{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:25:03Z","timestamp":1792153503699,"version":"4.4.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2020YFA0803601"],"award-info":[{"award-number":["2020YFA0803601"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32125022"],"award-info":[{"award-number":["32125022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32101046"],"award-info":[{"award-number":["32101046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2019M661348"],"award-info":[{"award-number":["2019M661348"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020T130115"],"award-info":[{"award-number":["2020T130115"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Brown adipose tissue (BAT) plays a key role in thermogenesis during acute cold exposure. However, it remains unclear how BAT is prepared to rapidly turn on thermogenic genes. Here, we show that damage-specific DNA binding protein 1 (DDB1) mediates the rapid transcription of thermogenic genes upon acute cold exposure. Adipose- or BAT-specific Ddb1 knockout mice show severely whitened BAT and significantly decreased expression of thermogenic genes. These mice develop hypothermia when subjected to acute cold exposure at 4 \u00b0C and partial lipodystrophy on a high-fat diet due to deficiency in fatty acid oxidation. Mechanistically, DDB1 binds the promoters of Ucp1 and Ppargc1a and recruits positive transcriptional elongation factor b (P-TEFb) to release promoter-proximally paused RNA polymerase II (Pol II), thereby enabling rapid and synchronized transcription of thermogenic genes upon acute cold exposure. Our findings have thus provided a regulatory mechanism of how BAT is prepared to respond to acute cold challenge.<\/jats:p>","DOI":"10.1093\/lifemeta\/loac003","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T19:05:51Z","timestamp":1652382351000},"page":"39-53","source":"Crossref","is-referenced-by-count":14,"title":["DDB1 prepares brown adipocytes for cold-induced thermogenesis"],"prefix":"10.1093","volume":"1","author":[{"given":"Xu","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Zhongshan Hospital, Fudan University , Shanghai , China"},{"name":"Shanghai Qi Zhi Institute , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen-Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Zhongshan Hospital, Fudan University , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Sheng","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University , Xiamen, Fujian , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University , Xiamen, Fujian , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Liang","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University , Xiamen, Fujian , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Cen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University , Xiamen, Fujian , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Ting","family":"Xiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Zhongshan Hospital, Fudan University , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University , Xiamen, Fujian , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Zhongshan Hospital, Fudan University , Shanghai , China"},{"name":"Shanghai Qi Zhi Institute , Shanghai , China"},{"name":"State Key Laboratory of Membrane Biology and Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haobin","family":"Ye","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Zhongshan Hospital, Fudan University , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong-Jin","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Zhongshan Hospital, Fudan University , Shanghai , China"},{"name":"Shanghai Qi Zhi Institute , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,5,13]]},"reference":[{"key":"2022110316302935300_CIT0001","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1152\/physrev.00015.2003","article-title":"Brown adipose tissue: function and physiological significance","volume":"84","author":"Cannon","year":"2004","journal-title":"Physiol Rev"},{"key":"2022110316302935300_CIT0002","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/387090a0","article-title":"Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese","volume":"387","author":"Enerback","year":"1997","journal-title":"Nature"},{"key":"2022110316302935300_CIT0003","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S2213-8587(13)70055-X","article-title":"Regulation of glucose homoeostasis by brown adipose tissue","volume":"1","author":"Peirce","year":"2013","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2022110316302935300_CIT0004","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1172\/JCI62308","article-title":"Brown adipose tissue regulates glucose