{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T22:45:12Z","timestamp":1792881912405,"version":"4.5.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"3-4","funder":[{"DOI":"10.13039\/100007188","name":"Uniformed Services University of the Health Sciences","doi-asserted-by":"publisher","award":["HU0001-11-1-0004"],"award-info":[{"award-number":["HU0001-11-1-0004"]}],"id":[{"id":"10.13039\/100007188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007188","name":"Uniformed Services University of the Health Sciences","doi-asserted-by":"publisher","award":["HU0001-15-2-0003"],"award-info":[{"award-number":["HU0001-15-2-0003"]}],"id":[{"id":"10.13039\/100007188","id-type":"DOI","asserted-by":"publisher"}]},{"name":"DoD-VA Extremity Trauma and Amputation Center of Excellence","award":["HU0001-20-2-0038"],"award-info":[{"award-number":["HU0001-20-2-0038"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,27]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Knee osteoarthritis (KOA) is a primary source of long-term disability and decreased quality of life (QoL) in service members (SM) with lower limb loss (LL); however, it remains difficult to preemptively identify and mitigate the progression of KOA and KOA-related symptoms. The objective of this study was to explore a comprehensive cross-sectional evaluation, at the baseline of a prospective study, for characterizing KOA in SM with traumatic LL.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and Methods<\/jats:title>\n                  <jats:p>Thirty-eight male SM with traumatic unilateral LL (23 transtibial and 15 transfemoral), 9.5\u2009\u00b1\u20095.9\u2009years post-injury, were cross-sectionally evaluated at initial enrollment into a prospective, longitudinal study utilizing a comprehensive evaluation to characterize knee joint health, functionality, and QoL in SM with LL. Presences of medial, lateral, and\/or patellofemoral articular degeneration within the contralateral knee were identified via magnetic resonance imaging(for medically eligible SM; Kellgren\u2013Lawrence Grade [n\u2009=\u200932]; and Outerbridge classification [OC; n\u2009=\u200922]). Tri-planar trunk and pelvic motions, knee kinetics, along with temporospatial parameters, were quantified via full-body gait evaluation and inverse dynamics. Concentrations of 26 protein biomarkers of osteochondral tissue degradation and inflammatory activity were identified via serum immunoassays. Physical function, knee symptoms, and QoL were collected via several patient reported outcome measures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>KOA was identified in 12 of 32 (37.5%; KL\u2009\u2265\u20091) SM with LL; however, 16 of 22 SM presented with patellofemoral degeneration (72.7%; OC\u2009\u2265\u20091). Service members with versus without KOA had a 26% reduction in the narrowest medial tibiofemoral joint space. Biomechanically, SM with versus without KOA walked with a 24% wider stride width and with a negative correlation between peak knee adduction moments and minimal medial tibiofemoral joint space. Physiologically, SM with versus without KOA exhibited elevated concentrations of pro-inflammatory biomarker interleukin-7 (+180%), collagen breakdown markers collagen II cleavage (+44%), and lower concentrations of hyaluronic acid (\u221273%) and bone resorption biomarker N-telopeptide of Type 1 Collagen (\u221249%). Lastly, there was a negative correlation between patient-reported contralateral knee pain severity and patient-reported functionality and QoL.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>While 37.5% of SM with LL had KOA at the tibiofemoral joint (KL\u2009\u2265\u20091), 72.7% of SM had the presence of patellofemoral degeneration (OC\u2009\u2265\u20091). These findings demonstrate that the patellofemoral joint may be more susceptible to degeneration than the medial tibiofemoral compartment following traumatic LL.