{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:15:16Z","timestamp":1792757716078,"version":"4.5.0"},"reference-count":93,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Psoriasis is a chronic, immune-mediated inflammation. Platelet derivatives, such as platelet-rich plasma (PRP), are used in regenerative medicine because of their high cytokine and growth factor content. Platelet lysate (PL) is a promising substitute, potentially improving tissue regeneration and reducing inflammation, but its therapeutic potential remains unexplored. This study aimed to evaluate and compare the therapeutic efficacy of PRP and PL in ameliorating imiquimod (IMQ)-induced psoriatic skin changes. To that end, 50 rats were divided into five groups: the blood donor group (I); the control group (II); the psoriasis-induced group (III), which received topical treatment with IMQ (62.5\u2005mg, 5% cream); the group treated with PRP (IV); and the group treated with PL (V). In groups IV and V, psoriasis was induced, then subcutaneously injected with PRP and PL, respectively. Skin samples were collected for gross, histological, morphometric, ultrastructural, biochemical, and statistical evaluations. Our analysis showed that group III exhibited hallmark psoriatic changes, including acanthosis, hyperkeratosis, parakeratosis, and dermal inflammatory infiltration, confirmed by ultrastructural analysis. The levels of both IL-17A and MDA, the PASI score, PCNA, NF-\u03baB, and PDGF immunoreactivity were significantly elevated. However, SOD levels were reduced. When compared to the PRP-treated group IV, the PL-treated group V exhibited a marked improvement in these pathological changes. In conclusion, PRP and PL showed potential in reducing IMQ-induced psoriatic skin changes, with PL showing superior efficacy.<\/jats:p>","DOI":"10.1093\/mam\/ozag017","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T03:33:07Z","timestamp":1774841587000},"source":"Crossref","is-referenced-by-count":2,"title":["Effect of Platelet-Rich Plasma Versus Platelet Lysate on Imiquimod-Induced Psoriasis-Like Skin Inflammation in Adult Male Albino Rat Model: A Histological, Immunohistochemical, and Ultrastructural Study"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6957-3603","authenticated-orcid":false,"given":"Eman M","family":"El-Beltagi","sequence":"first","affiliation":[{"name":"Histology & Cell Biology Department, Faculty of Medicine, Tanta University, El-Geish Street, Tanta 31527, Gharbya ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3289-1982","authenticated-orcid":false,"given":"Mohamed","family":"Abumandour","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Alexandria University, Abis 10th P.O., Alexandria 21944 ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Shukry","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, P.O. Box 400, Al-Ahsa 31982 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youstina Samuel","family":"Salib","sequence":"additional","affiliation":[{"name":"Histology & Cell Biology Department, Faculty of Medicine, Tanta University, El-Geish Street, Tanta 31527, Gharbya ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"issue":"11","key":"2026042911221396000_ozag017-B1","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1002\/jemt.23530","article-title":"Retinal characterization in the eyes of two bats endemic in the Egyptian fauna, the Egyptian fruit bat (Rousettus aegyptiacus) and insectivorous bat (Pipistrellus kuhlii), using the light microscope and transmission electron microscope","volume":"83","author":"Aboelnour","year":"2020","journal-title":"Microsc Res Tech"},{"key":"2026042911221396000_ozag017-B2","doi-asserted-by":"publisher","first-page":"102397","DOI":"10.1016\/j.tice.2024.102397","article-title":"Immunolabeling for filaggrin and acidic keratins in the granular layer of mammalian epidermis indicates that an acidic-basic interaction is involved in cornification","volume":"88","author":"Alibardi","year":"2024","journal-title":"Tissue Cell"},{"issue":"11","key":"2026042911221396000_ozag017-B3","doi-asserted-by":"publisher","first-page":"2140","DOI":"10.1016\/j.jid.2016.06.613","article-title":"Effects of imiquimod on hair follicle stem cells and hair cycle progression","volume":"136","author":"Amberg","year":"2016","journal-title":"J Invest