{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:46:18Z","timestamp":1792136778496,"version":"4.4.0"},"reference-count":89,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82522038"],"award-info":[{"award-number":["82522038"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Research and Development Project of China","award":["2024YFC270660"],"award-info":[{"award-number":["2024YFC270660"]}]},{"name":"Shenzhen Bay Laboratory Startup Fund","award":["C1032626001"],"award-info":[{"award-number":["C1032626001"]}],"id":[{"id":"https:\/\/ror.org\/00sdcjz77","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Shanghai Eastern Talent Plan","award":["QNKJ2025057"],"award-info":[{"award-number":["QNKJ2025057"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Metabolism plays a central role in coordinating mammalian oocyte maturation and early embryonic development. The metabolic changes that occur during these stages are essential for the acquisition of developmental competence and successful reproduction. This review summarizes metabolic regulation from oocyte growth and maturation through fertilization and preimplantation development, with particular emphasis on glucose, lipid, and amino acid metabolism, as well as mitochondrial function. We also discuss how metabolic disturbances associated with maternal obesity, ovarian aging, and polyendocrine metabolic ovarian syndrome (formerly termed polycystic ovary syndrome) impair oocyte quality and embryonic developmental potential. By integrating recent insights from multi-omics, live-cell imaging, and genetic studies, we propose a framework for understanding how metabolism not only supports but also actively governs developmental decisions. We further discuss mechanism-based strategies to restore metabolic balance and improve reproductive outcomes.<\/jats:p>","DOI":"10.1093\/lifemeta\/loag024","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T11:57:03Z","timestamp":1786017423000},"source":"Crossref","is-referenced-by-count":0,"title":["Metabolic regulation of oocyte maturation and early embryo development in mammals"],"prefix":"10.1093","volume":"5","author":[{"given":"Sifan","family":"Rong","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, The First School of Medicine, Wenzhou Medical University , Wenzhou, Zhejiang 325000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Fu","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, The First School of Medicine, Wenzhou Medical University , Wenzhou, Zhejiang 325000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, The First School of Medicine, Wenzhou Medical University , Wenzhou, Zhejiang 325000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxin Celia","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Renji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200127,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanruo","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Molecular Physiology, Shenzhen Bay Laboratory , Shenzhen, Guangdong 518132,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3016-9654","authenticated-orcid":false,"given":"Yue","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital , Beijing 100191,","place":["China"]},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital) , Beijing 100191,","place":["China"]},{"name":"Key Laboratory of Assisted Reproduction, Ministry of Education , Beijing 100191,","place":["China"]},{"name":"Beijing Key Laboratory of Collaborative Innovation in Frontier Technologies for Population Quality , Beijing 100191,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wencheng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute of Molecular Physiology, Shenzhen Bay Laboratory , Shenzhen, Guangdong 518132,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2498-3825","authenticated-orcid":false,"given":"Liangshan","family":"Mu","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Zhongshan Hospital, Fudan University , Shanghai 200032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"2026101602565984400_loag024-B1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jare.2021.06.022","article-title":"O-GlcNAc modification mediates aquaporin 3 to coordinate endometrial cell glycolysis and affects embryo implantation","volume":"37","author":"Zhang","year":"2022","journal-title":"J Adv Res"},{"key":"2026101602565984400_loag024-B2","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1016\/j.devcel.2021.07.020","article-title":"Metabolic plasticity drives development during mammalian embryogenesis","volume":"56","author":"Sharpley","year":"2021","journal-title":"Dev