{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:24:35Z","timestamp":1787765075574,"version":"build-2784847793"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministry of Science, Technological Development and Innovation of Republic of Serbia","doi-asserted-by":"publisher","award":["451-03-33\/2026-03\/200053"],"award-info":[{"award-number":["451-03-33\/2026-03\/200053"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004564","name":"Ministry of Science, Technological Development and Innovation of Republic of Serbia","doi-asserted-by":"publisher","award":["451-03-33\/2026-03\/200178"],"award-info":[{"award-number":["451-03-33\/2026-03\/200178"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004564","name":"Ministry of Science, Technological Development and Innovation of Republic of Serbia","doi-asserted-by":"publisher","award":["451-03-33\/2026-03\/200007"],"award-info":[{"award-number":["451-03-33\/2026-03\/200007"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017592","name":"Institute of Physics Belgrade","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016047","name":"Science Fund of the Republic of Serbia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Astrocytes, the abundant glial cells of the central nervous system (CNS), maintain water and glutamate homeostasis through aquaporin-4 (AQP4) and glutamate transporter-1 (EAAT2). In the hSODG93A animal model of amyotrophic lateral sclerosis, astrocytes exhibit alterations in these homeostatic proteins. AQP4 and EAAT2 changes are observed in both hSODG93A-expressing astrocytes in the CNS and in cell cultures. Here, we provide a detailed analysis of differences between cultured control and hSOD1G93A astrocytes in AQP4 and EAAT2 fluorescence patterns, subcellular localization, and spatial overlap, using side-by-side epifluorescence and structured illumination microscopy modes of a custom imaging system [two-dimensional structured illumination microscopy (2D SIM)]. 2D SIM system characterization and fluorescence signal analysis demonstrated uniform epifluorescence illumination and high-contrast SIM patterns, enabling whole-cell imaging of AQP4 and EAAT2 and resolving their signals into distinct puncta in both control and hSOD1G93A astrocytes with SIM. Compared with control astrocytes, AQP4 expression increased and EAAT2 expression decreased in the plasma membrane and cytoplasm of hSOD1G93A astrocytes at both diffraction-limited and superresolution scales. Subdiffraction-scale analysis revealed differences in the spatial distributions of AQP4 and EAAT2, showing increased colocalization between these proteins in hSOD1G93A astrocytes. These findings demonstrate the utility of integrated imaging approaches for quantitative, single-cell-resolution analysis of disease-associated protein alterations in astrocytes.<\/jats:p>","DOI":"10.1093\/mam\/ozag095","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:00:33Z","timestamp":1785412833000},"source":"Crossref","is-referenced-by-count":0,"title":["Characterizing Single-Cell Differences in Aquaporin-4 and Glutamate Transporter-1 Between Control and hSOD1G93A Astrocytes Using Integrated Epifluorescence and Structured Illumination Microscopy"],"prefix":"10.1093","volume":"32","author":[{"given":"Aleksa","family":"Den\u010devski","sequence":"first","affiliation":[{"name":"Laboratory for Biophysics, Institute of Physics Belgrade, University of Belgrade, National Institute of the Republic of Serbia , Pregrevica 118, Belgrade 11000, Republic of Serbia"},{"name":"Department of Life Sciences, University of Belgrade\u2014Institute for Multidisciplinary Research, National Institute of Republic of Serbia , Kneza Vi\u0161eslava 1, Belgrade 11030, Republic of Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danijela","family":"Batavelji\u0107","sequence":"additional","affiliation":[{"name":"Institute of Physiology and Biochemistry \u201cIvan Djaja\u201d, Faculty of Biology, University of Belgrade , Studentski trg 16, Belgrade 11000, Republic of Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Bogdanovi\u0107 Pristov","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, University of Belgrade\u2014Institute for Multidisciplinary Research, National Institute of Republic of Serbia , Kneza Vi\u0161eslava 1, Belgrade 11030, Republic of Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2751-7395","authenticated-orcid":false,"given":"Aleksandar J","family":"Krmpot","sequence":"additional","affiliation":[{"name":"Laboratory for Biophysics, Institute of Physics