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/milmed\/usac203","type":"journal-article","created":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T01:57:01Z","timestamp":1657331821000},"page":"581-591","source":"Crossref","is-referenced-by-count":6,"title":["A Comprehensive, Multidisciplinary Assessment for Knee Osteoarthritis Following Traumatic Unilateral Lower Limb Loss in Service Members"],"prefix":"10.1093","volume":"189","author":[{"given":"Joseph G","family":"Wasser","sequence":"first","affiliation":[{"name":"Research and Development Section, Department of Rehabilitation, Walter Reed National Military Medical Center , Bethesda, MD 20814, USA"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine , Bethesda, MD 20817, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad D","family":"Hendershot","sequence":"additional","affiliation":[{"name":"Research and Development Section, Department of Rehabilitation, Walter Reed National Military Medical Center , Bethesda, MD 20814, USA"},{"name":"Research & Surveillance Division, DoD-VA Extremity Trauma and Amputation Center of Excellence , Bethesda, MD 20814, USA"},{"name":"Department of Rehabilitation Medicine, Uniformed Services University of the Health Sciences , Bethesda, MD 20814, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian C","family":"Acasio","sequence":"additional","affiliation":[{"name":"Research and Development Section, Department of Rehabilitation, Walter Reed National Military Medical Center , Bethesda, MD 20814, USA"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine , Bethesda, MD 20817, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L","family":"Krupenevich","sequence":"additional","affiliation":[{"name":"Research and Development Section, Department of Rehabilitation, Walter Reed National Military Medical Center , Bethesda, MD 20814, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison L","family":"Pruziner","sequence":"additional","affiliation":[{"name":"Research and Development Section, Department of Rehabilitation, Walter Reed National Military Medical Center , Bethesda, MD 20814, USA"},{"name":"Research & Surveillance Division, DoD-VA Extremity Trauma and Amputation Center of Excellence , Bethesda, MD 20814, USA"},{"name":"Department of Rehabilitation Medicine, Uniformed Services University of the Health Sciences , Bethesda, MD 20814, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross H","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, University of Maryland , College Park, MD 20742, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M","family":"Goldman","sequence":"additional","affiliation":[{"name":"Research & Surveillance Division, DoD-VA Extremity Trauma and Amputation Center of Excellence , Bethesda, MD 20814, USA"},{"name":"Department of Surgery, Uniformed Services University of the Health Sciences , Bethesda, MD 20814, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S","family":"Valerio","sequence":"additional","affiliation":[{"name":"Research & Surveillance Division, DoD-VA Extremity Trauma and Amputation Center of Excellence , Bethesda, MD 20814, USA"},{"name":"Department of Surgery, Uniformed Services University of the Health Sciences , Bethesda, MD 20814, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lien T","family":"Senchak","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Walter Reed National Military Medical Center , Bethesda, MD 20814, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D","family":"Murphey","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Walter Reed National Military Medical Center , Bethesda, MD 20814, USA"},{"name":"American Institute for Radiologic Pathology , Silver Spring, MD 20910, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Heltzel","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Walter Reed National Military Medical Center , Bethesda, MD 20814, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G","family":"Fazio","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Walter Reed National Military Medical Center , Bethesda, MD 20814, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L","family":"Dearth","sequence":"additional","affiliation":[{"name":"Research & Surveillance Division, DoD-VA Extremity Trauma and Amputation Center of Excellence , Bethesda, MD 20814, USA"},{"name":"Department of Surgery, Uniformed Services University of the Health Sciences , Bethesda, MD 20814, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson A","family":"Hager","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Uniformed Services University of the Health Sciences , Bethesda, MD 20814, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,7,9]]},"reference":[{"issue":"7","key":"2024022721544266500_R1","first-page":"10","article-title":"Major deployment-related amputations of lower and upper limbs, active and reserve components, U.S. Armed Forces, 2001-2017","volume":"25","author":"Farrokhi","year":"2018","journal-title":"MSMR"},{"issue":"3","key":"2024022721544266500_R2","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.jvs.2016.04.052","article-title":"Contemporary outcomes of civilian lower extremity arterial trauma","volume":"64","author":"Liang","year":"2016","journal-title":"J