Cell"},{"key":"2026101602565984400_loag024-B3","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.cell.2016.12.026","article-title":"Nuclear localization of mitochondrial TCA cycle enzymes as a critical step in mammalian zygotic genome activation","volume":"168","author":"Nagaraj","year":"2017","journal-title":"Cell"},{"key":"2026101602565984400_loag024-B4","doi-asserted-by":"crossref","first-page":"e727","DOI":"10.1002\/mco2.727","article-title":"Nicotinamide mononucleotide supplementation rescues mitochondrial and energy metabolism functions and ameliorates inflammatory states in the ovaries of aging mice","volume":"5","author":"Liang","year":"2024","journal-title":"MedComm (2020)"},{"key":"2026101602565984400_loag024-B5","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41421-022-00440-z","article-title":"Metabolic control of histone acetylation for precise and timely regulation of minor ZGA in early mammalian embryos","volume":"8","author":"Li","year":"2022","journal-title":"Cell Discov"},{"key":"2026101602565984400_loag024-B6","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1038\/s41556-026-01993-x","article-title":"Proteomics-based insights into mammalian oocyte and early embryo development","volume":"28","author":"Rong","year":"2026","journal-title":"Nat Cell Biol"},{"key":"2026101602565984400_loag024-B7","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/s41556-023-01341-3","article-title":"Low-input lipidomics reveals lipid metabolism remodelling during early mammalian embryo development","volume":"26","author":"Zhang","year":"2024","journal-title":"Nat Cell Biol"},{"key":"2026101602565984400_loag024-B8","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1530\/REP-09-0345","article-title":"The pivotal role of glucose metabolism in determining oocyte developmental competence","volume":"139","author":"Sutton-McDowall","year":"2010","journal-title":"Reproduction"},{"key":"2026101602565984400_loag024-B9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/10409238.2023.2201945","article-title":"The tricarboxylic acid (TCA) cycle: a malleable metabolic network to counter cellular stress","volume":"58","author":"MacLean","year":"2023","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"2026101602565984400_loag024-B10","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.molcel.2020.09.022","article-title":"Characterization of metabolic patterns in mouse oocytes during meiotic maturation","volume":"80","author":"Li","year":"2020","journal-title":"Mol Cell"},{"key":"2026101602565984400_loag024-B11","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1038\/s42255-023-00863-2","article-title":"The pentose phosphate pathway in health and disease","volume":"5","author":"TeSlaa","year":"2023","journal-title":"Nat Metab"},{"key":"2026101602565984400_loag024-B12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1530\/jrf.0.0720009","article-title":"Pyruvate and glucose uptake by mouse ova and preimplantation embryos","volume":"72","author":"Leese","year":"1984","journal-title":"J Reprod Fertil"},{"key":"2026101602565984400_loag024-B13","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/s41556-025-01658-1","article-title":"\u03b1-ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells","volume":"27","author":"Van Nerum","year":"2025","journal-title":"Nat Cell Biol"},{"key":"2026101602565984400_loag024-B14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.devcel.2020.02.015","article-title":"Glycolysis-independent glucose metabolism distinguishes TE from ICM fate during mammalian embryogenesis","volume":"53","author":"Chi","year":"2020","journal-title":"Dev Cell"},{"key":"2026101602565984400_loag024-B15","doi-asserted-by":"crossref","first-page":"e83299","DOI":"10.7554\/eLife.83299","article-title":"Glycolytic flux-signaling controls mouse embryo mesoderm development","volume":"11","author":"Miyazawa","year":"2022","journal-title":"Elife"},{"key":"2026101602565984400_loag024-B16","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.stem.2025.03.011","article-title":"Glycolytic activity instructs germ layer proportions through regulation of nodal and Wnt signaling","volume":"32","author":"Stapornwongkul","year":"2025","journal-title":"Cell Stem Cell"},{"key":"2026101602565984400_loag024-B17","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/s41586-024-08044-1","article-title":"Selective utilization of glucose metabolism guides mammalian gastrulation","volume":"634","author":"Cao","year":"2024","journal-title":"Nature"},{"key":"2026101602565984400_loag024-B18","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1095\/biolreprod62.1.16","article-title":"Lactate