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The aim of this study was to investigate the possible beneficial effect of intermittent fasting in delaying age-related renal changes and the possible mechanisms of this effect. Thirty male albino rats were classified into three groups: control, adult rats aged 3 months; aged group, 15-month-old rats and maintained until the age of 18 months; and intermittent fasting-aged groups, 15-month-old rats maintained on intermittent fasting for 3 months. Kidneys were processed for histological and immunohistochemical study. Aging resulted in a significant reduction in renal function and significant several degenerative changes in renal corpuscles and tubules which showed abnormal histological structure with increased collagen deposition. Aging caused significant reduction in the expression of autophagic marker light chain 3 with increased expression of active caspase-3 and inducible nitric oxide synthase. Intermittent fasting significantly improved these age-related renal changes. Intermittent fasting effectively prevents age-related renal changes through the reduction of age-related oxidative stress, inflammation, apoptosis, and activation of autophagy.<\/jats:p>","DOI":"10.1093\/mam\/ozae102","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T18:26:41Z","timestamp":1729016801000},"source":"Crossref","is-referenced-by-count":9,"title":["Intermittent Fasting Ameliorates Age-Induced Morphological Changes in Aged Albino Rat Kidney <i>via<\/i> Autophagy Activation and Reduction of Apoptosis and Inflammation"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7481-2656","authenticated-orcid":false,"given":"Rehab Ahmed","family":"Rifaai","sequence":"first","affiliation":[{"name":"Department of Histology and Cell Biology, Faculty of Medicine, Minia University , Cairo Aswan Agricultural Rd, Minia, 61519 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