{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:46:17Z","timestamp":1792136777891,"version":"4.4.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,21]]},"DOI":"10.1093\/lifemeta\/loag023","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T12:06:46Z","timestamp":1784722006000},"source":"Crossref","is-referenced-by-count":0,"title":["Lithocholic acid alleviates fatty liver in mice and non-human primate macaques"],"prefix":"10.1093","volume":"5","author":[{"given":"Qi","family":"Qu","sequence":"first","affiliation":[{"name":"Zhongzhou Laboratory for Integrative Biology, School of Basic Medical Sciences, Henan University , Kaifeng, Henan 475004,","place":["China"]},{"name":"State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University , Xiamen, Fujian 361102,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University , Xiamen, Fujian 361102,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo","family":"Shen","sequence":"additional","affiliation":[{"name":"Guangxi Huaren Jiying Biotechnology Co., Ltd. , Nanning, Guangxi 530000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojiao","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangxi Huaren Jiying Biotechnology Co., Ltd. , Nanning, Guangxi 530000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Han","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University , Xiamen, Fujian 361102,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University , Xiamen, Fujian 361102,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cixiong","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University , Xiamen, Fujian 361102,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhumei","family":"Wei","sequence":"additional","affiliation":[{"name":"Guangxi Huaren Jiying Biotechnology Co., Ltd. , Nanning, Guangxi 530000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Xie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University , Xiamen, Fujian 361102,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Laboratory Animal Research Center, Xiamen University , Xiamen, Fujian 361102,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlong","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Key Laboratory of Smart Drug Delivery, State Key Laboratory of Advanced Drug Formulations, Fudan University , Shanghai 201203,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianru","family":"Xu","sequence":"additional","affiliation":[{"name":"Zhongzhou Laboratory for Integrative Biology, School of Basic Medical Sciences, Henan University , Kaifeng, Henan 475004,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Xu","sequence":"additional","affiliation":[{"name":"Zhongzhou Laboratory for Integrative Biology, School of Basic Medical Sciences, Henan University , Kaifeng, Henan 475004,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hepatic Surgery, Shanghai Cancer Center, Fudan University , Shanghai 200032,","place":["China"]},{"name":"Department of Oncology, Shanghai Medical College, Fudan University , Shanghai 200032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su","family":"Chen","sequence":"additional","affiliation":[{"name":"Zhongzhou Laboratory for Integrative Biology, School of Basic Medical Sciences, Henan University , Kaifeng, Henan 475004,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Qi","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Key Laboratory of Smart Drug Delivery, State Key Laboratory of Advanced Drug Formulations, Fudan University , Shanghai 201203,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Song","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhongzhou Laboratory for Integrative Biology, School of Basic Medical Sciences, Henan University , Kaifeng, Henan 475004,","place":["China"]},{"name":"State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University , Xiamen, Fujian 361102,","place":["China"]},{"name":"Department of Gastrointestinal Surgery, Institute of Gastrointestinal Oncology, Zhongshan Hospital of Xiamen University , Xiamen, Fujian 361004,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Cai","family":"Lin","sequence":"additional","affiliation":[{"name":"Zhongzhou Laboratory for Integrative Biology, School of Basic Medical Sciences, Henan University , Kaifeng, Henan 475004,","place":["China"]},{"name":"State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University , Xiamen, Fujian 361102,","place":["China"]},{"name":"Department of Gastrointestinal Surgery, Institute of Gastrointestinal Oncology, Zhongshan Hospital of Xiamen University , Xiamen, Fujian 