{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T04:47:03Z","timestamp":1773377223075,"version":"3.50.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"Supplement_6","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>The primary purpose of this study was to examine the prevalence and percent agreement of clinician-identified mild traumatic brain injury (mTBI) clinical profiles and cutoff scores for selected Federal Interagency Traumatic Brain Injury Research common data elements (CDEs). A secondary purpose was to investigate the predictive value of established CDE assessments in determining clinical profiles in adults with mTBI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and Methods<\/jats:title>\n                  <jats:p>Seventy-one (23 males; 48 females) participants (M\u2009=\u200929.00, SD\u2009=\u20097.60, range 18-48\u2009years) within 1-5\u2009months (M\u2009=\u200924.20, SD\u2009=\u200925.30, range 8-154\u2009days) of mTBI completed a clinical interview\/exam and a multidomain assessment conducted by a licensed clinician with specialized training in concussion, and this information was used to identify mTBI clinical profile(s). A researcher administered CDE assessments to all participants, and scores exceeding CDE cutoffs were used to identify an mTBI clinical profile. The clinician- and CDE-identified clinical profiles were submitted to a multidisciplinary team for adjudication. The prevalence and percent agreement between clinician- and CDE-identified clinical profiles was documented, and a series of logistic regressions with adjusted odds ratios were performed to identify which CDE assessments best predicted clinician-identified mTBI clinical profiles.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Migraine\/headache, vestibular, and anxiety\/mood mTBI clinical profiles exhibited the highest prevalence and overall percent agreement among CDE and clinician approaches. Participants exceeding cutoff scores for the Global Severity Index and Headache Impact Test-6 assessments were 3.90 and 8.81 times more likely to have anxiety\/mood and migraine\/headache profiles, respectively. The Vestibular\/Ocular Motor Screening vestibular items and the Pittsburgh Sleep Quality Index total score were predictive of clinician-identified vestibular and sleep profiles, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The CDEs from migraine\/headache, vestibular, and anxiety\/mood domains, and to a lesser extent the sleep modifier, may be clinically useful for identifying patients with these profiles following mTBI. However, CDEs for cognitive and ocular may have more limited clinical value for identifying mTBI profiles.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/milmed\/usad149","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T15:06:08Z","timestamp":1699628768000},"page":"354-362","source":"Crossref","is-referenced-by-count":3,"title":["A Common Data Element\u2013Based Adjudication Process for mTBI Clinical Profiles: A Targeted Multidomain Clinical Trial Preliminary Study"],"prefix":"10.1093","volume":"188","author":[{"given":"Kori J","family":"Durfee","sequence":"first","affiliation":[{"name":"Office for Sport Concussion Research, University of Arkansas , Fayetteville, AR 72701, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9144-2119","authenticated-orcid":false,"given":"R J","family":"Elbin","sequence":"additional","affiliation":[{"name":"Office for Sport Concussion Research, University of Arkansas , Fayetteville, AR 72701, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia M","family":"Trbovich","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, UPMC Sports Medicine Concussion Program , Pittsburgh, PA 15260, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa N","family":"Womble","sequence":"additional","affiliation":[{"name":"Inova Sports Medicine Concussion Program , Fairfax, VA 22031, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Mucha","sequence":"additional","affiliation":[{"name":"UPMC Rehabilitation Institute , Pittsburgh, PA 15203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4590-8122","authenticated-orcid":false,"given":"Katie","family":"Stephenson","sequence":"additional","affiliation":[{"name":"College of Osteopathic Medicine, University of New England , Biddeford, ME 04005, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyndi L","family":"Holland","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, UPMC Sports Medicine Concussion Program , Pittsburgh, PA 15260, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina M","family":"Dollar","sequence":"additional","affiliation":[{"name":"Inova Sports Medicine Concussion Program , Fairfax, VA 22031, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick J","family":"Sparto","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, University of Pittsburgh , Pittsburgh, PA 15260, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael W","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, UPMC Sports Medicine Concussion Program , Pittsburgh, PA 15260, USA"},{"name":"Department of Orthopaedic Surgery, University of Pittsburgh , Pittsburgh, PA 15260, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony P","family":"Kontos","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, UPMC Sports Medicine Concussion Program , Pittsburgh, PA 15260, USA"},{"name":"Department of Orthopaedic Surgery, University of Pittsburgh , Pittsburgh, PA 15260, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,11,8]]},"reference":[{"issue":"2","key":"2023111015060046500_R1","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s00167-013-2791-6","article-title":"A comprehensive, targeted approach to the clinical care of athletes following sport-related