regulates pyruvate uptake and metabolism in the preimplantation mouse embryo","volume":"62","author":"Lane","year":"2000","journal-title":"Biol Reprod"},{"key":"2026101602565984400_loag024-B19","doi-asserted-by":"crossref","first-page":"nwad295","DOI":"10.1093\/nsr\/nwad295","article-title":"Lactate regulates major zygotic genome activation by H3K18 lactylation in mammals","volume":"11","author":"Li","year":"2024","journal-title":"Natl Sci Rev"},{"key":"2026101602565984400_loag024-B20","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.stem.2025.03.012","article-title":"Integrated molecular-phenotypic profiling reveals metabolic control of morphological variation in a stem-cell-based embryo model","volume":"32","author":"Villaronga-Luque","year":"2025","journal-title":"Cell Stem Cell"},{"key":"2026101602565984400_loag024-B21","doi-asserted-by":"crossref","first-page":"727612","DOI":"10.3389\/fcell.2021.727612","article-title":"Melatonin modulates lipid metabolism in porcine cumulus-oocyte complex via its receptors","volume":"9","author":"Zhu","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"2026101602565984400_loag024-B22","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1530\/REP-11-0484","article-title":"Metabolism of the preimplantation embryo: 40 years on","volume":"143","author":"Leese","year":"2012","journal-title":"Reproduction"},{"key":"2026101602565984400_loag024-B23","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1038\/s41467-022-31323-2","article-title":"Dynamic enlargement and mobilization of lipid droplets in pluripotent cells coordinate morphogenesis during mouse peri-implantation development","volume":"13","author":"Mau","year":"2022","journal-title":"Nat Commun"},{"key":"2026101602565984400_loag024-B24","doi-asserted-by":"crossref","first-page":"e2018362118","DOI":"10.1073\/pnas.2018362118","article-title":"Lipid droplets in mammalian eggs are utilized during embryonic diapause","volume":"118","author":"Arena","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026101602565984400_loag024-B25","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41556-023-01325-3","article-title":"FOXO1-mediated lipid metabolism maintains mammalian embryos in dormancy","volume":"26","author":"van der Weijden","year":"2024","journal-title":"Nat Cell Biol"},{"key":"2026101602565984400_loag024-B26","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.tem.2023.03.001","article-title":"Serine signaling governs metabolic homeostasis and health","volume":"34","author":"He","year":"2023","journal-title":"Trends Endocrinol Metab"},{"key":"2026101602565984400_loag024-B27","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s40364-023-00487-4","article-title":"Targeting serine-glycine-one-carbon metabolism as a vulnerability in cancers","volume":"11","author":"Sun","year":"2023","journal-title":"Biomark Res"},{"key":"2026101602565984400_loag024-B28","doi-asserted-by":"crossref","DOI":"10.1126\/science.aan2788","article-title":"Spermidine in health and disease","volume":"359","author":"Madeo","year":"2018","journal-title":"Science"},{"key":"2026101602565984400_loag024-B29","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1038\/s43587-023-00498-8","article-title":"Polyamine metabolite spermidine rejuvenates oocyte quality by enhancing mitophagy during female reproductive aging","volume":"3","author":"Zhang","year":"2023","journal-title":"Nat Aging"},{"key":"2026101602565984400_loag024-B30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod64.1.1","article-title":"Amino acid transport regulation and early embryo development","volume":"64","author":"Van Winkle","year":"2001","journal-title":"Biol Reprod"},{"key":"2026101602565984400_loag024-B31","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1038\/s42255-021-00464-x","article-title":"Metabolic remodelling during early mouse embryo development","volume":"3","author":"Zhao","year":"2021","journal-title":"Nat Metab"},{"key":"2026101602565984400_loag024-B32","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/humupd\/dmp016","article-title":"Mitochondrial functionality in reproduction: from gonads and gametes to embryos and embryonic stem cells","volume":"15","author":"Ramalho-Santos","year":"2009","journal-title":"Hum Reprod Update"},{"key":"2026101602565984400_loag024-B33","first-page":"2828","article-title":"NAD+ metabolism and mitochondrial activity in the aged oocyte: focus on the effects of NAMPT stimulation","volume":"15","author":"Di Emidio","year":"2024","journal-title":"Aging