{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:10:38Z","timestamp":1792451438701,"version":"4.5.0"},"reference-count":345,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T00:00:00Z","timestamp":1709337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFA0800403"],"award-info":[{"award-number":["2018YFA0800403"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2701903"],"award-info":[{"award-number":["2021YFC2701903"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91857110"],"award-info":[{"award-number":["91857110"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670740"],"award-info":[{"award-number":["81670740"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32000817"],"award-info":[{"award-number":["32000817"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100904"],"award-info":[{"award-number":["82100904"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300910"],"award-info":[{"award-number":["82300910"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014717","name":"National Outstanding Youth Science Fund Project of National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81722012"],"award-info":[{"award-number":["81722012"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LZ21H070001"],"award-info":[{"award-number":["LZ21H070001"]}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LHDMD22H02001"],"award-info":[{"award-number":["LHDMD22H02001"]}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LHDMD24H030001"],"award-info":[{"award-number":["LHDMD24H030001"]}]},{"name":"Innovative Institute of Basic Medical Sciences of Zhejiang University"},{"name":"Fundamental Research Funds"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Skeletal muscle plays a vital role in the regulation of systemic metabolism, partly through its secretion of endocrine factors which are collectively known as myokines. Altered myokine levels are associated with metabolic diseases, such as type 2 diabetes (T2D). The significance of interorgan crosstalk, particularly through myokines, has emerged as a fundamental aspect of nutrient and energy homeostasis. However, a comprehensive understanding of myokine biology in the setting of obesity and T2D remains a major challenge. In this review, we discuss the regulation and biological functions of key myokines that have been extensively studied during the past two decades, namely interleukin 6 (IL-6), irisin, myostatin (MSTN), growth differentiation factor 11 (GDF11), fibroblast growth factor 21 (FGF21), apelin, brain-derived neurotrophic factor (BDNF), meteorin-like (Metrnl), secreted protein acidic and rich in cysteine (SPARC), \u03b2-aminoisobutyric acid (BAIBA), Musclin, and Dickkopf 3 (Dkk3). Related to these, we detail the role of exercise in myokine expression and secretion together with their contributions to metabolic physiology and disease. Despite significant advancements in myokine research, many myokines remain challenging to measure accurately and investigate thoroughly. Hence, new research techniques and detection methods should be developed and rigorously tested. Therefore, developing a comprehensive perspective on myokine biology is crucial, as this will likely offer new insights into the pathophysiological mechanisms underlying obesity and T2D and may reveal novel targets for therapeutic interventions.<\/jats:p>","DOI":"10.1093\/lifemeta\/loae006","type":"journal-article","created":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T18:15:06Z","timestamp":1709403306000},"source":"Crossref","is-referenced-by-count":61,"title":["Myokines: metabolic regulation in obesity and type 2 diabetes"],"prefix":"10.1093","volume":"3","author":[{"given":"Zhi-Tian","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pathology and Pathophysiology and Department of Cardiology of the Second Affiliated Hospital, School of Medicine, Zhejiang University , Hangzhou, Zhejiang 310058 , China"},{"name":"Key Laboratory of Disease Proteomics of Zhejiang Province, School of Medicine, Zhejiang University , Hangzhou, Zhejiang 310058 , China"},{"name":"Zhejiang University-University of Edinburgh Institute (ZJE), School of Medicine, Zhejiang University , Haining, Zhejiang 314400 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Xuan","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Pathology and Pathophysiology and Department of Cardiology of the Second Affiliated Hospital, School of Medicine, Zhejiang University , Hangzhou, Zhejiang 310058 , China"},{"name":"Key Laboratory of Disease Proteomics of Zhejiang Province, School of Medicine, Zhejiang University , Hangzhou, Zhejiang 310058 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiandie D","family":"Lin","sequence":"additional","affiliation":[{"name":"Life Sciences Institute and Department of Cell and Developmental Biology, University of Michigan , Ann Arbor, MI 48109 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo-Xian","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Pathology and Pathophysiology and Department of Cardiology of the Second Affiliated Hospital, School of Medicine, Zhejiang University , Hangzhou, Zhejiang 310058 , China"},{"name":"Key Laboratory of Disease Proteomics of Zhejiang Province, School of Medicine, Zhejiang University , Hangzhou, Zhejiang 310058 , China"},{"name":"Department of Geriatrics, Affiliated Hangzhou First People\u2019s Hospital , Hangzhou, Zhejiang 310006 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,2]]},"reference":[{"key":"2024040314582428800_CIT0001","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrendo.2012.49","article-title":"Muscles, exercise and obesity: skeletal muscle as a secretory organ","volume":"8","author":"Pedersen","year":"2012","journal-title":"Nat Rev Endocrinol"},{"key":"2024040314582428800_CIT0002","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1053\/j.gastro.2019.12.054","article-title":"Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in nonalcoholic fatty liver disease","volume":"158","author":"Azzu","year":"2020","journal-title":"Gastroenterology"},{"key":"2024040314582428800_CIT0003","doi-asserted-by":"crossref","first-page":"892672","DOI":"10.3389\/fendo.2022.892672","article-title":"Contribution of liver and pancreatic islet crosstalk to \u03b2-cell function\/dysfunction in the presence of fatty liver","volume":"13","author":"L\u00f3pez-Bermudo","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2024040314582428800_CIT0004","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s12276-021-00597-9","article-title":"Neuroendocrine control of appetite and metabolism","volume":"53","author":"Yoo","year":"2021","journal-title":"Exp Mol Med"},{"key":"2024040314582428800_CIT0005","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1016\/j.neuron.2022.10.017","article-title":"The sympathetic nervous system in the 21st century: neuroimmune interactions in metabolic homeostasis and obesity","volume":"110","author":"Martinez-Sanchez","year":"2022","journal-title":"Neuron"},{"key":"2024040314582428800_CIT0006","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1210\/endrev\/bnaa016","article-title":"Muscle-organ crosstalk: the emerging roles of myokines","volume":"41","author":"Severinsen","year":"2020","journal-title":"Endocr Rev"},{"key":"2024040314582428800_CIT0007","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ctrv.2013.06.005","article-title":"Hormones of adipose tissue and their biologic role in lung cancer","volume":"40","author":"Ntikoudi","year":"2014","journal-title":"Cancer Treat Rev"},{"key":"2024040314582428800_CIT0008","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.mam.2019.07.001","article-title":"The role of brown and beige adipose tissue in glycaemic control","volume":"68","author":"Klepac","year":"2019","journal-title":"Mol Aspects Med"},{"key":"2024040314582428800_CIT0009","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.3390\/ijms22052639","article-title":"Adipokines, myokines, and hepatokines: crosstalk and metabolic repercussions","volume":"22","author":"de Oliveira Dos Santos","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2024040314582428800_CIT0010","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.cytogfr.2011.11.004","article-title":"Chemerin and its receptors in leukocyte trafficking, inflammation and metabolism","volume":"22","author":"Bondue","year":"2011","journal-title":"Cytokine Growth Factor Rev"},{"key":"2024040314582428800_CIT0011","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.cytogfr.2021.05.002","article-title":"Asprosin, a novel pleiotropic adipokine implicated in fasting and obesity-related cardio-metabolic disease: comprehensive review of preclinical and clinical evidence","volume":"60","author":"Shabir","year":"2021","journal-title":"Cytokine Growth Factor Rev"},{"key":"2024040314582428800_CIT0012","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nrendo.2012.258","article-title":"The role of hepatokines in metabolism","volume":"9","author":"Stefan","year":"2013","journal-title":"Nat Rev Endocrinol"},{"key":"2024040314582428800_CIT0013","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1210\/er.2019-00034","article-title":"The liver as an endocrine organ-linking NAFLD and insulin resistance","volume":"40","author":"Watt","year":"2019","journal-title":"Endocr Rev"},{"key":"2024040314582428800_CIT0014","doi-asserted-by":"crossref","first-page":"101138","DOI":"10.1016\/j.molmet.2020.101138","article-title":"Hepatokines and metabolism: deciphering communication from the liver","volume":"44","author":"Jensen-Cody","year":"2021","journal-title":"Mol Metab"},{"key":"2024040314582428800_CIT0015","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/jnc.15875","article-title":"Proteomics of the astrocyte secretome reveals changes in their response to soluble oligomeric A\u03b2","volume":"166","author":"Matafora","year":"2023","journal-title":"J Neurochem"},{"key":"2024040314582428800_CIT0016","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1007\/s11427-021-2103-5","article-title":"Interactions between central nervous system and peripheral metabolic organs","volume":"65","author":"Zeng","year":"2022","journal-title":"Sci China Life Sci"},{"key":"2024040314582428800_CIT0017","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/s41580-023-00606-x","article-title":"Exercise metabolism and adaptation in skeletal muscle","volume":"24","author":"Smith","year":"2023","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2024040314582428800_CIT0018","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/nm.3144","article-title":"Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation","volume":"19","author":"Meng","year":"2013","journal-title":"Nat Med"},{"key":"2024040314582428800_CIT0019","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.molcel.2017.04.007","article-title":"Glucose sensing by skeletal myocytes couples nutrient signaling to systemic homeostasis","volume":"66","author":"Meng","year":"2017","journal-title":"Mol Cell"},{"key":"2024040314582428800_CIT0020","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/nature00904","article-title":"Transcriptional co-activator PGC-1\u03b1 drives the formation of slow-twitch muscle fibres","volume":"418","author":"Lin","year":"2002","journal-title":"Nature"},{"key":"2024040314582428800_CIT0021","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1023\/A:1026070911202","article-title":"Searching for the exercise factor: is IL-6 a candidate","volume":"24","author":"Pedersen","year":"2003","journal-title":"J Muscle Res Cell Motil"},{"key":"2024040314582428800_CIT0022","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.cmet.2013.12.003","article-title":"\u03b2-aminoisobutyric acid induces browning of white fat and hepatic \u03b2-oxidation and is inversely correlated with cardiometabolic risk factors","volume":"19","author":"Roberts","year":"2014","journal-title":"Cell Metab"},{"key":"2024040314582428800_CIT0023","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.semcancer.2023.02.008","article-title":"The role of exercise in obesity-related cancers: current evidence and biological mechanisms","volume":"91","author":"Larson","year":"2023","journal-title":"Semin Cancer Biol"},{"key":"2024040314582428800_CIT0024","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1002\/jcp.30033","article-title":"Myokines mediate the cross talk between skeletal muscle and other organs","volume":"236","author":"Chen","year":"2021","journal-title":"J Cell Physiol"},{"key":"2024040314582428800_CIT0025","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s12272-017-0994-y","article-title":"The role of exercise-induced myokines in regulating metabolism","volume":"41","author":"Huh","year":"2018","journal-title":"Arch Pharm Res"},{"key":"2024040314582428800_CIT0026","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/s41574-019-0174-x","article-title":"Physical activity and muscle-brain crosstalk","volume":"15","author":"Pedersen","year":"2019","journal-title":"Nat Rev Endocrinol"},{"key":"2024040314582428800_CIT0027","doi-asserted-by":"crossref","first-page":"5795","DOI":"10.3390\/ijms22115795","article-title":"Physical exercise-induced myokines in neurodegenerative diseases","volume":"22","author":"Lee","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2024040314582428800_CIT0028","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1007\/s00125-019-4927-9","article-title":"Myokines in metabolic homeostasis and diabetes","volume":"62","author":"Eckel","year":"2019","journal-title":"Diabetologia"},{"key":"2024040314582428800_CIT0029","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.autrev.2017.11.010","article-title":"Physical activity and autoimmune diseases: get moving and manage the disease","volume":"17","author":"Sharif","year":"2018","journal-title":"Autoimmun Rev"},{"key":"2024040314582428800_CIT0030","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/nrd.2016.153","article-title":"The ever-expanding myokinome: discovery challenges and therapeutic implications","volume":"15","author":"Whitham","year":"2016","journal-title":"Nat Rev Drug Discov"},{"key":"2024040314582428800_CIT0031","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1146\/annurev-physiol-021115-105305","article-title":"Systemic nutrient and stress signaling via myokines and myometabolites","volume":"78","author":"Rai","year":"2016","journal-title":"Annu Rev Physiol"},{"key":"2024040314582428800_CIT0032","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cmet.2021.12.012","article-title":"Why does obesity cause diabetes","volume":"34","author":"Klein","year":"2022","journal-title":"Cell Metab"},{"key":"2024040314582428800_CIT0033","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41586-019-1797-8","article-title":"The integrative biology of type 2 diabetes","volume":"576","author":"Roden","year":"2019","journal-title":"Nature"},{"key":"2024040314582428800_CIT0034","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41574-020-0355-7","article-title":"Pancreatic \u03b2-cells in type 1 and type 2 diabetes mellitus: different pathways to failure","volume":"16","author":"Eizirik","year":"2020","journal-title":"Nat Rev Endocrinol"},{"key":"2024040314582428800_CIT0035","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1016\/S0140-6736(17)30058-2","article-title":"Type 2 diabetes","volume":"389","author":"Chatterjee","year":"2017","journal-title":"Lancet"},{"key":"2024040314582428800_CIT0036","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1469-7793.2000.00237.x","article-title":"Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6","volume":"529 Pt 1","author":"Steensberg","year":"2000","journal-title":"J Physiol"},{"key":"2024040314582428800_CIT0037","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.2337\/diabetes.53.7.1643","article-title":"Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction","volume":"53","author":"Febbraio","year":"2004","journal-title":"Diabetes"},{"key":"2024040314582428800_CIT0038","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1249\/MSS.0b013e31822f94ac","article-title":"Muscular interleukin-6 and its role as an energy sensor","volume":"44","author":"Pedersen","year":"2012","journal-title":"Med Sci Sports Exerc"},{"key":"2024040314582428800_CIT0039","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1152\/physrev.90100.2007","article-title":"Muscle as an endocrine organ: focus on muscle-derived interleukin-6","volume":"88","author":"Pedersen","year":"2008","journal-title":"Physiol Rev"},{"key":"2024040314582428800_CIT0040","doi-asserted-by":"crossref","first-page":"E397","DOI":"10.1152\/ajpendo.00134.2003","article-title":"Hepatosplanchnic clearance of interleukin-6 in humans during exercise","volume":"285","author":"Febbraio","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2024040314582428800_CIT0041","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1152\/japplphysiol.00590.2005","article-title":"Effect of exercise, training, and glycogen availability on IL-6 receptor expression in human skeletal muscle","volume":"99","author":"Keller","year":"2005","journal-title":"J Appl Physiol (1985)"},{"key":"2024040314582428800_CIT0042","doi-asserted-by":"crossref","first-page":"16186","DOI":"10.1074\/jbc.M116.718551","article-title":"Different soluble forms of the interleukin-6 family signal transducer gp130 fine-tune the blockade of interleukin-6 trans-signaling","volume":"291","author":"Wolf","year":"2016","journal-title":"J Biol Chem"},{"key":"2024040314582428800_CIT0043","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/ni.3632","article-title":"Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells","volume":"18","author":"Heink","year":"2017","journal-title":"Nat Immunol"},{"key":"2024040314582428800_CIT0044","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cmet.2007.11.011","article-title":"Interleukin-6 is an essential regulator of satellite cell-mediated skeletal muscle hypertrophy","volume":"7","author":"Serrano","year":"2008","journal-title":"Cell Metab"},{"key":"2024040314582428800_CIT0045","doi-asserted-by":"crossref","first-page":"e57141","DOI":"10.1371\/journal.pone.0057141","article-title":"Early activation of rat skeletal muscle IL-6\/STAT1\/STAT3 dependent gene expression in resistance exercise linked to hypertrophy","volume":"8","author":"Begue","year":"2013","journal-title":"PLoS One"},{"key":"2024040314582428800_CIT0046","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1210\/jc.2002-021687","article-title":"Interleukin-6 stimulates lipolysis and fat oxidation in humans","volume":"88","author":"van Hall","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"2024040314582428800_CIT0047","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/dom.12299","article-title":"Interleukin-6 in combination with the interleukin-6 receptor stimulates glucose uptake in resting human skeletal muscle independently of insulin action","volume":"16","author":"Saini","year":"2014","journal-title":"Diabetes Obes Metab"},{"key":"2024040314582428800_CIT0048","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1152\/japplphysiol.00195.2004","article-title":"Suppressing lipolysis increases interleukin-6 at rest and during prolonged moderate-intensity exercise in humans","volume":"97","author":"Holmes","year":"2004","journal-title":"J Appl Physiol (1985)"},{"key":"2024040314582428800_CIT0049","doi-asserted-by":"crossref","first-page":"e154611","DOI":"10.1172\/JCI154611","article-title":"A Piezo1\/KLF15\/IL-6 axis mediates immobilization-induced muscle atrophy","volume":"132","author":"Hirata","year":"2022","journal-title":"J Clin Invest"},{"key":"2024040314582428800_CIT0050","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.2337\/db05-1404","article-title":"Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase","volume":"55","author":"Carey","year":"2006","journal-title":"Diabetes"},{"key":"2024040314582428800_CIT0051","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1113\/jphysiol.2003.042374","article-title":"Glucose ingestion attenuates interleukin-6 release from contracting skeletal muscle in humans","volume":"549","author":"Febbraio","year":"2003","journal-title":"J Physiol"},{"key":"2024040314582428800_CIT0052","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s42255-022-00538-4","article-title":"Interleukin 6 as an energy allocator in muscle tissue","volume":"4","author":"Kistner","year":"2022","journal-title":"Nat Metab"},{"key":"2024040314582428800_CIT0053","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1113\/EP087429","article-title":"The regulation of skeletal muscle fatigability and mitochondrial function by chronically elevated interleukin-6","volume":"104","author":"VanderVeen","year":"2019","journal-title":"Exp Physiol"},{"key":"2024040314582428800_CIT0054","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1161\/CIRCRESAHA.119.315644","article-title":"Age-associated mitochondrial dysfunction accelerates atherogenesis","volume":"126","author":"Tyrrell","year":"2020","journal-title":"Circ Res"},{"key":"2024040314582428800_CIT0055","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s10863-011-9361-8","article-title":"IL-6 induces lipolysis and mitochondrial dysfunction, but does not affect insulin-mediated glucose transport in 3T3-L1 adipocytes","volume":"43","author":"Ji","year":"2011","journal-title":"J Bioenerg Biomembr"},{"key":"2024040314582428800_CIT0056","doi-asserted-by":"crossref","first-page":"e51233","DOI":"10.1371\/journal.pone.0051233","article-title":"IL-6 is not necessary for the regulation of adipose tissue mitochondrial content","volume":"7","author":"Wan","year":"2012","journal-title":"PLoS One"},{"key":"2024040314582428800_CIT0057","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.3390\/ijms19092474","article-title":"IL-6: a potential role in cardiac metabolic homeostasis","volume":"19","author":"Xu","year":"2018","journal-title":"Int J Mol Sci"},{"key":"2024040314582428800_CIT0058","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.bbrc.2022.03.013","article-title":"IL-6 protects cardiomyocytes from oxidative stress at the early stage of LPS-induced sepsis","volume":"603","author":"Peng","year":"2022","journal-title":"Biochem Biophys Res Commun"},{"key":"2024040314582428800_CIT0059","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1161\/HYPERTENSIONAHA.118.12267","article-title":"HIMF (hypoxia-induced mitogenic factor)-IL (interleukin)-6 signaling mediates cardiomyocyte-fibroblast crosstalk to promote cardiac hypertrophy and fibrosis","volume":"73","author":"Kumar","year":"2019","journal-title":"Hypertension"},{"key":"2024040314582428800_CIT0060","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/ajt.17206","article-title":"Targeting IL-6 to prevent cardiac allograft rejection","volume":"22","author":"Miller","year":"2022","journal-title":"Am J Transplant"},{"key":"2024040314582428800_CIT0061","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cyto.2014.12.024","article-title":"The varying faces of IL-6: from cardiac protection to cardiac failure","volume":"74","author":"Fontes","year":"2015","journal-title":"Cytokine"},{"key":"2024040314582428800_CIT0062","doi-asserted-by":"crossref","first-page":"E433","DOI":"10.1152\/ajpendo.00074.2003","article-title":"IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans","volume":"285","author":"Steensberg","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2024040314582428800_CIT0063","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1038\/nm.2513","article-title":"Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and \u03b1 cells","volume":"17","author":"Ellingsgaard","year":"2011","journal-title":"Nat Med"},{"key":"2024040314582428800_CIT0064","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nature10777","article-title":"A PGC1-\u03b1-dependent myokine that drives brown-fat-like development of white fat and thermogenesis","volume":"481","author":"Bostr\u00f6m","year":"2012","journal-title":"Nature"},{"key":"2024040314582428800_CIT0065","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1042\/CS20190016","article-title":"FNDC5\/irisin inhibits pathological cardiac hypertrophy","volume":"133","author":"Yu","year":"2019","journal-title":"Clin Sci (Lond)"},{"key":"2024040314582428800_CIT0066","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/j.molcel.2023.05.008","article-title":"Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90\u03b1","volume":"83","author":"A","year":"2023","journal-title":"Mol Cell"},{"key":"2024040314582428800_CIT0067","doi-asserted-by":"crossref","first-page":"1106529","DOI":"10.3389\/fendo.2023.1106529","article-title":"Irisin: an anti-inflammatory exerkine in aging and redox-mediated comorbidities","volume":"14","author":"Trettel","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2024040314582428800_CIT0068","doi-asserted-by":"crossref","first-page":"101680","DOI":"10.1016\/j.arr.2022.101680","article-title":"Irisin, an exercise-induced bioactive peptide beneficial for health promotion during aging process","volume":"80","author":"Zhang","year":"2022","journal-title":"Ageing Res Rev"},{"key":"2024040314582428800_CIT0069","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/nrendo.2016.221","article-title":"Physiology and role of irisin in glucose homeostasis","volume":"13","author":"Perakakis","year":"2017","journal-title":"Nat Rev Endocrinol"},{"key":"2024040314582428800_CIT0070","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/j.metabol.2012.09.002","article-title":"FNDC5 and irisin in humans. I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise","volume":"61","author":"Huh","year":"2012","journal-title":"Metabolism"},{"key":"2024040314582428800_CIT0071","doi-asserted-by":"crossref","first-page":"12157","DOI":"10.1073\/pnas.1516622112","article-title":"The myokine irisin increases cortical bone mass","volume":"112","author":"Colaianni","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024040314582428800_CIT0072","doi-asserted-by":"crossref","first-page":"E769","DOI":"10.1210\/jc.2012-2749","article-title":"Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance","volume":"98","author":"Moreno-Navarrete","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"2024040314582428800_CIT0073","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/s00125-014-3224-x","article-title":"Myokines in insulin resistance and type 2 diabetes","volume":"57","author":"Eckardt","year":"2014","journal-title":"Diabetologia"},{"key":"2024040314582428800_CIT0074","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1080\/10641963.2021.2018601","article-title":"Serum irisin and adropin levels may be predictors for coronary artery ectasia","volume":"44","author":"Uysal","year":"2022","journal-title":"Clin Exp Hypertens"},{"key":"2024040314582428800_CIT0075","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1210\/endrev\/bnab003","article-title":"Progress and challenges in the biology of FNDC5 and Irisin","volume":"42","author":"Maak","year":"2021","journal-title":"Endocr Rev"},{"key":"2024040314582428800_CIT0076","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1249\/JES.0000000000000278","article-title":"Physical exercise and liver autophagy: potential roles of IL-6 and irisin","volume":"50","author":"Pinto","year":"2022","journal-title":"Exerc Sport Sci Rev"},{"key":"2024040314582428800_CIT0077","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.peptides.2014.03.003","article-title":"Exercise-mimicking