concussion","volume":"22","author":"Collins","year":"2014","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"6","key":"2023111015060046500_R2","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1227\/NEU.0000000000001447","article-title":"Statements of agreement from the Targeted Evaluation and Active Management (TEAM) approaches to treating concussion meeting held in Pittsburgh","volume":"79","author":"Collins","year":"2016","journal-title":"Neurosurgery"},{"issue":"3","key":"2023111015060046500_R3","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1249\/JSR.0000000000000573","article-title":"Sport-related concussion clinical profiles: clinical characteristics, targeted treatments, and preliminary evidence","volume":"18","author":"Kontos","year":"2019","journal-title":"Curr Sports Med Rep"},{"issue":"1","key":"2023111015060046500_R4","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1093\/neuros\/nyz332","article-title":"Concussion guidelines step 2: evidence for subtype classification","volume":"86","author":"Lumba-Brown","year":"2020","journal-title":"Neurosurgery"},{"issue":"23","key":"2023111015060046500_R5","doi-asserted-by":"publisher","first-page":"2776","DOI":"10.1089\/neu.2018.5643","article-title":"National Institute of Neurological Disorders and Stroke and Department of Defense Sport-Related Concussion Common Data Elements Version 1.0 Recommendations","volume":"35","author":"Broglio","year":"2018","journal-title":"J Neurotrauma"},{"issue":"1","key":"2023111015060046500_R6","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1177\/1740774507087972","article-title":"Do we need to adjudicate major clinical events?","volume":"5","author":"Granger","year":"2008","journal-title":"Clin Trials"},{"issue":"3","key":"2023111015060046500_R7","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1177\/1740774509105223","article-title":"Evaluating the benefit of event adjudication of cardiovascular outcomes in large simple RCTs","volume":"6","author":"Pogue","year":"2009","journal-title":"Clin Trials"},{"issue":"2","key":"2023111015060046500_R8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055807","article-title":"Effects of the endpoint adjudication process on the results of a randomised controlled trial: the ADVANCE trial","volume":"8","author":"Hata","year":"2013","journal-title":"PLoS One"},{"issue":"Suppl 1","key":"2023111015060046500_R9","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1093\/milmed\/usx172","article-title":"Preliminary evidence for improvement in symptoms, cognitive, vestibular, and oculomotor outcomes following targeted intervention with chronic mTBI patients","volume":"183","author":"Kontos","year":"2018","journal-title":"Mil Med"},{"issue":"10","key":"2023111015060046500_R10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001744","article-title":"Critical appraisal and data extraction for systematic reviews of prediction modelling studies: the CHARMS checklist","volume":"11","author":"Moons","year":"2014","journal-title":"PLoS Med"},{"issue":"10","key":"2023111015060046500_R11","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1177\/0363546512455400","article-title":"A revised factor structure for the Post-concussion Symptom Scale: baseline and postconcussion factors","volume":"40","author":"Kontos","year":"2012","journal-title":"Am J Sports Med"},{"issue":"11","key":"2023111015060046500_R12","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1001\/jamapediatrics.2021.2782","article-title":"Effect of screen time on recovery from concussion: a randomized clinical trial","volume":"175","author":"Macnow","year":"2021","journal-title":"JAMA Pediatr"},{"issue":"1","key":"2023111015060046500_R13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40621-015-0045-4","article-title":"Epidemiology of sports-related concussion in seven US high school and collegiate sports","volume":"2","author":"Marshall","year":"2015","journal-title":"Inj Epidemiol"},{"key":"2023111015060046500_R14","doi-asserted-by":"publisher","DOI":"10.1167\/jov.21.13.11","article-title":"Fixational eye movements following concussion","volume":"21","author":"Leonard","year":"2021","journal-title":"Journal of Vision"},{"issue":"2","key":"2023111015060046500_R15","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","article-title":"The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research","volume":"28","author":"Buysse","year":"1989","journal-title":"Psychiatry Res"},{"issue":"8","key":"2023111015060046500_R16","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1023\/A:1026119331193","article-title":"A six-item short-form survey for measuring headache impact: the HIT-6TM","volume":"12","author":"Kosinski","year":"2003","journal-title":"Qual Life Res"},{"issue":"3","key":"2023111015060046500_R17","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1212\/01.WNL.0000078940.53438.83","article-title":"A self-administered screener for migraine in primary care: the ID MigraineTM validation study","volume":"61","author":"Lipton","year":"2003","journal-title":"Neurology"},{"issue":"10","key":"2023111015060046500_R18","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.4236\/psych.2022.1310097","article-title":"Psychometrics of the Brief Symptom Inventory in university-enrolled emerging adults: factor structure and clinical caseness cutoff","volume":"13","author":"Pashak","year":"2022","journal-title":"Psychology"},{"issue":"10","key":"2023111015060046500_R19","doi-asserted-by":"publisher","first-page":"2479","DOI":"10.1177\/0363546514543775","article-title":"A Brief Vestibular\/Ocular Motor Screening (VOMS) assessment to evaluate concussions: preliminary findings","volume":"42","author":"Mucha","year":"2014","journal-title":"Am J Sports