361004,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"2026101602570462300_loag023-B1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/s41586-024-08329-5","volume":"643","author":"Qu Q, Chen Y, Wang Y","year":"2025","journal-title":"Nature"},{"key":"2026101602570462300_loag023-B2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s41586-024-08348-2","volume":"643","author":"Qu Q, Chen Y, Wang Y","year":"2025","journal-title":"Nature"},{"key":"2026101602570462300_loag023-B3","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.cmet.2014.06.014","volume":"20","author":"Zhang","year":"2014","journal-title":"Cell Metab"},{"key":"2026101602570462300_loag023-B4","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature23275","volume":"548","author":"Zhang","year":"2017","journal-title":"Nature"},{"key":"2026101602570462300_loag023-B5","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.cmet.2019.05.018","volume":"30","author":"Li","year":"2019","journal-title":"Cell Metab"},{"key":"2026101602570462300_loag023-B6","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.cmet.2013.09.005","volume":"18","author":"Zhang","year":"2013","journal-title":"Cell Metab"},{"key":"2026101602570462300_loag023-B7","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.cmet.2016.09.003","volume":"24","author":"Zhang","year":"2016","journal-title":"Cell Metab"},{"key":"2026101602570462300_loag023-B8","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41586-022-04431-8","volume":"603","author":"Ma T, Tian X, Zhang B","year":"2022","journal-title":"Nature"},{"key":"2026101602570462300_loag023-B9","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1073\/pnas.051551698","volume":"98","author":"Staudinger","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026101602570462300_loag023-B10","doi-asserted-by":"crossref","first-page":"881231","DOI":"10.3389\/fphar.2022.881231","volume":"13","author":"Wang Q, Song GC, Weng FY","year":"2022","journal-title":"Front Pharmacol"},{"key":"2026101602570462300_loag023-B11","doi-asserted-by":"crossref","first-page":"907271","DOI":"10.3389\/fphar.2022.907271","volume":"13","author":"Li W, Chen H, Qian Y","year":"2022","journal-title":"Front Pharmacol"},{"key":"2026101602570462300_loag023-B12","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0378-4274(92)90156-E","volume":"61","author":"Delzenne","year":"1992","journal-title":"Toxicol Lett"},{"key":"2026101602570462300_loag023-B13","doi-asserted-by":"crossref","first-page":"410","DOI":"10.2353\/ajpath.2006.050404","volume":"168","author":"Fickert","year":"2006","journal-title":"Am J Pathol"},{"key":"2026101602570462300_loag023-B14","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.toxlet.2014.04.001","volume":"228","author":"Woolbright","year":"2014","journal-title":"Toxicol Lett"},{"key":"2026101602570462300_loag023-B15","first-page":"471","volume":"19","author":"Kr\u00e4henb\u00fchl","year":"1994","journal-title":"Hepatology"},{"key":"2026101602570462300_loag023-B16","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/bcpt.12449","volume":"118","author":"Woolbright","year":"2016","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"2026101602570462300_loag023-B17","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/toxsci\/kfv155","volume":"147","author":"Sharanek","year":"2015","journal-title":"Toxicol Sci"},{"key":"2026101602570462300_loag023-B18","first-page":"192","volume":"45","author":"Kawasumi","year":"1988","journal-title":"Oncology"},{"key":"2026101602570462300_loag023-B19","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1126\/science.adl4100","volume":"387","author":"Varanasi SK, Chen D, Liu Y","year":"2025","journal-title":"Science"},{"key":"2026101602570462300_loag023-B20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.livres.2026.02.002","volume":"10","author":"Sun","year":"2026","journal-title":"Liver Res"},{"key":"2026101602570462300_loag023-B21","doi-asserted-by":"crossref","first-page":"e64721","DOI":"10.1371\/journal.pone.0064721","volume":"8","author":"Bjursell","year":"2013","journal-title":"PLoS One"},{"key":"2026101602570462300_loag023-B22","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ebiom.2018.10.030","volume":"37","author":"Xie","year":"2018","journal-title":"EBioMedicine"},{"key":"2026101602570462300_loag023-B23","doi-asserted-by":"crossref","first-page":"101543","DOI":"10.1016\/j.xcrm.2024.101543","volume":"5","author":"Ren","year":"2024","journal-title":"Cell Rep Med"},{"key":"2026101602570462300_loag023-B24","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.bbadis.2018.05.011","volume":"1865","author":"Li","year":"2019","journal-title":"Biochim Biophys Acta (BBA) Mol Basis