{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T11:22:40Z","timestamp":1775474560977,"version":"3.50.1"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"11-12","license":[{"start":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T00:00:00Z","timestamp":1670025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Iatrogenic calcinosis cutis represents a subset of calcinosis cutis resulting secondary to treatments or procedures. We present the first report of calcinosis cutis resulting from the intraosseous infusion and one of a few cases with associated transepidermal elimination. A previously healthy 2-year-old female presented with a new-onset unilateral shin rash 1 week following hospitalization for a near-drowning event. A dermatologic exam revealed multiple small, tender, firm, chalky-white papules with surrounding erythema, in addition to two erythematous macules superior and medial to the papular lesions, corresponding to prior intraosseous access sites. The rash persisted despite trials of topical mupirocin and acyclovir cream, prompting a referral to a dermatologist. An excisional biopsy was performed, revealing circumscribed dermal deposits of acellular basophilic material connected to the overlying epidermis through an invaginated keratin plug. A von Kossa silver stain highlighted the deposits, confirming the diagnosis of perforating calcinosis cutis. The lesions did not recur following the excisional biopsy. Iatrogenic calcinosis cutis may be seen as a complication of the infusion of calcium-containing fluids via intraosseous access, in addition to the more commonly observed peripheral intravenous access. Awareness of this disorder is important in order to distinguish it from an infectious mimic and guide the selection of therapy.<\/jats:p>","DOI":"10.1093\/milmed\/usac385","type":"journal-article","created":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T07:53:17Z","timestamp":1670053997000},"page":"e3703-e3706","source":"Crossref","is-referenced-by-count":2,"title":["Perforating Calcinosis Cutis as a Complication of Intraosseous Fluid Infusion in the Setting of a Near-Drowning Event"],"prefix":"10.1093","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8649-5259","authenticated-orcid":false,"given":"Lisa M","family":"Marinelli","sequence":"first","affiliation":[{"name":"Department of Pathology and Area Laboratory Service, Brooke Army Medical Center , Ft Sam Houston, TX 78234, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia M","family":"Arballo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Blanchfield Army Community Hospital , Fort Campbell, KY 42223, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giselle","family":"Guerrero","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, UT Health San Antonio , San Antonio, TX 78229, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8293-1217","authenticated-orcid":false,"given":"Wendi E","family":"Wohltmann","sequence":"additional","affiliation":[{"name":"Departments of Dermatology and Pathology, Brooke Army Medical Center , Ft Sam Houston, TX 78234, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,12,3]]},"reference":[{"issue":"3","key":"2023110723484741300_R1","doi-asserted-by":"publisher","first-page":"166","DOI":"10.4103\/0970-9371.177146","article-title":"Iatrogenic calcinosis cutis: a rare cytological diagnosis","volume":"33","author":"Sawke","year":"2016","journal-title":"J Cytol"},{"issue":"Suppl 2","key":"2023110723484741300_R2","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1111\/j.1600-0560.2006.00519.x","article-title":"Calcinosis cutis: a complication of intravenous administration of calcium glucanate","volume":"33","author":"Moss","year":"2006","journal-title":"J Cutan Pathol"},{"issue":"8","key":"2023110723484741300_R3","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.9712","article-title":"Severe iatrogenic calcinosis cutis from extravasated calcium gluconate","volume":"12","author":"Rumancik","year":"2020","journal-title":"Cureus"},{"issue":"2","key":"2023110723484741300_R4","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1177\/230949900501300218","article-title":"Iatrogenic calcinosis cutis\u2014a rare differential diagnosis of soft-tissue infection in a neonate: a case report","volume":"13","author":"Arora","year":"2005","journal-title":"J Orthop Surg (Hong Kong)"},{"issue":"6","key":"2023110723484741300_R5","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1542\/peds.55.6.802","article-title":"Subcutaneous calcium deposition in the neonate associated with intravenous administration of calcium gluconate","volume":"55","author":"Ramamurthy","year":"1975","journal-title":"Pediatrics"},{"issue":"4","key":"2023110723484741300_R6","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/BF02012558","article-title":"Initiation and inhibition of subcutaneous calcification","volume":"10","author":"Leonard","year":"1972","journal-title":"Calcif Tissue Res"},{"issue":"2","key":"2023110723484741300_R7","doi-asserted-by":"publisher","first-page":"162","DOI":"10.5021\/ad.2014.26.2.162","article-title":"A clinicopathologic study of thirty cases of acquired perforating dermatosis in Korea","volume":"26","author":"Kim","year":"2014","journal-title":"Ann Dermatol"},{"issue":"1","key":"2023110723484741300_R8","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.1.97-b","article-title":"Perforating papules in chronic renal failure. 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