treatment fails to increase Fndc5 mRNA & irisin secretion in primary human myotubes","volume":"56","author":"Kurdiova","year":"2014","journal-title":"Peptides"},{"key":"2024040314582428800_CIT0078","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1007\/s40279-014-0293-4","article-title":"Chronic exercise training and circulating irisin in adults: a meta-analysis","volume":"45","author":"Qiu","year":"2015","journal-title":"Sports Med"},{"key":"2024040314582428800_CIT0079","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.tem.2022.06.003","article-title":"Irisin, a fascinating field in our times","volume":"33","author":"Bao","year":"2022","journal-title":"Trends Endocrinol Metab"},{"key":"2024040314582428800_CIT0080","doi-asserted-by":"crossref","first-page":"e0152545","DOI":"10.1371\/journal.pone.0152545","article-title":"Circulating microRNA responses between \u201chigh\u201d and \u201clow\u201d responders to a 16-wk diet and exercise weight loss intervention","volume":"11","author":"Parr","year":"2016","journal-title":"PLoS One"},{"key":"2024040314582428800_CIT0081","doi-asserted-by":"crossref","first-page":"103189","DOI":"10.1016\/j.jtherbio.2022.103189","article-title":"Exercise in the heat induces similar elevations in serum irisin in young and older men despite lower resting irisin concentrations in older adults","volume":"104","author":"McCormick","year":"2022","journal-title":"J Therm Biol"},{"key":"2024040314582428800_CIT0082","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00592-014-0576-0","article-title":"High circulating irisin levels are associated with insulin resistance and vascular atherosclerosis in a cohort of nondiabetic adult subjects","volume":"51","author":"Sesti","year":"2014","journal-title":"Acta Diabetol"},{"key":"2024040314582428800_CIT0083","doi-asserted-by":"crossref","first-page":"4899","DOI":"10.1210\/jc.2013-2373","article-title":"Circulating irisin in relation to insulin resistance and the metabolic syndrome","volume":"98","author":"Park","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"2024040314582428800_CIT0084","doi-asserted-by":"crossref","first-page":"S467","DOI":"10.1016\/j.dsx.2017.03.037","article-title":"Lower circulating irisin is associated with nonalcoholic fatty liver disease and type 2 diabetes","volume":"11","author":"Shanaki","year":"2017","journal-title":"Diabetes Metab Syndr"},{"key":"2024040314582428800_CIT0085","doi-asserted-by":"crossref","first-page":"e230","DOI":"10.1016\/j.clinthera.2021.05.003","article-title":"Circulating IRAPe, irisin, and IL-34 in relation to insulin resistance in patients with type 2 diabetes","volume":"43","author":"Mostafa","year":"2021","journal-title":"Clin Ther"},{"key":"2024040314582428800_CIT0086","doi-asserted-by":"crossref","first-page":"E2154","DOI":"10.1210\/jc.2014-1437","article-title":"Exercise-induced irisin secretion is independent of age or fitness level and increased irisin may directly modulate muscle metabolism through AMPK activation","volume":"99","author":"Huh","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"2024040314582428800_CIT0087","doi-asserted-by":"crossref","first-page":"514","DOI":"10.2337\/db13-1106","article-title":"Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling","volume":"63","author":"Zhang","year":"2014","journal-title":"Diabetes"},{"key":"2024040314582428800_CIT0088","doi-asserted-by":"crossref","first-page":"101679","DOI":"10.1016\/j.jbc.2022.101679","article-title":"FNDC5\/irisin facilitates muscle-adipose-bone connectivity through ubiquitination-dependent activation of runt-related transcriptional factors RUNX1\/2","volume":"298","author":"He","year":"2022","journal-title":"J Biol Chem"},{"key":"2024040314582428800_CIT0089","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.cell.2020.06.021","article-title":"CD81 controls beige fat progenitor cell growth and energy balance via FAK signaling","volume":"182","author":"Oguri","year":"2020","journal-title":"Cell"},{"key":"2024040314582428800_CIT0090","doi-asserted-by":"crossref","first-page":"e73680","DOI":"10.1371\/journal.pone.0073680","article-title":"Evidence against a beneficial effect of irisin in humans","volume":"8","author":"Raschke","year":"2013","journal-title":"PLoS One"},{"key":"2024040314582428800_CIT0091","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1530\/JOE-14-0189","article-title":"Browning of white fat: does irisin play a role in humans","volume":"222","author":"Elsen","year":"2014","journal-title":"J Endocrinol"},{"key":"2024040314582428800_CIT0092","doi-asserted-by":"crossref","first-page":"737872","DOI":"10.3389\/fcell.2021.737872","article-title":"Irisin stimulates the release of CXCL1 from differentiating human subcutaneous and deep-neck derived adipocytes via upregulation of NF\u03baB pathway","volume":"9","author":"Shaw","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"2024040314582428800_CIT0093","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.3390\/biom12121895","article-title":"Effects of the myokine irisin on stromal cells from swine adipose tissue","volume":"12","author":"Basini","year":"2022","journal-title":"Biomolecules"},{"key":"2024040314582428800_CIT0094","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1038\/ijo.2014.42","article-title":"Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans","volume":"38","author":"Huh","year":"2014","journal-title":"Int J Obes (Lond)"},{"key":"2024040314582428800_CIT0095","doi-asserted-by":"crossref","first-page":"170120","DOI":"10.1016\/j.peptides.2019.170120","article-title":"Irisin reverses insulin resistance in C2C12 cells via the p38-MAPK-PGC-1\u03b1 pathway","volume":"119","author":"Ye","year":"2019","journal-title":"Peptides"},{"key":"2024040314582428800_CIT0096","doi-asserted-by":"crossref","first-page":"E791","DOI":"10.1152\/ajpendo.00219.2019","article-title":"Irisin counteracts high glucose and fatty acid-induced cytotoxicity by preserving the AMPK-insulin receptor signaling axis in C2C12 myoblasts","volume":"318","author":"Yano","year":"2020","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2024040314582428800_CIT0097","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/ijo.2015.199","article-title":"Irisin improves fatty acid oxidation and glucose utilization in type 2 diabetes by regulating the AMPK signaling pathway","volume":"40","author":"Xin","year":"2016","journal-title":"Int J Obes (Lond)"},{"key":"2024040314582428800_CIT0098","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.2337\/db17-0002","article-title":"The myokine irisin is released in response to saturated fatty acids and promotes pancreatic \u03b2-cell survival and insulin secretion","volume":"66","author":"Natalicchio","year":"2017","journal-title":"Diabetes"},{"key":"2024040314582428800_CIT0099","doi-asserted-by":"crossref","first-page":"2616539","DOI":"10.1155\/2016\/2616539","article-title":"Circulating levels of betatrophin and irisin are not associated with pancreatic \u03b2-cell function in previously diagnosed type 2 diabetes mellitus patients","volume":"2016","author":"Wang","year":"2016","journal-title":"J Diabetes Res"},{"key":"2024040314582428800_CIT0100","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3390\/biomedicines10020258","article-title":"Irisin\u2014A pancreatic islet hormone","volume":"10","author":"Norman","year":"2022","journal-title":"Biomedicines"},{"key":"2024040314582428800_CIT0101","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ebiom.2016.02.041","article-title":"Irisin inhibits hepatic cholesterol synthesis via AMPK-SREBP2 signaling","volume":"6","author":"Tang","year":"2016","journal-title":"EBioMedicine"},{"key":"2024040314582428800_CIT0102","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.3390\/cells10123306","article-title":"Exercise-induced irisin decreases inflammation and improves NAFLD by competitive binding with MD2","volume":"10","author":"Zhu","year":"2021","journal-title":"Cells"},{"key":"2024040314582428800_CIT0103","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.redox.2018.10.019","article-title":"Irisin alleviates liver ischemia-reperfusion injury by inhibiting excessive mitochondrial fission, promoting mitochondrial biogenesis and decreasing oxidative stress","volume":"20","author":"Bi","year":"2019","journal-title":"Redox Biol"},{"key":"2024040314582428800_CIT0104","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.biocel.2016.07.022","article-title":"Irisin ameliorates hepatic glucose\/lipid metabolism and enhances cell survival in insulin-resistant human HepG2 cells through adenosine monophosphate-activated protein kinase signaling","volume":"78","author":"So","year":"2016","journal-title":"Int J Biochem Cell Biol"},{"key":"2024040314582428800_CIT0105","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/387083a0","article-title":"Regulation of skeletal muscle mass in mice by a new TGF-\u03b2 superfamily member","volume":"387","author":"McPherron","year":"1997","journal-title":"Nature"},{"key":"2024040314582428800_CIT0106","doi-asserted-by":"crossref","first-page":"e148372","DOI":"10.1172\/JCI148372","article-title":"Targeting the myostatin signaling pathway to treat muscle loss and metabolic dysfunction","volume":"131","author":"Lee","year":"2021","journal-title":"J Clin Invest"},{"key":"2024040314582428800_CIT0107","doi-asserted-by":"crossref","first-page":"12457","DOI":"10.1073\/pnas.94.23.12457","article-title":"Double muscling in cattle due to mutations in the myostatin gene","volume":"94","author":"McPherron","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024040314582428800_CIT0108","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1006\/bbrc.2001.4435","article-title":"Inhibition of preadipocyte differentiation by myostatin treatment in 3T3-L1 cultures","volume":"281","author":"Kim","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"2024040314582428800_CIT0109","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/mt.2010.171","article-title":"Blocking the myostatin signal with a dominant negative receptor improves the success of human myoblast transplantation in dystrophic mice","volume":"19","author":"Fakhfakh","year":"2011","journal-title":"Mol Ther"},{"key":"2024040314582428800_CIT0110","doi-asserted-by":"crossref","first-page":"8221","DOI":"10.1038\/sj.onc.1207177","article-title":"Inhibition of autocrine secretion of myostatin enhances terminal differentiation in human rhabdomyosarcoma cells","volume":"22","author":"Ricaud","year":"2003","journal-title":"Oncogene"},{"key":"2024040314582428800_CIT0111","doi-asserted-by":"crossref","first-page":"40235","DOI":"10.1074\/jbc.M004356200","article-title":"Myostatin, a negative regulator of muscle growth, functions by inhibiting myoblast proliferation","volume":"275","author":"Thomas","year":"2000","journal-title":"J Biol Chem"},{"key":"2024040314582428800_CIT0112","doi-asserted-by":"crossref","first-page":"e494","DOI":"10.1038\/cddis.2013.31","article-title":"Myostatin induces mitochondrial metabolic alteration and typical apoptosis in cancer cells","volume":"4","author":"Liu","year":"2013","journal-title":"Cell Death Dis"},{"key":"2024040314582428800_CIT0113","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2337\/db08-0943","article-title":"Increased secretion and expression of myostatin in skeletal muscle from extremely obese women","volume":"58","author":"Hittel","year":"2009","journal-title":"Diabetes"},{"key":"2024040314582428800_CIT0114","doi-asserted-by":"crossref","first-page":"E918","DOI":"10.1152\/ajpendo.00798.2007","article-title":"Myostatin, activin receptor IIb, and follistatin-like-3 gene expression are altered in adipose tissue and skeletal muscle of obese mice","volume":"294","author":"Allen","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2024040314582428800_CIT0115","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/apha.12631","article-title":"Myostatin in relation to physical activity and dysglycaemia and its effect on energy metabolism in human skeletal muscle cells","volume":"217","author":"Hjorth","year":"2016","journal-title":"Acta Physiol (Oxf)"},{"key":"2024040314582428800_CIT0116","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1073\/pnas.1525795113","article-title":"Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice","volume":"113","author":"Camporez","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024040314582428800_CIT0117","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1002\/oby.20117","article-title":"Inhibition of in vitro and in vivo brown fat differentiation program by myostatin","volume":"21","author":"Braga","year":"2013","journal-title":"Obesity (Silver Spring)"},{"key":"2024040314582428800_CIT0118","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1128\/MCB.06575-11","article-title":"Blockade of the activin receptor IIb activates functional brown adipogenesis and thermogenesis by inducing mitochondrial oxidative metabolism","volume":"32","author":"Fournier","year":"2012","journal-title":"Mol Cell Biol"},{"key":"2024040314582428800_CIT0119","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00125-011-2304-4","article-title":"Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice","volume":"55","author":"Zhang","year":"2012","journal-title":"Diabetologia"},{"key":"2024040314582428800_CIT0120","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1093\/gerona\/glp068","article-title":"Myostatin inhibition enhances the effects of exercise on performance and metabolic outcomes in aged