{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:36:33Z","timestamp":1770813393138,"version":"3.50.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"11-12","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>The purpose of this study was to evaluate optimal neutral wrist splint duration in treatment-naive mild and mild to moderate carpal tunnel syndrome (CTS). Neutral wrist splinting is a conservative treatment for CTS; however, no clear guidelines exist for how long splinting should be prescribed for optimal outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and Methods<\/jats:title>\n                  <jats:p>In this prospective clinical trial subjects were assigned to wear a neutral wrist splint for 6 (group A) or 12\u00a0weeks (group B). Symptom and functional outcomes were assessed by questionnaire at baseline, 6 and 12\u00a0weeks. Median nerve sensory and motor latencies were recorded at baseline and 12\u00a0weeks. Pretreatment, midtreatment, and posttreatment measures were compared within and between treatment groups where applicable. This study was approved by the United States Air Force Academy institutional review board.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 30 subjects (37 hands) were randomized to 2 treatment groups. Mean symptom severity and median sensory peak latency significantly improved in both groups at 12\u00a0weeks, without a significant difference between groups. Mean functional severity significantly improved only in group A.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Neutral wrist splint for 6\u00a0weeks resulted in better clinical improvements in patients with untreated mild and mild to moderate CTS. There was no additional benefit in extending splinting 6 additional weeks. This is the first study to compare duration of wrist splint use beyond 8\u00a0weeks. A larger sample size is needed to identify the reason for lack of functional improvement in group B. Long-term follow-up of this cohort will be helpful to determine the natural history of initial wrist splint use.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/milmed\/usaa222","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T14:52:49Z","timestamp":1598971969000},"page":"e2049-e2054","source":"Crossref","is-referenced-by-count":21,"title":["Splinting in Carpal Tunnel Syndrome: The Optimal Duration"],"prefix":"10.1093","volume":"185","author":[{"given":"Michele A","family":"Gatheridge","sequence":"first","affiliation":[{"name":"United States Air Force Academy, 10th Medical Group, 4102 Pinion Dr., USAF Academy, CO 80840"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsa A","family":"Sholty","sequence":"additional","affiliation":[{"name":"United States Air Force Academy, 10th Medical Group, 4102 Pinion Dr., USAF Academy, CO 80840"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Inman","sequence":"additional","affiliation":[{"name":"United States Air Force Academy, 10th Medical Group, 4102 Pinion Dr., USAF Academy, CO 80840"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghan","family":"Pattillo","sequence":"additional","affiliation":[{"name":"Department of Mathematics, United States Air Force Academy, 2354 Fairchild Drive, Suite 6D102, USAF Academy, CO 80840"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Mindrup","sequence":"additional","affiliation":[{"name":"Department of Mathematics, United States Air Force Academy, 2354 Fairchild Drive, Suite 6D102, USAF Academy, CO 80840"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawn L","family":"Sanderson","sequence":"additional","affiliation":[{"name":"Department of Mathematics, United States Air Force Academy, 2354 Fairchild Drive, Suite 6D102, USAF Academy, CO 80840"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,12,30]]},"reference":[{"issue":"2","key":"2020123002504762100_ref1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1001\/jama.282.2.153","article-title":"Prevalence of carpal tunnel syndrome in a general population","volume":"282","author":"Atroshi","year":"1999","journal-title":"JAMA"},{"issue":"12","key":"2020123002504762100_ref2","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1136\/jnnp.74.12.1674","article-title":"Clinical surveillance of carpal tunnel syndrome in two areas of the United Kingdom","volume":"74","author":"Bland","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"8","key":"2020123002504762100_ref3","first-page":"952","article-title":"Carpal tunnel syndrome","volume":"83","author":"LeBlanc","year":"2011","journal-title":"Am Fam Physician"},{"issue":"2","key":"2020123002504762100_ref4","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s10926-006-9026-3","article-title":"Evaluation of work-related carpal tunnel syndrome","volume":"16","author":"Werner","year":"2006","journal-title":"J Occup Rehabil"},{"issue":"7","key":"2020123002504762100_ref5","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1136\/oem.54.7.519","article-title":"Carpal tunnel syndrome: what is attributable to work? 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