{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T04:40:46Z","timestamp":1784004046886,"version":"3.55.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"7-8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Evidence from military populations showed that resuscitation using whole blood (WB), as opposed to component therapies, may provide additional survival benefits to traumatically injured patients. However, there is a paucity of data available for the use of WB in uninjured patients requiring transfusion. We sought to describe the use of WB in non-trauma patients at Brooke Army Medical Center (BAMC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Between January and December 2019, the BAMC ClinComp electronic medical record system was reviewed for all patients admitted to the hospital who received at least one unit of WB during this time period. Patients were sorted based on their primary admission diagnosis. Patients with a primary trauma-based admission were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred patients were identified who received at least one unit of WB with a primary non-trauma admission diagnosis. Patients, on average, received 1,064\u2009mL (750\u20132,458\u2009mL) of WB but received higher volumes of component therapy. Obstetric\/gynecologic (OBGYN) indications represented the largest percentage of non-trauma patients who received WB (23%), followed by hematologic\/oncologic indications (16%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this retrospective study, WB was most commonly used for OBGYN-associated bleeding. As WB becomes more widespread across the USA for use in traumatically injured patients, it is likely that WB will be more commonly used for non-trauma patients. More outcome data are required to safely expand the indications for WB use beyond trauma.<\/jats:p><\/jats:sec>","DOI":"10.1093\/milmed\/usab128","type":"journal-article","created":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T03:01:02Z","timestamp":1618628462000},"page":"e821-e825","source":"Crossref","is-referenced-by-count":18,"title":["The Use of Whole Blood Transfusion During Non-Traumatic Resuscitation"],"prefix":"10.1093","volume":"187","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7742-749X","authenticated-orcid":false,"given":"Craig D","family":"Nowadly","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Brooke Army Medical Center, JBSA Fort Sam Houston , San Antonio, TX 78234, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1994-7774","authenticated-orcid":false,"given":"Andrew D","family":"Fisher","sequence":"additional","affiliation":[{"name":"Medical Command, Texas Army National Guard , Austin, TX 78703, USA"},{"name":"Department of Surgery, UNM School of Medicine , Albuquerque, NM 87131, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A","family":"Borgman","sequence":"additional","affiliation":[{"name":"Department of pediatric, Brooke Army Medical Center , JBSA Fort Sam Houston, San Antonio, TX, USA"},{"name":"Uniformed Services Univeristy of the Health Sciences , Bethesda, Maryland 20814, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kennedy S","family":"Mdaki","sequence":"additional","affiliation":[{"name":"United States Army Institute of Surgical Research, JBSA Fort Sam Houston , San Antonio, TX 78234, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronnie L","family":"Hill","sequence":"additional","affiliation":[{"name":"United States Army Institute of Surgical Research, JBSA Fort Sam Houston , San Antonio, TX 78234, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susannah E","family":"Nicholson","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Texas Health Science Center , San Antonio, TX 78229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A","family":"Bynum","sequence":"additional","affiliation":[{"name":"United States Army Institute of Surgical Research, JBSA Fort Sam Houston , San Antonio, TX 78234, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2322-5216","authenticated-orcid":false,"given":"Steven G","family":"Schauer","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Brooke Army Medical Center, JBSA Fort Sam Houston , San Antonio, TX 78234, USA"},{"name":"Uniformed Services Univeristy of the Health Sciences , Bethesda, Maryland 20814, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,4,15]]},"reference":[{"issue":"2","key":"2022070112164979400_R1","first-page":"307","article-title":"Damage control resuscitation: directly addressing the early coagulopathy of trauma","volume":"62","author":"Holcomb","year":"2007","journal-title":"J Trauma"},{"issue":"1","key":"2022070112164979400_R2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.55460\/OTXQ-H2DO","article-title":"Slow and Risky to Safe and Briskly: Modern Implementation of Whole Blood","volume":"20","author":"Fisher","year":"2020","journal-title":"J Spec Oper Med"},{"issue":"Suppl 2","key":"2022070112164979400_R3","doi-asserted-by":"crossref","first-page":"S190","DOI":"10.1111\/trf.13491","article-title":"Whole blood for hemostatic resuscitation of major bleeding","volume":"56","author":"Spinella","year":"2016","journal-title":"Transfusion"},{"issue":"3","key":"2022070112164979400_R4","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/trf.15086","article-title":"The use of whole blood in US military operations in Iraq, Syria, and Afghanistan since the introduction of low-titer Type O whole blood: feasibility, acceptability, challenges","volume":"59","author":"Vanderspurt","year":"2019","journal-title":"Transfusion"},{"issue":"4","key":"2022070112164979400_R5","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/SLA.0b013e3182a4ffa0","article-title":"A randomized controlled pilot trial of modified whole blood versus component therapy in severely injured patients requiring large volume transfusions","volume":"258","author":"Cotton","year":"2013","journal-title":"Ann Surg"},{"issue":"8","key":"2022070112164979400_R6","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1111\/trf.14779","article-title":"Clinical outcomes among low-titer group O whole blood recipients compared to recipients of conventional components in civilian trauma resuscitation","volume":"58","author":"Seheult","year":"2018","journal-title":"Transfusion"},{"issue":"1","key":"2022070112164979400_R7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/TA.0000000000002340","article-title":"Cold-stored whole blood platelet function is preserved in injured children with hemorrhagic