mice","volume":"64","author":"LeBrasseur","year":"2009","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2024040314582428800_CIT0121","doi-asserted-by":"crossref","first-page":"15675","DOI":"10.1073\/pnas.0607501103","article-title":"Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects","volume":"103","author":"Feldman","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024040314582428800_CIT0122","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1172\/JCI0213562","article-title":"Suppression of body fat accumulation in myostatin-deficient mice","volume":"109","author":"McPherron","year":"2002","journal-title":"J Clin Invest"},{"key":"2024040314582428800_CIT0123","doi-asserted-by":"crossref","first-page":"13703","DOI":"10.3390\/ijms232213703","article-title":"Myostatin knockout affects mitochondrial function by inhibiting the AMPK\/SIRT1\/PGC1\u03b1 Pathway in skeletal muscle","volume":"23","author":"Gu","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2024040314582428800_CIT0124","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/s42003-020-01348-8","article-title":"Myostatin regulates fatty acid desaturation and fat deposition through MEF2C\/miR222\/SCD5 cascade in pigs","volume":"3","author":"Ren","year":"2020","journal-title":"Commun Biol"},{"key":"2024040314582428800_CIT0125","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1530\/JME-15-0038","article-title":"The effect of myostatin on proliferation and lipid accumulation in 3T3-L1 preadipocytes","volume":"54","author":"Zhu","year":"2015","journal-title":"J Mol Endocrinol"},{"key":"2024040314582428800_CIT0126","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1016\/j.biocel.2010.09.017","article-title":"Myostatin regulates glucose metabolism via the AMP-activated protein kinase pathway in skeletal muscle cells","volume":"42","author":"Chen","year":"2010","journal-title":"Int J Biochem Cell Biol"},{"key":"2024040314582428800_CIT0127","doi-asserted-by":"crossref","first-page":"E163","DOI":"10.1152\/ajpendo.00185.2019","article-title":"Local myostatin inhibition improves skeletal muscle glucose uptake in insulin-resistant high-fat diet-fed mice","volume":"319","author":"Eilers","year":"2020","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2024040314582428800_CIT0128","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1249\/MSS.0b013e3181e0b9a8","article-title":"Myostatin decreases with aerobic exercise and associates with insulin resistance","volume":"42","author":"Hittel","year":"2010","journal-title":"Med Sci Sports Exerc"},{"key":"2024040314582428800_CIT0129","doi-asserted-by":"crossref","first-page":"15707","DOI":"10.3390\/ijms232415707","article-title":"Loss of myostatin alters mitochondrial oxidative phosphorylation, TCA cycle activity, and ATP production in skeletal muscle","volume":"23","author":"Wang","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2024040314582428800_CIT0130","doi-asserted-by":"crossref","first-page":"e122247","DOI":"10.1172\/jci.insight.122247","article-title":"Mss51 deletion enhances muscle metabolism and glucose homeostasis in mice","volume":"4","author":"Rovira Gonzalez","year":"2019","journal-title":"JCI Insight"},{"key":"2024040314582428800_CIT0131","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/ijo.2016.110","article-title":"Myostatin signals through miR-34a to regulate Fndc5 expression and browning of white adipocytes","volume":"41","author":"Ge","year":"2017","journal-title":"Int J Obes (Lond)"},{"key":"2024040314582428800_CIT0132","doi-asserted-by":"crossref","first-page":"101703","DOI":"10.1016\/j.molmet.2023.101703","article-title":"Hepatic follistatin increases basal metabolic rate and attenuates diet-induced obesity during hepatic insulin resistance","volume":"71","author":"Tao","year":"2023","journal-title":"Mol Metab"},{"key":"2024040314582428800_CIT0133","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1868-7083-6-27","article-title":"Leucine alters hepatic glucose\/lipid homeostasis via the myostatin-AMP-activated protein kinase pathway\u2014potential implications for nonalcoholic fatty liver disease","volume":"6","author":"Zarfeshani","year":"2014","journal-title":"Clin Epigenetics"},{"key":"2024040314582428800_CIT0134","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0925-4773(98)00205-6","article-title":"Expression of growth\/differentiation factor 11, a new member of the BMP\/TGF\u03b2 superfamily during mouse embryogenesis","volume":"80","author":"Nakashima","year":"1999","journal-title":"Mech Dev"},{"key":"2024040314582428800_CIT0135","doi-asserted-by":"crossref","first-page":"81604","DOI":"10.18632\/oncotarget.20258","article-title":"Role of growth differentiation factor 11 in development, physiology and disease","volume":"8","author":"Zhang","year":"2017","journal-title":"Oncotarget"},{"key":"2024040314582428800_CIT0136","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1126\/science.1251152","article-title":"Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle","volume":"344","author":"Sinha","year":"2014","journal-title":"Science"},{"key":"2024040314582428800_CIT0137","doi-asserted-by":"crossref","first-page":"110869","DOI":"10.1016\/j.exger.2020.110869","article-title":"The effects of concurrent training order on body composition and serum concentrations of follistatin, myostatin and GDF11 in sarcopenic elderly men","volume":"133","author":"Bagheri","year":"2020","journal-title":"Exp Gerontol"},{"key":"2024040314582428800_CIT0138","doi-asserted-by":"crossref","first-page":"e13038","DOI":"10.1111\/acel.13038","article-title":"Systemic GDF11 stimulates the secretion of adiponectin and induces a calorie restriction-like phenotype in aged mice","volume":"19","author":"Katsimpardi","year":"2020","journal-title":"Aging Cell"},{"key":"2024040314582428800_CIT0139","doi-asserted-by":"crossref","first-page":"e13310","DOI":"10.1111\/cpr.13310","article-title":"GDF11 inhibits adipogenesis and improves mature adipocytes metabolic function via WNT\/\u03b2-catenin and ALK5\/SMAD2\/3 pathways","volume":"55","author":"Frohlich","year":"2022","journal-title":"Cell Prolif"},{"key":"2024040314582428800_CIT0140","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1186\/s12967-019-02166-1","article-title":"Gdf11 gene transfer prevents high fat diet-induced obesity and improves metabolic homeostasis in obese and STZ-induced diabetic mice","volume":"17","author":"Lu","year":"2019","journal-title":"J Transl Med"},{"key":"2024040314582428800_CIT0141","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.1038\/s41598-020-61443-y","article-title":"Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice","volume":"10","author":"Walker","year":"2020","journal-title":"Sci Rep"},{"key":"2024040314582428800_CIT0142","doi-asserted-by":"crossref","first-page":"970","DOI":"10.3389\/fphys.2019.00970","article-title":"Effects of exercise training on growth and differentiation factor 11 expression in aged mice","volume":"10","author":"Lee","year":"2019","journal-title":"Front Physiol"},{"key":"2024040314582428800_CIT0143","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.2337\/db17-0086","article-title":"GDF11 attenuates development of type 2 diabetes via improvement of islet \u03b2-cell function and survival","volume":"66","author":"Li","year":"2017","journal-title":"Diabetes"},{"key":"2024040314582428800_CIT0144","first-page":"1795","article-title":"GDF11 does not improve the palmitate induced insulin resistance in C2C12","volume":"21","author":"Jing","year":"2017","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"2024040314582428800_CIT0145","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.18632\/aging.101865","article-title":"Circulating GDF11 levels are decreased with age but are unchanged with obesity and type 2 diabetes","volume":"11","author":"A\u00f1\u00f3n-Hidalgo","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"2024040314582428800_CIT0146","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.cmet.2016.05.023","article-title":"Quantification of GDF11 and myostatin in human aging and cardiovascular disease","volume":"23","author":"Schafer","year":"2016","journal-title":"Cell Metab"},{"key":"2024040314582428800_CIT0147","doi-asserted-by":"crossref","first-page":"e118","DOI":"10.2337\/dc15-0868","article-title":"Effects of age, diabetes, and vascular disease on growth differentiation factor 11: first-in-human study","volume":"38","author":"Fadini","year":"2015","journal-title":"Diabetes Care"},{"key":"2024040314582428800_CIT0148","doi-asserted-by":"crossref","first-page":"e12631","DOI":"10.1111\/cpr.12631","article-title":"Growth differentiation factor 11 inhibits adipogenic differentiation by activating TGF-\u03b2\/Smad signalling pathway","volume":"52","author":"Luo","year":"2019","journal-title":"Cell Prolif"},{"key":"2024040314582428800_CIT0149","doi-asserted-by":"crossref","first-page":"e13088","DOI":"10.1016\/j.heliyon.2023.e13088","article-title":"GDF11 inhibits adipogenesis of human adipose-derived stromal cells through ALK5\/KLF15\/\u03b2-catenin\/PPAR\u03b3 cascade","volume":"9","author":"Lin","year":"2023","journal-title":"Heliyon"},{"key":"2024040314582428800_CIT0150","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1007\/s12257-020-0254-8","article-title":"BMP11 negatively regulates lipid metabolism in C2C12 muscle cells","volume":"25","author":"Pham","year":"2020","journal-title":"Biotechnol Bioprocess Eng"},{"key":"2024040314582428800_CIT0151","doi-asserted-by":"crossref","first-page":"16012","DOI":"10.1038\/boneres.2016.12","article-title":"Relationship of serum GDF11 levels with bone mineral density and bone turnover markers in postmenopausal Chinese women","volume":"4","author":"Chen","year":"2016","journal-title":"Bone Res"},{"key":"2024040314582428800_CIT0152","doi-asserted-by":"crossref","first-page":"12794","DOI":"10.1038\/ncomms12794","article-title":"GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation","volume":"7","author":"Liu","year":"2016","journal-title":"Nat Commun"},{"key":"2024040314582428800_CIT0153","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.1016\/j.bbadis.2018.09.015","article-title":"The GDF11-FTO-PPAR\u03b3 axis controls the shift of osteoporotic MSC fate to adipocyte and inhibits bone formation during osteoporosis","volume":"1864","author":"Shen","year":"2018","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"2024040314582428800_CIT0154","doi-asserted-by":"crossref","first-page":"4910","DOI":"10.1073\/pnas.1916034117","article-title":"GDF11 promotes osteogenesis as opposed to MSTN, and follistatin, a MSTN\/GDF11 inhibitor, increases muscle mass but weakens bone","volume":"117","author":"Suh","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024040314582428800_CIT0155","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3389\/fphys.2019.00419","article-title":"FGF21 as modulator of metabolism in health and disease","volume":"10","author":"Tezze","year":"2019","journal-title":"Front Physiol"},{"key":"2024040314582428800_CIT0156","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1747-0285.2012.01325.x","article-title":"Understanding the physical interactions in the FGF21\/FGFR\/\u03b2-Klotho complex: structural requirements and implications in FGF21 signaling","volume":"79","author":"Yie","year":"2012","journal-title":"Chem Biol Drug Des"},{"key":"2024040314582428800_CIT0157","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3389\/fendo.2014.00107","article-title":"FGF21 as a hepatokine, adipokine, and myokine in metabolism and diseases","volume":"5","author":"Itoh","year":"2014","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2024040314582428800_CIT0158","doi-asserted-by":"crossref","first-page":"981315","DOI":"10.1155\/2011\/981315","article-title":"FGF21 as an endocrine regulator in lipid metabolism: from molecular evolution to physiology and pathophysiology","volume":"2011","author":"Murata","year":"2011","journal-title":"J Nutr Metab"},{"key":"2024040314582428800_CIT0159","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.cmet.2013.12.017","article-title":"Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans","volume":"19","author":"Lee","year":"2014","journal-title":"Cell Metab"},{"key":"2024040314582428800_CIT0160","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41374-021-00680-9","article-title":"Hepatocyte-specific fibroblast growth factor 21 overexpression ameliorates high-fat diet-induced obesity and liver steatosis in mice","volume":"102","author":"Yano","year":"2022","journal-title":"Lab Invest"},{"key":"2024040314582428800_CIT0161","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3389\/fendo.2013.00194","article-title":"Stressed liver and muscle call on adipocytes with FGF21","volume":"4","author":"Luo","year":"2013","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2024040314582428800_CIT0162","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev-physiol-021115-105339","article-title":"Understanding the physiology of FGF21","volume":"78","author":"Fisher","year":"2016","journal-title":"Annu Rev Physiol"},{"key":"2024040314582428800_CIT0163","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1016\/j.febslet.2008.10.021","article-title":"FGF21 is an Akt-regulated myokine","volume":"582","author":"Izumiya","year":"2008","journal-title":"FEBS Lett"},{"key":"2024040314582428800_CIT0164","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/jcsm.12409","article-title":"Fibroblast growth factor 21 controls mitophagy and muscle mass","volume":"10","author":"Oost","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"2024040314582428800_CIT0165","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.molmet.2015.11.002","article-title":"Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action","volume":"5","author":"Ost","year":"2016","journal-title":"Mol