Vasc Surg"},{"issue":"5","key":"2024022721544266500_R3","doi-asserted-by":"crossref","first-page":"e1619","DOI":"10.7205\/MILMED-D-16-00328","article-title":"Psychological and physical health in military amputees during rehabilitation: secondary analysis of a randomized controlled trial","volume":"182","author":"Talbot","year":"2017","journal-title":"Mil Med"},{"issue":"Suppl 1","key":"2024022721544266500_R4","doi-asserted-by":"crossref","first-page":"S64","DOI":"10.5435\/JAAOS-20-08-S64","article-title":"Posttraumatic osteoarthritis caused by battlefield injuries: the primary source of disability in warriors","volume":"20","author":"Rivera","year":"2012","journal-title":"J Am Acad Orthop Surg"},{"issue":"3","key":"2024022721544266500_R5","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.apmr.2004.04.034","article-title":"The prevalence of knee pain and symptomatic knee osteoarthritis among veteran traumatic amputees and nonamputees","volume":"86","author":"Norvell","year":"2005","journal-title":"Arch Phys Med Rehabil"},{"issue":"1","key":"2024022721544266500_R6","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1682\/JRRD.2006.11.0147","article-title":"Review of secondary physical conditions associated with lower-limb amputation and long-term prosthesis use","volume":"45","author":"Gailey","year":"2008","journal-title":"J Rehabil Res Dev"},{"issue":"5","key":"2024022721544266500_R7","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/BF03327364","article-title":"Osteoarthritis and osteoporosis: clinical and research evidence of inverse relationship","volume":"15","author":"Dequeker","year":"2003","journal-title":"Aging Clin Exp Res"},{"issue":"4","key":"2024022721544266500_R8","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/00007632-199104000-00009","article-title":"Disc degeneration and associated abnormalities of the spine in elite gymnasts. A magnetic resonance imaging study","volume":"16","author":"Sw\u00e4rd","year":"1991","journal-title":"Spine"},{"issue":"5","key":"2024022721544266500_R9","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1007\/s00296-010-1749-y","article-title":"Pattern of joint damage in persons with knee osteoarthritis and concomitant ACL tears","volume":"32","author":"Stein","year":"2012","journal-title":"Rheumatol Int"},{"key":"2024022721544266500_R10","article-title":"Osteoarthritis (OA) | Basics | Arthritis | CDC","year":"2019"},{"issue":"5 Suppl","key":"2024022721544266500_R11","first-page":"S3","article-title":"The pathophysiology of osteoarthritis: a mechanical perspective on the knee joint","volume":"4","author":"Vincent","year":"2012","journal-title":"PM R"},{"key":"2024022721544266500_R12","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1097\/01.blo.0000197079.26600.09","article-title":"Rotational changes at the knee after ACL injury cause cartilage thinning","volume":"442","author":"Andriacchi","year":"2006","journal-title":"Clin Orthop"},{"issue":"2","key":"2024022721544266500_R13","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0966-6362(02)00066-8","article-title":"Adjustments in gait symmetry with walking speed in trans-femoral and trans-tibial amputees","volume":"17","author":"Nolan","year":"2003","journal-title":"Gait Posture"},{"key":"2024022721544266500_R14","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5190816","article-title":"Relationship between asymmetry of gait and muscle torque in patients after unilateral transfemoral amputation","volume":"2018","author":"Rutkowska-Kucharska","year":"2018","journal-title":"Appl Bionics Biomech"},{"key":"2024022721544266500_R15","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.gaitpost.2019.06.012","article-title":"Trunk flexion during walking in people with knee osteoarthritis","volume":"72","author":"Preece","year":"2019","journal-title":"Gait Posture"},{"issue":"5 Suppl","key":"2024022721544266500_R16","first-page":"S20","article-title":"Osteoarthritis in the disabled population: a mechanical perspective","volume":"4","author":"Morgenroth","year":"2012","journal-title":"PM R"},{"key":"2024022721544266500_R17","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.gaitpost.2018.04.040","article-title":"Knee adduction moment peak and impulse do not change during the first six months of walking with a prosthesis","volume":"63","author":"Krupenevich","year":"2018","journal-title":"Gait Posture"},{"key":"2024022721544266500_R18","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.2960","article-title":"Medial knee joint contact force in the