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Urolithin A (UA), a metabolite produced from ellagitannins by gut bacteria, is known to exert antioxidant effects by improving mitochondrial function and biogenesis. Therefore, this study aimed to investigate the effects of UA on preimplantation embryo development and its mitochondrial function and quantity. In this study, EX-527, a specific inhibitor of sirtuin 1 (SIRT1), was used to explore whether the effects of UA are mediated by the SIRT1\/peroxisome proliferator-activated receptor-co-activator 1\u03b1 (PGC-1\u03b1) signaling pathway. UA significantly enhanced preimplantation development of porcine parthenotes. In addition, UA significantly increased mitochondrial function and quantity, intracellular glutathione levels, and the protein levels of SIRT1 and PGC-1\u03b1, whereas it reduced intracellular reactive oxygen species levels. Furthermore, the expression levels of SIRT1\/PGC-1\u03b1 signaling pathway- and mitochondrial biogenesis-related transcripts were significantly increased by UA treatment. However, the effects of UA were completely abolished by EX-527 cotreatment. These results suggest that UA improves preimplantation embryo development by enhancing mitochondrial function and quantity via the SIRT1\/PGC-1\u03b1 signaling pathway.<\/jats:p>","DOI":"10.1093\/mam\/ozag100","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T11:45:31Z","timestamp":1787139931000},"source":"Crossref","is-referenced-by-count":0,"title":["Urolithin A Enhances the Development of Porcine Parthenogenetic Embryos by Promoting Mitochondrial Function and Quantity Through the SIRT1\/PGC-1\n                    <i>\u03b1<\/i>\n                    Signaling Pathway"],"prefix":"10.1093","volume":"32","author":[{"given":"Seunghyun","family":"Choi","sequence":"first","affiliation":[{"name":"Laboratory of Theriogenology, College of Veterinary Medicine, Chungnam National University , Daejeon 34134 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dabin","family":"Cha","sequence":"additional","affiliation":[{"name":"Laboratory of Theriogenology, College of Veterinary Medicine, Chungnam National University , Daejeon 34134 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumin","family":"Lee","sequence":"additional","affiliation":[{"name":"Laboratory of Theriogenology, College of Veterinary Medicine, Chungnam National University , Daejeon 34134 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyeonghyeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Laboratory of Theriogenology, College of Veterinary Medicine, Chungnam National University , Daejeon 34134 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeonjoo","family":"Lee","sequence":"additional","affiliation":[{"name":"Laboratory of Theriogenology, College of Veterinary Medicine, Chungnam National University , Daejeon 34134 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jongki","family":"Cho","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University , Seoul 08826 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1265-3821","authenticated-orcid":false,"given":"Sanghoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Laboratory of Theriogenology, College of Veterinary Medicine, Chungnam National University , Daejeon 34134 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"issue":"2","key":"2026100103531178700_ozag100-B1","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1093\/biolre\/ioac024","article-title":"Oocyte mitochondria-key regulators of oocyte function and potential therapeutic targets for improving fertility","volume":"106","author":"Adhikari","year":"2022","journal-title":"Biol Reprod"},{"key":"2026100103531178700_ozag100-B2","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1196\/annals.1338.020","article-title":"Abnormal mitochondrial structure in human unfertilized oocytes and arrested embryos","volume":"1042","author":"Au","year":"2005","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"2026100103531178700_ozag100-B3","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1097\/GCO.0000000000000164","article-title":"Oocyte mitochondrial function and reproduction","volume":"27","author":"Babayev","year":"2015","journal-title":"Curr Opin Obstet Gynecol"},{"issue":"Suppl 2","key":"2026100103531178700_ozag100-B4","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1093\/humrep\/15.suppl_2.189","article-title":"Mitochondrial distribution and function in oocytes and early embryos","volume":"15","author":"Bavister","year":"2000","journal-title":"Hum. 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