{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T11:55:29Z","timestamp":1788609329381,"version":"build-2803163510"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"3-4","license":[{"start":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T00:00:00Z","timestamp":1623974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,28]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Prehospital cardiopulmonary resuscitation has commonly been considered ineffective in traumatic cardiopulmonary arrest because traditional chest compressions do not produce substantial cardiac output. However, recent evidence suggests that chest compressions located over the left ventricle (LV) produce greater hemodynamics when compared to traditional compressions. We hypothesized that chest compressions located directly over the LV would result in an increase in return of spontaneous circulation (ROSC) and hemodynamic variables, when compared to traditional chest compressions, in a swine model of traumatic pulseless electrical activity (PEA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Transthoracic echocardiography was used to mark the location of the aortic root (traditional compressions) and the center of the LV on animals (n\u2009=\u200934) that were randomized to receive chest compressions in one of the two locations. Animals were hemorrhaged to mean arterial pressure\u2009&amp;lt;20 to simulate traumatic PEA. After 5\u2009minutes of PEA, basic life support (BLS) with mechanical cardiopulmonary resuscitation was initiated and performed for 10\u2009minutes followed by advanced life support for an additional 10\u2009minutes. Hemodynamic variables were averaged over the final 2\u2009minutes of BLS and advanced life support periods.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Six of the LV group (35%) achieved ROSC compared to eight of the traditional group (47%) (P\u2009=\u2009.73). There was an increase in aortic systolic blood pressure (P\u2009&amp;lt;\u2009.01), right atrial systolic blood pressure (P\u2009&amp;lt;\u2009.01), and right atrial diastolic blood pressure (P\u2009=\u2009.02) at the end of BLS in the LV group compared to the traditional group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In our swine model of traumatic PEA, chest compressions performed directly over the LV improved blood pressures during BLS but not ROSC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/milmed\/usab229","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T15:28:26Z","timestamp":1624030106000},"page":"351-359","source":"Crossref","is-referenced-by-count":5,"title":["Effects of Left Ventricular Versus Traditional Chest Compressions in a Traumatic Pulseless Electrical Activity Model"],"prefix":"10.1093","volume":"187","author":[{"given":"Kenton L","family":"Anderson","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Stanford University School of Medicine, Palo Alto, CA 94304, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline C","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, San Antonio Military Medical Center, Fort Sam Houston, TX 78234, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria G","family":"Castaneda","sequence":"additional","affiliation":[{"name":"Wilford Hall Ambulatory Surgical Center, CREST Research Program, Lackland AFB, TX 78236, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M","family":"Boudreau","sequence":"additional","affiliation":[{"name":"Wilford Hall Ambulatory Surgical Center, CREST Research Program, Lackland AFB, TX 78236, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph K","family":"Maddry","sequence":"additional","affiliation":[{"name":"United States Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, San Antonio Military Medical Center, Fort Sam Houston, TX 78234, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,6,18]]},"reference":[{"issue":"4","key":"2022050519080696400_R1","first-page":"78","article-title":"Injury prevention, violence prevention, and trauma care: building the scientific base","volume":"60","author":"Sleet","year":"2011","journal-title":"MMWR 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