","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.theriogenology.2016.04.019","article-title":"Bidirectional communication between cumulus cells and the oocyte: old hands and new players?","volume":"86","author":"Russell","year":"2016","journal-title":"Theriogenology"},{"key":"2026101522213812200_lnag028-B32","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1095\/biolreprod33.5.1041","article-title":"Hypoxanthine and adenosine in murine ovarian follicular fluid: concentrations and activity in maintaining oocyte meiotic arrest","volume":"33","author":"Eppig","year":"1985","journal-title":"Biol Reprod"},{"key":"2026101522213812200_lnag028-B33","doi-asserted-by":"crossref","first-page":"RP97507","DOI":"10.7554\/eLife.97507.3","article-title":"Maternal obesity may disrupt offspring metabolism by inducing oocyte genome hyper-methylation via increased DNMTs","volume":"13","author":"Chao","year":"2024","journal-title":"Elife"},{"key":"2026101522213812200_lnag028-B34","doi-asserted-by":"crossref","first-page":"416","DOI":"10.3109\/09513591003632118","article-title":"Impact of overweight and underweight on IVF treatment in Chinese women","volume":"26","author":"Li","year":"2010","journal-title":"Gynecol Endocrinol"},{"key":"2026101522213812200_lnag028-B35","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1095\/biolreprod60.6.1446","article-title":"Metabolism of radiolabeled glucose by mouse oocytes and oocyte-cumulus cell complexes","volume":"60","author":"Downs","year":"1999","journal-title":"Biol Reprod"},{"key":"2026101522213812200_lnag028-B36","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1095\/biolreprod.106.059899","article-title":"Oxidative metabolism of pyruvate is required for meiotic maturation of murine oocytes in vivo","volume":"77","author":"Johnson","year":"2007","journal-title":"Biol Reprod"},{"key":"2026101522213812200_lnag028-B37","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1080\/15384101.2015.1026517","article-title":"Sirt3 prevents maternal obesity-associated oxidative stress and meiotic defects in mouse oocytes","volume":"14","author":"Zhang","year":"2015","journal-title":"Cell Cycle"},{"key":"2026101522213812200_lnag028-B38","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.anireprosci.2004.05.017","article-title":"Oocyte-somatic cell interactions during follicle development in mammals","volume":"82\u201383","author":"Gilchrist","year":"2004","journal-title":"Anim Reprod Sci"},{"key":"2026101522213812200_lnag028-B39","doi-asserted-by":"crossref","first-page":"18395","DOI":"10.1038\/s41598-019-54693-y","article-title":"Participation of the adenosine salvage pathway and cyclic AMP modulation in oocyte energy metabolism","volume":"9","author":"Richani","year":"2019","journal-title":"Sci Rep"},{"key":"2026101522213812200_lnag028-B40","doi-asserted-by":"crossref","first-page":"117078","DOI":"10.1016\/j.ecoenv.2024.117078","article-title":"Metabolic changes induced by heavy metal copper exposure in human ovarian granulosa cells","volume":"285","author":"Lin","year":"2024","journal-title":"Ecotoxicol Environ Saf"},{"key":"2026101522213812200_lnag028-B41","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12958-025-01344-9","article-title":"Biochanin a modulates steroidogenesis and cellular metabolism in human granulosa cells through TAS2Rs activation: a spotlight on ovarian function","volume":"23","author":"Luongo","year":"2025","journal-title":"Reprod Biol Endocrinol"},{"key":"2026101522213812200_lnag028-B42","doi-asserted-by":"crossref","first-page":"20836","DOI":"10.1038\/s41598-022-22688-x","article-title":"Evolutionarily conserved gene expression patterns for affective disorders revealed using cross-species brain transcriptomic analyses in humans, rats and zebrafish","volume":"12","author":"Demin","year":"2022","journal-title":"Sci Rep"},{"key":"2026101522213812200_lnag028-B43","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41421-021-00361-3","article-title":"Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor","volume":"8","author":"Liu","year":"2022","journal-title":"Cell Discov"},{"key":"2026101522213812200_lnag028-B44","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.tjog.2016.11.005","article-title":"Does different BMI influence oocyte and embryo quality by inducing fatty acid in follicular fluid?","volume":"56","author":"Mirabi","year":"2017","journal-title":"Taiwan J Obstet Gynecol"},{"key":"2026101522213812200_lnag028-B45","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.cmet.2016.05.026","article-title":"Integrated network analysis reveals an association between plasma mannose levels and insulin resistance","volume":"24","author":"Lee","year":"2016","journal-title":"Cell Metab"},{"key":"2026101522213812200_lnag028-B46","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1007\/s00394-021-02542-y","article-title":"Endoplasmic reticulum stress as the basis of obesity and metabolic diseases: focus on adipose tissue, liver, and pancreas","volume":"60","author":"Fernandes-da-Silva","year":"2021","journal-title":"Eur J Nutr"},{"key":"2026101522213812200_lnag028-B47","doi-asserted-by":"crossref","first-page":"733860","DOI":"10.3389\/fcell.2021.733860","article-title":"Glycine ameliorates endoplasmic reticulum stress induced by thapsigargin in porcine oocytes","volume":"9","author":"Yu","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"2026101522213812200_lnag028-B48","doi-asserted-by":"crossref","first-page":"616","DOI":"10.4239\/wjd.v12.i5.616","article-title":"Role of insulin and insulin resistance in androgen excess disorders","volume":"12","author":"Unluhizarci","year":"2021","journal-title":"World J Diabetes"}],"container-title":["Life Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/lifemedi\/advance-article-pdf\/doi\/10.1093\/lifemedi\/lnag028\/68760327\/lnag028.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/lifemedi\/article-pdf\/5\/4\/lnag028\/68760327\/lnag028.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/lifemedi\/article-pdf\/5\/4\/lnag028\/68760327\/lnag028.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:21:49Z","timestamp":1792117309000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/lifemedi\/article\/doi\/10.1093\/lifemedi\/lnag028\/8732682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,11]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7,21]]}},"URL":"https:\/\/doi.org\/10.1093\/lifemedi\/lnag028","relation":{},"ISSN":["2755-1733"],"issn-type":[{"value":"2755-1733","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,8]]},"published":{"date-parts":[[2026,7,11]]},"article-number":"lnag028"}}