Belgrade, University of Belgrade, National Institute of the Republic of Serbia , Pregrevica 118, Belgrade 11000, Republic of Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9235-4388","authenticated-orcid":false,"given":"Mihailo D","family":"Rabasovi\u0107","sequence":"additional","affiliation":[{"name":"Laboratory for Biophysics, Institute of Physics Belgrade, University of Belgrade, National Institute of the Republic of Serbia , Pregrevica 118, Belgrade 11000, Republic of Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8575-7824","authenticated-orcid":false,"given":"Ljiljana","family":"Nikoli\u0107","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology, Institute for Biological Research \u201cSini\u0161a Stankovi\u0107\u201d, National Institute of Republic of Serbia, University of Belgrade , Bulevar despota Stefana 142, Belgrade 11108, Republic of Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"2026082612554403300_ozag095-B1","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s11910-996-0008-9","article-title":"Amyotrophic lateral sclerosis associated with mutations in the CuZn superoxide dismutase gene","volume":"6","author":"Andersen","year":"2006","journal-title":"Curr Neurol Neurosci Rep"},{"key":"2026082612554403300_ozag095-B2","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1038\/s42003-023-05364-2","article-title":"Scanning single molecule localization microscopy (scanSMLM) for super-resolution volume imaging","volume":"6","author":"Basumatary","year":"2023","journal-title":"Commun Biol"},{"key":"2026082612554403300_ozag095-B3","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1002\/glia.22414","article-title":"Changes in the astrocytic aquaporin-4 and inwardly rectifying potassium channel expression in the brain of the amyotrophic lateral sclerosis SOD1G93A rat model","volume":"60","author":"Batavelji\u0107","year":"2012","journal-title":"GLIA"},{"key":"2026082612554403300_ozag095-B4","doi-asserted-by":"publisher","first-page":"7325","DOI":"10.1523\/JNEUROSCI.20-19-07325.2000","article-title":"NGF signals through TrkA to increase clathrin at the plasma membrane and enhance clathrin-mediated membrane trafficking","volume":"20","author":"Beattie","year":"2000","journal-title":"J Neurosci"},{"key":"2026082612554403300_ozag095-B5","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1046\/j.1471-4159.2001.00572.x","article-title":"Transgenic SOD1 G93A mice develop reduced GLT-1 in spinal cord without alterations in cerebrospinal fluid glutamate levels","volume":"79","author":"Bendotti","year":"2001","journal-title":"J Neurochem"},{"key":"2026082612554403300_ozag095-B6","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.micron.2010.06.016","article-title":"Structured illumination microscopy of autofluorescent aggregations in human tissue","volume":"42","author":"Best","year":"2011","journal-title":"Micron (Oxford, England: 1993)"},{"key":"2026082612554403300_ozag095-B7","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/j.1365-2818.2006.01706.x","article-title":"A guided tour into subcellular colocalization analysis in light microscopy","volume":"224","author":"Bolte","year":"2006","journal-title":"J Microsc"},{"key":"2026082612554403300_ozag095-B8","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/0896-6273(95)90158-2","article-title":"Glutamate transporters in glial plasma membranes: Highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry","volume":"15","author":"Chaudhry","year":"1995","journal-title":"Neuron"},{"key":"2026082612554403300_ozag095-B901","doi-asserted-by":"publisher","first-page":"30246","DOI":"10.1364\/OE.466225","article-title":"Integrated optical device for Structured Illumination Microscopy","volume":"30","author":"Calvarese","year":"2022","journal-title":"Opt Express"},{"key":"2026082612554403300_ozag095-B9","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1038\/s41377-023-01204-4","article-title":"Superresolution structured illumination microscopy reconstruction algorithms: A review","volume":"12","author":"Chen","year":"2023","journal-title":"Light Sci Appl"},{"key":"2026082612554403300_ozag095-B10","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1002\/jemt.24756","article-title":"Development of structured illumination microscope using transmission diffraction grating obtained by analog microfilming method","volume":"88","author":"Den\u010devski","year":"2025","journal-title":"Microsc Res Tech"},{"key":"2026082612554403300_ozag095-B11","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1126\/science.8351519","article-title":"Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase","volume":"261","author":"Deng","year":"1993","journal-title":"Science (New York, N.Y.)"