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Thirty guinea pigs were divided into six groups: control, PCM (2\u2005g\/kg), CR1 group (100\u2005mg\/kg), CR2 group (200\u2005mg\/kg), CR1 (100\u2005mg\/kg) + PCM, and CR2 (200\u2005mg\/kg) + PCM. The hematological results showed that the PCM-treated groups experienced significant reductions in Hb, red blood corpuscles, packed cell volume, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, white blood cell, platelets, neutrophils, lymphocyte, and monocyte, in addition to albumin and total protein levels compared with the control group. In contrast, the groups treated with CR showed increases in all the abovementioned parameters. Morphologically, kidney tissues of PCM and CR-treated groups showed focal leukocytic infiltrations and extensive necrosis, while CR1 + PCM- and CR2 + PCM-treated groups revealed more pathological changes than PCM alone. The Bax immunohistochemical reaction showed strong positive reactions in both the PCM and CR-treated groups, while the CR + PCM-treated groups displayed very strong positive compared with the PCM-only group. In conclusion, the results from the hematological and biochemical parameters indicated that CR extract had an ameliorative effect against PCM toxicity.<\/jats:p>","DOI":"10.1093\/mam\/ozaf003","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T09:03:02Z","timestamp":1745312582000},"source":"Crossref","is-referenced-by-count":1,"title":["Role of <i>Crepis rueppellii<\/i> Leaf Extract Against Paracetamol-Inducing Nephrotoxicity in Guinea Pigs: A Histological, Immunohistochemical, and Biochemical Study"],"prefix":"10.1093","volume":"31","author":[{"given":"Warda Mohamed Abdu","family":"Kaidama","sequence":"first","affiliation":[{"name":"Biology Department, Science College, Ibb University , 70270 Ibb ,","place":["Yemen"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esam Mohammed Qasem","family":"Aqlan","sequence":"additional","affiliation":[{"name":"Biology Department, Science College, Ibb University , 70270 Ibb ,","place":["Yemen"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamal H","family":"El-Sokkary","sequence":"additional","affiliation":[{"name":"Zoology and Entomology Department, Faculty of Science, Assiut University , 71516 Assiut ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7646-2592","authenticated-orcid":false,"given":"Shaimaa M M","family":"Saleh","sequence":"additional","affiliation":[{"name":"Zoology and Entomology Department, Faculty of Science, Assiut University , 71516 Assiut ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"issue":"5","key":"2025042205025577800_ozaf003-B1","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1159\/000452243","article-title":"New description of telocyte sheaths in the bovine uterine tube: An immunohistochemical and scanning microscopic study","volume":"203","author":"Abd-Elhafeez","year":"2017","journal-title":"Cells Tissues Organs"},{"issue":"1","key":"2025042205025577800_ozaf003-B2","doi-asserted-by":"publisher","first-page":"41","DOI":"10.21608\/ASSJM.2023.281901","article-title":"The hypolipidemic effect of aqueous extract of Crepis rueppellii and Rhamnus staddo on acetaminophen-induced hepatotoxicity of Guinea pigs","volume":"61","author":"Abdu Kaidama","year":"2023","journal-title":"Ann Agric Sci Moshtohor (ASSJM)"},{"issue":"1-2","key":"2025042205025577800_ozaf003-B3","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/s0009-8981(99)00140-0","article-title":"Oxidative damage to the lipids and proteins of the lungs, testis and kidneys of rats during carbon tetrachloride intoxication","volume":"289","author":"Abraham","year":"1999","journal-title":"Clin Chim Acta"},{"issue":"2","key":"2025042205025577800_ozaf003-B4","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.jep.2008.04.025","article-title":"Protective effect of the aqueous leaf and seed extract of Phyllanthus amarus on gentamicin and acetaminophen-induced nephrotoxic rats","volume":"118","author":"Adeneye","year":"2008","journal-title":"J Ethno-Pharmacol"},{"issue":"1","key":"2025042205025577800_ozaf003-B5","doi-asserted-by":"publisher","first-page":"83","DOI":"10.4067\/S0716-97602010000100010","article-title":"Effect of Crocus sativus on gentamicin induced nephrotoxicity","volume":"43","author":"Ajami","year":"2010","journal-title":"Biol Res"},{"key":"2025042205025577800_ozaf003-B6","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.bse.2018.06.009","article-title":"Phytochemical investigation of Crepis incana Sm. 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