Dermatol"},{"issue":"7","key":"2026042911221396000_ozag017-B4","doi-asserted-by":"publisher","first-page":"763","DOI":"10.3390\/biom14070763","article-title":"Effect of health status and heat-induced inactivation on the proteomic profile of plasma rich in growth factors obtained from donors with chronic inflammatory skin conditions","volume":"14","author":"Anitua","year":"2024","journal-title":"Biomolecules"},{"issue":"12","key":"2026042911221396000_ozag017-B5","doi-asserted-by":"publisher","first-page":"e50356","DOI":"10.7759\/cureus.50356","article-title":"Platelet-rich plasma for the treatment of plaque psoriasis: A systematic review","volume":"15","author":"Armando","year":"2023","journal-title":"Cureus"},{"key":"2026042911221396000_ozag017-B6","doi-asserted-by":"publisher","first-page":"124376","DOI":"10.1016\/j.ijpharm.2024.124376","article-title":"Therapeutic potential of limonene-based syringic acid nanoemulsion: Enhanced ex-vivo cutaneous deposition and clinical anti-psoriatic efficacy","volume":"660","author":"Assalem","year":"2024","journal-title":"Int J Pharm"},{"issue":"3","key":"2026042911221396000_ozag017-B7","doi-asserted-by":"publisher","first-page":"614","DOI":"10.5603\/FM.a2021.0076","article-title":"A potential role of mesenchymal stem cells derived from human umbilical cord blood in ameliorating psoriasis-like skin lesion in the rats","volume":"81","author":"Attia","year":"2022","journal-title":"Folia Morphol (Warsz)"},{"issue":"1","key":"2026042911221396000_ozag017-B8","doi-asserted-by":"publisher","first-page":"671","DOI":"10.3892\/mmr.2016.5299","article-title":"Influence of different types of contact hypersensitivity on imiquimod-induced psoriasis-like inflammation in mice in mol","volume":"14","author":"Bai","year":"2016","journal-title":"Med. Rep"},{"issue":"2","key":"2026042911221396000_ozag017-B9","doi-asserted-by":"publisher","first-page":"939","DOI":"10.21608\/ejh.2022.125141.1650","article-title":"The effect of bone marrow derived mesenchymal stem cells versus their exosomes on imiquimod-induced psoriasis-like skin inflammation in female albino rats: A histological study","volume":"46","author":"Bakr","year":"2023","journal-title":"Egypt J Histol"},{"issue":"2","key":"2026042911221396000_ozag017-B10","doi-asserted-by":"publisher","first-page":"280","DOI":"10.5603\/FM.a2019.0076","article-title":"Histological characterisation of the skin of the Paraechinus hypomelas, Brandt, 1836 (erinaceidae: Eulipotyphla)","volume":"79","author":"Bazm","year":"2020","journal-title":"Folia Morphol (Warsz)"},{"issue":"1","key":"2026042911221396000_ozag017-B11","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1080\/23144599.2024.2380586","article-title":"Freeze-drying protocols and methods of maintaining the in-vitro biological activity of horse platelet lysate","volume":"12","author":"Bernardini","year":"2024","journal-title":"Int J Vet Sci Med"},{"issue":"22","key":"2026042911221396000_ozag017-B12","doi-asserted-by":"publisher","first-page":"5460","DOI":"10.3390\/molecules29225460","article-title":"Oxidative imbalance in psoriasis with an emphasis on psoriatic arthritis: Therapeutic antioxidant targets","volume":"29","author":"Bilski","year":"2024","journal-title":"Molecules"},{"issue":"6","key":"2026042911221396000_ozag017-B13","doi-asserted-by":"publisher","first-page":"118","DOI":"10.31083\/j.fbl2806118","article-title":"The role of oxidative stress in the induction and development of psoriasis","volume":"28","author":"Blagov","year":"2023","journal-title":"Front Biosci Landmark"},{"issue":"11","key":"2026042911221396000_ozag017-B14","doi-asserted-by":"publisher","first-page":"2985","DOI":"10.3390\/cells10112985","article-title":"Use of cytokine mix-, imiquimod-, and serum-induced monoculture and lipopolysaccharide-and interferon gamma-treated co-culture to establish in vitro psoriasis-like inflammation models","volume":"10","author":"Boche\u0144ska","year":"2021","journal-title":"Cells"},{"key":"2026042911221396000_ozag017-B15","volume-title":"Electron Microscopy. Methods in Molecular Biology","author":"Bozzola","year":"2013"},{"issue":"1","key":"2026042911221396000_ozag017-B16","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s12929-023-00972-w","article-title":"Expanding applications of allogeneic platelets, platelet lysates, and platelet extracellular vesicles in cell therapy, regenerative medicine, and targeted drug delivery","volume":"30","author":"Burnouf","year":"2023","journal-title":"J