{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:05:54Z","timestamp":1792368354440,"version":"4.4.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T00:00:00Z","timestamp":1657324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100012615","name":"University of Texas Health Science Center at Houston","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012615","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Chronic pain and posttraumatic stress disorder (PTSD) are prevalent comorbid conditions, particularly in Veterans; however, there are few integrated treatments for chronic pain and PTSD. Instead, interventions are typically implemented separately and may involve addictive opioids. Although there are highly effective, non-pharmacological treatments for PTSD, they are plagued by high dropout, which may be exacerbated by comorbid pain, as these PTSD treatments typically require increased activity. Importantly, a noninvasive pain treatment, tDCS (transcranial direct current stimulation) shows indications of effectiveness and may be integrated with psychological treatments, even when delivered via telehealth. This study examines the feasibility and initial efficacy of integrating home telehealth tDCS with prolonged exposure (PE), an evidence-based PTSD treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and Methods<\/jats:title>\n                  <jats:p>Thirty-nine Veterans were contacted, 31 consented to evaluation, 21 were enrolled, and 16 completed treatment and provided pre- and post-treatment data at one of two Veterans Affairs Medical Centers. Transcranial direct current stimulation sessions corresponded with PE exposure assignments, as there is theoretical reason to believe that tDCS may potentiate extinction learning featured in PE.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patients evinced significant improvement in both pain interference and PTSD symptoms and a trend toward improvement in depression symptoms. However, a significant change in pain intensity was not observed, likely because of the small sample size.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>The findings provide initial support for the feasibility of an entirely home-based, integrated treatment for comorbid PTSD and pain.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/milmed\/usac200","type":"journal-article","created":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T11:49:52Z","timestamp":1657367392000},"source":"Crossref","is-referenced-by-count":10,"title":["Management of Chronic Pain and PTSD in Veterans With tDCS+Prolonged Exposure: A Pilot Study"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0732-1248","authenticated-orcid":false,"given":"Melba A","family":"Hernandez-Tejada","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston , Houston, TX 77054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn E","family":"Cherry","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston , Houston, TX 77054, USA"},{"name":"Department of Psychological Sciences, University of Missouri, St. Louis , St. Louis, MO 63121, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila A M","family":"Rauch","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine , Atlanta, GA 30329, USA"},{"name":"Atlanta VA Healthcare System , Atlanta, GA 30329, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Acierno","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston , Houston, TX 77054, USA"},{"name":"Ralph H. Johnson VA Medical Center , Charleston, SC 29401, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel R","family":"Fries","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston , Houston, TX 77054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Muzzy","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina , Charleston, SC 29425, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen J","family":"Teng","sequence":"additional","affiliation":[{"name":"Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine , Houston, TX 77030, USA"},{"name":"Michael E. 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