},{"key":"2026082612554403300_ozag095-B12","doi-asserted-by":"publisher","first-page":"112","DOI":"10.2174\/157015910791233150","article-title":"Aquaporins and neurodegenerative diseases","volume":"8","author":"Foglio","year":"2010","journal-title":"Curr Neuropharmacol"},{"key":"2026082612554403300_ozag095-B13","doi-asserted-by":"publisher","first-page":"20663","DOI":"10.1364\/OE.22.020663","article-title":"Simple structured illumination microscope setup with high acquisition speed by using a spatial light modulator","volume":"22","author":"F\u00f6rster","year":"2014","journal-title":"Opt Express"},{"key":"2026082612554403300_ozag095-B14","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/S0091-679X(06)81018-6","article-title":"Evaluating optical aberration using fluorescent microspheres: Methods, analysis, and corrective actions","volume":"81","author":"Goodwin","year":"2007","journal-title":"Methods Cell Biol"},{"key":"2026082612554403300_ozag095-B15","doi-asserted-by":"publisher","first-page":"7950","DOI":"10.1523\/JNEUROSCI.16-24-07950.1996","article-title":"Endocytosis of activated TrkA: Evidence that nerve growth factor induces formation of signaling endosomes","volume":"16","author":"Grimes","year":"1996","journal-title":"J Neurosci"},{"key":"2026082612554403300_ozag095-B16","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1046\/j.1365-2818.2000.00710.x","article-title":"Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy","volume":"198","author":"Gustafsson","year":"2000","journal-title":"J Microsc"},{"key":"2026082612554403300_ozag095-B17","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1084\/jem.20081241","article-title":"Aquaporin-4-binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down-regulating EAAT2","volume":"205","author":"Hinson","year":"2008","journal-title":"J Exp Med"},{"key":"2026082612554403300_ozag095-B18","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1073\/pnas.032539299","article-title":"Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)","volume":"99","author":"Howland","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026082612554403300_ozag095-B19","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1093\/mam\/ozae061","article-title":"Application of the knife-edge technique on transition metal dichalcogenide monolayers for resolution assessment of nonlinear microscopy modalities","volume":"30","author":"Jeli\u0107","year":"2024","journal-title":"Microsc Microanal"},{"key":"2026082612554403300_ozag095-B20","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/j.neuron.2020.08.022","article-title":"ALS genetics: Gains, losses, and implications for future therapies","volume":"108","author":"Kim","year":"2020","journal-title":"Neuron"},{"key":"2026082612554403300_ozag095-B21","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1093\/bioinformatics\/btv576","article-title":"SIMToolbox: A MATLAB toolbox for structured illumination fluorescence microscopy","volume":"32","author":"K\u0159\u00ed\u017eek","year":"2016","journal-title":"Bioinformatics (Oxford, England)"},{"key":"2026082612554403300_ozag095-B22","doi-asserted-by":"publisher","first-page":"233","DOI":"10.5607\/en.2016.25.5.233","article-title":"Astrocytes and microglia as non-cell autonomous players in the pathogenesis of ALS","volume":"25","author":"Lee","year":"2016","journal-title":"Exp Neurobiol"},{"key":"2026082612554403300_ozag095-B23","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"2026082612554403300_ozag095-B24","doi-asserted-by":"publisher","first-page":"10748","DOI":"10.1523\/JNEUROSCI.0776-17.2017","article-title":"AQP4e-Based orthogonal arrays regulate rapid cell volume changes in astrocytes","volume":"37","author":"Lisjak","year":"2017","journal-title":"J Neurosci"},{"key":"2026082612554403300_ozag095-B25","doi-asserted-by":"publisher","first-page":"735","DOI":"10.3390\/cells9030735","article-title":"Indirect role of AQP4b and AQP4d isoforms in dynamics of astrocyte volume and orthogonal arrays of particles","volume":"9","author":"Lisjak","year":"2020","journal-title":"Cells"},{"key":"2026082612554403300_ozag095-B26","doi-asserted-by":"publisher","first-page":"29805","DOI":"10.1364\/OE.22.029805","article-title":"Three-dimensional super-resolution structured illumination microscopy with maximum a posteriori probability image