{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T05:30:12Z","timestamp":1744349412830,"version":"3.37.3"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"3-4","license":[{"start":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T00:00:00Z","timestamp":1621123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,20]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>We report two cases of Brazilian patients (a 22-year-old male and a 48-year-old male) with ischemic stroke, whose arterial vascular study and echocardiographic investigation did not reveal any steno-occlusive arterial disease or typical cardioembolic finding, such as atrial fibrillation or myocardial dysfunction. A transcranial Doppler ultrasound and a transesophageal echocardiogram showed a patent foramen ovale (PFO), and the laboratory screening for coagulation abnormalities showed heterozygosity for MTHFR C677T and A1298C in one of the patients and heterozygosity for factor V Leiden gene mutations in the other patient. The significance of the association of PFO with Methylenetetrahydrofolate (MTHFR) C677T and A1298C variants or factor V Leiden mutation is discussed as a possible cause of ischemic stroke through paradoxical embolism from a venous source. There is a high prevalence of these two mentioned conditions in the general population, so we discuss two cases in which indication for anticoagulant therapy or percutaneous closure of PFO prevails.<\/jats:p>","DOI":"10.1093\/milmed\/usab192","type":"journal-article","created":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T14:18:51Z","timestamp":1621174731000},"page":"e885-e889","source":"Crossref","is-referenced-by-count":4,"title":["Stroke in Young Military Men With Heterozygous for MTHFR Gene Mutation or Factor V Leiden Gene Mutation Associated With Patent Foramen Ovale: Report of Two Cases and Therapeutic Strategy"],"prefix":"10.1093","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7153-3523","authenticated-orcid":false,"given":"Rodrigo Tavares","family":"Brisson","sequence":"first","affiliation":[{"name":"Division of Neurology, Hospital Naval Marc\u00edlio Dias , Rio de Janeiro, Rio de Janeiro 20725-090, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josev\u00e2nia Fulg\u00eancio de Lima","family":"Arruda","sequence":"additional","affiliation":[{"name":"Division of Neurology, Hospital Naval Marc\u00edlio Dias , Rio de Janeiro, Rio de Janeiro 20725-090, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9472-4752","authenticated-orcid":false,"given":"Liene Duarte","family":"Silva","sequence":"additional","affiliation":[{"name":"Division of Neurology, Hospital Naval Marc\u00edlio Dias , Rio de Janeiro, Rio de Janeiro 20725-090, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilermando Leal J\u00fanio","family":"de Jesus","sequence":"additional","affiliation":[{"name":"Division of Neurology, Hospital Naval Marc\u00edlio Dias , Rio de Janeiro, Rio de Janeiro 20725-090, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8464-9488","authenticated-orcid":false,"given":"Viviane Flumignan","family":"Zetola","sequence":"additional","affiliation":[{"name":"Neurosonology Laboratory, Cerebrovascular Disease Unit, Federal University of Paran\u00e1 , Curitiba, Paran\u00e1 80060-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcia Aparecida Camacho","family":"Kauffmann Nogueira","sequence":"additional","affiliation":[{"name":"Division of Neurology, Hospital Naval Marc\u00edlio Dias , Rio de Janeiro, Rio de Janeiro 20725-090, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,5,16]]},"reference":[{"issue":"1","key":"2023033100393445200_","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1161\/01.STR.24.1.35","article-title":"Classification of subtype of acute ischemic stroke. 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