{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T02:22:48Z","timestamp":1751336568978},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,25]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Zika virus (ZIKV) is a mild febrile illness generally transmitted via the bite of infected Aedes species mosquitoes, including Aedes aegypti, with the potential to cause neurological complications. Nearly 200 U.S. military installations are located within areas where Aedes mosquitos are found, putting thousands of personnel at risk for infection with ZIKV. This analysis aims to quantify the benefits of interventions, including vaccination, to decrease the risk of ZIKV on U.S. military installations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The authors developed a dynamic transmission model to test the \u201ceffectiveness\u201d of vaccination, personal protective measures (PPM), and mosquito control at reducing morbidity within U.S. military populations. ZIKV transmission was modeled as a compartmental susceptible-exposed-infected-recovered model tracking interactions between humans and mosquitos and incorporating seasonality of mosquito populations and the potential for herd immunity. The model included two-dose vaccination as well as symptomatic and asymptomatic infection. The model was calibrated against 2016 public health data in Puerto Rico; sensitivity analyses were performed on model parameters and interventions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The greatest reduction in total modeled ZIKV cases resulted from vaccination combined with mosquito control and PPM. All three interventions at their highest estimated level of efficiency reduced ZIKV cases by 99.9% over the baseline case of low-level adherence to PPM. The addition of vaccination had limited additional benefit over effective vector control and PPM since the significant lag to vaccine-induced protection limited effectiveness of vaccination.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Given the current vaccine, the model predicted that up to 92.8% of Zika cases occurring in deployment settings over a 10-year period could be prevented by adding vaccination to current low-level PPM. Combining vaccination with other interventions can reduce cases further. A location-specific cost-benefit analysis would be a valuable contribution to outbreak control policy as it could evaluate the economic impact of the interventions versus the reduced level of illness and downtime in this setting.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/milmed\/usaa340","type":"journal-article","created":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T01:52:42Z","timestamp":1611625962000},"page":"82-90","source":"Crossref","is-referenced-by-count":2,"title":["Modeling Zika Vaccination Combined With Vector Interventions in DoD Populations"],"prefix":"10.1093","volume":"186","author":[{"given":"Colleen","family":"Burgess","sequence":"first","affiliation":[{"name":"Ramboll US Corporation, Amherst, MA 01002, USA"},{"name":"MathEcology LLC, Health Sciences practice area, Phoenix, AZ 85086, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lis","family":"Nelis","sequence":"additional","affiliation":[{"name":"Ramboll US Corporation, Ecosystem Services practice area, Seattle, Washington 98164, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassie","family":"Huang","sequence":"additional","affiliation":[{"name":"Ramboll US Corporation, Health Sciences practice area, Boston, MA 02108, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,1,25]]},"reference":[{"issue":"16","key":"2021012914151545100_R1","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1056\/NEJMra1602113","article-title":"Zika virus","volume":"374","author":"Petersen","year":"2016","journal-title":"N Engl J Med"},{"key":"2021012914151545100_R2","article-title":"Zika Virus","author":"U.S. Centers for Disease Control and Prevention"},{"key":"2021012914151545100_R3","article-title":"Zika Virus Fact Sheet","author":"World Health 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Zika Virus Information for Department of Defense Medical Personnel. 2016","author":"Department of Defense Health Affairs Assistant Secretary of Defense"},{"issue":"12","key":"2021012914151545100_R23","first-page":"7","article-title":"Zika virus infections in Military Health System beneficiaries since the introduction of the virus in the Western Hemisphere, 1 January 2016 through 30 November 2016","volume":"23","author":"Poss","year":"2016","journal-title":"MSMR"},{"issue":"5","key":"2021012914151545100_R24","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1007\/s00436-016-4971-z","article-title":"Declining malaria, rising of dengue and Zika virus: insights for mosquito vector control","volume":"115","author":"Benelli","year":"2016","journal-title":"Parasitol Res"},{"key":"2021012914151545100_R25","article-title":"Vector Control Operations Framework for Zika Virus","author":"World Health Organization","year":"2016"},{"issue":"10020","key":"2021012914151545100_R26","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(16)00390-1","article-title":"WHO reveals its shopping list for weapons against Zika","volume":"387","author":"Maurice","year":"2016","journal-title":"Lancet"},{"key":"2021012914151545100_R27","article-title":"Zika Virus Vaccines","author":"National Institutes of Allergy and Infectious Diseases","year":"2018"},{"issue":"10120","key":"2021012914151545100_R28","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0140-6736(17)33106-9","article-title":"Preliminary aggregate safety and immunogenicity results from three trials of a purified inacti-vated Zika virus vaccine candidate: phase 1, randomised, double-blind, placebo-controlled clinical trials","volume":"391","author":"Modjarrad","year":"2018","journal-title":"Lancet"},{"issue":"2","key":"2021012914151545100_R29","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/s41591-019-0746-2","article-title":"Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor","volume":"26","author":"Dussupt","year":"2020","journal-title":"Nature Med"},{"key":"2021012914151545100_R30","volume-title":"Zika Suspected and Confirmed Cases Reported by Countries and Territories in the Americas Cumulative Cases, 2015-2017","author":"Pan American Health Organization\/World Health Organization","year":"2017"}],"container-title":["Military Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/milmed\/article-pdf\/186\/Supplement_1\/82\/36145366\/usaa340.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/milmed\/article-pdf\/186\/Supplement_1\/82\/36145366\/usaa340.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T14:16:36Z","timestamp":1611929796000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/milmed\/article\/186\/Supplement_1\/82\/6119465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,1]]},"references-count":30,"journal-issue":{"issue":"Supplement_1","published-online":{"date-parts":[[2021,1,25]]},"published-print":{"date-parts":[[2021,1,25]]}},"URL":"https:\/\/doi.org\/10.1093\/milmed\/usaa340","relation":{},"ISSN":["0026-4075","1930-613X"],"issn-type":[{"value":"0026-4075","type":"print"},{"value":"1930-613X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,1,1]]},"published":{"date-parts":[[2021,1,1]]}}}