intact limb during walking in recently ambulatory service members with unilateral limb loss: a cross-sectional study","volume":"5","author":"Miller","year":"2017","journal-title":"PeerJ"},{"issue":"3","key":"2024022721544266500_R19","doi-asserted-by":"crossref","first-page":"324","DOI":"10.2522\/ptj.20150025","article-title":"Clinical tests of standing balance in the knee osteoarthritis population: systematic review and meta-analysis","volume":"96","author":"Hatfield","year":"2016","journal-title":"Phys Ther"},{"issue":"11","key":"2024022721544266500_R20","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/j.joca.2014.08.009","article-title":"Baseline knee adduction and flexion moments during walking are both associated with 5 year cartilage changes in patients with medial knee osteoarthritis","volume":"22","author":"Chehab","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"issue":"9","key":"2024022721544266500_R21","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1002\/acr.22822","article-title":"Comparison of gait characteristics between patients with nontraumatic and posttraumatic medial knee osteoarthritis","volume":"68","author":"Robbins","year":"2016","journal-title":"Arthritis Care Res"},{"issue":"1","key":"2024022721544266500_R22","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.joca.2012.09.012","article-title":"Osteoarthritis as a disease of mechanics","volume":"21","author":"Felson","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"2024022721544266500_R23","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.joca.2012.11.012","article-title":"Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)","volume":"21","author":"Berenbaum","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"issue":"4","key":"2024022721544266500_R24","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/00003677-200510000-00008","article-title":"The role of mechanical loading in the onset and progression of osteoarthritis","volume":"33","author":"Griffin","year":"2005","journal-title":"Exerc Sport Sci Rev"},{"issue":"2","key":"2024022721544266500_R25","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.bone.2012.04.001","article-title":"Biological markers in osteoarthritis","volume":"51","author":"Rousseau","year":"2012","journal-title":"Bone"},{"key":"2024022721544266500_R26","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/561459","article-title":"The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis","volume":"2014","author":"Wojdasiewicz","year":"2014","journal-title":"Mediators Inflamm"},{"issue":"6","key":"2024022721544266500_R27","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1007\/s00167-016-4068-3","article-title":"Early osteoarthritis of the knee","volume":"24","author":"Madry","year":"2016","journal-title":"Knee Surg Sports Traumatol Arthrosc Off J ESSKA"},{"issue":"2","key":"2024022721544266500_R28","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/TA.0000000000002999","article-title":"Time to weigh in on obesity and associated comorbidities in combat-wounded amputees","volume":"90","author":"Tavares","year":"2021","journal-title":"J Trauma Acute Care Surg"},{"issue":"3","key":"2024022721544266500_R29","doi-asserted-by":"crossref","DOI":"10.1097\/BOT.0000000000001921","article-title":"Pain, depression, and posttraumatic stress disorder following major extremity trauma among United States Military serving in Iraq and Afghanistan: results from the Military Extremity Trauma and Amputation\/Limb Salvage Study","volume":"35","author":"Castillo","year":"2021","journal-title":"J Orthop Trauma"},{"issue":"3","key":"2024022721544266500_R30","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOSGlobal-D-17-00088","article-title":"Validation of digital visual analog scale pain scoring with a traditional paper-based visual analog scale in adults","volume":"2","author":"Delgado","year":"2018","journal-title":"J Am Acad Orthop Surg Glob Res Rev"},{"key":"2024022721544266500_R31","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-1-64","article-title":"The Knee injury and Osteoarthritis Outcome Score (KOOS): from joint injury to osteoarthritis","volume":"1","author":"Roos","year":"2003","journal-title":"Health Qual Life Outcomes"},{"issue":"2","key":"2024022721544266500_R32","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0167-6296(01)00130-8","article-title":"The estimation of a preference-based measure of health from the SF-36","volume":"21","author":"Brazier","year":"2002","journal-title":"J Health Econ"},{"key":"2024022721544266500_R33","article-title":"Instrument: PROMIS pain interference - Short Form 6b v1.0","author":"NIDA CTN Common Data Elements"},{"issue":"10","key":"2024022721544266500_R34","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.joca.2007.03.020","article-title":"Patella malalignment, pain and patellofemoral progression: The Health ABC Study","volume":"15","author":"Hunter","year":"2007","journal-title":"Osteoarthr Cartil OARS Osteoarthr Res Soc"},{"key":"2024022721544266500_R35","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4396139","article-title":"Evaluation of the effect of the sulcus angle and lateral to medial facet ratio of the patellar groove on patella tracking in aging subjects with stable knee joint","volume":"2018","author":"Qin","year":"2018","journal-title":"BioMed Res Int"},{"issue":"4","key":"2024022721544266500_R36","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.joca.2009.12.004","article-title":"What should be considered in using standard knee radiographs to estimate mechanical alignment of the knee?","volume":"18","author":"Chang","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"2024022721544266500_R37","article-title":"Assessment of the radioanatomic positioning of the osteoarthritic knee in serial radiographs: comparison of three acquisition techniques","author":"PubMed \u2013 NCBI"},{"issue":"3","key":"2024022721544266500_R38","first-page":"197","article-title":"Abnormal patella height based on Insall-Salvati ratio and its correlation with patellar cartilage lesions: an extremity-dedicated low-field magnetic resonance imaging analysis of 1703 Chinese cases","volume":"105","author":"Lu","year":"2016","journal-title":"Scand J Surg SJS Off Organ Finn Surg Soc Scand Surg Soc"},{"key":"2024022721544266500_R39","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.clinbiomech.2019.11.009","article-title":"Relationships between mediolateral trunk-pelvic motion, hip strength, and knee joint moments during gait among persons with lower limb amputation","volume":"71","author":"Butowicz","year":"2020","journal-title":"Clin Biomech"},{"issue":"1","key":"2024022721544266500_R40","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.joca.2009.08.010","article-title":"Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis","volume":"18","author":"Blagojevic","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"2024022721544266500_R41","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen","year":"1988","edition":"2nd"},{"issue":"10","key":"2024022721544266500_R42","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/s00256-008-0530-8","article-title":"Radiographic joint space narrowing in osteoarthritis of the knee: relationship to meniscal tears and duration of pain","volume":"37","author":"Chan","year":"2008","journal-title":"Skeletal Radiol"},{"issue":"1","key":"2024022721544266500_R43","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/art.21534","article-title":"Associations between pain, function, and radiographic features in osteoarthritis of the knee","volume":"54","author":"Szebenyi","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"6","key":"2024022721544266500_R44","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.clinbiomech.2014.04.008","article-title":"The relationship between knee joint loading rate during walking and degenerative changes on magnetic resonance imaging","volume":"29","author":"Morgenroth","year":"2014","journal-title":"Clin Biomech Bristol Avon"},{"issue":"3","key":"2024022721544266500_R45","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.apmr.2008.08.220","article-title":"The prevalence of osteoarthritis of the intact hip and knee among traumatic leg amputees","volume":"90","author":"Struyf","year":"2009","journal-title":"Arch Phys Med Rehabil"},{"issue":"5","key":"2024022721544266500_R46","doi-asserted-by":"crossref","DOI":"10.1186\/ar2314","article-title":"Cartilage markers and their association with cartilage loss on magnetic resonance imaging in knee osteoarthritis: the Boston Osteoarthritis Knee Study","volume":"9","author":"Hunter","year":"2007","journal-title":"Arthritis Res Ther"},{"key":"2024022721544266500_R47","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0793-0","article-title":"Serum hyaluronic acid concentration predicts the progression of joint space narrowing in normal knees and established knee osteoarthritis \u2013 a five-year prospective cohort study","volume":"2015","author":"Sasaki","year":"2015","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"2024022721544266500_R48","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/art.21527","article-title":"Association