{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:53:15Z","timestamp":1787921595230,"version":"build-2784847793"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"9-10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,18]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Erythema multiforme and Stevens\u2013Johnson syndrome\/toxic epidermal necrolysis are immune-mediated epidermal conditions with variable clinical presentations. Although their clinical presentations often overlap, they have distinct etiologies and potential outcomes, which necessitate specific management strategies. This case is presented to highlight the subtle differences and review management given that Stevens\u2013Johnson syndrome\/toxic epidermal necrolysis can rapidly become life-threatening. The need for astute diagnostic work-up and accuracy is magnified in the military setting given operations in austere environments and availability of medical and medical evacuation resources. Herein, we present a less common case of bullous erythema-multiforme, the diagnostic approach, and clinical differential with special attention to the importance of the military physician.<\/jats:p>","DOI":"10.1093\/milmed\/usaa029","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T13:24:40Z","timestamp":1588771480000},"page":"e1847-e1850","source":"Crossref","is-referenced-by-count":17,"title":["Erythema Multiforme Versus Stevens\u2013Johnson Syndrome\/Toxic Epidermal Necrolysis: Subtle Difference in Presentation, Major Difference in Management"],"prefix":"10.1093","volume":"185","author":[{"given":"Russell E","family":"Newkirk","sequence":"first","affiliation":[{"name":"School of Medicine, Uniformed Services University, 4301 Jones Bridge Road, Bethesda MD 20814"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daren A","family":"Fomin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Walter Reed National Military Medical Center, 8901 Rockville Pike, Bethesda MD 20889"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary M","family":"Braden","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Walter Reed National Military Medical Center, 8901 Rockville Pike, Bethesda MD 20889"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,5,6]]},"reference":[{"key":"2020092112144280200_ref1","first-page":"3459","article-title":"Varients of erythema Multiforme: a case report and literature review","volume":"10","author":"Paulino","year":"2018","journal-title":"Cureus"},{"issue":"10","key":"2020092112144280200_ref2","first-page":"1570","article-title":"Hematological abnormalities and the use of granulocyte-colony-stimulating factor in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis","volume":"50","author":"Chia-Chun","year":"2011","journal-title":"Int J Dermatol"},{"issue":"2","key":"2020092112144280200_ref3","doi-asserted-by":"crossref","first-page":"187.e1","DOI":"10.1016\/j.jaad.2013.05.002","article-title":"Toxic epidermal Necrolysis","volume":"69","author":"Schwartz","year":"2013","journal-title":"J Am Acad Dermatol"},{"key":"2020092112144280200_ref4","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/vde.12142","article-title":"Erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis: a comparative review","volume":"25","author":"Yager","year":"2014","journal-title":"Vet Dermatol"},{"key":"2020092112144280200_ref5","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1111\/j.1365-4632.2011.05348.x","article-title":"Clinical features, diagnosis, and treatment of erythema multiforme: a review for the practicing dermatologist","volume":"51","author":"Sokumbi","year":"2012","journal-title":"Int J Dermatol"},{"key":"2020092112144280200_ref6","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/ICO.0b013e31802eb264","article-title":"Erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis: acute ocular manifestations, causes, and management","volume":"26","author":"Chang","year":"2007","journal-title":"Cornea"},{"issue":"2","key":"2020092112144280200_ref7","first-page":"12449","article-title":"Treatment of antiviral-resistant recurrent erythema multiforme with dapsone","volume":"30","author":"Oak","year":"2017","journal-title":"Dermatol Online J"},{"issue":"1","key":"2020092112144280200_ref8","doi-asserted-by":"crossref","first-page":"14","DOI":"10.5070\/D3231033682","article-title":"Apremilast for treatment of recurrent erythema multiforme","volume":"23","author":"Chen","year":"2017","journal-title":"Dermatol Online J"},{"issue":"2","key":"2020092112144280200_ref9","first-page":"82","article-title":"Erythema multiforme: recognition and management","volume":"100","author":"Trayes","year":"2019","journal-title":"Am Fam Physician"},{"issue":"1","key":"2020092112144280200_ref10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jaad.2009.06.046","article-title":"Recurrent erythema multiforme: clinical characteristics, etiologic associations, and treatment in a series of 48 patients at Mayo Clinic, 2000 to 2007","volume":"62","author":"Wetter","year":"2010","journal-title":"J Am Acad Dermatol"},{"issue":"7","key":"2020092112144280200_ref11","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1111\/jdv.13313","article-title":"Rituximab, a new treatment fo difficult-to-treat chronic erythema multiforme major? Five cases","volume":"30","author":"Hirsch","year":"2016","journal-title":"J Eur Acad Dermatol Venereol"}],"container-title":["Military Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/milmed\/article-pdf\/185\/9-10\/e1847\/33765892\/usaa029.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/milmed\/article-pdf\/185\/9-10\/e1847\/33765892\/usaa029.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T05:32:21Z","timestamp":1666503141000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/milmed\/article\/185\/9-10\/e1847\/5830797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,6]]},"references-count":11,"journal-issue":{"issue":"9-10","published-online":{"date-parts":[[2020,5,6]]},"published-print":{"date-parts":[[2020,9,18]]}},"URL":"https:\/\/doi.org\/10.1093\/milmed\/usaa029","relation":{},"ISSN":["0026-4075","1930-613X"],"issn-type":[{"value":"0026-4075","type":"print"},{"value":"1930-613X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,9]]},"published":{"date-parts":[[2020,5,6]]}}}