Dis"},{"key":"2026101602565984400_loag024-B34","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.tem.2012.06.005","article-title":"The dynamic regulation of NAD metabolism in mitochondria","volume":"23","author":"Stein","year":"2012","journal-title":"Trends Endocrinol Metab"},{"key":"2026101602565984400_loag024-B35","doi-asserted-by":"crossref","first-page":"e13904","DOI":"10.1111\/acel.13904","article-title":"Deletion of enzymes for de novo NAD+ biosynthesis accelerated ovarian aging","volume":"22","author":"Yang","year":"2023","journal-title":"Aging Cell"},{"key":"2026101602565984400_loag024-B36","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/jcp.31156","article-title":"NAMPT regulates mitochondria function and lipid metabolism during porcine oocyte maturation","volume":"239","author":"Guo","year":"2024","journal-title":"J Cell Physiol"},{"key":"2026101602565984400_loag024-B37","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/s41586-022-04979-5","article-title":"Oocytes maintain ROS-free mitochondrial metabolism by suppressing complex I","volume":"607","author":"Rodr\u00edguez-Nuevo","year":"2022","journal-title":"Nature"},{"key":"2026101602565984400_loag024-B38","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.cmet.2019.09.007","article-title":"Regulation of mother-to-offspring transmission of mtDNA heteroplasmy","volume":"30","author":"Latorre-Pellicer","year":"2019","journal-title":"Cell Metab"},{"key":"2026101602565984400_loag024-B39","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.tibs.2020.03.009","article-title":"Reciprocal regulation of mitochondrial fission and fusion","volume":"45","author":"Sabouny","year":"2020","journal-title":"Trends Biochem Sci"},{"key":"2026101602565984400_loag024-B40","doi-asserted-by":"crossref","first-page":"eabl8070","DOI":"10.1126\/sciadv.abl8070","article-title":"Depletion of oocyte dynamin-related protein 1 shows maternal-effect abnormalities in embryonic development","volume":"8","author":"Adhikari","year":"2022","journal-title":"Sci Adv"},{"key":"2026101602565984400_loag024-B41","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1002\/stem.3152","article-title":"Nicotinamide adenine dinucleotide induces a bivalent metabolism and maintains pluripotency in human embryonic stem cells","volume":"38","author":"Lees","year":"2020","journal-title":"Stem Cells"},{"key":"2026101602565984400_loag024-B42","doi-asserted-by":"crossref","first-page":"e2309184","DOI":"10.1002\/advs.202309184","article-title":"Maternal obesity induces the meiotic defects and epigenetic alterations during fetal oocyte development","volume":"11","author":"Tang","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"2026101602565984400_loag024-B43","doi-asserted-by":"crossref","first-page":"e13603","DOI":"10.1111\/obr.13603","article-title":"Maternal obesity: a potential disruptor of female fertility and current interventions to reduce associated risks","volume":"24","author":"Muhammad","year":"2023","journal-title":"Obes Rev"},{"key":"2026101602565984400_loag024-B44","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1038\/s41562-024-01994-6","article-title":"Maternal adiposity and perinatal and offspring outcomes: an umbrella review","volume":"8","author":"Yang","year":"2024","journal-title":"Nat Hum Behav"},{"key":"2026101602565984400_loag024-B45","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1093\/humrep\/dead177","article-title":"Human ovarian aging is characterized by oxidative damage and mitochondrial dysfunction","volume":"38","author":"Smits","year":"2023","journal-title":"Hum Reprod"},{"key":"2026101602565984400_loag024-B46","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3389\/fgene.2020.00396","article-title":"Single-cell transcriptomic analysis reveals mitochondrial dynamics in oocytes of patients with polycystic ovary syndrome","volume":"11","author":"Qi","year":"2020","journal-title":"Front Genet"},{"key":"2026101602565984400_loag024-B47","doi-asserted-by":"crossref","first-page":"18858","DOI":"10.1038\/srep18858","article-title":"Both diet and gene mutation induced obesity affect oocyte quality in mice","volume":"6","author":"Hou","year":"2016","journal-title":"Sci Rep"},{"key":"2026101602565984400_loag024-B48","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12958-024-01279-7","article-title":"Single-cell RNA sequencing reveals the effects of high-fat diet on oocyte and early embryo development in female mice","volume":"22","author":"Zhu","year":"2024","journal-title":"Reprod Biol Endocrinol"},{"key":"2026101602565984400_loag024-B49","doi-asserted-by":"crossref","first-page":"97507","DOI":"10.7554\/eLife.97507.3","article-title":"Maternal obesity