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Forty Wistar rats were randomly allocated into control, IR, and CAR + IR groups. Myocardial IR injury was surgically induced for 45\u2005min followed by 120\u2005min of reperfusion. CAR (2\u202fmg\/kg\/day) was administered orally for 7 days prior to IR induction. Cardiac effects were assessed via physiological measurements, serum biomarkers of creatine kinase-MB (CK-MB) and cardiac troponin I (cTnI), immunohistochemical detection of Bcl-2-associated X-protein (Bax) and B cell lymphoma 2 (Bcl-2), light and electron microscopy, histopathological grading, and morphometric and statistical analysis. CAR pretreatment markedly preserved cardiac function in IR-injured rats by significantly reducing QTc and ST-segment elevations and suppressing ventricular arrhythmias. Biochemically, serum CK-MB and cTnI levels were significantly lowered, while Bax expression decreased and Bcl-2 increased. Histologically, CAR mitigated necrosis, hemorrhage, and cellular degeneration. Ultrastructurally, myocardial integrity, capillary patency, and telocyte morphology were preserved. CAR pretreatment effectively mitigated myocardial IR injury through multifaceted mechanisms including improving cardiac electrical stability, reducing biochemical and apoptotic damage, and preserving histological and ultrastructural integrity.<\/jats:p>","DOI":"10.1093\/mam\/ozaf133","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T13:41:58Z","timestamp":1764942118000},"source":"Crossref","is-referenced-by-count":0,"title":["The Potential Protective Effect of Carvedilol on Induced Myocardial Ischemia-Reperfusion Injury in Rats: A Histological and Immunohistochemical Study"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2602-2083","authenticated-orcid":false,"given":"Walaa","family":"Baher","sequence":"first","affiliation":[{"name":"Department of Histology, Faculty of Medicine, Ain Shams University, Abbasyia, Cairo 1181 ,","place":["Egypt"]},{"name":"Department of Histology, Faculty of Medicine, Galala University, Galala Plateau, Attaka, Suez 35111 ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8899-6057","authenticated-orcid":false,"given":"Eman K","family":"Habib","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology, Faculty of Medicine, Ain Shams University, Abbasyia, Cairo 1181 ,","place":["Egypt"]},{"name":"Department of Anatomy and Embryology, Faculty of Medicine, Galala University, Galala Plateau, Attaka, Suez 35111 ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2335-3242","authenticated-orcid":false,"given":"Walaa A","family":"Fadda","sequence":"additional","affiliation":[{"name":"Human Anatomy and Embryology Department, Faculty of Medicine, Menoufia University, Shibin Al Kawm, Menoufia 32626 ,","place":["Egypt"]},{"name":"Department of Basic Medical Sciences, Unaizah College of Medicine and Medical Sciences, 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