{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T21:10:09Z","timestamp":1721423409568},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"1-2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,30]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The novel human coronavirus of 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has quickly swept throughout the entire world. As the ongoing pandemic has spread, recent studies have described children presenting with a multisystem inflammatory disorder sharing the features of Kawasaki disease (KD) and toxic shock syndrome, now named Multisystem Inflammatory Syndrome in Children (MIS-C). These cases report a similar phenotype of prolonged fever, multisystem involvement, and biomarkers demonstrating marked hyperinflammation that occurs temporally in association with local community spread of SARS-CoV-2. Herein, we describe the presentation, clinical characteristics, and management of an 11-year-old boy with prolonged fever, strikingly elevated inflammatory markers, and profound, early coronary artery aneurysm consistent with a hyperinflammatory, multisystem disease temporally associated with coronavirus disease 2019. We highlight our multidisciplinary team\u2019s management with intravenous immunoglobulin, methylprednisolone, and an interleukin-1 receptor antagonist, anakinra, as a strategy to manage this multisystem, hyperinflammatory disease process.<\/jats:p>","DOI":"10.1093\/milmed\/usaa508","type":"journal-article","created":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T04:32:34Z","timestamp":1607315554000},"page":"e270-e276","source":"Crossref","is-referenced-by-count":6,"title":["Multisystem Inflammatory Syndrome in Children during the COVID-19 Pandemic: A Case Report on Managing the Hyperinflammation"],"prefix":"10.1093","volume":"186","author":[{"given":"Blake T","family":"Cirks","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD 20889, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer C","family":"Geracht","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD 20889, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olcay Y","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD 20889, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph W","family":"May","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD 20889, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia P","family":"Mikita","sequence":"additional","affiliation":[{"name":"Department of Allergy\/Immunology, Walter Reed National Military Medical Center, Bethesda, MD 20889, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Rajnik","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison M","family":"Helfrich","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD 20889, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,1,30]]},"reference":[{"issue":"6","key":"2021013015161913800_R1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2020-0702","article-title":"Epidemiology of COVID-19 among children in China","volume":"145","author":"Dong","year":"2020","journal-title":"Pediatrics"},{"issue":"5","key":"2021013015161913800_R2","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1097\/INF.0000000000002660","article-title":"Coronavirus infections in children including COVID-19: an overview of the epidemiology, clinical features, diagnosis, treatment and prevention options in children","volume":"39","author":"Zimmermann","year":"2020","journal-title":"Pediatr Infect Dis J"},{"key":"2021013015161913800_R3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2020.104425","article-title":"Coronavirus disease 2019 in children: characteristics, antimicrobial treatment, and outcomes","volume":"128","author":"Peng","year":"2020","journal-title":"J Clin Virol"},{"issue":"10239","key":"2021013015161913800_R4","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1016\/S0140-6736(20)31103-X","article-title":"An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study","volume":"395","author":"Verdoni","year":"2020","journal-title":"Lancet"},{"issue":"5","key":"2021013015161913800_R5","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1161\/CIRCULATIONAHA.120.048360","article-title":"Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic","volume":"142","author":"Belhadjer","year":"2020","journal-title":"Circulation"},{"issue":"8","key":"2021013015161913800_R6","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s13312-020-1924-5","article-title":"Novel coronavirus mimicking Kawasaki disease in an infant. 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