Metab"},{"key":"2024040314582428800_CIT0166","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.15252\/embj.201696179","article-title":"OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance","volume":"36","author":"Pereira","year":"2017","journal-title":"EMBO J"},{"key":"2024040314582428800_CIT0167","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3390\/cells8060597","article-title":"Inhibition of the fission machinery mitigates OPA1 impairment in adult skeletal muscles","volume":"8","author":"Romanello","year":"2019","journal-title":"Cells"},{"key":"2024040314582428800_CIT0168","doi-asserted-by":"crossref","first-page":"E469","DOI":"10.1152\/ajpendo.00330.2013","article-title":"Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine","volume":"306","author":"Keipert","year":"2014","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2024040314582428800_CIT0169","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.cmet.2013.04.005","article-title":"Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice","volume":"17","author":"Lin","year":"2013","journal-title":"Cell Metab"},{"key":"2024040314582428800_CIT0170","doi-asserted-by":"crossref","first-page":"4625","DOI":"10.1210\/en.2009-0119","article-title":"Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver","volume":"150","author":"Hotta","year":"2009","journal-title":"Endocrinology"},{"key":"2024040314582428800_CIT0171","doi-asserted-by":"crossref","first-page":"H88","DOI":"10.1152\/ajpheart.00935.2007","article-title":"In vivo genetic profiling and cellular localization of apelin reveals a hypoxia-sensitive, endothelial-centered pathway activated in ischemic heart failure","volume":"294","author":"Sheikh","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2024040314582428800_CIT0172","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.tips.2015.04.014","article-title":"Adipokines in health and disease","volume":"36","author":"Fasshauer","year":"2015","journal-title":"Trends Pharmacol Sci"},{"key":"2024040314582428800_CIT0173","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1006\/bbrc.1998.9489","article-title":"Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor","volume":"251","author":"Tatemoto","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"2024040314582428800_CIT0174","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/ijo.2013.158","article-title":"Effect of endurance training on skeletal muscle myokine expression in obese men: identification of apelin as a novel myokine","volume":"38","author":"Besse-Patin","year":"2014","journal-title":"Int J Obes (Lond)"},{"key":"2024040314582428800_CIT0175","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1038\/s41591-018-0131-6","article-title":"The exerkine apelin reverses age-associated sarcopenia","volume":"24","author":"Vinel","year":"2018","journal-title":"Nat Med"},{"key":"2024040314582428800_CIT0176","doi-asserted-by":"crossref","first-page":"E59","DOI":"10.1152\/ajpendo.00385.2009","article-title":"Apelin is necessary for the maintenance of insulin sensitivity","volume":"298","author":"Yue","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2024040314582428800_CIT0177","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.cmet.2008.10.003","article-title":"Apelin stimulates glucose utilization in normal and obese insulin-resistant mice","volume":"8","author":"Dray","year":"2008","journal-title":"Cell Metab"},{"key":"2024040314582428800_CIT0178","doi-asserted-by":"crossref","first-page":"310","DOI":"10.2337\/db11-0100","article-title":"Apelin treatment increases complete fatty acid oxidation, mitochondrial oxidative capacity, and biogenesis in muscle of insulin-resistant mice","volume":"61","author":"Attane","year":"2012","journal-title":"Diabetes"},{"key":"2024040314582428800_CIT0179","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/jcsm.13159","article-title":"The G protein-coupled receptor ligand apelin-13 ameliorates skeletal muscle atrophy induced by chronic kidney disease","volume":"14","author":"Enoki","year":"2023","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"2024040314582428800_CIT0180","doi-asserted-by":"crossref","first-page":"104589","DOI":"10.1016\/j.isci.2022.104589","article-title":"A Tead1-apelin axis directs paracrine communication from myogenic to endothelial cells in skeletal muscle","volume":"25","author":"Lee","year":"2022","journal-title":"Iscience"},{"key":"2024040314582428800_CIT0181","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cardiores.2004.08.018","article-title":"The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo","volume":"65","author":"Ashley","year":"2005","journal-title":"Cardiovasc Res"},{"key":"2024040314582428800_CIT0182","doi-asserted-by":"crossref","first-page":"103318","DOI":"10.1016\/j.drudis.2022.07.003","article-title":"Neurotrophin-targeted therapeutics: a gateway to cognition and more","volume":"27","author":"Nordvall","year":"2022","journal-title":"Drug Discov Today"},{"key":"2024040314582428800_CIT0183","doi-asserted-by":"crossref","first-page":"16111","DOI":"10.1073\/pnas.1900544116","article-title":"BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle","volume":"116","author":"Delezie","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024040314582428800_CIT0184","first-page":"1063","article-title":"Is brain-derived neurotrophic factor a metabolic hormone in peripheral tissues","volume":"11","author":"Iu","year":"2022","journal-title":"Biology (Basel)"},{"key":"2024040314582428800_CIT0185","doi-asserted-by":"crossref","first-page":"eaau1468","DOI":"10.1126\/scisignal.aau1468","article-title":"Muscle-generated BDNF is a sexually dimorphic myokine that controls metabolic flexibility","volume":"12","author":"Yang","year":"2019","journal-title":"Sci Signal"},{"key":"2024040314582428800_CIT0186","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1007\/s00125-009-1364-1","article-title":"Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase","volume":"52","author":"Matthews","year":"2009","journal-title":"Diabetologia"},{"key":"2024040314582428800_CIT0187","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1080\/15548627.2021.1985257","article-title":"Muscle-generated BDNF (brain derived neurotrophic factor) maintains mitochondrial quality control in female mice","volume":"18","author":"Ahuja","year":"2022","journal-title":"Autophagy"},{"key":"2024040314582428800_CIT0188","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1017\/S1092852920001431","article-title":"Brain-derived neurotrophic factor among patients with alcoholism","volume":"26","author":"Mart\u00edn-Gonz\u00e1lez","year":"2021","journal-title":"CNS Spectr"},{"key":"2024040314582428800_CIT0189","first-page":"2368","article-title":"BDNF gene polymorphism and serum level correlate with liver function in patients with hepatitis B-induced cirrhosis","volume":"12","author":"Shu","year":"2019","journal-title":"Int J Clin Exp Pathol"},{"key":"2024040314582428800_CIT0190","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1002\/hep.30921","article-title":"hnRNPU\/TrkB defines a chromatin accessibility checkpoint for liver injury and nonalcoholic steatohepatitis pathogenesis","volume":"71","author":"Xiong","year":"2020","journal-title":"Hepatology"},{"key":"2024040314582428800_CIT0191","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1080\/13813455.2018.1489850","article-title":"Endoplasmic reticulum stress in the livers of BDNF heterozygous knockout mice","volume":"125","author":"C\u0131rr\u0131k","year":"2019","journal-title":"Arch Physiol Biochem"},{"key":"2024040314582428800_CIT0192","doi-asserted-by":"crossref","first-page":"1098570","DOI":"10.3389\/fimmu.2023.1098570","article-title":"Meteorin-like\/Metrnl, a novel secreted protein implicated in inflammation, immunology, and metabolism: a comprehensive review of preclinical and clinical studies","volume":"14","author":"Li","year":"2023","journal-title":"Front Immunol"},{"key":"2024040314582428800_CIT0193","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.cell.2014.03.065","article-title":"Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis","volume":"157","author":"Rao","year":"2014","journal-title":"Cell"},{"key":"2024040314582428800_CIT0194","doi-asserted-by":"crossref","first-page":"108068","DOI":"10.1016\/j.diabres.2020.108068","article-title":"Inverse relationship between serum Metrnl levels and visceral fat obesity (VFO) in patients with type 2 diabetes","volume":"161","author":"Du","year":"2020","journal-title":"Diabetes Res Clin Pract"},{"key":"2024040314582428800_CIT0195","doi-asserted-by":"crossref","first-page":"e0204180","DOI":"10.1371\/journal.pone.0204180","article-title":"Lower serum levels of Meteorin-like\/Subfatin in patients with coronary artery disease and type 2 diabetes mellitus are negatively associated with insulin resistance and inflammatory cytokines","volume":"13","author":"Dadmanesh","year":"2018","journal-title":"PLoS One"},{"key":"2024040314582428800_CIT0196","doi-asserted-by":"crossref","first-page":"938341","DOI":"10.3389\/fendo.2022.938341","article-title":"Serum Metrnl levels are decreased in subjects with overweight or obesity and are independently associated with adverse lipid profile","volume":"13","author":"Ding","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2024040314582428800_CIT0197","doi-asserted-by":"crossref","first-page":"4338","DOI":"10.3390\/jcm10194338","article-title":"Meteorin-like protein (Metrnl) in obesity, during weight loss and in adipocyte differentiation","volume":"10","author":"Schmid","year":"2021","journal-title":"J Clin Med"},{"key":"2024040314582428800_CIT0198","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.diabres.2019.02.026","article-title":"Association of low serum Meteorin like (Metrnl) concentrations with worsening of glucose tolerance, impaired endothelial function and atherosclerosis","volume":"150","author":"El-Ashmawy","year":"2019","journal-title":"Diabetes Res Clin Pract"},{"key":"2024040314582428800_CIT0199","doi-asserted-by":"crossref","first-page":"5732","DOI":"10.2174\/1381612826666201007163930","article-title":"Circulating Meteorin-like levels in patients with type 2 diabetes mellitus: a meta-analysis","volume":"26","author":"Wu","year":"2020","journal-title":"Curr Pharm Des"},{"key":"2024040314582428800_CIT0200","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.3390\/cells8101283","article-title":"Increased expression of Meteorin-LIKE HORMONE in type 2 diabetes and obesity and its association with irisin","volume":"8","author":"AlKhairi","year":"2019","journal-title":"Cells"},{"key":"2024040314582428800_CIT0201","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.diabres.2017.10.005","article-title":"Serum Meteorin-like protein levels decreased in patients newly diagnosed with type 2 diabetes","volume":"135","author":"Lee","year":"2018","journal-title":"Diabetes Res Clin Pract"},{"key":"2024040314582428800_CIT0202","doi-asserted-by":"crossref","first-page":"6283932","DOI":"10.1155\/2018\/6283932","article-title":"Aerobic exercise increases Meteorin-like protein in muscle and adipose tissue of chronic high-fat diet-induced obese mice","volume":"2018","author":"Bae","year":"2018","journal-title":"Biomed Res Int"},{"key":"2024040314582428800_CIT0203","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jshs.2017.01.003","article-title":"Impact of a single bout of high-intensity interval exercise and short-term interval training on interleukin-6, FNDC5, and METRNL mRNA expression in human skeletal muscle","volume":"7","author":"Eaton","year":"2018","journal-title":"J Sport Health Sci"},{"key":"2024040314582428800_CIT0204","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/ijo.2017.268","article-title":"Opposite changes in meteorin-like and oncostatin m levels are associated with metabolic improvements after bariatric surgery","volume":"42","author":"Pellitero","year":"2018","journal-title":"Int J Obes (Lond)"},{"key":"2024040314582428800_CIT0205","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1002\/oby.23473","article-title":"Changes in the expression of meteorin-like (METRNL), irisin (FNDC5), and uncoupling proteins (UCPs) after bariatric surgery","volume":"30","author":"Jamal","year":"2022","journal-title":"Obesity (Silver Spring)"},{"key":"2024040314582428800_CIT0206","doi-asserted-by":"crossref","first-page":"611","DOI":"10.2337\/db22-0680","article-title":"Metrnl alleviates lipid accumulation by modulating mitochondrial homeostasis in diabetic nephropathy","volume":"72","author":"Zhou","year":"2023","journal-title":"Diabetes"},{"key":"2024040314582428800_CIT0207","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/aps.2016.9","article-title":"Metrnl: a secreted protein with new emerging functions","volume":"37","author":"Zheng","year":"2016","journal-title":"Acta Pharmacol Sin"},{"key":"2024040314582428800_CIT0208","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/ijo.2016.180","article-title":"METRNL decreases during adipogenesis and inhibits adipocyte differentiation leading to adipocyte hypertrophy in humans","volume":"41","author":"L\u00f6ffler","year":"2017","journal-title":"Int J Obes (Lond)"},{"key":"2024040314582428800_CIT0209","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.2337\/db15-0274","article-title":"Adipocyte Metrnl antagonizes insulin resistance through PPAR\u03b3 signaling","volume":"64","author":"Li","year":"2015","journal-title":"Diabetes"},{"key":"2024040314582428800_CIT0210","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1093\/ecco-jcc\/jjz001","article-title":"The Adipokine Metrnl ameliorates chronic colitis in Il-10\u2013\/\u2013 mice by attenuating mesenteric adipose tissue