{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:02:44Z","timestamp":1791576164620,"version":"4.3.4"},"reference-count":236,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T00:00:00Z","timestamp":1732320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Serotonin is one of the most potent gastrointestinal, peripheral, and neuronal signaling molecules and plays a key role in regulating energy metabolism. Accumulating evidence has shown the complex interplay between gut microbiota and host energy metabolism. In this review, we summarize recent findings on the role of gut microbiota in serotonin metabolism and discuss the complicated mechanisms by which serotonin, working in conjunction with the gut microbiota, affects total body energy metabolism in the host. Gut microbiota affects serotonin synthesis, storage, release, transport, and catabolism. In addition, serotonin plays an indispensable role in regulating host energy homeostasis through organ crosstalk and microbe\u2013host communication, particularly with a wide array of serotonergic effects mediated by diverse serotonin receptors with unique tissue specificity. This fresh perspective will help broaden the understanding of serotonergic signaling in modulating energy metabolism, thus shedding light on the design of innovative serotonin-targeting strategies to treat metabolic diseases.<\/jats:p>","DOI":"10.1093\/lifemeta\/loae039","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T15:24:43Z","timestamp":1732202683000},"source":"Crossref","is-referenced-by-count":37,"title":["Serotonin signaling to regulate energy metabolism: a gut microbiota perspective"],"prefix":"10.1093","volume":"4","author":[{"given":"Guoli","family":"Li","sequence":"first","affiliation":[{"name":"Med-X Institute, Center for Immunological and Metabolic Diseases, First Affiliated Hospital of Xi\u2019an Jiaotong University , Xi\u2019an, Shaanxi 710061 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijing","family":"Dong","sequence":"additional","affiliation":[{"name":"Med-X Institute, Center for Immunological and Metabolic Diseases, First Affiliated Hospital of Xi\u2019an Jiaotong University , Xi\u2019an, Shaanxi 710061 ,","place":["China"]},{"name":"Department of Endocrinology, First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an Jiaotong University , Xi\u2019an, Shaanxi 710061 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhao","family":"Liu","sequence":"additional","affiliation":[{"name":"Med-X Institute, Center for Immunological and Metabolic Diseases, First Affiliated Hospital of Xi\u2019an Jiaotong University , Xi\u2019an, Shaanxi 710061 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Med-X Institute, Center for Immunological and Metabolic Diseases, First Affiliated Hospital of Xi\u2019an Jiaotong University , Xi\u2019an, Shaanxi 710061 ,","place":["China"]},{"name":"Department of Endocrinology, First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an Jiaotong University , Xi\u2019an, Shaanxi 710061 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick C N","family":"Rensen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an Jiaotong University , Xi\u2019an, Shaanxi 710061 ,","place":["China"]},{"name":"Department of Medicine, Division of Endocrinology, and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center , Albinusdreef 2, 2333 ZA Leiden ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Wang","sequence":"additional","affiliation":[{"name":"Med-X Institute, Center for Immunological and Metabolic Diseases, First Affiliated Hospital of Xi\u2019an Jiaotong University , Xi\u2019an, Shaanxi 710061 ,","place":["China"]},{"name":"Department of Endocrinology, First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an Jiaotong University , Xi\u2019an, Shaanxi 710061 ,","place":["China"]},{"name":"Department of Medicine, Division of Endocrinology, and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center , Albinusdreef 2, 2333 ZA Leiden ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,11,23]]},"reference":[{"key":"2025020710554631100_CIT0001","doi-asserted-by":"crossref","first-page":"13525","DOI":"10.1073\/pnas.2233056100","article-title":"Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function","volume":"100","author":"C\u00f4t\u00e9","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025020710554631100_CIT0002","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1021\/acschemneuro.6b00414","article-title":"Diverse effects of gut-derived serotonin in intestinal inflammation","volume":"8","author":"Shajib","year":"2017","journal-title":"ACS Chem Neurosci"},{"key":"2025020710554631100_CIT0003","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0021-9258(18)57137-4","article-title":"Serum vasoconstrictor (serotonin): IV. 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