estimation","volume":"22","author":"Luke\u0161","year":"2014","journal-title":"Opt Express"},{"key":"2026082612554403300_ozag095-B27","doi-asserted-by":"publisher","DOI":"10.1088\/2050-6120\/3\/1\/014001","article-title":"fastSIM: A practical implementation of fast structured illumination microscopy","volume":"3","author":"Lu-Walther","year":"2015","journal-title":"Methods Appl Fluoresc"},{"key":"2026082612554403300_ozag095-B28","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1038\/nn1876","article-title":"Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons","volume":"10","author":"Nagai","year":"2007","journal-title":"Nat Neurosci"},{"key":"2026082612554403300_ozag095-B29","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1002\/(SICI)1098-1136(199903)26:1&lt;47::AID-GLIA5&gt;3.0.CO;2-5","article-title":"Immunogold evidence suggests that coupling of K+ siphoning and water transport in rat retinal M\u00fcller cells is mediated by a coenrichment of Kir4.1 and AQP4 in specific membrane domains","volume":"26","author":"Nagelhus","year":"1999","journal-title":"Glia"},{"key":"2026082612554403300_ozag095-B30","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/j.neuroscience.2004.08.053","article-title":"Aquaporin-4 in the central nervous system: Cellular and subcellular distribution and coexpression with KIR4.1","volume":"129","author":"Nagelhus","year":"2004","journal-title":"Neuroscience"},{"key":"2026082612554403300_ozag095-B31","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1002\/ar.20838","article-title":"Aquaporin-4 overexpression in rat ALS model","volume":"292","author":"Nicaise","year":"2009","journal-title":"Anat Rec (Hoboken)"},{"key":"2026082612554403300_ozag095-B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.03.002","article-title":"The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: Potential targets for neurotherapeutics","volume":"161","author":"Pajarillo","year":"2019","journal-title":"Neuropharmacology"},{"key":"2026082612554403300_ozag095-B33","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/nrn3468","article-title":"Aquaporin water channels in the nervous system","volume":"14","author":"Papadopoulos","year":"2013","journal-title":"Nat Rev Neurosci"},{"key":"2026082612554403300_ozag095-B34","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/j.1471-4159.2012.07664.x","article-title":"Glial cells in (patho)physiology","volume":"121","author":"Parpura","year":"2012","journal-title":"J Neurochem"},{"key":"2026082612554403300_ozag095-B35","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1172\/JCI71601","article-title":"Emerging mechanisms of molecular pathology in ALS","volume":"125","author":"Peters","year":"2015","journal-title":"J Clin Invest"},{"key":"2026082612554403300_ozag095-B36","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.95873","article-title":"Astrocyte aquaporin mediates a tonic water efflux maintaining brain homeostasis","volume":"13","author":"Pham","year":"2024","journal-title":"eLife"},{"key":"2026082612554403300_ozag095-B37","doi-asserted-by":"publisher","first-page":"E756","DOI":"10.1073\/pnas.1222361110","article-title":"Intricate interplay between astrocytes and motor neurons in ALS","volume":"110","author":"Phatnani","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026082612554403300_ozag095-B38","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giy126","article-title":"Imaging tissues and cells beyond the diffraction limit with structured illumination microscopy and Bayesian image reconstruction","volume":"8","author":"Posp\u00ed\u0161il","year":"2019","journal-title":"GigaScience"},{"key":"2026082612554403300_ozag095-B39","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.brainresbull.2016.12.013","article-title":"Molecular and cellular physiology of sodium-dependent glutamate transporters","volume":"136","author":"Rose","year":"2018","journal-title":"Brain Res Bull"},{"key":"2026082612554403300_ozag095-B40","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/978-3-319-55769-4_6","article-title":"EAAT2 and the molecular signature of amyotrophic lateral sclerosis","volume":"16","author":"Rosenblum","year":"2017","journal-title":"Adv Neurobiol"},{"key":"2026082612554403300_ozag095-B41","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/ana.410380114","article-title":"Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis","volume":"38","author":"Rothstein","year":"1995","journal-title":"Ann Neurol"},{"key":"2026082612554403300_ozag095-B42","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1093\/brain\/awab311","article-title":"Emerging