lesions during spontaneous colitis","volume":"13","author":"Zuo","year":"2019","journal-title":"J Crohns Colitis"},{"key":"2024040314582428800_CIT0211","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1111\/febs.15301","article-title":"The myokine meteorin-like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPK\u03b12","volume":"287","author":"Lee","year":"2020","journal-title":"FEBS J"},{"key":"2024040314582428800_CIT0212","first-page":"1","article-title":"METRNL attenuates lipid-induced inflammation and insulin resistance via AMPK or PPAR\u03b4-dependent pathways in skeletal muscle of mice","volume":"50","author":"Jung","year":"2018","journal-title":"Exp Mol Med"},{"key":"2024040314582428800_CIT0213","doi-asserted-by":"crossref","first-page":"627147","DOI":"10.3389\/fphar.2021.627147","article-title":"Meteorin-like ameliorates \u03b2 cell function by inhibiting \u03b2 cell apoptosis of and promoting \u03b2 cell proliferation via activating the WNT\/\u03b2-catenin pathway","volume":"12","author":"Hu","year":"2021","journal-title":"Front Pharmacol"},{"key":"2024040314582428800_CIT0214","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.semcdb.2021.10.009","article-title":"Muscle-derived factors influencing bone metabolism","volume":"123","author":"Gries","year":"2022","journal-title":"Semin Cell Dev Biol"},{"key":"2024040314582428800_CIT0215","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1002\/jor.25286","article-title":"The role of meteorin-like in skeletal development and bone fracture healing","volume":"40","author":"Huang","year":"2022","journal-title":"J Orthop Res"},{"key":"2024040314582428800_CIT0216","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nrendo.2010.18","article-title":"SPARC: a key player in the pathologies associated with obesity and diabetes","volume":"6","author":"Kos","year":"2010","journal-title":"Nat Rev Endocrinol"},{"key":"2024040314582428800_CIT0217","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.2337\/db09-0211","article-title":"Regulation of the fibrosis and angiogenesis promoter SPARC\/osteonectin in human adipose tissue by weight change, leptin, insulin, and glucose","volume":"58","author":"Kos","year":"2009","journal-title":"Diabetes"},{"key":"2024040314582428800_CIT0218","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0092-8674(81)90037-4","article-title":"Osteonectin, a bone-specific protein linking mineral to collagen","volume":"26","author":"Termine","year":"1981","journal-title":"Cell"},{"key":"2024040314582428800_CIT0219","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.biocel.2011.12.021","article-title":"Diverse biological functions of the SPARC family of proteins","volume":"44","author":"Bradshaw","year":"2012","journal-title":"Int J Biochem Cell Biol"},{"key":"2024040314582428800_CIT0220","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1136\/gutjnl-2011-300776","article-title":"A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise","volume":"62","author":"Aoi","year":"2013","journal-title":"Gut"},{"key":"2024040314582428800_CIT0221","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.molmet.2017.01.007","article-title":"Global mRNA sequencing of human skeletal muscle: search for novel exercise-regulated myokines","volume":"6","author":"Pourteymour","year":"2017","journal-title":"Mol Metab"},{"key":"2024040314582428800_CIT0222","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1042\/CS20180714","article-title":"SPARC is required for the maintenance of glucose homeostasis and insulin secretion in mice","volume":"133","author":"Atorrasagasti","year":"2019","journal-title":"Clin Sci (Lond)"},{"key":"2024040314582428800_CIT0223","doi-asserted-by":"crossref","first-page":"752892","DOI":"10.3389\/fendo.2021.752892","article-title":"Association between factors involved in bone remodeling (Osteoactivin and OPG) with plasma levels of irisin and meteorin-like protein in people with T2D and obesity","volume":"12","author":"Cherian","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2024040314582428800_CIT0224","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fphys.2020.00018","article-title":"Plasma myokine concentrations after acute exercise in non-obese and obese sedentary women","volume":"11","author":"Garneau","year":"2020","journal-title":"Front Physiol"},{"key":"2024040314582428800_CIT0225","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1080\/17461391.2021.1974573","article-title":"Sedentary time, physical activity, and serum SPARC in a middle-aged population","volume":"22","author":"Nishida","year":"2022","journal-title":"Eur J Sport Sci"},{"key":"2024040314582428800_CIT0226","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.3389\/fphys.2017.01063","article-title":"Exercise-induced hypertrophic and oxidative signaling pathways and myokine expression in fast muscle of adult Zebrafish","volume":"8","author":"Rovira","year":"2017","journal-title":"Front Physiol"},{"key":"2024040314582428800_CIT0227","doi-asserted-by":"crossref","first-page":"10551","DOI":"10.1096\/fj.201900453R","article-title":"Secreted protein acidic and rich in cysteine (SPARC) improves glucose tolerance via AMP-activated protein kinase activation","volume":"33","author":"Aoi","year":"2019","journal-title":"FASEB J"},{"key":"2024040314582428800_CIT0228","doi-asserted-by":"crossref","first-page":"12017","DOI":"10.1073\/pnas.0705070104","article-title":"AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1\u03b1","volume":"104","author":"J\u00e4ger","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024040314582428800_CIT0229","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.lfs.2019.05.070","article-title":"Sparc, an EPS-induced gene, modulates the extracellular matrix and mitochondrial function via ILK\/AMPK pathways in C2C12 cells","volume":"229","author":"Melouane","year":"2019","journal-title":"Life Sci"},{"key":"2024040314582428800_CIT0230","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1002\/jmri.21754","article-title":"Intermuscular adipose tissue (IMAT): association with other adipose tissue compartments and insulin sensitivity","volume":"29","author":"Boettcher","year":"2009","journal-title":"J Magn Reson Imaging"},{"key":"2024040314582428800_CIT0231","doi-asserted-by":"crossref","first-page":"e2021013118","DOI":"10.1073\/pnas.2021013118","article-title":"FGF-2-dependent signaling activated in aged human skeletal muscle promotes intramuscular adipogenesis","volume":"118","author":"Mathes","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024040314582428800_CIT0232","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1007\/s00109-015-1322-y","article-title":"Growth hormone replacement therapy regulates microRNA-29a and targets involved in insulin resistance","volume":"93","author":"Galimov","year":"2015","journal-title":"J Mol Med (Berl)"},{"key":"2024040314582428800_CIT0233","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1007\/s00109-022-02260-w","article-title":"Growth hormone\/IGF-I-dependent signaling restores decreased expression of the myokine SPARC in aged skeletal muscle","volume":"100","author":"Mathes","year":"2022","journal-title":"J Mol Med (Berl)"},{"key":"2024040314582428800_CIT0234","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1074\/jbc.M808285200","article-title":"SPARC inhibits adipogenesis by its enhancement of \u03b2-catenin signaling","volume":"284","author":"Nie","year":"2009","journal-title":"J Biol Chem"},{"key":"2024040314582428800_CIT0235","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s12079-009-0064-4","article-title":"SPARC functions as an inhibitor of adipogenesis","volume":"3","author":"Nie","year":"2009","journal-title":"J Cell Commun Signal"},{"key":"2024040314582428800_CIT0236","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/nrendo.2009.220","article-title":"Inflammation: where is the SPARC in adipose-tissue inflammation","volume":"5","author":"Na\u00efmi","year":"2009","journal-title":"Nat Rev Endocrinol"},{"key":"2024040314582428800_CIT0237","doi-asserted-by":"crossref","first-page":"e169173","DOI":"10.1172\/JCI169173","article-title":"Reduction of SPARC protects mice against NLRP3 inflammasome activation and obesity","volume":"133","author":"Ryu","year":"2023","journal-title":"J Clin Invest"},{"key":"2024040314582428800_CIT0238","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1111\/liv.14857","article-title":"SPARC inhibition accelerates NAFLD-associated hepatocellular carcinoma development by dysregulating hepatic lipid metabolism","volume":"41","author":"Onorato","year":"2021","journal-title":"Liver Int"},{"key":"2024040314582428800_CIT0239","doi-asserted-by":"crossref","first-page":"1192458","DOI":"10.3389\/fendo.2023.1192458","article-title":"Signaling metabolite \u03b2-aminoisobutyric acid as a metabolic regulator, biomarker, and potential exercise pill","volume":"14","author":"Yi","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2024040314582428800_CIT0240","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/167307a0","article-title":"\u03b2-aminoisobutyric acid (\u03b1-methyl-\u03b2-alanine): a new amino-acid obtained from human urine","volume":"167","author":"Crumpler","year":"1951","journal-title":"Nature"},{"key":"2024040314582428800_CIT0241","doi-asserted-by":"crossref","first-page":"17212","DOI":"10.1038\/s41598-023-44249-6","article-title":"L-\u03b2-aminoisobutyric acid, L-BAIBA, a marker of bone mineral density and body mass index, and D-BAIBA of physical performance and age","volume":"13","author":"Lyssikatos","year":"2023","journal-title":"Sci Rep"},{"key":"2024040314582428800_CIT0242","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3390\/nu11030524","article-title":"\u03b2-aminoisobutyric acid as a novel regulator of carbohydrate and lipid metabolism","volume":"11","author":"Tanianskii","year":"2019","journal-title":"Nutrients"},{"key":"2024040314582428800_CIT0243","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.3389\/fphys.2019.01240","article-title":"Acute aerobic exercise leads to increased plasma levels of R- and S-\u03b2-aminoisobutyric acid in humans","volume":"10","author":"Stautemas","year":"2019","journal-title":"Front Physiol"},{"key":"2024040314582428800_CIT0244","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/0009-8981(74)90159-4","article-title":"The absolute configuration of \u03b2-aminoisobutyric acid in human serum and urine","volume":"50","author":"Solem","year":"1974","journal-title":"Clin Chim Acta"},{"key":"2024040314582428800_CIT0245","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1080\/07315724.2016.1256240","article-title":"BAIBA does not regulate UCP-3 expression in human skeletal muscle as a response to aerobic exercise","volume":"36","author":"Morales","year":"2017","journal-title":"J Am Coll Nutr"},{"key":"2024040314582428800_CIT0246","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.cmet.2020.01.013","article-title":"Targeting hepatic glutaminase 1 ameliorates non-alcoholic steatohepatitis by restoring very-low-density lipoprotein triglyceride assembly","volume":"31","author":"Simon","year":"2020","journal-title":"Cell Metab"},{"key":"2024040314582428800_CIT0247","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.atherosclerosis.2010.01.028","article-title":"Abnormal hepatic apolipoprotein B metabolism in type 2 diabetes","volume":"211","author":"Verg\u00e8s","year":"2010","journal-title":"Atherosclerosis"},{"key":"2024040314582428800_CIT0248","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1038\/oby.2008.337","article-title":"\u03b2-aminoisobutyric acid prevents diet-induced obesity in mice with partial leptin deficiency","volume":"16","author":"Begriche","year":"2008","journal-title":"Obesity (Silver Spring)"},{"key":"2024040314582428800_CIT0249","doi-asserted-by":"crossref","first-page":"21924","DOI":"10.1038\/srep21924","article-title":"\u03b2-aminoisobutyric acid attenuates hepatic endoplasmic reticulum stress and glucose\/lipid metabolic disturbance in mice with type 2 diabetes","volume":"6","author":"Shi","year":"2016","journal-title":"Sci Rep"},{"key":"2024040314582428800_CIT0250","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/j.celrep.2018.01.041","article-title":"\u03b2-aminoisobutyric acid, l-BAIBA, is a muscle-derived osteocyte survival factor","volume":"22","author":"Kitase","year":"2018","journal-title":"Cell Rep"},{"key":"2024040314582428800_CIT0251","doi-asserted-by":"crossref","first-page":"e10746","DOI":"10.1002\/jbm4.10746","article-title":"L-BAIBA synergizes with sub-optimal mechanical loading to promote new bone formation","volume":"7","author":"Prideaux","year":"2023","journal-title":"Jbmr Plus"},{"key":"2024040314582428800_CIT0252","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1210\/er.2005-0014","article-title":"Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions","volume":"27","author":"Potter","year":"2006","journal-title":"Endocr Rev"},{"key":"2024040314582428800_CIT0253","doi-asserted-by":"crossref","first-page":"4257","DOI":"10.1038\/s41467-023-39710-z","article-title":"The muscle-enriched myokine musclin impairs beige fat thermogenesis and systemic energy homeostasis via Tfr1\/PKA signaling in male mice","volume":"14","author":"Jin","year":"2023","journal-title":"Nat Commun"},{"key":"2024040314582428800_CIT0254","doi-asserted-by":"crossref","first-page":"50563","DOI":"10.1074\/jbc.M307310200","article-title":"Osteocrin, a novel bone-specific secreted protein that modulates the osteoblast phenotype","volume":"278","author":"Thomas","year":"2003","journal-title":"J Biol Chem"},{"key":"2024040314582428800_CIT0255","doi-asserted-by":"crossref","first-page":"36454","DOI":"10.1074\/jbc.M708596200","article-title":"Osteocrin