{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:48:18Z","timestamp":1740170898415,"version":"3.37.3"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"Supplement_6","license":[{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100006977","name":"Indiana State Department of Health","doi-asserted-by":"publisher","award":["PI: BSD"],"award-info":[{"award-number":["PI: BSD"]}],"id":[{"id":"10.13039\/100006977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["SC190164"],"award-info":[{"award-number":["SC190164"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006977","name":"Indiana State Department of Health","doi-asserted-by":"publisher","award":["PI: BSD"],"award-info":[{"award-number":["PI: BSD"]}],"id":[{"id":"10.13039\/100006977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["SC190164"],"award-info":[{"award-number":["SC190164"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Rodent models are often used in spinal cord injury investigations to measure physiological parameters but require rats to be restrained during data collection to prevent motion and stress-induced artifacts.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and Methods<\/jats:title>\n                  <jats:p>A 4-week acclimation protocol was developed to reduce sympathetic activity during experimentation to collect clean data. Physiological parameters were analyzed throughout the acclimation protocol using surface-based electrodes and an implanted sensor. The sensor was used to extract systolic blood pressure, skin nerve activity, and heart rate variability parameters.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Our protocol exposed a minimal increase in sympathetic activity during experimentation despite long periods of restraint. The data suggest that the acclimation protocol presented successfully minimized changes in physiological parameters because of prolonged restraint.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This is necessary to ensure that physiological recordings are not affected by undue stress because of the process of wearing the sensor. This is important when determining the effects of stress when studying dysautonomia after spinal cord injury, Parkinson\u2019s disease, and other neurological disorders.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/milmed\/usad208","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T15:10:11Z","timestamp":1699629011000},"page":"474-479","source":"Crossref","is-referenced-by-count":2,"title":["Acclimation Protocol to Minimize Stress in\u00a0Immobilized Rats During Non-Invasive Multimodal Sensing of\u00a0the Autonomic Nervous System"],"prefix":"10.1093","volume":"188","author":[{"given":"Ana Karina","family":"Kirby","sequence":"first","affiliation":[{"name":"Weldon School of Biomedical Engineering, Purdue University Flex Lab , West Lafayette, IN 47906,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sidharth","family":"Pancholi","sequence":"additional","affiliation":[{"name":"Weldon School of Biomedical 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