Biomed Sci"},{"issue":"84","key":"2026042911221396000_ozag017-B17","doi-asserted-by":"publisher","first-page":"eabq7991","DOI":"10.1126\/sciimmunol.abq7991","article-title":"Spatial transcriptomics stratifies psoriatic disease severity by emergent cellular ecosystems","volume":"8","author":"Castillo","year":"2023","journal-title":"Sci Immunol"},{"issue":"3","key":"2026042911221396000_ozag017-B18","doi-asserted-by":"publisher","first-page":"2744","DOI":"10.3390\/ijms24032744","article-title":"Molecular and biologic effects of platelet-rich plasma (PRP) in ligament and tendon healing and regeneration: A systematic review","volume":"24","author":"Chalidis","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2026042911221396000_ozag017-B19","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.3389\/fimmu.2018.02092","article-title":"Esculetin ameliorates psoriasis-like skin disease in mice by inducing CD4 + Foxp3+ regulatory T cells","volume":"9","author":"Chen","year":"2018","journal-title":"Front Immunol"},{"key":"2026042911221396000_ozag017-B20","volume-title":"Guide for the Care and Use of Laboratory Animals: Eighth Edition","author":"National Research Council","year":"2011"},{"key":"2026042911221396000_ozag017-B21","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1007\/s00403-021-02186-2","article-title":"The effect of lyophilized platelet rich-plasma on skin aging: A non-randomized, controlled, pilot trial","volume":"313","author":"da Silva","year":"2021","journal-title":"Arch Dermatol Res"},{"issue":"2","key":"2026042911221396000_ozag017-B22","doi-asserted-by":"publisher","first-page":"282","DOI":"10.3390\/antiox11020282","article-title":"The involvement of oxidative stress in psoriasis: A systematic review","volume":"11","author":"Dobric\u0103","year":"2022","journal-title":"Antioxidants"},{"key":"2026042911221396000_ozag017-B23","doi-asserted-by":"publisher","first-page":"1335551","DOI":"10.3389\/fmed.2024.1335551","article-title":"Skin barrier-inflammatory pathway is a driver of the psoriasis-atopic dermatitis transition","volume":"11","author":"Dong","year":"2024","journal-title":"Front Med (Lausanne)"},{"key":"2026042911221396000_ozag017-B24","doi-asserted-by":"publisher","first-page":"155560","DOI":"10.1016\/j.cyto.2021.155560","article-title":"The regenerative mechanisms of platelet-rich plasma: A review","volume":"144","author":"Dos Santos","year":"2021","journal-title":"Cytokine"},{"issue":"14","key":"2026042911221396000_ozag017-B25","doi-asserted-by":"publisher","first-page":"7914","DOI":"10.3390\/ijms25147914","article-title":"Profound properties of protein-rich, platelet-rich plasma matrices as novel, multi-purpose biological platforms in tissue repair, regeneration, and wound healing","volume":"25","author":"Everts","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"3","key":"2026042911221396000_ozag017-B26","doi-asserted-by":"publisher","first-page":"554","DOI":"10.21608\/ejh.2019.9750.1090","article-title":"The possible therapeutic role of platelet rich plasma on a model of osteoarthritis in male albino rat. Histological and immunohistochemical study","volume":"42","author":"Gamal","year":"2019","journal-title":"Egypt J Histol"},{"issue":"1","key":"2026042911221396000_ozag017-B27","doi-asserted-by":"publisher","first-page":"56","DOI":"10.3390\/pharmaceutics17010056","article-title":"Pathophysiology and treatment of psoriasis: From clinical practice to basic research","volume":"17","author":"Gao","year":"2025","journal-title":"Pharmaceutics"},{"issue":"1","key":"2026042911221396000_ozag017-B28","doi-asserted-by":"publisher","first-page":"20134","DOI":"10.1038\/srep20134","article-title":"Topical imiquimod yields systemic effects due to unintended oral uptake","volume":"6","author":"Grine","year":"2016","journal-title":"Sci Rep"},{"key":"2026042911221396000_ozag017-B29","doi-asserted-by":"publisher","first-page":"114517","DOI":"10.1016\/j.biopha.2023.114517","article-title":"Platelet lysate promotes hair growth: In vitro and in vivo mechanism and randomized, controlled trial","volume":"161","author":"Guan","year":"2023","journal-title":"Biomed Pharmacother"},{"issue":"17","key":"2026042911221396000_ozag017-B30","doi-asserted-by":"publisher","first-page":"9254","DOI":"10.3390\/ijms25179254","article-title":"Evaluation of clobetasol and tacrolimus treatments in an imiquimod-induced psoriasis