{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:10:09Z","timestamp":1772172609963,"version":"3.50.1"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"JSPS KAKENHI","award":["JP20J22559"],"award-info":[{"award-number":["JP20J22559"]}]},{"name":"JSPS KAKENHI","award":["JP19K22352"],"award-info":[{"award-number":["JP19K22352"]}]},{"name":"JSPS KAKENHI","award":["JP21H04751"],"award-info":[{"award-number":["JP21H04751"]}]},{"DOI":"10.13039\/100012319","name":"National Center for Global Health and Medicine","doi-asserted-by":"crossref","award":["20A1019"],"award-info":[{"award-number":["20A1019"]}],"id":[{"id":"10.13039\/100012319","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Systemic autoimmune diseases frequently induce lupus nephritis, causing altered balance and expression of interleukin 36 receptor (IL-36R) ligands, including agonists (IL-36\u03b1, \u03b2, \u03b3) and antagonists (IL-36Ra, IL-38), in kidneys. Here, we established and analyzed a mouse model of lupus nephritis, MRL\/MpJ-Faslpr\/lpr with IL-36R-knockout (KO), compared to wild-type (WT) mice. In both genotypes, indices for immune abnormalities and renal functions were comparable, although female WT mice showed higher serum autoantibody levels than males. IL-36R ligand expression did not differ significantly between genotypes at the mRNA level or in IL-36\u03b1 and IL-38 scores. However, glomerular lesions, especially mesangial matrix expansion, were significantly ameliorated in both sexes of IL-36R-KO mice compared to WT mice. Cell infiltration into the tubulointerstitium with the development of tertiary lymphoid structures was comparable between genotypes. However, the positive correlation with the IL-36\u03b1 score in WT mice was not evident in IL-36R-KO mice. Fibrosis was less in female IL-36R-KO mice than in WT mice. Importantly, some IL-36\u03b1+ nuclei co-localized with acetylated lysine and GCN5 histone acetyltransferase, in both genotypes. Therefore, IL-36R ligands, especially IL-36\u03b1, contribute to the progression of renal pathology in lupus nephritis via IL-36R-dependent and IL-36R-independent pathways.<\/jats:p>","DOI":"10.1093\/micmic\/ozac046","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T15:15:01Z","timestamp":1674227701000},"page":"675-685","source":"Crossref","is-referenced-by-count":2,"title":["Ameliorated Renal Pathological Feature in MRL\/MpJ-<i>Faslpr\/lpr<\/i>Background Interleukin-36 Receptor-Deficient Mice"],"prefix":"10.1093","volume":"29","author":[{"given":"Takashi","family":"Namba","sequence":"first","affiliation":[{"name":"Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University , Sapporo, Hokkaido 060-0818 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6643-1554","authenticated-orcid":false,"given":"Osamu","family":"Ichii","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University , Sapporo, Hokkaido 060-0818 , Japan"},{"name":"Laboratory of Agrobiomedical Science, Faculty of Agriculture, Hokkaido University , Sapporo, Hokkaido 060-8589 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Okamura","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animal Medicine, Research Institute, National Center for Global Health and Medicine , Tokyo 162-8655 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenta","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animal Medicine, Research Institute, National Center for Global Health and Medicine , Tokyo 162-8655 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teppei","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Laboratory of Laboratory Animal Science and Medicine, Department of Applied Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University , Sapporo, Hokkaido 060-0818 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Otani","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University , Sapporo, Hokkaido 060-0818 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Kon","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University , Sapporo, Hokkaido 060-0818 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,12,20]]},"reference":[{"key":"2023040512120122700_","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1038\/s41598-018-19476-x","article-title":"IL-36\/LXR axis modulates cholesterol metabolism and immune defense to Mycobacterium tuberculosis","volume":"8","author":"Ahsan","year":"2018","journal-title":"Sci Rep"},{"key":"2023040512120122700_","doi-asserted-by":"crossref","first-page":"825","DOI":"10.2215\/CJN.05780616","article-title":"Update on lupus nephritis","volume":"12","author":"Almaani","year":"2017","journal-title":"Clin J Am Soc Nephrol"},{"key":"2023040512120122700_","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1084\/jem.148.5.1198","article-title":"Spontaneous murine lupus-like syndromes. 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