may disrupt offspring metabolism by inducing oocyte genome hyper-methylation via increased DNMTs","volume":"13","author":"Chao","year":"2024","journal-title":"Elife"},{"key":"2026101602565984400_loag024-B50","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1530\/REP-22-0302","article-title":"Maternal high-fat diet changes DNA methylation in the early embryo by disrupting the TCA cycle intermediary alpha ketoglutarate","volume":"165","author":"Penn","year":"2023","journal-title":"Reproduction"},{"key":"2026101602565984400_loag024-B51","doi-asserted-by":"crossref","first-page":"e13496","DOI":"10.1111\/acel.13496","article-title":"NAMPT reduction-induced NAD+ insufficiency contributes to the compromised oocyte quality from obese mice","volume":"20","author":"Wang","year":"2021","journal-title":"Aging Cell"},{"key":"2026101602565984400_loag024-B52","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.cell.2020.01.009","article-title":"Single-cell transcriptomic atlas of primate ovarian aging","volume":"180","author":"Wang","year":"2020","journal-title":"Cell"},{"key":"2026101602565984400_loag024-B53","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s43587-023-00552-5","article-title":"A single-cell atlas of the aging mouse ovary","volume":"4","author":"Isola","year":"2024","journal-title":"Nat Aging"},{"key":"2026101602565984400_loag024-B54","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.tem.2025.01.005","article-title":"Hallmarks of ovarian aging","volume":"36","author":"Wu","year":"2025","journal-title":"Trends Endocrinol Metab"},{"key":"2026101602565984400_loag024-B55","doi-asserted-by":"crossref","first-page":"103195","DOI":"10.1016\/j.redox.2024.103195","article-title":"Iron accumulation in ovarian microenvironment damages the local redox balance and oocyte quality in aging mice","volume":"73","author":"Chen","year":"2024","journal-title":"Redox Biol"},{"key":"2026101602565984400_loag024-B56","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1530\/REP-15-0419","article-title":"The effects of voluntary exercise on oocyte quality in a diet-induced obese murine model","volume":"151","author":"Boudoures","year":"2016","journal-title":"Reproduction"},{"key":"2026101602565984400_loag024-B57","doi-asserted-by":"crossref","first-page":"e360","DOI":"10.1210\/clinem\/dgad059","article-title":"Effects of maternal exercise modes on glucose and lipid metabolism in offspring stem cells","volume":"108","author":"Jevtovic","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"key":"2026101602565984400_loag024-B58","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.3390\/ijms25042236","article-title":"Preconception diet interventions in obese outbred mice and the impact on female offspring metabolic health and oocyte quality","volume":"25","author":"Meulders","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2026101602565984400_loag024-B59","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.freeradbiomed.2022.12.084","article-title":"Intermittent fasting reverses the declining quality of aged oocytes","volume":"195","author":"Li","year":"2023","journal-title":"Free Radic Biol Med"},{"key":"2026101602565984400_loag024-B60","doi-asserted-by":"crossref","first-page":"21187","DOI":"10.1038\/s41598-021-00533-x","article-title":"Nutritional restriction during the peri-conceptional period alters the myometrial transcriptome during the peri-implantation period","volume":"11","author":"Drzewiecka","year":"2021","journal-title":"Sci Rep"},{"key":"2026101602565984400_loag024-B61","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.cmet.2025.01.014","article-title":"Caloric restriction prevents inheritance of polycystic ovary syndrome through oocyte-mediated DNA methylation reprogramming","volume":"37","author":"Liu","year":"2025","journal-title":"Cell Metab"},{"key":"2026101602565984400_loag024-B62","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s12958-021-00848-4","article-title":"Diet normalization or caloric restriction as a preconception care strategy to improve metabolic health and oocyte quality in obese outbred mice","volume":"19","author":"Smits","year":"2021","journal-title":"Reprod Biol Endocrinol"},{"key":"2026101602565984400_loag024-B63","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12958-024-01209-7","article-title":"Effect of melatonin on developmental competence, mitochondrial distribution, and intensity of fresh and vitrified\/thawed in vitro matured buffalo oocytes","volume":"22","author":"Kandil","year":"2024","journal-title":"Reprod Biol