rat model","volume":"25","author":"Guillaume","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"4","key":"2026042911221396000_ozag017-B31","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.3390\/ijms23042112","article-title":"Selenium-rich yeast peptide fraction ameliorates imiquimod-induced psoriasis-like dermatitis in mice by inhibiting inflammation via MAPK and NF-\u03baB signaling pathways","volume":"23","author":"Guo","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2026042911221396000_ozag017-B32","doi-asserted-by":"publisher","first-page":"12","DOI":"10.59345\/sjim.v2i2.168","article-title":"Activated Growth Factor (AGF): An advanced modality of platelet-rich plasma as a new biological agent for the treatment of degenerative and traumatic conditions","volume":"3","author":"Hidayat","year":"2025","journal-title":"Sriwijaya J Intern Med"},{"issue":"3","key":"2026042911221396000_ozag017-B33","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1080\/08977194.2023.2227273","article-title":"Comparative evaluation of autologous platelet-rich plasma and platelet lysate in patients with knee osteoarthritis","volume":"41","author":"Hosseini","year":"2023","journal-title":"Growth Factors"},{"issue":"3","key":"2026042911221396000_ozag017-B34","doi-asserted-by":"publisher","first-page":"3096","DOI":"10.3892\/etm.2018.5794","article-title":"Platelet-rich plasma shows beneficial effects for patients with knee osteoarthritis by suppressing inflammatory factors","volume":"15","author":"Huang","year":"2018","journal-title":"Exp Ther Med"},{"key":"2026042911221396000_ozag017-B35","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.reth.2022.01.006","article-title":"Role of platelet rich plasma mediated repair and regeneration of cell in early stage of cardiac injury","volume":"19","author":"Imam","year":"2022","journal-title":"Regen Ther"},{"issue":"1","key":"2026042911221396000_ozag017-B36","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/j.1600-065X.2008.00699.x","article-title":"The roles of IL-17A in inflammatory immune responses and host defense against pathogens","volume":"226","author":"Iwakura","year":"2008","journal-title":"Immunol Rev"},{"issue":"1","key":"2026042911221396000_ozag017-B37","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1186\/s12951-022-01390-0","article-title":"PDGF-BB-derived supramolecular hydrogel for promoting skin wound healing","volume":"20","author":"Jian","year":"2022","journal-title":"J Nanobiotechnol"},{"issue":"20","key":"2026042911221396000_ozag017-B38","doi-asserted-by":"publisher","first-page":"e142067","DOI":"10.1172\/jci.insight.142067","article-title":"Cytokinocytes: The diverse contribution of keratinocytes to immune responses in skin","volume":"5","author":"Jiang","year":"2020","journal-title":"JCI Insight"},{"issue":"1","key":"2026042911221396000_ozag017-B39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15324\/kjcls.2025.57.1.1","article-title":"Desmosomes: Structure, pathologies, and signaling dynamics","volume":"57","author":"Jiyun","year":"2025","journal-title":"Korean J Clin Lab Sci"},{"key":"2026042911221396000_ozag017-B40","doi-asserted-by":"publisher","first-page":"102966","DOI":"10.1016\/j.tice.2025.102966","article-title":"Dorso-ventral skin of flowered racer snake (Coluber flourulentus, perreti Schatti, 1988): Histological, keratin immunohistochemical, and ultrastructural characterization","volume":"96","author":"Kandyel","year":"2025","journal-title":"Tissue Cell"},{"issue":"3","key":"2026042911221396000_ozag017-B41","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1002\/jemt.23980","article-title":"A histological and immunohistochemical study on the parabronchial epithelium of the domestic fowl's (Gallus gallus domesticus) lung with special reference to its scanning and transmission electron microscopic characteristics","volume":"85","author":"Kandyel","year":"2022","journal-title":"Microsc Res Tech"},{"key":"2026042911221396000_ozag017-B42","doi-asserted-by":"publisher","first-page":"2104","DOI":"10.1002\/jemt.23766","article-title":"Comparative ultrastructural-functional characterizations of the skin in three reptile species; Chalcides ocellatus, Uromastyx aegyptia aegyptia, and Psammophis schokari aegyptia (FORSKAL, 1775): Adaptive strategies to their habitat","volume":"84","author":"Kandyel","year":"2021","journal-title":"Microsc Res