Dis"},{"key":"2026101602570462300_loag023-B25","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1194\/jlr.RA119000307","volume":"61","author":"Straniero","year":"2020","journal-title":"J Lipid Res"},{"key":"2026101602570462300_loag023-B26","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/nature07813","volume":"458","author":"Cant\u00f3","year":"2009","journal-title":"Nature"},{"key":"2026101602570462300_loag023-B27","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3390\/metabo11020099","volume":"11","author":"Zhao","year":"2021","journal-title":"Metabolites"},{"key":"2026101602570462300_loag023-B28","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1038\/s41467-022-29589-7","volume":"13","author":"Li","year":"2022","journal-title":"Nat Commun"},{"key":"2026101602570462300_loag023-B29","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J"},{"key":"2026101602570462300_loag023-B30","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1038\/nm.3372","volume":"19","author":"Fullerton","year":"2013","journal-title":"Nat Med"},{"key":"2026101602570462300_loag023-B31","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1016\/j.celrep.2017.03.011","volume":"18","author":"Woods","year":"2017","journal-title":"Cell Rep"},{"key":"2026101602570462300_loag023-B32","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1126\/science.284.5418.1362","volume":"284","author":"Makishima","year":"1999","journal-title":"Science"},{"key":"2026101602570462300_loag023-B33","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1126\/science.284.5418.1365","volume":"284","author":"Parks","year":"1999","journal-title":"Science"},{"key":"2026101602570462300_loag023-B34","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/S0006-291X(02)02550-0","volume":"298","author":"Maruyama","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"2026101602570462300_loag023-B35","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/s42255-024-01041-8","volume":"6","author":"Yun","year":"2024","journal-title":"Nat Metab"},{"key":"2026101602570462300_loag023-B36","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cmet.2009.08.001","volume":"10","author":"Thomas","year":"2009","journal-title":"Cell Metab"},{"key":"2026101602570462300_loag023-B37","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1038\/ncomms3384","volume":"4","author":"Li","year":"2013","journal-title":"Nat Commun"},{"key":"2026101602570462300_loag023-B38","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1038\/s41591-018-0222-4","volume":"24","author":"Sun","year":"2018","journal-title":"Nat Med"},{"key":"2026101602570462300_loag023-B39","doi-asserted-by":"crossref","first-page":"G554","DOI":"10.1152\/ajpgi.00223.2019","volume":"318","author":"Chiang","year":"2020","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2026101602570462300_loag023-B40","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.jhep.2010.09.032","volume":"54","author":"Ben-Shlomo","year":"2011","journal-title":"J Hepatol"},{"key":"2026101602570462300_loag023-B41","doi-asserted-by":"crossref","first-page":"e0240338","DOI":"10.1371\/journal.pone.0240338","volume":"15","author":"Luong","year":"2020","journal-title":"PLoS One"},{"key":"2026101602570462300_loag023-B42","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1194\/jlr.M071183","volume":"57","author":"Takahashi","year":"2016","journal-title":"J Lipid Res"},{"key":"2026101602570462300_loag023-B43","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1194\/jlr.RA119000395","volume":"61","author":"Honda","year":"2020","journal-title":"J Lipid Res"},{"key":"2026101602570462300_loag023-B44","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1538\/expanim.51.125","volume":"51","author":"Chen","year":"2002","journal-title":"Exp Anim"}],"container-title":["Life Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/lifemeta\/advance-article-pdf\/doi\/10.1093\/lifemeta\/loag023\/69922012\/loag023.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/lifemeta\/article-pdf\/5\/6\/loag023\/69922012\/loag023.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/lifemeta\/article-pdf\/5\/6\/loag023\/69922012\/loag023.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:57:17Z","timestamp":1792133837000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/lifemeta\/article\/doi\/10.1093\/lifemeta\/loag023\/8740997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,23]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,9,21]]}},"URL":"https:\/\/doi.org\/10.1093\/lifemeta\/loag023","relation":{},"ISSN":["2755-0230"],"issn-type":[{"value":"2755-0230","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,12]]},"published":{"date-parts":[[2026,7,23]]},"article-number":"loag023"}}