homeostasis and insulin sensitivity","volume":"123","author":"Stanford","year":"2013","journal-title":"J Clin Invest"},{"key":"2022110316302935300_CIT0005","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/s41574-021-00562-6","article-title":"The evolving view of thermogenic adipocytes \u2013 ontogeny, niche and function","volume":"17","author":"Shamsi","year":"2021","journal-title":"Nat Rev Endocrinol"},{"key":"2022110316302935300_CIT0006","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1038\/nm.3361","article-title":"Brown and beige fat: development, function and therapeutic potential","volume":"19","author":"Harms","year":"2013","journal-title":"Nat Med"},{"key":"2022110316302935300_CIT0007","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1056\/NEJMoa0810780","article-title":"Identification and importance of brown adipose tissue in adult humans","volume":"360","author":"Cypess","year":"2009","journal-title":"N Engl J Med"},{"key":"2022110316302935300_CIT0008","doi-asserted-by":"crossref","first-page":"E444","DOI":"10.1152\/ajpendo.00691.2006","article-title":"Unexpected evidence for active brown adipose tissue in adult humans","volume":"293","author":"Nedergaard","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2022110316302935300_CIT0009","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.2337\/db09-0530","article-title":"High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity","volume":"58","author":"Saito","year":"2009","journal-title":"Diabetes"},{"key":"2022110316302935300_CIT0010","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1056\/NEJMoa0808949","article-title":"Functional brown adipose tissue in healthy adults","volume":"360","author":"Virtanen","year":"2009","journal-title":"N Engl J Med"},{"key":"2022110316302935300_CIT0011","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1056\/NEJMoa0808718","article-title":"Cold-activated brown adipose tissue in healthy men","volume":"360","author":"van Marken Lichtenbelt","year":"2009","journal-title":"N Engl J Med"},{"key":"2022110316302935300_CIT0012","doi-asserted-by":"crossref","first-page":"4089","DOI":"10.2337\/db14-0746","article-title":"Brown adipose tissue improves whole-body glucose homeostasis and insulin sensitivity in humans","volume":"63","author":"Chondronikola","year":"2014","journal-title":"Diabetes"},{"key":"2022110316302935300_CIT0013","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.cmet.2016.04.029","article-title":"Brown adipose tissue activation is linked to distinct systemic effects on lipid metabolism in humans","volume":"23","author":"Chondronikola","year":"2016","journal-title":"Cell Metab"},{"key":"2022110316302935300_CIT0014","doi-asserted-by":"crossref","first-page":"3686","DOI":"10.2337\/db14-0513","article-title":"Temperature-acclimated brown adipose tissue modulates insulin sensitivity in humans","volume":"63","author":"Lee","year":"2014","journal-title":"Diabetes"},{"key":"2022110316302935300_CIT0015","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.mce.2016.08.002","article-title":"Hypothalamus and thermogenesis: heating the BAT, browning the WAT","volume":"438","author":"Contreras","year":"2016","journal-title":"Mol Cell Endocrinol"},{"key":"2022110316302935300_CIT0016","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nrm.2016.62","article-title":"Transcriptional and epigenetic control of brown and beige adipose cell fate and function","volume":"17","author":"Inagaki","year":"2016","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2022110316302935300_CIT0017","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.biochi.2016.09.017","article-title":"Transcriptional regulation of the uncoupling protein-1 gene","volume":"134","author":"Villarroya","year":"2017","journal-title":"Biochimie"},{"key":"2022110316302935300_CIT0018","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nrg3293","article-title":"Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans","volume":"13","author":"Adelman","year":"2012","journal-title":"Nat Rev Genet"},{"key":"2022110316302935300_CIT0019","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.cell.2011.04.021","article-title":"Paused RNA polymerase II as a developmental checkpoint","volume":"145","author":"Levine","year":"2011","journal-title":"Cell"},{"key":"2022110316302935300_CIT0020","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nrm3953","article-title":"Getting up to speed with transcription elongation by RNA polymerase II","volume":"16","author":"Jonkers","year":"2015","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2022110316302935300_CIT0021","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.molcel.2006.06.014","article-title":"Controlling the elongation