{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:54:48Z","timestamp":1790391288562,"version":"4.1.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T00:00:00Z","timestamp":1611532800000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000006","name":"Office of Naval Research","doi-asserted-by":"publisher","award":["N00014-13-C-0063"],"award-info":[{"award-number":["N00014-13-C-0063"]}],"id":[{"id":"10.13039\/100000006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,25]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Military operations often involve intense exposure to stressors combined with acute sleep deprivation, while military personnel also experience high prevalence of chronic sleep deficiency from insomnia and other sleep disorders. However, the impact of acute and chronic sleep deficiency on physiologic stressor responses is poorly understood. In a controlled laboratory study with normal sleepers and individuals with chronic sleep-onset insomnia, we measured responses to an acute stressor administered in a sleep deprivation condition or a control condition.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Twenty-two adults (aged 22-40 years; 16 females)\u201411 healthy normal sleepers and 11 individuals with sleep-onset insomnia\u2014completed a 5-day (4-night) in-laboratory study. After an adaptation day and a baseline day, subjects were assigned to a 38-hour total sleep deprivation (TSD) condition or a control condition; the study ended with a recovery day. At 8:00 PM after 36 hours awake in the sleep deprivation condition or 12 hours awake in the control condition, subjects underwent a Maastricht Acute Stress Test (MAST). Salivary cortisol was measured immediately before the MAST at 8:00 PM, every 15 minutes after the MAST from 8:15 PM until 9:15 PM, and 30 minutes later at 9:45 PM. Baseline salivary cortisol was collected in the evening of the baseline day. Additionally, before and immediately upon completion of the MAST, self-report ratings of affect and pain were collected.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The MAST elicited a stressor response in both normal sleepers and individuals with sleep-onset insomnia, regardless of the condition, as evidenced by increases in negative affect and pain ratings. Relative to baseline, cortisol levels increased immediately following the MAST, peaked 30 minutes later, and then gradually returned to pre-MAST levels. At the cortisol peak, there was a significant difference across groups and conditions, reflecting a pronounced blunting of the cortisol response in the normal sleepers in the TSD condition and the sleep-onset insomnia group in both the TSD and control conditions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Blunted stressor reactivity as a result of sleep deficiency, whether acute or chronic, may reflect reduced resiliency attributable to allostatic load and may put warfighters at increased risk in high-stakes, rapid response scenarios.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/milmed\/usaa464","type":"journal-article","created":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T01:53:10Z","timestamp":1611625990000},"page":"246-252","source":"Crossref","is-referenced-by-count":28,"title":["Sleep Deprivation and Sleep-Onset Insomnia are Associated with Blunted Physiological Reactivity to Stressors"],"prefix":"10.1093","volume":"186","author":[{"suffix":"PhD","given":"Devon A","family":"Hansen","sequence":"first","affiliation":[{"name":"Sleep and Performance Research Center and Elson S. Floyd College of Medicine, Washington State University , Spokane, WA 99202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"PhD","given":"Brieann C","family":"Satterfield","sequence":"additional","affiliation":[{"name":"Sleep and Performance Research Center and Elson S. Floyd College of Medicine, Washington State University , Spokane, WA 99202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"MD, PhD","given":"Matthew E","family":"Layton","sequence":"additional","affiliation":[{"name":"Sleep and Performance Research Center and Elson S. Floyd College of Medicine, Washington State University , Spokane, WA 99202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"PhD","given":"Hans P A","family":"Van Dongen","sequence":"additional","affiliation":[{"name":"Sleep and Performance Research Center and Elson S. 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