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Platelet-rich plasma (PRP) has supra-physiological levels of growth factors (GFs), enhances biosynthesis of antioxidant enzymes, and suppresses oxidative stress. This study compared the ameliorative effects of carvedilol and PRP on paclitaxel-induced femoral neuropathy. Eighty-eight adult male albino rats were equally randomized into four groups: group I served as the control; group II received paclitaxel (16\u2005mg\/kg intraperitoneally, weekly); group III received carvedilol (10\u2005mg\/kg daily, orally) concomitant with paclitaxel; and group IV received PRP (0.5\u2005mL\/kg subcutaneously, twice weekly) concomitant with paclitaxel. After 5 weeks, femoral nerve conduction velocity was measured, and blood samples were collected to assess catalase and superoxide dismutase levels. All animals were sacrificed, and gene expression of miR-21 was quantified. Tissue sections were stained with hematoxylin and eosin and toluidine blue. Then, the ultrathin sections were examined by transmission electron microscopy. Both carvedilol and PRP reversed paclitaxel-induced changes in the peripheral nerve, but PRP demonstrated a stronger antioxidant effect and a more pronounced presence of GFs, as evidenced by electron microscopy. PRP may represent a promising therapeutic approach for paclitaxel-induced neuropathy.<\/jats:p>","DOI":"10.1093\/mam\/ozaf002","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T04:16:00Z","timestamp":1736568960000},"source":"Crossref","is-referenced-by-count":5,"title":["Ameliorative Potential of Carvedilol Versus Platelet-Rich Plasma Against Paclitaxel-Induced Femoral Neuropathy in Wistar Rats: A Light and Electron Microscopic Study"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4585-4264","authenticated-orcid":false,"given":"Ereny","family":"Fekry","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Histology and Cell Biology Department, Suez Canal University , Ismailia 8366004 ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George Nagi","family":"Refaat","sequence":"additional","affiliation":[{"name":"Internal Medicine and Cardiology Department, Suez Canal 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