Tech"},{"issue":"1","key":"2026042911221396000_ozag017-B43","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1007\/s12272-021-01305-x","article-title":"Skin barrier dysfunction and filaggrin","volume":"44","author":"Kim","year":"2021","journal-title":"Arch Pharm Res"},{"key":"2026042911221396000_ozag017-B44","doi-asserted-by":"publisher","first-page":"113626","DOI":"10.1016\/j.intimp.2024.113626","article-title":"Navigating psoriasis: From immune mechanisms to natural healing approaches","volume":"144","author":"Kshirsagar","year":"2025","journal-title":"Int Immunopharmacol"},{"issue":"10","key":"2026042911221396000_ozag017-B45","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1038\/sj.onc.1206223","article-title":"PDGF-D is a potent transforming and angiogenic growth factor","volume":"22","author":"Li","year":"2003","journal-title":"Oncogene"},{"issue":"4","key":"2026042911221396000_ozag017-B46","doi-asserted-by":"publisher","first-page":"e13212","DOI":"10.1111\/cpr.13212","article-title":"Growth factors-based platelet lysate rejuvenates skin against ageing through NF-\u03baB signalling pathway: In vitro and in vivo mechanistic and clinical studies","volume":"55","author":"Li","year":"2022","journal-title":"Cell Prolif"},{"issue":"4","key":"2026042911221396000_ozag017-B150","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s13555-024-01134-y","article-title":"Effectiveness of ixekizumab in Chinese patients with moderate-severe plaque psoriasis with special area involvement: Subanalysis of a prospective, multicenter, observational real-world study","volume":"14","author":"Li","year":"2024","journal-title":"Dermatol Ther"},{"key":"2026042911221396000_ozag017-B47","doi-asserted-by":"publisher","first-page":"1541776","DOI":"10.3389\/fimmu.2025.1541776","article-title":"Beyond the dichotomy: Understanding the overlap between atopic dermatitis and psoriasis","volume":"16","author":"Li","year":"2025","journal-title":"Front Immunol"},{"key":"2026042911221396000_ozag017-B48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13018-019-1076-2","article-title":"Positive effect on spinal fusion by the combination of platelet-rich plasma and collagen-mineral scaffold using lumbar posterolateral fusion model in rats","volume":"14","author":"Liao","year":"2019","journal-title":"J Orthop Surg Res"},{"issue":"2","key":"2026042911221396000_ozag017-B49","doi-asserted-by":"publisher","first-page":"148","DOI":"10.5114\/dr.2024.142716","article-title":"Dermoscopic features of connective tissue disease","volume":"111","author":"Liluashvili","year":"2024","journal-title":"Dermatol Rev\/Przegld Dermatologiczny"},{"issue":"4","key":"2026042911221396000_ozag017-B50","doi-asserted-by":"publisher","first-page":"e258","DOI":"10.1002\/der2.258","article-title":"Basic science and principles of stem cells, platelet-rich plasma, and exosomes","volume":"5","author":"Lyles","year":"2024","journal-title":"Dermatol Rev"},{"issue":"2","key":"2026042911221396000_ozag017-B51","doi-asserted-by":"publisher","first-page":"101506","DOI":"10.1016\/j.jbc.2021.101506","article-title":"The ubiquitin-binding domain of DNA polymerase \u03b7 directly binds to DNA clamp PCNA and regulates translesion DNA synthesis","volume":"298","author":"Manohar","year":"2022","journal-title":"J Biol Chem"},{"key":"2026042911221396000_ozag017-B52","doi-asserted-by":"publisher","first-page":"1469829","DOI":"10.3389\/fimmu.2024.1469829","article-title":"Sphingosine 1-phosphate receptor 2 in keratinocytes plays a key role in reducing inflammation in psoriasis","volume":"15","author":"Masuda-Kuroki","year":"2024","journal-title":"Front Immunol"},{"issue":"1","key":"2026042911221396000_ozag017-B53","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1038\/s41598-023-28822-7","article-title":"Induction of psoriasis-and atopic dermatitis-like phenotypes in 3D skin equivalents with a fibroblast-derived matrix","volume":"13","author":"Morgner","year":"2023","journal-title":"Sci Rep"},{"issue":"2","key":"2026042911221396000_ozag017-B54","doi-asserted-by":"publisher","first-page":"212","DOI":"10.3390\/life15020212","article-title":"Association between systemic inflammation, metabolic syndrome and quality of life in psoriasis patients","volume":"15","author":"Musta\u021b\u0103","year":"2025","journal-title":"Life"},{"issue":"1","key":"2026042911221396000_ozag017-B55","doi-asserted-by":"publisher","first-page":"27701","DOI":"10.1038\/s41598-024-79050-6","article-title":"Human