{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T13:55:58Z","timestamp":1772718958165,"version":"3.50.1"},"reference-count":98,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pulmonary arterial hypertension (PAH) is characterized by elevated arterial pressure and vascular resistance. PAH may cause alterations in the microcirculation of several organs, including the kidney, liver, brain, and testes. However, it remains unclear whether monocrotaline-induced PAH exerts detrimental effects on animal testes. Thus, we analyzed the impact of PAH on testicular morphology and function. Additionally, we investigated the effect of resistance exercise training (RT) on testicular parameters in PAH rats. Eight healthy Wistar rats and eight PAH rats were subjected to RT training for 30 days; the other PAH and healthy rats (n = 8\/group) did not exercise. PAH rats had lower reproductive organ weight, serum testosterone levels, testicular glucose, and nitric oxide (NO) levels, Leydig cell parameters, tubular morphometry, germ cell counts, and daily sperm production than healthy animals did. The practice of RT attenuated the negative impact of PAH on the relative weights of the testes and epididymides, Leydig cell number, nuclear volume, testicular NO levels, and seminiferous epithelium architecture. Moreover, RT positively influenced testosterone levels in PAH animals. We conclude that PAH exerts deleterious effects on testicular histology and function. However, RT can be beneficial to the PAH-affected testicular parameters.<\/jats:p>","DOI":"10.1093\/micmic\/ozac037","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T01:32:11Z","timestamp":1675819931000},"page":"635-648","source":"Crossref","is-referenced-by-count":6,"title":["Effect of Induced Pulmonary Arterial Hypertension on Testicular Parameters of Wistar Rats Subjected to Resistance Exercise Training"],"prefix":"10.1093","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6355-2492","authenticated-orcid":false,"given":"Luiz Ot\u00e1vio","family":"Guimar\u00e3es-Ervilha","sequence":"first","affiliation":[{"name":"Departamento de Biologia Geral, Universidade Federal de Vi\u00e7osa , Avenida Peter Henry Rolfs, s\/n, Campus Universit\u00e1rio, Vi\u00e7osa, MG 36570-900 , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le\u00f4ncio Lopes","family":"Soares","sequence":"additional","affiliation":[{"name":"Departamento de Educa\u00e7\u00e3o F\u00edsica, Universidade Federal de Vi\u00e7osa , Avenida Peter Henry Rolfs, s\/n, Campus Universit\u00e1rio, Vi\u00e7osa, MG 36570-900 , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabela da Silva Pereira","family":"Bento","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Geral, Universidade Federal de Vi\u00e7osa , Avenida Peter Henry Rolfs, s\/n, Campus Universit\u00e1rio, Vi\u00e7osa, MG 36570-900 , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6024-204X","authenticated-orcid":false,"given":"Renner Philipe Rodrigues","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Geral, Universidade Federal de Vi\u00e7osa , Avenida Peter Henry Rolfs, s\/n, Campus Universit\u00e1rio, Vi\u00e7osa, MG 36570-900 , 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