{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:22:07Z","timestamp":1768292527043,"version":"3.49.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"11-12","license":[{"start":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T00:00:00Z","timestamp":1617753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>We describe a patient with subclinical coccidioidomycosis who experienced rapid disease dissemination shortly after SARS-CoV-2 infection, suggesting host immune response dysregulation to coccidioidomycosis by SARS-CoV-2. We hypothesize that disrupted cell-mediated signaling may result after SARS-CoV-2 infection leading to functional exhaustion and CD8+ T-cell senescence with impairment in host cellular response to Coccidioides infection.<\/jats:p>","DOI":"10.1093\/milmed\/usab132","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T22:07:49Z","timestamp":1617833269000},"page":"1254-1256","source":"Crossref","is-referenced-by-count":20,"title":["Accelerated Progression of Disseminated Coccidioidomycosis Following SARS-CoV-2 Infection: A Case Report"],"prefix":"10.1093","volume":"186","author":[{"given":"Daniel S","family":"Krauth","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Naval Medical Center, San Diego, CA 92134, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina M","family":"Jamros","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Naval Medical Center, San Diego, CA 92134, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shayna C","family":"Rivard","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, US Naval Hospital, Tutuhan, GU 96910, USA"},{"name":"Department of Dermatology, US Naval Hospital, Tutuhan, GU 96910, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels H","family":"Olson","sequence":"additional","affiliation":[{"name":"Department of Pathology, US Naval Hospital, Tutuhan, GU 96910, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan C","family":"Maves","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Naval Medical Center, San Diego, CA 92134, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,4,7]]},"reference":[{"issue":"1","key":"2021110307350243200_R1","first-page":"185","article-title":"Coccidioidomycosis: epidemiology","volume":"5","author":"Brown","year":"2013","journal-title":"Clin Epidemiol"},{"issue":"12","key":"2021110307350243200_R2","first-page":"2","article-title":"Pulmonary and extrapulmonary cocciodioidomycosis, active component, U.S. Armed Forces, 1999\u20132011","volume":"19","author":"Mease","year":"2012","journal-title":"MSMR"},{"issue":"9","key":"2021110307350243200_R3","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1086\/502972","article-title":"Both CD4+ and CD8+ T cells can mediate vaccine-induced protection against coccidioides immitis infection in mice","volume":"193","author":"Fierer","year":"2006","journal-title":"J Infect Dis"},{"key":"2021110307350243200_R4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinf.2011.07.006","article-title":"Two cases illustrating successful adjunctive interferon-\u03b3 immunotherapy in refractory disseminated coccidioidomycosis","author":"Duplessis","year":"2011","journal-title":"J Infect"},{"issue":"6","key":"2021110307350243200_R5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1086\/605532","article-title":"Refractory disseminated coccidioidomycosis and mycobacteriosis in interferon-\u03b3 receptor 1 deficiency","volume":"49","author":"Vinh","year":"2009","journal-title":"Clin Infect Dis"},{"key":"2021110307350243200_R6","doi-asserted-by":"crossref","DOI":"10.1172\/JCI58762","article-title":"Protective antifungal memory CD8 + T cells are maintained in the absence of CD4 + T cell help and cognate antigen in mice","author":"Nanjappa","year":"2012","journal-title":"J Clin Invest"},{"issue":"7","key":"2021110307350243200_R7","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102567","article-title":"Should we stimulate or suppress immune responses in COVID-19? 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