phase of transcription with P-TEFb","volume":"23","author":"Peterlin","year":"2006","journal-title":"Mol Cell"},{"key":"2022110316302935300_CIT0022","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev-biochem-052610-095910","article-title":"RNA polymerase II elongation control","volume":"81","author":"Zhou","year":"2012","journal-title":"Annu Rev Biochem"},{"key":"2022110316302935300_CIT0023","doi-asserted-by":"crossref","first-page":"330","DOI":"10.4172\/2157-7633.1000330","article-title":"Mechanisms and developmental roles of promoter-proximal pausing of RNA polymerase II","volume":"6","author":"Robinson","year":"2016","journal-title":"J Stem Cell Res Ther"},{"key":"2022110316302935300_CIT0024","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.molcel.2015.02.003","article-title":"Pausing of RNA polymerase II regulates mammalian developmental potential through control of signaling networks","volume":"58","author":"Williams","year":"2015","journal-title":"Mol Cell"},{"key":"2022110316302935300_CIT0025","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1101\/gad.2005511","article-title":"Regulating RNA polymerase pausing and transcription elongation in embryonic stem cells","volume":"25","author":"Min","year":"2011","journal-title":"Genes Dev"},{"key":"2022110316302935300_CIT0026","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.cell.2006.09.045","article-title":"Deletion of DDB1 in mouse brain and lens leads to p53-dependent elimination of proliferating cells","volume":"127","author":"Cang","year":"2006","journal-title":"Cell"},{"key":"2022110316302935300_CIT0027","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/j.biocel.2011.09.001","article-title":"Damage-specific DNA binding protein 1 (DDB1): a protein with a wide range of functions","volume":"43","author":"Iovine","year":"2011","journal-title":"Int J Biochem Cell Biol"},{"key":"2022110316302935300_CIT0028","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.tibs.2009.07.002","article-title":"CRL4s: the CUL4-RING E3 ubiquitin ligases","volume":"34","author":"Jackson","year":"2009","journal-title":"Trends Biochem Sci"},{"key":"2022110316302935300_CIT0029","doi-asserted-by":"crossref","first-page":"109281","DOI":"10.1016\/j.celrep.2021.109281","article-title":"DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity","volume":"35","author":"Wang","year":"2021","journal-title":"Cell Rep"},{"key":"2022110316302935300_CIT0030","doi-asserted-by":"crossref","first-page":"109314","DOI":"10.1016\/j.celrep.2021.109314","article-title":"The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity","volume":"36","author":"Tang","year":"2021","journal-title":"Cell Rep"},{"key":"2022110316302935300_CIT0031","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1101\/gad.294405.116","article-title":"EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex","volume":"31","author":"Shapira","year":"2017","journal-title":"Genes Dev"},{"key":"2022110316302935300_CIT0032","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/nature22819","article-title":"Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge","volume":"546","author":"Emmett","year":"2017","journal-title":"Nature"},{"key":"2022110316302935300_CIT0033","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.bbalip.2015.02.003","article-title":"Role of developmental transcription factors in white, brown and beige adipose tissues","volume":"1851","author":"Hilton","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"2022110316302935300_CIT0034","doi-asserted-by":"crossref","first-page":"224","DOI":"10.4161\/nucl.29347","article-title":"RNA polymerase II transcription elongation and Pol II CTD Ser2 phosphorylation: a tail of two kinases","volume":"5","author":"Bowman","year":"2014","journal-title":"Nucleus"},{"key":"2022110316302935300_CIT0035","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/nature09504","article-title":"Selective inhibition of BET bromodomains","volume":"468","author":"Filippakopoulos","year":"2010","journal-title":"Nature"},{"key":"2022110316302935300_CIT0036","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.cell.2013.10.056","article-title":"Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release","volume":"155","author":"Liu","year":"2013","journal-title":"Cell"},{"key":"2022110316302935300_CIT0037","doi-asserted-by":"crossref","first-page":"7052","DOI":"10.1038\/ncomms8052","article-title":"JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI\/SNF association for thermogenesis","volume":"6","author":"Abe","year":"2015","journal-title":"Nat