Endocrinol"},{"key":"2026101602565984400_loag024-B64","doi-asserted-by":"crossref","first-page":"e70052","DOI":"10.1096\/fj.202400574R","article-title":"Melatonin facilitates oocyte growth in goats and mice through increased nutrient reserves and enhanced mitochondrial function","volume":"38","author":"He","year":"2024","journal-title":"FASEB J"},{"key":"2026101602565984400_loag024-B65","doi-asserted-by":"crossref","first-page":"e14475","DOI":"10.1111\/acel.14475","article-title":"Salidroside improves oocyte competence of reproductively old mice by enhancing mitophagy","volume":"24","author":"Gu","year":"2025","journal-title":"Aging Cell"},{"key":"2026101602565984400_loag024-B66","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/j.devcel.2024.03.031","article-title":"Mannose controls mesoderm specification and symmetry breaking in mouse gastruloids","volume":"59","author":"Dingare","year":"2024","journal-title":"Dev Cell"},{"key":"2026101602565984400_loag024-B67","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12958-019-0458-y","article-title":"Preovulatory exposure to a protein-restricted diet disrupts amino acid kinetics and alters mitochondrial structure and function in the rat oocyte and is partially rescued by folic acid","volume":"17","author":"Schutt","year":"2019","journal-title":"Reprod Biol Endocrinol"},{"key":"2026101602565984400_loag024-B68","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s13048-024-01454-9","article-title":"The role of vitamin D3 in follicle development","volume":"17","author":"Li","year":"2024","journal-title":"J Ovarian Res"},{"key":"2026101602565984400_loag024-B69","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/mrd.23537","article-title":"Metformin improves epigenetic modification involved in oocyte growth and embryo development in polycystic ovary syndrome mice model","volume":"88","author":"Amani Abkenari","year":"2021","journal-title":"Mol Reprod Dev"},{"key":"2026101602565984400_loag024-B70","doi-asserted-by":"crossref","first-page":"1028510","DOI":"10.3389\/fcell.2022.1028510","article-title":"Metformin promotes in vitro maturation of oocytes from aged mice by attenuating mitochondrial oxidative stress via SIRT3-dependent SOD2ac","volume":"10","author":"Cao","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"2026101602565984400_loag024-B71","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s10815-020-01709-6","article-title":"Antidiabetic drug metformin affects the developmental competence of cleavage-stage embryos","volume":"37","author":"Nayak","year":"2020","journal-title":"J Assist Reprod Genet"},{"key":"2026101602565984400_loag024-B72","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s11845-020-02320-5","article-title":"Comparing the effect of sitagliptin and metformin on the oocyte and embryo quality in classic PCOS patients undergoing ICSI","volume":"190","author":"Daneshjou","year":"2021","journal-title":"Ir J Med Sci"},{"key":"2026101602565984400_loag024-B73","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1093\/biolre\/ioaa141","article-title":"Pachymic acid protects oocyte by improving the ovarian microenvironment in polycystic ovary syndrome mice","volume":"103","author":"Fu","year":"2020","journal-title":"Biol Reprod"},{"key":"2026101602565984400_loag024-B74","doi-asserted-by":"crossref","first-page":"66","DOI":"10.4103\/ijmr.IJMR_2139_20","article-title":"Comparative evaluation of metformin & sitaformin in classic PCOS patients undergoing intracytoplasmic sperm injection: a randomized controlled pilot study","volume":"157","author":"Modarres","year":"2023","journal-title":"Indian J Med Res"},{"key":"2026101602565984400_loag024-B75","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1038\/s41401-025-01501-1","article-title":"Semaglutide ameliorates metabolic disorders in offspring via regulation of oocyte ROS of pre-pregnancy obesity mice","volume":"46","author":"Zhang","year":"2025","journal-title":"Acta Pharmacol Sin"},{"key":"2026101602565984400_loag024-B76","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1073\/pnas.58.2.560","article-title":"The pattern of energy metabolism in the mouse oocyte and zygote","volume":"58","author":"Biggers","year":"1967","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026101602565984400_loag024-B77","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1242\/dev.112.1.99","article-title":"The roles of pyruvate, lactate and glucose during preimplantation development of embryos from F1 hybrid mice","volume":"112","author":"Brown","year":"1991","journal-title":"Development"},{"key":"2026101602565984400_loag024-B78","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.fertnstert.2012.12.004","article-title":"Analysis