platelet lysate combined with mesenchymal stem cells pretreated with platelet lysate improved cardiac function in rats with myocardial infarction","volume":"14","author":"Najafipour","year":"2024","journal-title":"Sci Rep"},{"issue":"1","key":"2026042911221396000_ozag017-B56","doi-asserted-by":"publisher","first-page":"399","DOI":"10.21608\/ejh.2024.272096.2026","article-title":"Comparative histological and immunohistochemical study on the effect of platelet-rich plasma, adipose tissue derived mesenchymal stem cells, and mesenchymal stem cells derived exosomes in experimentally induced corneal alkali burn in albino rats","volume":"47","author":"Nasr","year":"2024","journal-title":"Egypt J Histol"},{"issue":"2","key":"2026042911221396000_ozag017-B57","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1080\/09537104.2020.1849605","article-title":"PRP in wound healing applications","volume":"32","author":"Oneto","year":"2021","journal-title":"Platelets"},{"issue":"19","key":"2026042911221396000_ozag017-B58","doi-asserted-by":"publisher","first-page":"10841","DOI":"10.3390\/ijms221910841","article-title":"Skin barrier dysregulation in psoriasis","volume":"22","author":"Orsmond","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"2","key":"2026042911221396000_ozag017-B59","doi-asserted-by":"publisher","first-page":"749","DOI":"10.3390\/ijms26020749","article-title":"Understanding the intricate pathophysiology of psoriasis and related skin disorders","volume":"26","author":"Orzan","year":"2025","journal-title":"Int J Mol Sci"},{"issue":"2","key":"2026042911221396000_ozag017-B60","doi-asserted-by":"publisher","first-page":"125","DOI":"10.4103\/ijp.IJP_506_19","article-title":"Development of a psoriatic-like skin inflammation rat model using imiquimod as an inducing agent","volume":"53","author":"Parmar","year":"2021","journal-title":"Indian J Pharmacol"},{"issue":"1","key":"2026042911221396000_ozag017-B61","doi-asserted-by":"publisher","first-page":"2142035","DOI":"10.1080\/09546634.2022.2142035","article-title":"A comprehensive review of platelet-rich plasma for the treatment of dermatologic disorders","volume":"34","author":"Pixley","year":"2023","journal-title":"J Dermatolog Treat"},{"issue":"1","key":"2026042911221396000_ozag017-B62","doi-asserted-by":"publisher","first-page":"236","DOI":"10.3390\/ijms25010236","article-title":"Key factors in the complex and coordinated network of skin keratinization: Their significance and involvement in common skin conditions","volume":"25","author":"Pondeljak","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"2","key":"2026042911221396000_ozag017-B63","doi-asserted-by":"publisher","first-page":"e79097","DOI":"10.7759\/cureus.79097","article-title":"Therapeutic advancements in the management of psoriasis: A clinical overview and update","volume":"17","author":"Qasem","year":"2025","journal-title":"Cureus"},{"issue":"2","key":"2026042911221396000_ozag017-B64","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s10787-024-01602-z","article-title":"Naturally derived bioactive compounds as precision modulators of immune and inflammatory mechanisms in psoriatic conditions","volume":"33","author":"Radu","year":"2025","journal-title":"Inflammopharmacology"},{"issue":"2","key":"2026042911221396000_ozag017-B65","doi-asserted-by":"publisher","first-page":"682","DOI":"10.21608\/ejh.2023.191587.1852","article-title":"The potential protective effect of curcumin nanoparticles on radiated tongue of male albino rats (Histological and Immunohistochemical Study)","volume":"47","author":"Riad","year":"2023","journal-title":"Egypt J Histol"},{"issue":"8","key":"2026042911221396000_ozag017-B66","doi-asserted-by":"publisher","first-page":"8627","DOI":"10.3390\/cimb46080508","article-title":"Keratins 6, 16, and 17 in health and disease: A summary of recent findings","volume":"46","author":"Romashin","year":"2024","journal-title":"Curr Issues Mol Biol"},{"issue":"1","key":"2026042911221396000_ozag017-B67","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s12906-024-04406-4","article-title":"Novel drug therapy of acute hepatic failure induced in rats by a combination of tadalafil and Lepidium sativum","volume":"24","author":"Sabra","year":"2024","journal-title":"BMC Complement Med