{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T21:15:10Z","timestamp":1785618910499,"version":"3.56.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"7-8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Traumatic heterotopic ossification (HO) of the lower extremity is relatively rare but is of major importance in clinical practice. They are defined as posttraumatic abnormal formations of bone within soft tissue outside of the skeletal system. This article describes the clinical case of a 31-year-old male patient who suffered 2 traumatic events within 12\u2009months\u2014a gunshot wound in the lumbar spine\/gluteal region followed by a severe traumatic brain injury with intracranial hemorrhage in a traffic accident as a pedestrian. Clinically, the patient was bedridden because of complete stiffening of the lumbar spine, both hip joints, and the left knee joint. After preoperative diagnosis, 3 surgical ablations of the HO were performed on both the hip joints and the left knee joint. In addition, physiotherapeutic exercise, postoperative nonsteroidal anti-inflammatory drug administration (25\u2009mg of indomethazine for 6\u2009weeks, 3 times a day), and perioperative radiation with 7\u2009Gy for each operation were advised. After 4\u2009years of follow-up, the patient showed significant improvement. In HO treatment, prophylactic local radiotherapy (pre- and postoperative radiation with a local single dose of 7\u2009Gy) and postoperative administration of nonsteroidal anti-inflammatory drugs are often recommended. For therapeutic purposes, surgical resection is still indicated for pronounced cases.<\/jats:p>","DOI":"10.1093\/milmed\/usae109","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T09:53:34Z","timestamp":1713866014000},"page":"e1826-e1831","source":"Crossref","is-referenced-by-count":1,"title":["Fulminant Heterotopic Ossification of the Lower Extremity After Gunshot Injury and Blunt Trauma: A Case Report"],"prefix":"10.1093","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3648-388X","authenticated-orcid":false,"given":"Katharina","family":"Estel","sequence":"first","affiliation":[{"name":"Department for Traumatology and Orthopedics, Bundeswehr Hospital Berlin , 10115, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Alexander","family":"Back","sequence":"additional","affiliation":[{"name":"Department for Traumatology and Orthopedics, Bundeswehr Hospital Berlin , 10115, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina","family":"Scheuermann-Poley","sequence":"additional","affiliation":[{"name":"Department for Traumatology and Orthopedics, Bundeswehr Hospital Berlin , 10115, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Willy","sequence":"additional","affiliation":[{"name":"Department for Traumatology and Orthopedics, Bundeswehr Hospital Berlin , 10115, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"issue":"5","key":"2024070405065491400_R1","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1016\/j.ijrobp.2006.03.053","article-title":"Heterotopic ossification: pathophysiology, clinical features, and the role of radiotherapy for prophylaxis","volume":"65","author":"Balboni","year":"2006","journal-title":"Int J Radiat Oncol Biol 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