Commun"},{"key":"2022110316302935300_CIT0038","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/nature12652","article-title":"EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex","volume":"504","author":"Ohno","year":"2013","journal-title":"Nature"},{"key":"2022110316302935300_CIT0039","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.molcel.2014.12.005","article-title":"Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat","volume":"57","author":"Dempersmier","year":"2015","journal-title":"Mol Cell"},{"key":"2022110316302935300_CIT0040","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1101\/gad.1666108","article-title":"Regulation of the brown and white fat gene programs through a PRDM16\/CtBP transcriptional complex","volume":"22","author":"Kajimura","year":"2008","journal-title":"Genes Dev"},{"key":"2022110316302935300_CIT0041","doi-asserted-by":"crossref","first-page":"9635","DOI":"10.1073\/pnas.1207287109","article-title":"Development of insulin resistance in mice lacking PGC-1alpha in adipose tissues","volume":"109","author":"Kleiner","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022110316302935300_CIT0042","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s13679-017-0283-6","article-title":"Brown adipose tissue: an update on recent findings","volume":"6","author":"Marlatt","year":"2017","journal-title":"Curr Obes Rep"},{"key":"2022110316302935300_CIT0043","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1128\/MCB.21.1.319-329.2001","article-title":"Essential role of insulin receptor substrate 1 in differentiation of brown adipocytes","volume":"21","author":"Fasshauer","year":"2001","journal-title":"Mol Cell Biol"},{"key":"2022110316302935300_CIT0044","doi-asserted-by":"crossref","first-page":"25494","DOI":"10.1074\/jbc.M004046200","article-title":"Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes","volume":"275","author":"Fasshauer","year":"2000","journal-title":"J Biol Chem"},{"key":"2022110316302935300_CIT0045","doi-asserted-by":"crossref","first-page":"e37070","DOI":"10.1371\/journal.pone.0037070","article-title":"Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development","volume":"7","author":"Jiang","year":"2012","journal-title":"PLoS One"},{"key":"2022110316302935300_CIT0046","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.cmet.2011.02.005","article-title":"Transcriptional control of adipose lipid handling by IRF4","volume":"13","author":"Eguchi","year":"2011","journal-title":"Cell Metab"},{"key":"2022110316302935300_CIT0047","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cell.2014.04.049","article-title":"IRF4 is a key thermogenic transcriptional partner of PGC-1alpha","volume":"158","author":"Kong","year":"2014","journal-title":"Cell"},{"key":"2022110316302935300_CIT0048","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1073\/pnas.1423643112","article-title":"Reduced autophagy in livers of fasted, fat-depleted, ghrelin-deficient mice: reversal by growth hormone","volume":"112","author":"Zhang","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022110316302935300_CIT0049","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1073\/pnas.0604893104","article-title":"Lack of myostatin results in excessive muscle growth but impaired force generation","volume":"104","author":"Amthor","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022110316302935300_CIT0050","doi-asserted-by":"crossref","first-page":"15868","DOI":"10.1073\/pnas.1011116107","article-title":"Ghrelin secretion stimulated by \u03b21-adrenergic receptors in cultured ghrelinoma cells and in fasted mice","volume":"107","author":"Zhao","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022110316302935300_CIT0051","doi-asserted-by":"crossref","first-page":"24644","DOI":"10.1074\/jbc.M109.034397","article-title":"Accelerated fatty acid oxidation in muscle averts fasting-induced hepatic steatosis in SJL\/J mice","volume":"284","author":"Guan","year":"2009","journal-title":"J Biol Chem"}],"container-title":["Life Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/lifemeta\/advance-article-pdf\/doi\/10.1093\/lifemeta\/loac003\/45037300\/loac003.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/lifemeta\/article-pdf\/1\/1\/39\/46781776\/loac003.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/lifemeta\/article-pdf\/1\/1\/39\/46781776\/loac003.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T12:32:25Z","timestamp":1667478745000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/lifemeta\/article\/1\/1\/39\/6584503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,13]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,11,3]]}},"URL":"https:\/\/doi.org\/10.1093\/lifemeta\/loac003","relation":{},"ISSN":["2755-0230"],"issn-type":[{"value":"2755-0230","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,8,1]]},"published":{"date-parts":[[2022,5,13]]}}}