of metabolism to select viable human embryos for transfer","volume":"99","author":"Gardner","year":"2013","journal-title":"Fertil Steril"},{"key":"2026101602565984400_loag024-B79","doi-asserted-by":"crossref","first-page":"150256","DOI":"10.1016\/j.bbrc.2024.150256","article-title":"Metabolic regulation of preimplantation embryo development in vivo and in vitro: molecular mechanisms and insights","volume":"726","author":"Lee","year":"2024","journal-title":"Biochem Biophys Res Commun"},{"key":"2026101602565984400_loag024-B80","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1095\/biolreprod.106.059899","article-title":"Oxidative metabolism of pyruvate is required for meiotic maturation of murine oocytes","volume":"77","author":"Johnson","year":"2007","journal-title":"Biol Reprod"},{"key":"2026101602565984400_loag024-B81","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/humupd\/dmaa043","article-title":"Metabolic co-dependence of the oocyte and cumulus cells: essential role in determining oocyte developmental competence","volume":"27","author":"Richani","year":"2021","journal-title":"Hum Reprod Update"},{"key":"2026101602565984400_loag024-B82","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s00404-021-06219-z","article-title":"Effect of sequential versus single-step culture medium on IVF treatments, including embryo and clinical outcomes: a prospective randomized study","volume":"305","author":"Tao","year":"2022","journal-title":"Arch Gynecol Obstet"},{"key":"2026101602565984400_loag024-B83","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/humrep\/deae248","article-title":"The composition of commercially available human embryo culture media","volume":"40","author":"Zagers","year":"2025","journal-title":"Hum Reprod"},{"key":"2026101602565984400_loag024-B84","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1055\/s-0038-1675777","article-title":"Embryo culture conditions and the epigenome","volume":"36","author":"Mani","year":"2018","journal-title":"Semin Reprod Med"},{"key":"2026101602565984400_loag024-B85","doi-asserted-by":"crossref","first-page":"853999","DOI":"10.3389\/fendo.2022.853999","article-title":"Melatonin improves quality of repeated-poor and frozen-thawed embryos in human, a prospective clinical trial","volume":"13","author":"Bao","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2026101602565984400_loag024-B86","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1017\/S096719942400039X","article-title":"The role of L-carnitine in the control of oxidative stress and lipid \u03b2-oxidation during in vitro follicle growth, oocyte maturation, embryonic development and cryopreservation: a review","volume":"32","author":"Leitao","year":"2024","journal-title":"Zygote"},{"key":"2026101602565984400_loag024-B87","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/j.celrep.2020.01.058","article-title":"NAD+ repletion rescues female fertility during reproductive aging","volume":"30","author":"Bertoldo","year":"2020","journal-title":"Cell Rep"},{"key":"2026101602565984400_loag024-B88","doi-asserted-by":"crossref","first-page":"107987","DOI":"10.1016\/j.celrep.2020.107987","article-title":"Nicotinamide mononucleotide supplementation reverses the declining quality of maternally aged oocytes","volume":"32","author":"Miao","year":"2020","journal-title":"Cell Rep"},{"key":"2026101602565984400_loag024-B89","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.cell.2024.12.028","article-title":"Comparative proteomic landscapes elucidate human preimplantation development and failure","volume":"188","author":"Zhu","year":"2025","journal-title":"Cell"}],"container-title":["Life Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/lifemeta\/advance-article-pdf\/doi\/10.1093\/lifemeta\/loag024\/70510328\/loag024.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/lifemeta\/article-pdf\/5\/6\/loag024\/70510328\/loag024.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/lifemeta\/article-pdf\/5\/6\/loag024\/70510328\/loag024.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:57:15Z","timestamp":1792133835000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/lifemeta\/article\/doi\/10.1093\/lifemeta\/loag024\/8753574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,6]]},"references-count":89,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,9,21]]}},"URL":"https:\/\/doi.org\/10.1093\/lifemeta\/loag024","relation":{},"ISSN":["2755-0230"],"issn-type":[{"value":"2755-0230","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,12]]},"published":{"date-parts":[[2026,8,6]]},"article-number":"loag024"}}