{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:49:05Z","timestamp":1759160945846},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"7-8","license":[{"start":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:00:00Z","timestamp":1641340800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Global Emerging Infectious Disease Surveillance (GEIS) Branch","award":["P0073_20_AF"],"award-info":[{"award-number":["P0073_20_AF"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,22]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>The effective dual antibiotics ceftriaxone (CRO) and azithromycin (AZM) have successfully treated Neisseria gonorrhoeae (GC) infection, however, the CRO- and AZM-resistant strains have been sporadically detected globally and in Thailand. Furthermore, there are no currently antimicrobial susceptibility profiles of the GC isolates obtained from soldiers reported in Thailand. Hence, this is the first study to describe the antimicrobial susceptibility profiles of GC isolates obtained from predominately soldiers who seeking care at Military Camp Hospitals, in Thailand from 2014 to 2020.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and Methods<\/jats:title>\n                  <jats:p>A total of 624 symptomatic gonococcal samples were received from 10 military hospitals during 2014-2020. They were collected from urethral swabs and inoculated into selective media. The suspected GC isolates were subcultured and presumptively identified using conventional microbiology techniques. Antimicrobial susceptibility test was performed by Etest to determine minimal inhibitory concentration (\u03bcg\/mL) against AZM, benzylpenicillin, cefepime, cefixime, ceftriaxone (CRO), ciprofloxacin, spectinomycin, and tetracycline using the criteria outlined in the Clinical and Laboratory Standards Institute guidelines. This study was approved by Institutional Review Board, Royal Thai Army Medical Department under protocol number S036b\/56 and Walter Reed Army Institute of Research, and Silver Spring, MD under protocol number WR #2039.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 624 samples were collected from symptomatic gonococcal infectious patients with 91.5% (571\/624) of samples obtained from soldiers. Of those, 78% (488\/624) were identified as GC and 92% (449\/488) of them were isolated from soldiers. All GC samples collected were susceptible to CRO (first-line treatment) with only one GC isolate identified as non-susceptible to cefepime and three isolates identified as non-susceptible to AZM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The recommended dual treatment of GC infections with CRO and AZM is currently an effective empirical treatment for patients who are seeking care at military hospitals in Thailand. Nevertheless, cefepime is a fourth-generation cephalosporin with documented high activity against GC strains equal to other \u201cthird-generation\u201d cephalosporins such as CRO. Due to the active duty of military personnel, they concerned about the confidentiality and frequently seek treatment at civilian clinics. Additionally, due to the availability of antibiotics over the counter in Thailand, many choose the option to self-medicate without a physician\u2019s prescription. These could be subsequently driven the gradual increase of multidrug-resistant gonococcal strains throughout the country. Thus, the GC surveillance would be needed for further Force Health Protection and public health authorities in response to the drug-resistant GC threats.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/milmed\/usab549","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T17:10:50Z","timestamp":1641402650000},"page":"e1473-e1477","source":"Crossref","is-referenced-by-count":3,"title":["Antimicrobial Susceptibility of <i>Neisseria gonorrhoeae<\/i> in Adult Patients Seeking Care at Military Hospitals in Thailand From 2014 to 2020"],"prefix":"10.1093","volume":"188","author":[{"given":"Maneerat","family":"Somsri","sequence":"first","affiliation":[{"name":"Royal Thai Army, Armed Forces Research Institute of Medical Science (AFRIMS) , Bangkok 10400, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilawan","family":"Oransathid","sequence":"additional","affiliation":[{"name":"Bacterial and Parasitic Diseases Department, Armed Forces Research Institute of Medical Science (AFRIMS) , Bangkok 10400, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Vesely","sequence":"additional","affiliation":[{"name":"Bacterial and Parasitic Diseases Department, Armed Forces Research Institute of Medical Science (AFRIMS) , Bangkok 10400, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariusz","family":"Wojnarski","sequence":"additional","affiliation":[{"name":"Bacterial and Parasitic Diseases Department, Armed Forces Research Institute of Medical Science (AFRIMS) , Bangkok 10400, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samandra","family":"Demons","sequence":"additional","affiliation":[{"name":"Bacterial and Parasitic Diseases Department, Armed Forces Research Institute of Medical Science (AFRIMS) , Bangkok 10400, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norman","family":"Waters","sequence":"additional","affiliation":[{"name":"Bacterial and Parasitic Diseases Department, Armed Forces Research Institute of Medical Science (AFRIMS) , Bangkok 10400, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khunakorn","family":"Kana","sequence":"additional","affiliation":[{"name":"Royal Thai Army, Armed Forces Research Institute of Medical Science (AFRIMS) , Bangkok 10400, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nithinart","family":"Chaitaveep","sequence":"additional","affiliation":[{"name":"Royal Thai Army, Armed Forces Research Institute of Medical Science (AFRIMS) , Bangkok 10400, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thanainit","family":"Chotanaphuti","sequence":"additional","affiliation":[{"name":"Royal Thai Army, Armed Forces Research Institute of Medical Science (AFRIMS) , Bangkok 10400, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woradee","family":"Lurchachaiwong","sequence":"additional","affiliation":[{"name":"Bacterial and Parasitic Diseases Department, Armed Forces Research Institute of Medical Science (AFRIMS) , Bangkok 10400, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,1,5]]},"reference":[{"issue":"5","key":"2023072301085285100_R1","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1071\/SH19023","article-title":"World Health Organization Global Gonococcal Antimicrobial Surveillance Program (WHO GASP): review of new data and evidence to inform international collaborative actions and research efforts","volume":"16","author":"Unemo","year":"2019","journal-title":"Sex Health"},{"key":"2023072301085285100_R2","article-title":"Sexually Transmitted Disease Surveillance","author":"Center for Disease Control and Prevention (CDC)","year":"2019"},{"issue":"10102","key":"2023072301085285100_R3","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/S0140-6736(17)31449-6","article-title":"Effectiveness of a group B outer membrane vesicle meningococcal vaccine against gonorrhoea in New Zealand: a retrospective case-control study","volume":"390","author":"Petousis-Harris","year":"2017","journal-title":"Lancet"},{"issue":"6","key":"2023072301085285100_R4","doi-asserted-by":"crossref","first-page":"928","DOI":"10.3109\/1040841X.2015.1105782","article-title":"Is gonococcal disease preventable? 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