{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:35:57Z","timestamp":1791387357347,"version":"4.3.3"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"Supplement_6","funder":[{"name":"Triservice Nursing Research","award":["HU00011820040"],"award-info":[{"award-number":["HU00011820040"]}]},{"name":"Triservice Nursing Research","award":["HU00011820040"],"award-info":[{"award-number":["HU00011820040"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Metabolic syndrome (MetS) is a threat to the active component military as it impacts health, readiness, retention, and cost to the Military Health System. The most prevalent risk factors documented in service members\u2019 health records are high blood pressure (BP), low high-density lipoprotein cholesterol, and elevated triglycerides. Other risk factors include abdominal obesity and elevated fasting blood glucose. Precision nutrition counseling and wellness software applications have demonstrated positive results for weight management when coupled with high levels of participant engagement and motivation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and Methods<\/jats:title>\n                  <jats:p>In this prospective randomized controlled trial, trained registered dietitians conducted nutrition counseling using results of targeted sequencing, biomarkers, and expert recommendations to reduce the risk for MetS. Upon randomization, the treatment arm initiated six weekly sessions and the control arm received educational pamphlets. An eHealth application captured diet and physical activity. Anthropometrics and BP were measured at baseline, 6 weeks, and 12\u2009weeks, and biomarkers were measured at baseline and 12\u2009weeks. The primary outcome was a change in weight at 12\u2009weeks. Statistical analysis included descriptive statistics and t-tests or analysis of variance with significance set at P\u2009&amp;lt;\u2009.05.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Overall, 138 subjects enrolled from November 2019 to February 2021 between two military bases; 107 completed the study. Demographics were as follows: 66% male, mean age 31\u2009years, 66% married, and 49% Caucasian and non-Hispanic. Weight loss was not significant between groups or sites at 12\u2009weeks. Overall, 27% of subjects met the diagnostic criteria for MetS on enrollment and 17.8% upon study completion. High deleterious variant prevalence was identified for genes with single-nucleotide polymorphisms linked to obesity (40%), cholesterol (38%), and BP (58%). Overall, 65% of subjects had low 25(OH)D upon enrollment; 45% remained insufficient at study completion. eHealth app had low adherence yet sufficient correlation with a valid reference.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Early signs of progress with weight loss at 6\u2009weeks were not sustained at 12\u2009weeks. DNA-based nutrition counseling was not efficacious for weight loss.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/milmed\/usad276","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T15:19:22Z","timestamp":1699629562000},"page":"606-613","source":"Crossref","is-referenced-by-count":6,"title":["A Randomized Controlled Trial of\u00a0Precision Nutrition Counseling for\u00a0Service Members at Risk for\u00a0Metabolic Syndrome"],"prefix":"10.1093","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0230-9952","authenticated-orcid":false,"given":"Mary S","family":"McCarthy","sequence":"first","affiliation":[{"name":"Center for Nursing Science & Clinical Inquiry, Madigan Army Medical Center , Tacoma, WA 98431, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary T","family":"Colburn","sequence":"additional","affiliation":[{"name":"Center for Nursing Science & Clinical Inquiry, Madigan Army Medical Center , 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