Ther"},{"issue":"9","key":"2026042911221396000_ozag017-B68","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1242\/jcs.033969","article-title":"Filaggrin in the frontline: Role in skin barrier function and disease","volume":"122","author":"Sandilands","year":"2009","journal-title":"J Cell Sci"},{"key":"2026042911221396000_ozag017-B69","doi-asserted-by":"publisher","first-page":"114492","DOI":"10.1016\/j.intimp.2025.114492","article-title":"Amelioration of imiquimod induced psoriasis through reduction in IL-17A and Th17 population by dihydromyricetin involves regulation of ROR\u03b3t pathway","volume":"153","author":"Sarkar","year":"2025","journal-title":"Int Immunopharmacol"},{"issue":"4","key":"2026042911221396000_ozag017-B70","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.jid.2023.09.267","article-title":"Mature IL-36\u03b3 induces stratum corneum exfoliation in generalized pustular psoriasis by suppressing corneodesmosin","volume":"144","author":"Sato","year":"2024","journal-title":"J Invest Dermatol"},{"issue":"3","key":"2026042911221396000_ozag017-B71","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1007\/s10787-023-01198-w","article-title":"Diosmin nanocrystal gel alleviates imiquimod-induced psoriasis in rats via modulating TLR7, 8\/NF-\u03baB\/micro RNA-31, AKT\/mTOR\/P70S6K milieu, and Tregs\/Th17 balance","volume":"31","author":"Shahine","year":"2023","journal-title":"Inflammopharmacology"},{"issue":"1","key":"2026042911221396000_ozag017-B72","doi-asserted-by":"publisher","first-page":"24","DOI":"10.2174\/2589977513666210707114520","article-title":"IL-23\/Th17 axis: A potential therapeutic target of psoriasis","volume":"14","author":"Sharma","year":"2022","journal-title":"Curr Drug Res Rev"},{"issue":"4","key":"2026042911221396000_ozag017-B73","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/s41419-020-2495-z","article-title":"Keratinocyte transglutaminase 2 promotes CCR6+ \u03b3\u03b4T-cell recruitment by upregulating CCL20 in psoriatic inflammation","volume":"11","author":"Shin","year":"2020","journal-title":"Cell Death Dis"},{"issue":"11","key":"2026042911221396000_ozag017-B74","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.3390\/biom12111659","article-title":"Macrophages in skin wounds: Functions and therapeutic potential","volume":"12","author":"Sim","year":"2022","journal-title":"Biomolecules"},{"issue":"4","key":"2026042911221396000_ozag017-B75","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.jid.2023.10.044","article-title":"Newly discovered corneodesmosin defects in generalized pustular psoriasis","volume":"144","author":"Simon","year":"2024","journal-title":"J Invest Dermatol"},{"issue":"2","key":"2026042911221396000_ozag017-B76","doi-asserted-by":"publisher","first-page":"E230724232190","DOI":"10.2174\/0118715265298802240603120251","article-title":"Breakthrough opportunities of nanotheranostics in psoriasis: From pathogenesis to management strategy","volume":"25","author":"Singh","year":"2025","journal-title":"Infect Disord Drug Targets"},{"key":"2026042911221396000_ozag017-B77","volume-title":"Bancroft's Theory and Practice of Histological Techniques E-Book","author":"Suvarna","year":"2019","edition":"8th ed"},{"issue":"1","key":"2026042911221396000_ozag017-B78","doi-asserted-by":"publisher","first-page":"3852898","DOI":"10.1155\/2022\/3852898","article-title":"Variability in platelet-rich plasma preparations used in regenerative medicine: A comparative analysis","volume":"2022","author":"Tey","year":"2022","journal-title":"Stem Cells Int"},{"issue":"5","key":"2026042911221396000_ozag017-B79","doi-asserted-by":"publisher","first-page":"6387","DOI":"10.15419\/bmrat.v11i5.885","article-title":"Effects of imiquimod application durations on psoriasis-like lesions and cytokine expression in mice","volume":"11","author":"Tran","year":"2024","journal-title":"Biomed Res Ther"},{"issue":"7","key":"2026042911221396000_ozag017-B80","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.3390\/pharmaceutics13071064","article-title":"Therapeutic development based on the immunopathogenic mechanisms of psoriasis","volume":"13","author":"Tseng","year":"2021","journal-title":"Pharmaceutics"},{"issue":"45","key":"2026042911221396000_ozag017-B81","doi-asserted-by":"publisher","first-page":"e53112","DOI":"10.1002\/app.53112","article-title":"N-2-hydroxypropyl trimethyl ammonium chloride chitosan-glycerol complex temperature-sensitive hydrogel for