{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:20:31Z","timestamp":1791415231601,"version":"4.3.3"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"9-10","license":[{"start":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T00:00:00Z","timestamp":1650499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"the Major Program of Military Logistics Research Plan","award":["ALB18J001"],"award-info":[{"award-number":["ALB18J001"]}]},{"name":"the 13th Five-year Plan for Key Discipline Construction Project of PLA","award":["A350109"],"award-info":[{"award-number":["A350109"]}]},{"name":"the Program of Beijing Municipal Natural Science Foundation","award":["7204311"],"award-info":[{"award-number":["7204311"]}]},{"DOI":"10.13039\/501100001809","name":"the Program of National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82072169"],"award-info":[{"award-number":["82072169"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,29]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Acute kidney injury (AKI) is a common complication in severe burn patients with poor prognosis and high mortality. Reduced kidney perfusion induced by the decreased effective circulating blood volume after severe burn is a common cause of AKI. Routine intravenous resuscitation (IR) is difficult or delayed in extreme conditions such as war and disaster sites. Peritoneal resuscitation (PR) is a simple, rapid resuscitation strategy via a puncture in the abdominal wall. This study investigated whether PR is a validated resuscitation strategy for AKI after severe burns in rats and explored its mechanisms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and Methods<\/jats:title>\n                  <jats:p>Eighty Sprague\u2013Dawley rats were randomized into four groups: (1) sham group; (2) IR group, which was characterized by the full thickness burn of 50% of the total body surface area received IR immediately post-injury; (3) early PR group, in which rats with the same burn model received PR immediately post-injury; and (4) delayed resuscitation (DR) group, in which rats with the same burn model received no resuscitation within 3-hour post-injury. PR and DR groups animals received IR after 3-hour post-injury. The survival rate, mean arterial pressure, renal histopathology, renal function, indicators of renal injury, and renal hypoxia-inducible factor-1\u03b1 and NADPH oxidase 4 (NOX4) proteins of rats were measured at 3\u2009h, 12\u2009h, and 24\u2009h post-injury.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Compared with rats in the DR group, rats in the PR group had a significantly improved survival rate (100% vs. 58.3% at 24\u2009h, P\u2009=\u20090.0087), an increased mean arterial pressure (92.6\u2009\u00b1\u20096.6 vs. 65.3\u2009\u00b1\u200910.7, 85.1\u2009\u00b1\u20095.7 vs. 61.1\u2009\u00b1\u20096.9, 90.1\u2009\u00b1\u20098.7 vs. 74.9\u2009\u00b1\u20097.4\u2009mmHg, at 3\u2009h, 12\u2009h, and 24\u2009h, P\u2009&amp;lt;\u20090.01), a reduced renal water content rate (51.6%\u2009\u00b1\u20095.0% vs. 70.1%\u2009\u00b1\u20096.8%, 57.6%\u2009\u00b1\u20097.7% vs. 69.5%\u2009\u00b1\u20098.7%, at 12\u2009h and 24\u2009h, P\u2009&amp;lt;\u20090.01), attenuated histopathological damage, reduced serum creatinine expression (36.36\u2009\u00b1\u20094.27 vs. 49.98\u2009\u00b1\u20092.42, 52.29\u2009\u00b1\u20094.31 vs. 71.32\u2009\u00b1\u20095.2, 45.25\u2009\u00b1\u20092.55 vs. 81.15\u2009\u00b1\u20096.44\u2009\u03bcmol\/L, at 3\u2009h, 12\u2009h, and 24\u2009h, P\u2009&amp;lt;\u20090.01) and BUN expression (7.62\u2009\u00b1\u20090.30 vs. 10.80\u2009\u00b1\u20090.58, 8.61\u2009\u00b1\u20090.32 vs. 28.58\u2009\u00b1\u20091.99, 8.09\u2009\u00b1\u20090.99 vs. 20.95\u2009\u00b1\u20091.02\u2009mmol\/L, at 3\u2009h, 12\u2009h, and 24\u2009h, P\u2009&amp;lt;\u20090.01), increased kidney injury markers neutrophil gelatinase-associated lipocalin expression (95.09\u2009\u00b1\u20097.02 vs. 101.75\u2009\u00b1\u20096.23, 146.77\u2009\u00b1\u200911.54 vs. 190.03\u2009\u00b1\u20099.87, 112.79\u2009\u00b1\u200915.8 vs. 194.43\u2009\u00b1\u200911.47\u2009ng\/mL, at 3\u2009h, 12\u2009h, and 24\u2009h, P\u2009&amp;lt;\u20090.01) and cystatin C expression (0.185\u2009\u00b1\u20090.006 vs. 0.197\u2009\u00b1\u20090.006, 0.345\u2009\u00b1\u20090.036 vs. 0.382\u2009\u00b1\u20090.013, 0.297\u2009\u00b1\u20090.012 vs. 0.371\u2009\u00b1\u20090.028\u2009ng\/mL, at 3\u2009h, 12\u2009h, and 24\u2009h, P\u2009&amp;lt;\u20090.01), and reduced renal hypoxia-inducible factor-1\u03b1 and NADPH oxidase 4 protein expression (P\u2009&amp;lt;\u20090.01). There was no significant difference between rats in the PR group and the IR group in the above indicators.