is a specific ligand of the natriuretic peptide clearance receptor that modulates bone growth","volume":"282","author":"Moffatt","year":"2007","journal-title":"J Biol Chem"},{"key":"2024040314582428800_CIT0256","doi-asserted-by":"crossref","first-page":"6271","DOI":"10.1038\/s41467-021-26571-7","article-title":"Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin","volume":"12","author":"Wang","year":"2021","journal-title":"Nat Commun"},{"key":"2024040314582428800_CIT0257","doi-asserted-by":"crossref","first-page":"19391","DOI":"10.1074\/jbc.C400066200","article-title":"Musclin, a novel skeletal muscle-derived secretory factor","volume":"279","author":"Nishizawa","year":"2004","journal-title":"J Biol Chem"},{"key":"2024040314582428800_CIT0258","doi-asserted-by":"crossref","first-page":"16042","DOI":"10.1073\/pnas.1514250112","article-title":"Musclin is an activity-stimulated myokine that enhances physical endurance","volume":"112","author":"Subbotina","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024040314582428800_CIT0259","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1677\/JOE-08-0551","article-title":"Competitive binding of Musclin to natriuretic peptide receptor 3 with atrial natriuretic peptide","volume":"201","author":"Kita","year":"2009","journal-title":"J Endocrinol"},{"key":"2024040314582428800_CIT0260","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1080\/13543784.2023.2290064","article-title":"Augmentation of natriuretic peptide (NP) receptor A and B (NPR-A and NPR-B) and cyclic guanosine monophosphate (cGMP) signalling as a therapeutic strategy in heart failure","volume":"32","author":"Ajay","year":"2023","journal-title":"Expert Opin Investig Drugs"},{"key":"2024040314582428800_CIT0261","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.bbrc.2008.01.017","article-title":"cGMP rescues mitochondrial dysfunction induced by glucose and insulin in myocytes","volume":"367","author":"Mitsuishi","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"2024040314582428800_CIT0262","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1161\/CIRCRESAHA.117.312624","article-title":"A new secretory peptide of natriuretic peptide family, osteocrin, suppresses the progression of congestive heart failure after myocardial infarction","volume":"122","author":"Miyazaki","year":"2018","journal-title":"Circ Res"},{"key":"2024040314582428800_CIT0263","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41467-021-27634-5","article-title":"Skeletal muscle derived Musclin protects the heart during pathological overload","volume":"13","author":"Szaroszyk","year":"2022","journal-title":"Nat Commun"},{"key":"2024040314582428800_CIT0264","doi-asserted-by":"crossref","first-page":"109380","DOI":"10.1016\/j.celrep.2021.109380","article-title":"Mechanical load regulates bone growth via periosteal Osteocrin","volume":"36","author":"Watanabe-Takano","year":"2021","journal-title":"Cell Rep"},{"key":"2024040314582428800_CIT0265","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.3390\/cancers11101541","article-title":"Musclin, a myokine induced by aerobic exercise, retards muscle atrophy during cancer cachexia in mice","volume":"11","author":"Re Cecconi","year":"2019","journal-title":"Cancers (Basel)"},{"key":"2024040314582428800_CIT0266","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3389\/fphar.2018.00318","article-title":"The effects of PPAR stimulation on cardiac metabolic pathways in barth syndrome mice","volume":"9","author":"Schafer","year":"2018","journal-title":"Front Pharmacol"},{"key":"2024040314582428800_CIT0267","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.bbrc.2016.01.166","article-title":"Disruption of ATP-sensitive potassium channel function in skeletal muscles promotes production and secretion of musclin","volume":"471","author":"Sierra","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"2024040314582428800_CIT0268","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.stem.2023.12.011","article-title":"Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis","volume":"31","author":"Kang","year":"2024","journal-title":"Cell Stem Cell"},{"key":"2024040314582428800_CIT0269","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1080\/17461391.2022.2040597","article-title":"Exercise-induced changes on exerkines that might influence brown adipose tissue metabolism in young sedentary adults","volume":"23","author":"Mendez-Gutierrez","year":"2023","journal-title":"Eur J Sport Sci"},{"key":"2024040314582428800_CIT0270","doi-asserted-by":"crossref","first-page":"e5129","DOI":"10.1590\/1414-431x20165129","article-title":"Exercise improved lipid metabolism and insulin sensitivity in rats fed a high-fat diet by regulating glucose transporter 4 (GLUT4) and musclin expression","volume":"49","author":"Yu","year":"2016","journal-title":"Braz J Med Biol Res"},{"key":"2024040314582428800_CIT0271","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.3803\/EnM.2021.1104","article-title":"Musclin is related to insulin resistance and body composition, but not to body mass index or cardiorespiratory capacity in adults","volume":"36","author":"S\u00e1nchez","year":"2021","journal-title":"Endocrinol Metab (Seoul)"},{"key":"2024040314582428800_CIT0272","doi-asserted-by":"crossref","first-page":"1903366","DOI":"10.1002\/advs.201903366","article-title":"Transferrin receptor 1 regulates thermogenic capacity and cell fate in brown\/beige adipocytes","volume":"7","author":"Li","year":"2020","journal-title":"Adv Sci (Weinh)"},{"key":"2024040314582428800_CIT0273","doi-asserted-by":"crossref","first-page":"7469","DOI":"10.1038\/sj.onc.1210054","article-title":"Function and biological roles of the Dickkopf family of Wnt modulators","volume":"25","author":"Niehrs","year":"2006","journal-title":"Oncogene"},{"key":"2024040314582428800_CIT0274","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1007\/s00125-008-1084-y","article-title":"The WNT signalling pathway and diabetes mellitus","volume":"51","author":"Jin","year":"2008","journal-title":"Diabetologia"},{"key":"2024040314582428800_CIT0275","doi-asserted-by":"crossref","first-page":"e001000","DOI":"10.1161\/JAHA.114.001000","article-title":"Circulating Dickkopf-1 in diabetes mellitus: association with platelet activation and effects of improved metabolic control and low-dose aspirin","volume":"3","author":"Lattanzio","year":"2014","journal-title":"J Am Heart Assoc"},{"key":"2024040314582428800_CIT0276","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1161\/ATVBAHA.119.312612","article-title":"Dkk (Dickkopf) proteins","volume":"39","author":"Baetta","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2024040314582428800_CIT0277","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1007\/s00125-009-1615-1","article-title":"Thiazolidinediones increase the wingless-type MMTV integration site family (WNT) inhibitor Dickkopf-1 in adipocytes: a link with osteogenesis","volume":"53","author":"Gustafson","year":"2010","journal-title":"Diabetologia"},{"key":"2024040314582428800_CIT0278","doi-asserted-by":"crossref","first-page":"11402","DOI":"10.1073\/pnas.1205015109","article-title":"Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism","volume":"109","author":"Li","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024040314582428800_CIT0279","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.1111\/jcmm.16372","article-title":"A literature review on function and regulation mechanism of DKK4","volume":"25","author":"Lou","year":"2021","journal-title":"J Cell Mol Med"},{"key":"2024040314582428800_CIT0280","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/j.fertnstert.2009.06.010","article-title":"The acrosomal protein Dickkopf-like 1 (DKKL1) facilitates sperm penetration of the zona pellucida","volume":"93","author":"Kohn","year":"2010","journal-title":"Fertil Steril"},{"key":"2024040314582428800_CIT0281","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1016\/j.fertnstert.2009.06.011","article-title":"The acrosomal protein Dickkopf-like 1 (DKKL1) is not essential for fertility","volume":"93","author":"Kaneko","year":"2010","journal-title":"Fertil Steril"},{"key":"2024040314582428800_CIT0282","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1477-7827-10-51","article-title":"Developmental expression and function of DKKL1\/Dkkl1 in humans and mice","volume":"10","author":"Yan","year":"2012","journal-title":"Reprod Biol Endocrinol"},{"key":"2024040314582428800_CIT0283","first-page":"38","article-title":"The functions of sarcopenia related myokines","volume":"2","author":"Han","year":"2018","journal-title":"Trans Med Aging"},{"key":"2024040314582428800_CIT0284","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1038\/s41467-018-04038-6","article-title":"Dkk3 dependent transcriptional regulation controls age related skeletal muscle atrophy","volume":"9","author":"Yin","year":"2018","journal-title":"Nat Commun"},{"key":"2024040314582428800_CIT0285","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1006\/bbrc.1999.2067","article-title":"A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines","volume":"268","author":"Tsuji","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"2024040314582428800_CIT0286","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/j.1471-4159.2009.06158.x","article-title":"Dkk-3 is elevated in CSF and plasma of Alzheimer\u2019s disease patients","volume":"110","author":"Zenzmaier","year":"2009","journal-title":"J Neurochem"},{"key":"2024040314582428800_CIT0287","doi-asserted-by":"crossref","first-page":"8642","DOI":"10.1038\/s41598-021-88107-9","article-title":"The emerging plasma biomarker Dickkopf-3 (DKK3) and its association with renal and cardiovascular disease in the general population","volume":"11","author":"Piek","year":"2021","journal-title":"Sci Rep"},{"key":"2024040314582428800_CIT0288","doi-asserted-by":"crossref","first-page":"7435605","DOI":"10.1155\/2021\/7435605","article-title":"miR-129-5p promotes osteogenic differentiation of BMSCs and bone regeneration via repressing Dkk3","volume":"2021","author":"Zhao","year":"2021","journal-title":"Stem Cells Int"},{"key":"2024040314582428800_CIT0289","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.exger.2008.05.012","article-title":"Increase of Dkk-3 blood plasma levels in the elderly","volume":"43","author":"Zenzmaier","year":"2008","journal-title":"Exp Gerontol"},{"key":"2024040314582428800_CIT0290","first-page":"379","article-title":"Diabetic myopathy: impact of diabetes mellitus on skeletal muscle progenitor cells","volume":"4","author":"D\u2019Souza","year":"2013","journal-title":"Front Physiol"},{"key":"2024040314582428800_CIT0291","doi-asserted-by":"crossref","first-page":"371","DOI":"10.3389\/fphys.2013.00371","article-title":"The effects of obesity on skeletal muscle regeneration","volume":"4","author":"Akhmedov","year":"2013","journal-title":"Front Physiol"},{"key":"2024040314582428800_CIT0292","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1152\/physrev.00043.2011","article-title":"Satellite cells and the muscle stem cell niche","volume":"93","author":"Yin","year":"2013","journal-title":"Physiol Rev"},{"key":"2024040314582428800_CIT0293","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.cmet.2019.03.009","article-title":"Epigenetics in human obesity and type 2 diabetes","volume":"29","author":"Ling","year":"2019","journal-title":"Cell Metab"},{"key":"2024040314582428800_CIT0294","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.mam.2012.06.010","article-title":"Dietary factors, epigenetic modifications and obesity outcomes: progresses and perspectives","volume":"34","author":"Milagro","year":"2013","journal-title":"Mol Aspects Med"},{"key":"2024040314582428800_CIT0295","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s13238-017-0442-2","article-title":"The SWI\/SNF chromatin-remodeling factors BAF60a, b, and c in nutrient signaling and metabolic control","volume":"9","author":"Wang","year":"2018","journal-title":"Protein Cell"},{"key":"2024040314582428800_CIT0296","doi-asserted-by":"crossref","first-page":"e20221123","DOI":"10.1084\/jem.20221123","article-title":"Myofiber Baf60c controls muscle regeneration by modulating Dkk3-mediated paracrine signaling","volume":"220","author":"Xu","year":"2023","journal-title":"J Exp Med"},{"key":"2024040314582428800_CIT0297","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.2337\/db13-1061","article-title":"The Baf60c\/Deptor pathway links skeletal muscle inflammation to glucose homeostasis in obesity","volume":"63","author":"Meng","year":"2014","journal-title":"Diabetes"},{"key":"2024040314582428800_CIT0298","doi-asserted-by":"crossref","first-page":"232","DOI":"10.2337\/diab.10.3.232","article-title":"Humoral nature of the hypoglycemic factor of muscular work","volume":"10","author":"Goldstein","year":"1961","journal-title":"Diabetes"},{"key":"2024040314582428800_CIT0299","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/s41574-020-00408-7","article-title":"Who would have thought\u2014myokines two decades on","volume":"16","author":"Febbraio","year":"2020","journal-title":"Nat Rev Endocrinol"},{"key":"2024040314582428800_CIT0300","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41574-022-00641-2","article-title":"Exerkines in health, resilience and disease","volume":"18","author":"Chow","year":"2022","journal-title":"Nat Rev Endocrinol"},{"key":"2024040314582428800_CIT0301","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/s11914-020-00599-y","article-title":"Muscle, bone, and fat crosstalk: the biological role of myokines, osteokines, and adipokines","volume":"18","author":"Kirk","year":"2020","journal-title":"Curr