{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:13:44Z","timestamp":1778742824134,"version":"3.51.4"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"5-6","license":[{"start":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T00:00:00Z","timestamp":1635206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"French Armed Force Health Services"},{"name":"University Hospital Institut Mediterrane Infection"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,16]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Antibiotics are growth promotors used in animal farming. Doxycycline (DOXY) is a tetracycline antibiotic taken daily and continued 1\u00a0month after return to protect against malaria during travel and deployment in endemic areas. We evaluated DOXY impact on body weight in military international travelers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materiel and Methods<\/jats:title><jats:p>A prospective cohort analysis was conducted in 2016-2018, recruiting 170 French soldiers before a 4-month assignment overseas. Many clinical data including anthropometric measures by an investigator were collected before and after deployment. Weight gain was defined by an increase of 2% from baseline. The study protocol was supported by the French Armed Forces Health Services and approved by the French ethics committee (IRB no. 2015\u2013A01961\u201348, ref promoter 2015RC0). Written, informed consent was obtained with signature from each volunteer before inclusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After deployment, 84 soldiers were followed up. Overall, 38\/84 (45%) were deployed to Mali with DOXY malaria prophylaxis, and others were deployed to Iraq or Lebanon without malaria prophylaxis according to international recommendations. Body weight increased in 24\/84 (30%), of whom 14\/24 (58%) were exposed to DOXY. In bivariate analysis, DOXY had a positive but not significant effect on weight gain (P-value\u2009=\u2009.4). In the final logistic regression model (Fig. 3), weight gain after deployment positively correlated with an increase in waist circumference (odds ratio [OR] 1.23 with 95% CI [1.06-1.47]) suggesting fat gain; with sedentary work (OR 5.34; 95% CI [1.07-31.90]); and with probiotic intake (OR 5.27; 95% CI [1.51-20.40]). Weight impact of probiotics was more important when associated with DOXY intake (OR 6.86; 95% CI [1.52-38.1]; P-value\u2009=\u2009.016).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Doxycycline (DOXY) malaria prophylaxis during several months did not cause significant weight gain in soldiers. Further studies are required in older and less sportive traveling populations, and to investigate a cumulative effect over time and recurrent DOXY exposure. Doxycycline (DOXY) may enhance other growth-promoting factors including fatty food, sedentariness, and strain-specific probiotics contained in fermented dairy products which are also used as growth promotors.<\/jats:p><\/jats:sec>","DOI":"10.1093\/milmed\/usab434","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T04:34:21Z","timestamp":1635222861000},"page":"e1084-e1093","source":"Crossref","is-referenced-by-count":1,"title":["Clinical and Epidemiological Changes in French Soldiers After Deployment: Impact of Doxycycline Malaria Prophylaxis on Body Weight"],"prefix":"10.1093","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3760-3537","authenticated-orcid":false,"given":"Emilie","family":"Javelle","sequence":"first","affiliation":[{"name":"Infectious Diseases and Tropical Diseases unit, Laveran Military Teaching Hospital , Marseille 13013, France"},{"name":"IRD, AP-HM, SSA, VITROME, Aix-Marseille University , Marseille 13385, France"},{"name":"IHU-M\u00e9diterran\u00e9e Infection , Marseille 13005, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aur\u00e9lie","family":"Mayet","sequence":"additional","affiliation":[{"name":"Centre d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique des Arm\u00e9es (CESPA) , Marseille 13014, France"},{"name":"INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Sant\u00e9 & Traitement de l\u2019Information M\u00e9dicale, SITE SANT\u00c9 TIMONE (QuanTIM\u2014SanteRCom) Facult\u00e9 de M\u00e9decine, Aix-Marseille University , Marseille Cedex 5 13385, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigue S","family":"Allodji","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Team, CESP, Inserm U1018 , Villejuif 94 807, France"},{"name":"UVSQ, Inserm, CESP, Universit\u00e9 Paris-Saclay , Villejuif 94 807, France"},{"name":"Department of Research, Gustave Roussy , 94805, Villejuif, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Marimoutou","sequence":"additional","affiliation":[{"name":"Centre d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique des Arm\u00e9es (CESPA) , Marseille 13014, France"},{"name":"INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Sant\u00e9 & Traitement de l\u2019Information M\u00e9dicale, SITE SANT\u00c9 TIMONE (QuanTIM\u2014SanteRCom) Facult\u00e9 de M\u00e9decine, Aix-Marseille University , Marseille Cedex 5 13385, France"},{"name":"CIC Inserm 1410, CHU de La R\u00e9union, Site Sud , Saint Pierre Cedex 97448, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chrystel","family":"Lavagna","sequence":"additional","affiliation":[{"name":"Centre d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique des Arm\u00e9es (CESPA) , Marseille 13014, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"Desplans","sequence":"additional","affiliation":[{"name":"Centre d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique des Arm\u00e9es (CESPA) , Marseille 13014, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5556-6947","authenticated-orcid":false,"given":"Matthieu","family":"Million","sequence":"additional","affiliation":[{"name":"IHU-M\u00e9diterran\u00e9e Infection , Marseille 13005, France"},{"name":"IRD, AP-HM, SSA, MEPHI, Aix-Marseille University , Marseille 13385, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Raoult","sequence":"additional","affiliation":[{"name":"IHU-M\u00e9diterran\u00e9e Infection , Marseille 13005, France"},{"name":"IRD, AP-HM, SSA, MEPHI, Aix-Marseille University , Marseille 13385, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ga\u00ebtan","family":"Texier","sequence":"additional","affiliation":[{"name":"IRD, AP-HM, SSA, VITROME, Aix-Marseille University , Marseille 13385, France"},{"name":"Centre d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique des Arm\u00e9es (CESPA) , Marseille 13014, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,10,26]]},"reference":[{"issue":"3","key":"2023051613475951600_R1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1001\/jama.2017.7092","article-title":"Associations of weight gain from early to middle adulthood with major health outcomes later in life","volume":"318","author":"Zheng","year":"2017","journal-title":"JAMA"},{"key":"2023051613475951600_R2","article-title":"Pr\u00e9valence du surpoids et de l\u2019ob\u00e9sit\u00e9 au sein des forces arm\u00e9es fran\u00e7aises en 2017. 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