of higher levels of serum cartilage oligomeric matrix protein and N-telopeptide crosslinks with the development of radiographic hip osteoarthritis in elderly women","volume":"54","author":"Kelman","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"7","key":"2024022721544266500_R49","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1053\/joca.2002.0797","article-title":"Increased knee joint loads during walking are present in subjects with knee osteoarthritis","volume":"10","author":"Baliunas","year":"2002","journal-title":"Osteoarthritis Cartilage"},{"issue":"4","key":"2024022721544266500_R50","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/acr.20033","article-title":"Gait changes in patients with knee osteoarthritis are replicated by experimental knee pain","volume":"62","author":"Henriksen","year":"2010","journal-title":"Arthritis Care Res"},{"issue":"7","key":"2024022721544266500_R51","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1136\/ard.61.7.617","article-title":"Dynamic load at baseline can predict radiographic disease progression in medial compartment knee osteoarthritis","volume":"61","author":"Miyazaki","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"2024022721544266500_R52","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7603249","article-title":"The relationship between knee adduction moment and knee osteoarthritis symptoms according to static alignment and pelvic drop","volume":"2019","author":"Nie","year":"2019","journal-title":"BioMed Res Int"},{"issue":"9","key":"2024022721544266500_R53","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1016\/j.joca.2016.04.006","article-title":"Associations between patellofemoral joint cartilage T1\u03c1 and T2 and knee flexion moment and impulse during gait in individuals with and without patellofemoral joint osteoarthritis","volume":"24","author":"Teng","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"2024022721544266500_R54","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/jor.1100090114","article-title":"Interaction between active and passive knee stabilizers during level walking","volume":"9","author":"Schipplein","year":"1991","journal-title":"J Orthop Res Off Publ Orthop Res Soc"},{"issue":"8","key":"2024022721544266500_R55","first-page":"1509","article-title":"Mitigating the effect of pain severity on activity and disability in patients with chronic pain: the crucial context of acceptance","volume":"20","author":"Kanzler","year":"2019","journal-title":"Pain Med Off J Am Acad Pain Med"},{"issue":"8","key":"2024022721544266500_R56","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1136\/ard.2010.147520","article-title":"Impact of different descriptions of the Kellgren and Lawrence classification criteria on the diagnosis of knee osteoarthritis","volume":"70","author":"Schiphof","year":"2011","journal-title":"Ann Rheum Dis"},{"issue":"11","key":"2024022721544266500_R57","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1002\/art.1780341106","article-title":"Radiographic grading of the severity of knee osteoarthritis: relation of the Kellgren and Lawrence grade to a grade based on joint space narrowing, and correlation with arthroscopic evidence of articular cartilage degeneration","volume":"34","author":"Brandt","year":"1991","journal-title":"Arthritis Rheum"},{"issue":"7","key":"2024022721544266500_R58","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1002\/acr.24008","article-title":"Comorbidities in osteoarthritis: a systematic review and meta-analysis of observational studies","volume":"72","author":"Swain","year":"2020","journal-title":"Arthritis Care Res"}],"container-title":["Military Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/milmed\/article-pdf\/189\/3-4\/581\/56773463\/usac203.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/milmed\/article-pdf\/189\/3-4\/581\/56773463\/usac203.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T22:46:42Z","timestamp":1709074002000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/milmed\/article\/189\/3-4\/581\/6634270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,9]]},"references-count":58,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2022,7,9]]},"published-print":{"date-parts":[[2024,2,27]]}},"URL":"https:\/\/doi.org\/10.1093\/milmed\/usac203","relation":{},"ISSN":["0026-4075","1930-613X"],"issn-type":[{"value":"0026-4075","type":"print"},{"value":"1930-613X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,3,1]]},"published":{"date-parts":[[2022,7,9]]}}}