Osteoporos Rep"},{"key":"2024040314582428800_CIT0302","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cmet.2017.12.001","article-title":"Extracellular vesicles provide a means for tissue crosstalk during exercise","volume":"27","author":"Whitham","year":"2018","journal-title":"Cell Metab"},{"key":"2024040314582428800_CIT0303","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/prot.20803","article-title":"Computational reconstruction of the human skeletal muscle secretome","volume":"62","author":"Bortoluzzi","year":"2006","journal-title":"Proteins"},{"key":"2024040314582428800_CIT0304","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/pmic.200800187","article-title":"Comparative proteomic analysis of the insulin-induced L6 myotube secretome","volume":"9","author":"Yoon","year":"2009","journal-title":"Proteomics"},{"key":"2024040314582428800_CIT0305","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1074\/mcp.M110.002113","article-title":"Dynamics of the skeletal muscle secretome during myoblast differentiation","volume":"9","author":"Henningsen","year":"2010","journal-title":"Mol Cell Proteomics"},{"key":"2024040314582428800_CIT0306","first-page":"201","article-title":"RNAkines are secreted messengers shaping health and disease","volume-title":"Trends Endocrinol Metab","author":"Li","year":"2023"},{"key":"2024040314582428800_CIT0307","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.tcb.2022.07.009","article-title":"The adipocyte supersystem of insulin and cAMP signaling","volume":"33","author":"Guilherme","year":"2023","journal-title":"Trends Cell Biol"},{"key":"2024040314582428800_CIT0308","doi-asserted-by":"crossref","first-page":"7916","DOI":"10.1038\/s41467-023-43402-z","article-title":"Skeletal muscle-secreted DLPC orchestrates systemic energy homeostasis by enhancing adipose browning","volume":"14","author":"Hu","year":"2023","journal-title":"Nat Commun"},{"key":"2024040314582428800_CIT0309","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/s41574-022-00724-0","article-title":"Lactate as a major myokine and exerkine","volume":"18","author":"Brooks","year":"2022","journal-title":"Nat Rev Endocrinol"},{"key":"2024040314582428800_CIT0310","doi-asserted-by":"crossref","first-page":"9516","DOI":"10.1074\/jbc.M109.092429","article-title":"Glutamine synthetase in muscle is required for glutamine production during fasting and extrahepatic ammonia detoxification","volume":"285","author":"He","year":"2010","journal-title":"J Biol Chem"},{"key":"2024040314582428800_CIT0311","doi-asserted-by":"crossref","first-page":"114992","DOI":"10.1016\/j.addr.2023.114992","article-title":"Omics approaches for the assessment of biological responses to nanoparticles","volume":"200","author":"Abdelkader","year":"2023","journal-title":"Adv Drug Deliv Rev"},{"key":"2024040314582428800_CIT0312","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/978-3-319-41448-5_19","article-title":"Protein structural analysis via mass spectrometry-based proteomics","volume":"919","author":"Artigues","year":"2016","journal-title":"Adv Exp Med Biol"},{"key":"2024040314582428800_CIT0313","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1038\/s41467-020-17033-7","article-title":"Rapid, deep and precise profiling of the plasma proteome with multi-nanoparticle protein corona","volume":"11","author":"Blume","year":"2020","journal-title":"Nat Commun"},{"key":"2024040314582428800_CIT0314","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/prca.201300094","article-title":"The secretome of the working human skeletal muscle\u2014A promising opportunity to combat the metabolic disaster","volume":"8","author":"Weigert","year":"2014","journal-title":"Proteomics Clin Appl"},{"key":"2024040314582428800_CIT0315","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.cmet.2018.03.015","article-title":"A strategy for discovery of endocrine interactions with application to whole-body metabolism","volume":"27","author":"Seldin","year":"2018","journal-title":"Cell Metab"},{"key":"2024040314582428800_CIT0316","doi-asserted-by":"crossref","first-page":"e2000318","DOI":"10.1002\/pmic.202000318","article-title":"Microproteomic sample preparation","volume":"21","author":"Alexovic","year":"2021","journal-title":"Proteomics"},{"key":"2024040314582428800_CIT0317","doi-asserted-by":"crossref","first-page":"7242","DOI":"10.1038\/s41467-022-34824-2","article-title":"Spatially resolved proteomics via tissue expansion","volume":"13","author":"Li","year":"2022","journal-title":"Nat Commun"},{"key":"2024040314582428800_CIT0318","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1038\/mt.2014.17","article-title":"Enriched protein screening of human bone marrow mesenchymal stromal cell secretions reveals MFAP5 and PENK as novel IL-10 modulators","volume":"22","author":"Milwid","year":"2014","journal-title":"Mol Ther"},{"key":"2024040314582428800_CIT0319","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11154-021-09640-6","article-title":"The endocrine role of brown adipose tissue: an update on actors and actions","volume":"23","author":"Gavald\u00e0-Navarro","year":"2022","journal-title":"Rev Endocr Metab Disord"},{"key":"2024040314582428800_CIT0320","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.7150\/ijbs.4679","article-title":"Interleukin-6, a major cytokine in the central nervous system","volume":"8","author":"Erta","year":"2012","journal-title":"Int J Biol Sci"},{"key":"2024040314582428800_CIT0321","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3389\/fendo.2019.00524","article-title":"Irisin: a hope in understanding and managing obesity and metabolic syndrome","volume":"10","author":"Arhire","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2024040314582428800_CIT0322","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1111\/j.1460-9568.1993.tb00210.x","article-title":"Cellular localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain","volume":"5","author":"Sch\u00f6bitz","year":"1993","journal-title":"Eur J Neurosci"},{"key":"2024040314582428800_CIT0323","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.cmet.2018.07.004","article-title":"Brown adipose tissue controls skeletal muscle function via the secretion of myostatin","volume":"28","author":"Kong","year":"2018","journal-title":"Cell Metab"},{"key":"2024040314582428800_CIT0324","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.cmet.2015.05.010","article-title":"GDF11 increases with age and inhibits skeletal muscle regeneration","volume":"22","author":"Egerman","year":"2015","journal-title":"Cell Metab"},{"key":"2024040314582428800_CIT0325","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1136\/gutjnl-2019-318812","article-title":"Growth differentiation factor 11 attenuates liver fibrosis via expansion of liver progenitor cells","volume":"69","author":"Dai","year":"2020","journal-title":"Gut"},{"key":"2024040314582428800_CIT0326","doi-asserted-by":"crossref","first-page":"873699","DOI":"10.3389\/fendo.2022.873699","article-title":"Adipokines, hepatokines and myokines: focus on their role and molecular mechanisms in adipose tissue inflammation","volume":"13","author":"Ren","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2024040314582428800_CIT0327","doi-asserted-by":"crossref","first-page":"E1161","DOI":"10.1152\/ajpendo.00598.2009","article-title":"Apelin and APJ regulation in adipose tissue and skeletal muscle of type 2 diabetic mice and humans","volume":"298","author":"Dray","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2024040314582428800_CIT0328","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1007\/s00018-020-03461-7","article-title":"Apelin\/APJ system: an emerging therapeutic target for respiratory diseases","volume":"77","author":"Yan","year":"2020","journal-title":"Cell Mol Life Sci"},{"key":"2024040314582428800_CIT0329","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12974-022-02518-7","article-title":"Apelin alleviated neuroinflammation and promoted endogenous neural stem cell proliferation and differentiation after spinal cord injury in rats","volume":"19","author":"Liu","year":"2022","journal-title":"J Neuroinflammation"},{"key":"2024040314582428800_CIT0330","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1179\/1476830515Y.0000000039","article-title":"BDNF levels in adipose tissue and hypothalamus were reduced in mice with MSG-induced obesity","volume":"18","author":"Jin","year":"2015","journal-title":"Nutr Neurosci"},{"key":"2024040314582428800_CIT0331","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1053\/jhep.2001.20793","article-title":"Human and rat hepatic stellate cells express neurotrophins and neurotrophin receptors","volume":"33","author":"Cassiman","year":"2001","journal-title":"Hepatology"},{"key":"2024040314582428800_CIT0332","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/s41586-020-2527-y","article-title":"A leptin-BDNF pathway regulating sympathetic innervation of adipose tissue","volume":"583","author":"Wang","year":"2020","journal-title":"Nature"},{"key":"2024040314582428800_CIT0333","doi-asserted-by":"crossref","first-page":"e20201206","DOI":"10.1084\/jem.20201206","article-title":"Meteorin-like\/Meteorin-\u03b2 protects heart against cardiac dysfunction","volume":"218","author":"Rup\u00e9rez","year":"2021","journal-title":"J Exp Med"},{"key":"2024040314582428800_CIT0334","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1038\/aps.2016.70","article-title":"Intestinal Metrnl released into the gut lumen acts as a local regulator for gut antimicrobial peptides","volume":"37","author":"Li","year":"2016","journal-title":"Acta Pharmacol Sin"},{"key":"2024040314582428800_CIT0335","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s13105-022-00913-5","article-title":"The role of SPARC (secreted protein acidic and rich in cysteine) in the pathogenesis of obesity, type 2 diabetes, and non-alcoholic fatty liver disease","volume":"79","author":"Atorrasagasti","year":"2023","journal-title":"J Physiol Biochem"},{"key":"2024040314582428800_CIT0336","doi-asserted-by":"crossref","first-page":"13366","DOI":"10.1073\/pnas.1512202112","article-title":"SPARC triggers a cell-autonomous program of synapse elimination","volume":"112","author":"L\u00f3pez-Murcia","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024040314582428800_CIT0337","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jhep.2016.03.008","article-title":"DKK3 expression in hepatocytes defines susceptibility to liver steatosis and obesity","volume":"65","author":"Xie","year":"2016","journal-title":"J Hepatol"},{"key":"2024040314582428800_CIT0338","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.neuron.2016.11.024","article-title":"Primate neurons flex their musclin","volume":"92","author":"Pollen","year":"2016","journal-title":"Neuron"},{"key":"2024040314582428800_CIT0339","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12929-021-00714-w","article-title":"Rheumatoid cachexia: the underappreciated role of myoblast, macrophage and fibroblast interplay in the skeletal muscle niche","volume":"28","author":"Ollewagen","year":"2021","journal-title":"J Biomed Sci"},{"key":"2024040314582428800_CIT0340","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/s41589-020-00698-y","article-title":"Cell type-selective secretome profiling in vivo","volume":"17","author":"Wei","year":"2021","journal-title":"Nat Chem Biol"},{"key":"2024040314582428800_CIT0341","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.cmet.2020.07.013","article-title":"Quantitative fluxomics of circulating metabolites","volume":"32","author":"Hui","year":"2020","journal-title":"Cell Metab"},{"key":"2024040314582428800_CIT0342","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1038\/s41467-020-15747-2","article-title":"A live cell reporter of exosome secretion and uptake reveals pathfinding behavior of migrating cells","volume":"11","author":"Sung","year":"2020","journal-title":"Nat Commun"},{"key":"2024040314582428800_CIT0343","doi-asserted-by":"crossref","first-page":"5204","DOI":"10.1038\/s41467-021-25546-y","article-title":"Dynamic tracking and identification of tissue-specific secretory proteins in the circulation of live mice","volume":"12","author":"Kim","year":"2021","journal-title":"Nat Commun"},{"key":"2024040314582428800_CIT0344","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.abb.2012.03.001","article-title":"Antibody-cytokine fusion proteins","volume":"526","author":"Kontermann","year":"2012","journal-title":"Arch Biochem Biophys"},{"key":"2024040314582428800_CIT0345","doi-asserted-by":"crossref","first-page":"19.23.1","DOI":"10.1002\/cpps.51","article-title":"BioID: a screen for protein-protein interactions","volume":"91","author":"Roux","year":"2018","journal-title":"Curr Protoc Protein Sci"}],"container-title":["Life Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/lifemeta\/advance-article-pdf\/doi\/10.1093\/lifemeta\/loae006\/56822247\/loae006.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/lifemeta\/article-pdf\/3\/3\/loae006\/57146420\/loae006.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/lifemeta\/article-pdf\/3\/3\/loae006\/57146420\/loae006.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T13:40:10Z","timestamp":1712151610000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/lifemeta\/article\/doi\/10.1093\/lifemeta\/loae006\/7618092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,2]]},"references-count":345,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/lifemeta\/loae006","relation":{},"ISSN":["2755-0230"],"issn-type":[{"value":"2755-0230","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,6,1]]},"published":{"date-parts":[[2024,3,2]]},"article-number":"loae006"}}