roles for dynamic aquaporin-4 subcellular relocalization in CNS water homeostasis","volume":"145","author":"Salman","year":"2022","journal-title":"Brain"},{"key":"2026082612554403300_ozag095-B43","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/s41556-018-0251-8","article-title":"Super-resolution microscopy demystified","volume":"21","author":"Schermelleh","year":"2019","journal-title":"Nat Cell Biol"},{"key":"2026082612554403300_ozag095-B44","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1016\/j.bpj.2015.10.047","article-title":"Superresolution imaging of aquaporin-4 cluster size in antibody-stained paraffin brain sections","volume":"109","author":"Smith","year":"2015","journal-title":"Biophys J"},{"key":"2026082612554403300_ozag095-B45","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1080\/09687680701790925","article-title":"EAAT2 density at the astrocyte plasma membrane and Ca2+-regulated exocytosis","volume":"25","author":"Stenovec","year":"2008","journal-title":"Mol Membr Biol"},{"key":"2026082612554403300_ozag095-B46","doi-asserted-by":"publisher","first-page":"279","DOI":"10.4300\/JGME-D-12-00156.1","article-title":"Using effect size-or why the P value is not enough","volume":"4","author":"Sullivan","year":"2012","journal-title":"J Grad Med Educ"},{"key":"2026082612554403300_ozag095-B47","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nature20413","article-title":"Decoding ALS: From genes to mechanism","volume":"539","author":"Taylor","year":"2016","journal-title":"Nature"},{"key":"2026082612554403300_ozag095-B48","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.expneurol.2012.10.004","article-title":"Superresolution imaging for neuroscience","volume":"242","author":"T\u00f8nnesen","year":"2013","journal-title":"Exp Neurol"},{"key":"2026082612554403300_ozag095-B49","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1046\/j.1471-4159.2003.02208.x","article-title":"Expression of SOD1 G93A or wild-type SOD1 in primary cultures of astrocytes down-regulates the glutamate transporter GLT-1\u202f: Lack of involvement of oxidative stress","volume":"88","author":"Tortarolo","year":"2004","journal-title":"J Neurochem"},{"key":"2026082612554403300_ozag095-B50","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/s41598-017-00072-4","article-title":"Altered metabolic profiles associate with toxicity in SOD1(G93A) astrocyte-neuron co-cultures","volume":"7","author":"Valbuena","year":"2017","journal-title":"Sci Rep"},{"key":"2026082612554403300_ozag095-B51","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1016\/j.bbamem.2006.02.018","article-title":"Three distinct roles of aquaporin-4 in brain function revealed by knockout mice","volume":"1758","author":"Verkman","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"2026082612554403300_ozag095-B52","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s12031-017-0905-1","article-title":"Aquaporin 4 forms a macromolecular complex with glutamate transporter 1 and mu opioid receptor in astrocytes and participates in morphine dependence","volume":"62","author":"Wang","year":"2017","journal-title":"J Mol Neurosci"},{"key":"2026082612554403300_ozag095-B53","doi-asserted-by":"publisher","first-page":"11971","DOI":"10.1021\/acs.chemrev.0c01174","article-title":"Super-resolving microscopy in neuroscience","volume":"121","author":"Werner","year":"2021","journal-title":"Chem Rev"},{"key":"2026082612554403300_ozag095-B54","doi-asserted-by":"publisher","first-page":"27951","DOI":"10.1364\/OE.461615","article-title":"Large-field lattice structured illumination microscopy","volume":"30","author":"Zheng","year":"2022","journal-title":"Opt Express"}],"container-title":["Microscopy and Microanalysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/mam\/article-pdf\/32\/4\/ozag095\/70806857\/ozag095.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mam\/article-pdf\/32\/4\/ozag095\/70806857\/ozag095.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:55:48Z","timestamp":1787763348000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mam\/article\/doi\/10.1093\/mam\/ozag095\/8771270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":55,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/mam\/ozag095","relation":{},"ISSN":["1431-9276","1435-8115"],"issn-type":[{"value":"1431-9276","type":"print"},{"value":"1435-8115","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,8]]},"published":{"date-parts":[[2026,7,1]]},"article-number":"ozag095"}}