{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:48:48Z","timestamp":1740170928491,"version":"3.37.3"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"11-12","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Refractory osteomyelitis is typically defined as a chronic infection that persists or recurs despite definitive surgical management and antibiotic therapy. Cases often involve complex wounds or fractures and can be challenging to treat, resulting in multiple courses of broad-spectrum antibiotic therapy and numerous surgeries over periods of months to years. Adjuncts to improve resolution of these complicated infections are sorely needed. Here, we describe the case of a 47-year-old active duty military member who sustained an open right ankle fracture during a skydiving accident that was subsequently complicated by refractory osteomyelitis. The patient failed more than three courses of combined medical and surgical management over a 9-month period before undergoing adjunctive hyperbaric oxygen therapy (HBOT), ultimately resulting in resolution of the infection. Adjunctive HBOT for treatment of conditions such as refractory osteomyelitis may be an underutilized resource in part because of a general paucity of high-quality data in the literature supporting its use, as well as a relative lack of availability of this resource. Nonetheless, the overall accumulating body of evidence indicates that the use of adjunctive HBOT in select patients with refractory osteomyelitis is safe and effective and further research may be warranted given its relevance and potential impact to military populations.<\/jats:p>","DOI":"10.1093\/milmed\/usad505","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T01:55:04Z","timestamp":1704851704000},"page":"e2726-e2730","source":"Crossref","is-referenced-by-count":0,"title":["Refractory Osteomyelitis in a Military Service Member Resolved With Adjunctive Hyperbaric Oxygen Therapy"],"prefix":"10.1093","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9690-4132","authenticated-orcid":false,"given":"Jeffrey","family":"Spiro","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Naval Medical Center San Diego , San Diego, CA 92134,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Gedestad","sequence":"additional","affiliation":[{"name":"Division of General Surgery, Naval Medical Center San Diego , San Diego, CA 92134,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Wisniewski","sequence":"additional","affiliation":[{"name":"Department of Medicine, Uniformed Services University , Bethesda, MD 20814,","place":["USA"]},{"name":"2nd Medical Battalion, 2nd Marine Logistics Group, Camp Lejeune , Camp Lejeune, NC 28547,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,1,9]]},"reference":[{"issue":"1\u20132","key":"2024110620112327500_R1","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1093\/milmed\/usab022","article-title":"Alternative uses of hyperbaric oxygen therapy in military medicine: current positions and future directions","volume":"187","author":"Biggs","year":"2022","journal-title":"Mil Med"},{"key":"2024110620112327500_R2","first-page":"655","volume-title":"Mandell, Douglas, and Bennett\u2019s Principles and Practices of Infectious Diseases","author":"Sarria","year":"2020","edition":"9th"},{"issue":"6","key":"2024110620112327500_R3","first-page":"633","article-title":"Rapid analysis of hyperbaric oxygen therapy registry data for reimbursement purposes: technical communication","volume":"43","author":"Fife","year":"2016","journal-title":"Undersea Hyperb Med"},{"article-title":"Revision 7","year":"2016","author":"U.S. Navy Diving Manual","key":"2024110620112327500_R4"},{"issue":"3","key":"2024110620112327500_R5","doi-asserted-by":"publisher","first-page":"297","DOI":"10.22462\/05.06.2021.11","article-title":"Hyperbaric oxygen for refractory osteomyelitis","volume":"48","author":"Hart","year":"2021","journal-title":"Undersea Hyperb 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