shock","volume":"87","author":"Leeper","year":"2019","journal-title":"J Trauma Acute Care Surg"},{"issue":"S2","key":"2022070112164979400_R8","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1111\/trf.15264","article-title":"Give the trauma patient what they bleed, when and where they need it: establishing a comprehensive regional system of resuscitation based on patient need utilizing cold-stored, low-titer O+ whole blood","volume":"59","author":"Zhu","year":"2019","journal-title":"Transfusion"},{"issue":"5","key":"2022070112164979400_R9","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1001\/jamapediatrics.2017.5238","article-title":"Use of uncrossmatched cold-stored whole blood in injured children with hemorrhagic shock","volume":"172","author":"Leeper","year":"2018","journal-title":"JAMA Pediatr"},{"issue":"Suppl 3","key":"2022070112164979400_R10","first-page":"S2","article-title":"The use of low-titer group O whole blood is independently associated with improved survival compared to component therapy in adults with severe traumatic hemorrhage","volume":"60","author":"Shea","year":"2020","journal-title":"Transfusion"},{"issue":"4","key":"2022070112164979400_R11","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1097\/SLA.0000000000004378","article-title":"Whole blood is superior to component transfusion for injured children: a propensity matched analysis","volume":"272","author":"Leeper","year":"2020","journal-title":"Ann Surg"},{"key":"2022070112164979400_R12","volume-title":"StatPearls","author":"Hooper","year":"2020"},{"issue":"6","key":"2022070112164979400_R13","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1097\/AOG.0b013e3181a4b390","article-title":"Whole blood in the management of hypovolemia due to obstetric hemorrhage","volume":"113","author":"Alexander","year":"2009","journal-title":"Obstet Gynecol"},{"issue":"4","key":"2022070112164979400_R14","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1080\/10903127.2019.1671562","article-title":"Prehospital transfusion of low-titer O + whole blood for severe maternal hemorrhage: a case report","volume":"24","author":"Newberry","year":"2020","journal-title":"Prehosp Emerg Care"},{"issue":"5","key":"2022070112164979400_R15","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1365-2044.1975.tb00920.x","article-title":"Gastro-intestinal haemorrhage from peptic ulcer. An evaluation of bloodless transfusion and early surgery","volume":"30","author":"Alexiu","year":"1975","journal-title":"Anaesthesia"},{"issue":"1","key":"2022070112164979400_R16","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4103\/GJTM.GJTM_6_18","article-title":"Massive blood transfusion: a case report of transfusion of 70 units of blood and blood products in 24 hours","volume":"3","author":"Jain","year":"2018","journal-title":"Glob J Transfus Med"},{"issue":"3","key":"2022070112164979400_R17","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1051\/ject\/200739168","article-title":"Are there benefits to a fresh whole blood vs. packed red blood cell cardiopulmonary bypass prime on outcomes in neonatal and pediatric cardiac surgery?","volume":"39","author":"Valleley","year":"2007","journal-title":"J Extra Corpor Technol"},{"issue":"5","key":"2022070112164979400_R18","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1097\/SCS.0000000000003594","article-title":"Whole blood in pediatric craniofacial reconstruction surgery","volume":"28","author":"Thottathil","year":"2017","journal-title":"J Craniofac Surg"},{"issue":"Suppl 1","key":"2022070112164979400_R19","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/bja\/aep303","article-title":"Maternal haemorrhage","volume":"103","author":"Walfish","year":"2009","journal-title":"Br J Anaesth"},{"issue":"2","key":"2022070112164979400_R20","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1053\/j.semperi.2009.01.002","article-title":"Transfusion therapy in postpartum hemorrhage","volume":"33","author":"Padmanabhan","year":"2009","journal-title":"Semin Perinatol"},{"key":"2022070112164979400_R21","volume-title":"Technical Manual","author":"AABB","year":"2020","edition":"20th"},{"issue":"Suppl_2","key":"2022070112164979400_R22","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1093\/milmed\/usy112","article-title":"Damage control resuscitation","volume":"183","author":"Cap","year":"2018","journal-title":"Mil Med"},{"key":"2022070112164979400_R23","article-title":"TERUFLEX\u00ae blood bag system with CPD\/OPTISOL\u00ae","author":"Terumo Corporation"},{"issue":"3","key":"2022070112164979400_R24","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1213\/ANE.0000000000002312","article-title":"Abnormal calcium levels during trauma resuscitation are associated with increased mortality, increased blood product use, and greater hospital resource consumption: a pilot investigation","volume":"125","author":"MacKay","year":"2017","journal-title":"Anesth Analg"},{"issue":"8","key":"2022070112164979400_R25","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1136\/emermed-2015-205096","article-title":"Ionised calcium levels in major trauma patients who received blood in the emergency department","volume":"33","author":"Webster","year":"2016","journal-title":"Emerg Med J"},{"issue":"3","key":"2022070112164979400_R26","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1136\/emermed-2017-206717","article-title":"Ionised calcium levels in major trauma patients who received blood en route to a military medical treatment facility","volume":"35","author":"Kyle","year":"2018","journal-title":"Emerg Med J"}],"container-title":["Military Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/milmed\/article-pdf\/187\/7-8\/e821\/44369548\/usab128.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/milmed\/article-pdf\/187\/7-8\/e821\/44369548\/usab128.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T07:25:59Z","timestamp":1698909959000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/milmed\/article\/187\/7-8\/e821\/6226714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,15]]},"references-count":26,"journal-issue":{"issue":"7-8","published-online":{"date-parts":[[2021,4,15]]},"published-print":{"date-parts":[[2022,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/milmed\/usab128","relation":{},"ISSN":["0026-4075","1930-613X"],"issn-type":[{"value":"0026-4075","type":"print"},{"value":"1930-613X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,7,1]]},"published":{"date-parts":[[2021,4,15]]}}}