wound dressing","volume":"139","author":"Wang","year":"2022","journal-title":"J Appl Polym Sci"},{"issue":"8","key":"2026042911221396000_ozag017-B82","doi-asserted-by":"publisher","first-page":"50","DOI":"10.14715\/cmb\/2023.69.8.8","article-title":"Expression and function of VEGFRs in normal epidermis and psoriatic lesional keratinocytes","volume":"69","author":"Wang","year":"2023","journal-title":"Cell Mol Biol"},{"issue":"11","key":"2026042911221396000_ozag017-B83","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1016\/S0278-2391(97)90187-7","article-title":"Platelet gel: An autologous alternative to fibrin glue with applications in oral and maxillofacial surgery","volume":"55","author":"Whitman","year":"1997","journal-title":"J Oral Maxillofac Surg"},{"issue":"20","key":"2026042911221396000_ozag017-B84","doi-asserted-by":"publisher","first-page":"12137","DOI":"10.3390\/ijms232012137","article-title":"Impact of ROS-dependent lipid metabolism on psoriasis pathophysiology","volume":"23","author":"Wro\u0144ski","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2026042911221396000_ozag017-B85","doi-asserted-by":"publisher","first-page":"117922","DOI":"10.1016\/j.biopha.2025.117922","article-title":"Amlexanox ameliorates imiquimod-induced psoriasis-like dermatitis by inhibiting Th17 cells and the NF-\u03baB signal pathway","volume":"184","author":"Wu","year":"2025","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"2026042911221396000_ozag017-B86","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/imm.13873","article-title":"LGR4 deficiency aggravates skin inflammation and epidermal hyperplasia in imiquimod-induced psoriasis","volume":"174","author":"Xue","year":"2025","journal-title":"Immunology"},{"key":"2026042911221396000_ozag017-B87","doi-asserted-by":"publisher","first-page":"109945","DOI":"10.1016\/j.intimp.2023.109945","article-title":"Preclinical study models of psoriasis: State-of-the-art techniques for testing pharmaceutical products in animal and nonanimal models","volume":"117","author":"Yadav","year":"2023","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"2026042911221396000_ozag017-B88","doi-asserted-by":"publisher","first-page":"e75","DOI":"10.1002\/ski2.75","article-title":"Abnormal keratin expression pattern in prurigo nodularis epidermis","volume":"2","author":"Yang","year":"2022","journal-title":"Skin Health Dis"},{"key":"2026042911221396000_ozag017-B89","doi-asserted-by":"publisher","first-page":"109949","DOI":"10.1016\/j.biopha.2020.109949","article-title":"Therapeutic effects of combination of platelet lysate and sulfasalazine administration in TNBS-induced colitis in rat","volume":"125","author":"Yousefi-Ahmadipour","year":"2020","journal-title":"Biomed Pharmacother"},{"issue":"10","key":"2026042911221396000_ozag017-B90","doi-asserted-by":"publisher","first-page":"17172","DOI":"10.1002\/jcp.28496","article-title":"Novel therapeutic approaches in utilizing platelet lysate in regenerative medicine: Are we ready for clinical use?","volume":"234","author":"Zamani","year":"2019","journal-title":"J Cell Physiol"},{"issue":"2","key":"2026042911221396000_ozag017-B91","doi-asserted-by":"publisher","first-page":"e70066","DOI":"10.1111\/exd.70066","article-title":"The role of fibroblasts in chronic inflammatory and proliferative skin diseases","volume":"34","author":"Zang","year":"2025","journal-title":"Exp Dermatol"},{"key":"2026042911221396000_ozag017-B92","first-page":"85","volume-title":"Keratin","author":"Zhang","year":"2018"}],"container-title":["Microscopy and Microanalysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/mam\/article-pdf\/32\/2\/ozag017\/67638117\/ozag017.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mam\/article-pdf\/32\/2\/ozag017\/67638117\/ozag017.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:22:23Z","timestamp":1777476143000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mam\/article\/doi\/10.1093\/mam\/ozag017\/8555674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,3]]},"references-count":93,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3,3]]}},"URL":"https:\/\/doi.org\/10.1093\/mam\/ozag017","relation":{},"ISSN":["1431-9276","1435-8115"],"issn-type":[{"value":"1431-9276","type":"print"},{"value":"1435-8115","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,4]]},"published":{"date-parts":[[2026,3,3]]},"article-number":"ozag017"}}