Med"},{"issue":"19","key":"2023111015060046500_R20","doi-asserted-by":"publisher","first-page":"2556","DOI":"10.1001\/jama.290.19.2556","article-title":"Acute effects and recovery time following concussion in collegiate football players: the NCAA concussion study","volume":"290","author":"McCrea","year":"2003","journal-title":"JAMA"},{"issue":"2","key":"2023111015060046500_R21","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1177\/03635465030310020301","article-title":"Relationship between postconcussion headache and neuropsychological test performance in high school athletes","volume":"31","author":"Collins","year":"2003","journal-title":"Am J Sports Med"},{"issue":"2","key":"2023111015060046500_R22","doi-asserted-by":"publisher","first-page":"207","DOI":"10.3109\/02699052.2014.965213","article-title":"Sports concussion headache","volume":"29","author":"Zasler","year":"2015","journal-title":"Brain Inj"},{"key":"2023111015060046500_R23","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-020-00870-y","article-title":"Utilizing the biopsychosocial model in concussion treatment: post-traumatic headache and beyond","volume":"24","author":"Register-Mihalik","year":"2020","journal-title":"Curr Pain Headache Rep"},{"issue":"5","key":"2023111015060046500_R24","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1093\/arclin\/act024","article-title":"Individual and combined effects of LD and ADHD on computerized neurocognitive concussion test performance: evidence for separate norms","volume":"28","author":"Elbin","year":"2013","journal-title":"Arch Clin Neuropsychol"},{"issue":"2","key":"2023111015060046500_R25","doi-asserted-by":"publisher","first-page":"165","DOI":"10.3171\/2020.2.PEDS2025","article-title":"Association of time to initial clinic visit with prolonged recovery in pediatric patients with concussion","volume":"26","author":"Eagle","year":"2020","journal-title":"J Neurosurg Pediatr"},{"issue":"22","key":"2023111015060046500_R26","doi-asserted-by":"publisher","first-page":"2691","DOI":"10.1089\/neu.2017.5486","article-title":"Prediction of persistent post-concussion symptoms after mild traumatic brain injury","volume":"35","author":"Cnossen","year":"2018","journal-title":"J Neurotrauma"},{"issue":"2","key":"2023111015060046500_R27","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1227\/01.NEU.0000279972.95060.CB","article-title":"Sex differences in neuropsychological function and post-concussion symptoms of concussed collegiate athletes","volume":"61","author":"Covassin","year":"2007","journal-title":"Neurosurgery"},{"issue":"1","key":"2023111015060046500_R28","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/S1474-4422(16)30293-9","article-title":"Sex differences in the epidemiology, clinical features, and pathophysiology of migraine","volume":"16","author":"Vetvik","year":"2017","journal-title":"Lancet Neurol"},{"issue":"2","key":"2023111015060046500_R29","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1093\/neuros\/nyz545","article-title":"Concussion Clinical Profiles Screening (CP Screen) tool: preliminary evidence to inform a multidisciplinary approach","volume":"87","author":"Kontos","year":"2020","journal-title":"Neurosurgery"},{"key":"2023111015060046500_R30","volume-title":"BSI 18: Brief Symptom Inventory 18","author":"Derogatis","year":"2001"},{"issue":"3","key":"2023111015060046500_R31","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1097\/NPT.0000000000000230","article-title":"Prospective changes in vestibular and ocular motor impairment after concussion","volume":"42","author":"Elbin","year":"2018","journal-title":"J Neurol Phys Ther"},{"issue":"1","key":"2023111015060046500_R32","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1249\/00149619-200302000-00006","article-title":"Assessment of postural stability following sport-related concussion","volume":"2","author":"Guskiewicz","year":"2003","journal-title":"Curr Sports Med Rep"},{"key":"2023111015060046500_R33","first-page":"193","volume-title":"Sports Neuropsychology: Assessment and Management of Traumatic Brain Injury","author":"Lovell","year":"2006"},{"issue":"3","key":"2023111015060046500_R34","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1177\/0333102410379890","article-title":"Validation of the Headache Impact Test (HIT-6TM) across episodic and chronic migraine","volume":"31","author":"Yang","year":"2011","journal-title":"Cephalalgia"},{"issue":"4","key":"2023111015060046500_R35","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1002\/1097-4679(199007)46:4&lt;432::AID-JCLP2270460410&gt;3.0.CO;2-0","article-title":"Assessing the validity of memory complaints: performance of brain-damaged and normal individuals on Rey\u2019s task to detect malingering","volume":"46","author":"Bernard","year":"1990","journal-title":"J Clin Psychol"}],"container-title":["Military Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/milmed\/article-pdf\/188\/Supplement_6\/354\/53077879\/usad149.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/milmed\/article-pdf\/188\/Supplement_6\/354\/53077879\/usad149.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T15:06:12Z","timestamp":1699628772000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/milmed\/article\/188\/Supplement_6\/354\/7388275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,1]]},"references-count":35,"journal-issue":{"issue":"Supplement_6","published-online":{"date-parts":[[2023,11,8]]},"published-print":{"date-parts":[[2023,11,8]]}},"URL":"https:\/\/doi.org\/10.1093\/milmed\/usad149","relation":{},"ISSN":["0026-4075","1930-613X"],"issn-type":[{"value":"0026-4075","type":"print"},{"value":"1930-613X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,11,1]]},"published":{"date-parts":[[2023,11,1]]}}}