{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T20:03:39Z","timestamp":1778529819180,"version":"3.51.4"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"7-8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,22]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Coronavirus disease 2019 (COVID-19) infection is characterized by a dysregulated inflammatory response, which may result in severe hemodynamic instability and septic shock. The Seraph-100\u00ae Microbind\u00ae Affinity Blood Filter is a commercially available extracorporeal pathogen absorbent device with the ability to bind pathogens and cytokines present within the blood. Our study aimed to evaluate the efficacy of the Seraph-100\u00ae for patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and septic shock.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and Methods<\/jats:title>\n                  <jats:p>A retrospective review was performed to evaluate the use of the Seraph-100\u00ae blood filter at a Single Center tertiary-care facility at Brooke Army Medical Center from 2020 to 2021. Nine patients (11 treatments) were completed with the Seraph-100\u00ae blood filter in patients with SARS-CoV-2 infection and septic shock. The Seraph-100\u00ae blood filter was used in combination with continuous renal replacement therapy and slow low-efficiency dialysis or directly in parallel with the extracorporeal membrane oxygenation circuit.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Within this cohort, there was a statistically significant improvement in the following clinical parameters comparing values to before and after treatment with the Seraph-100\u00ae blood filter: Mean arterial pressure (mmHg) (64.2\u2009\u00b1\u20092.36 vs. 76.2\u2009\u00b1\u20092.68; P\u2009&amp;lt;\u2009.001), heart rate (beats per minute) (128\u2009\u00b1\u20096.6 vs. 100.3\u2009\u00b1\u20096.07; P\u2009&amp;lt;\u2009.001), administered fraction of oxygen (%) (74.4\u2009\u00b1\u200910.58 vs. 60.3\u2009\u00b1\u200910.35; P\u2009&amp;lt;\u2009.001), serum lactate (mmol\/L) (6.14\u2009\u00b1\u20091.25 vs. 2.8\u2009\u00b1\u20091.14; P\u2009=\u2009.0095), and pH (7.29\u2009\u00b1\u20090.03 vs. 7.39\u2009\u00b1\u20090.04; P\u2009=\u2009.0203). There were statistically significant improvements in vasopressor requirements: norepinephrine (mcg\/min) (36.3\u2009\u00b1\u20094.74 vs. 8.3\u2009\u00b1\u20093.92; P\u2009&amp;lt;\u2009.001), vasopressin (units\/min) (0.04\u2009\u00b1\u20090.004 vs. 0.02\u2009\u00b1\u20090.003; P\u2009&amp;lt;\u2009.001), dobutamine (mcg\/kg\/min) (2.3\u2009\u00b1\u20091.00 vs. 0.2\u2009\u00b1\u20090.75; P\u2009=\u2009.006) and angiotensin II (ng\/kg\/min) (34.5\u2009\u00b1\u20096.4 vs. 3.3\u2009\u00b1\u20095.26; P\u2009&amp;lt;\u2009.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The use of the Seraph-100\u00ae blood filter was associated with statistically and clinically significant improvements in hemodynamic parameters and decreased vasopressor requirements in patients with septic shock and SARS-CoV-2 infection.<\/jats:p>\n               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