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Early PR could protect severe burn injury rats from AKI. It may be an alternative resuscitation strategy in severe burn injury when IR cannot be achieved.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/milmed\/usac112","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T15:54:42Z","timestamp":1650556482000},"page":"2951-2959","source":"Crossref","is-referenced-by-count":2,"title":["Effects and Mechanisms of Peritoneal Resuscitation on Acute Kidney Injury After Severe Burns in Rats"],"prefix":"10.1093","volume":"188","author":[{"given":"Jinglong","family":"Ma","sequence":"first","affiliation":[{"name":"Graduate School, Medical School of Chinese PLA , Beijing 100048, China"},{"name":"Department of Burns and Plastic Surgery, The Fourth Medical Center of Chinese PLA General Hospital , Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Li","sequence":"additional","affiliation":[{"name":"Graduate School, Medical School of Chinese PLA , Beijing 100048, China"},{"name":"Department of Burns and Plastic Surgery, The Fourth Medical Center of Chinese PLA General Hospital , Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxing","family":"Liu","sequence":"additional","affiliation":[{"name":"Graduate School, Medical School of Chinese PLA , Beijing 100048, China"},{"name":"Department of Burns and Plastic Surgery, The Fourth Medical Center of Chinese PLA General Hospital , Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zang","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, The Fourth Medical Center of Chinese PLA General Hospital , Beijing 100048, China"},{"name":"Department of General Surgery, The Fourth Medical Center of Chinese PLA General Hospital , Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Graduate School, Medical School of Chinese PLA , Beijing 100048, China"},{"name":"Department of Burns and Plastic Surgery, The Fourth Medical Center of Chinese PLA General Hospital , Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinzhu","family":"Liu","sequence":"additional","affiliation":[{"name":"Graduate School, Medical School of Chinese PLA , Beijing 100048, China"},{"name":"Department of Burns and Plastic Surgery, The Fourth Medical Center of Chinese PLA General Hospital , Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Graduate School, Medical School of Chinese PLA , Beijing 100048, China"},{"name":"Department of Burns and Plastic Surgery, The Fourth Medical Center of Chinese PLA General Hospital , Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachen","family":"Sun","sequence":"additional","affiliation":[{"name":"Graduate School, Medical School of Chinese PLA , Beijing 100048, China"},{"name":"Department of Burns and Plastic Surgery, The Fourth Medical Center of Chinese PLA General Hospital , Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan\u2019an","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, The Fourth Medical Center of Chinese PLA General Hospital , Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,21]]},"reference":[{"issue":"5","key":"2023083018183615800_R1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/BCR.0000000000000438","article-title":"Risk factors for acute kidney injury in patients with burn injury: a meta-analysis and systematic review","volume":"38","author":"Wu","year":"2017","journal-title":"J Burn Care Res"},{"issue":"1","key":"2023083018183615800_R2","doi-asserted-by":"crossref","DOI":"10.1186\/s13054-019-2710-4","article-title":"Acute kidney injury in burn patients admitted to the intensive care unit: a systematic review and meta-analysis","volume":"24","author":"Folkestad","year":"2020","journal-title":"Crit Care"},{"issue":"1","key":"2023083018183615800_R3","first-page":"5","article-title":"Research on the field treatment technology of trauma (burns, war) wounds shock","volume":"15","author":"Sen","year":"2020","journal-title":"Chin J Inj Repair Wound Healing"},{"issue":"003","key":"2023083018183615800_R4","first-page":"104","article-title":"Characteristics and methods of intraperitoneal rehydration in piglets. 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